LOCUS       NM_030718               1761 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus ABO, alpha 1-3-N-acetylgalactosaminyltransferase and
            alpha 1-3-galactosyltransferase (Abo), transcript variant 1, mRNA.
ACCESSION   NM_030718
VERSION     NM_030718.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1761)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1761)
  AUTHORS   Steentoft,C., Yang,Z., Wang,S., Ju,T., Vester-Christensen,M.B.,
            Festari,M.F., King,S.L., Moremen,K., Larsen,I.S.B., Goth,C.K.,
            Schjoldager,K.T., Hansen,L., Bennett,E.P., Mandel,U. and
            Narimatsu,Y.
  TITLE     A validated collection of mouse monoclonal antibodies to human
            glycosyltransferases functioning in mucin-type O-glycosylation
  JOURNAL   Glycobiology 29 (9), 645-656 (2019)
   PUBMED   31172184
REFERENCE   3  (bases 1 to 1761)
  AUTHORS   Davenport,E.R., Goodrich,J.K., Bell,J.T., Spector,T.D., Ley,R.E.
            and Clark,A.G.
  TITLE     ABO antigen and secretor statuses are not associated with gut
            microbiota composition in 1,500 twins
  JOURNAL   BMC Genomics 17 (1), 941 (2016)
   PUBMED   27871240
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1761)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1761)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1761)
  AUTHORS   Cailleau-Thomas,A., Le Moullac-Vaidye,B., Rocher,J., Bouhours,D.,
            Szpirer,C. and Le Pendu,J.
  TITLE     Cloning of a rat gene encoding the histo-blood group A enzyme.
            Tissue expression of the gene and of the A and B antigens
  JOURNAL   Eur J Biochem 269 (16), 4040-4047 (2002)
   PUBMED   12180981
REFERENCE   7  (bases 1 to 1761)
  AUTHORS   Olson,F.J., Johansson,M.E., Klinga-Levan,K., Bouhours,D.,
            Enerback,L., Hansson,G.C. and Karlsson,N.G.
  TITLE     Blood group A glycosyltransferase occurring as alleles with high
            sequence difference is transiently induced during a Nippostrongylus
            brasiliensis parasite infection
  JOURNAL   J Biol Chem 277 (17), 15044-15052 (2002)
   PUBMED   11842091
REFERENCE   8  (bases 1 to 1761)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   9  (bases 1 to 1761)
  AUTHORS   Yamamoto,M., Lin,X.H., Kominato,Y., Hata,Y., Noda,R., Saitou,N. and
            Yamamoto,F.
  TITLE     Murine equivalent of the human histo-blood group ABO gene is a
            cis-AB gene and encodes a glycosyltransferase with both A and B
            transferase activity
  JOURNAL   J Biol Chem 276 (17), 13701-13708 (2001)
   PUBMED   11278752
REFERENCE   10 (bases 1 to 1761)
  AUTHORS   Merrick,B.A., Patterson,R.M., Witcher,L.L., He,C. and Selkirk,J.K.
  TITLE     Separation and sequencing of familiar and novel murine proteins
            using preparative two-dimensional gel electrophoresis
  JOURNAL   Electrophoresis 15 (5), 735-745 (1994)
   PUBMED   7523108
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773563.12.
            
            On Oct 27, 2022 this sequence version replaced NM_030718.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035261.1, AK033786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AL773563.12        68402-68492         c
            92-161              AL773563.12        52452-52521         c
            162-218             AL773563.12        51782-51838         c
            219-254             AL773563.12        50105-50140         c
            255-389             AL773563.12        49487-49621         c
            390-1761            AL773563.12        46034-47405         c
FEATURES             Location/Qualifiers
     source          1..1761
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.06 cM"
     gene            1..1761
                     /gene="Abo"
                     /gene_synonym="NAGAT"
                     /note="ABO, alpha 1-3-N-acetylgalactosaminyltransferase
                     and alpha 1-3-galactosyltransferase"
                     /db_xref="GeneID:80908"
                     /db_xref="MGI:MGI:2135738"
     exon            1..91
                     /gene="Abo"
                     /gene_synonym="NAGAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1077
                     /gene="Abo"
                     /gene_synonym="NAGAT"
                     /EC_number="2.4.1.37"
                     /EC_number="2.4.1.40"
                     /note="isoform a is encoded by transcript variant 1;
                     cis-AB transferase; histo-blood group ABO system
                     transferase; histo-blood group A transferase; histo-blood
                     group B transferase; fucosylglycoprotein
                     3-alpha-galactosyltransferase; fucosylglycoprotein
                     alpha-N-acetylgalactosaminyltransferase;
                     glycoprotein-fucosylgalactoside
                     alpha-galactosyltransferase; ABO blood group (transferase
                     A, alpha 1-3-N-acetylgalactosaminyltransferase,
                     transferase B, alpha 1-3-galactosyltransferase);
                     glycoprotein-fucosylgalactoside
                     alpha-N-acetylgalactosaminyltransferase"
                     /codon_start=1
                     /product="histo-blood group ABO system transferase isoform
                     a"
                     /protein_id="NP_109643.3"
                     /db_xref="CCDS:CCDS15811.1"
                     /db_xref="GeneID:80908"
                     /db_xref="MGI:MGI:2135738"
                     /translation="MNLRGRPKCNFLHLGILPFAVFVLVFFGYLFLSFRSQNLGHPGA
                     VTRNAYLQPRVLKPTRKDVLVLTPWLAPIIWEGTFNIDILNEQFRIRNTTIGLTVFAI
                     KKYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPADVPQVILGAGRQLVVLTVRNYTRW
                     QDVSMHRMEMISHFSERRFLREVDYLVCADADMKFSDHVGVEILSTFFGTLHPGFYSS
                     SREAFTYERRPQSQAYIPWDRGDFYYGGAFFGGSVLEVYHLTKACHEAMMEDKANGIE
                     PVWHDESYLNKYLLYHKPTKVLSPEYLWDQQLLGWPSIMKKLRYVAVPKDHQAIRN"
     exon            92..161
                     /gene="Abo"
                     /gene_synonym="NAGAT"
                     /inference="alignment:Splign:2.1.0"
     exon            162..218
                     /gene="Abo"
                     /gene_synonym="NAGAT"
                     /inference="alignment:Splign:2.1.0"
     exon            219..254
                     /gene="Abo"
                     /gene_synonym="NAGAT"
                     /inference="alignment:Splign:2.1.0"
     exon            255..389
                     /gene="Abo"
                     /gene_synonym="NAGAT"
                     /inference="alignment:Splign:2.1.0"
     exon            390..1761
                     /gene="Abo"
                     /gene_synonym="NAGAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1535..1540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abo"
                     /gene_synonym="NAGAT"
                     /note="hexamer: AATAAA"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abo"
                     /gene_synonym="NAGAT"
                     /note="hexamer: AATAAG"
     polyA_site      1554
                     /gene="Abo"
                     /gene_synonym="NAGAT"
                     /note="major polyA site"
     polyA_site      1563
                     /gene="Abo"
                     /gene_synonym="NAGAT"
ORIGIN      
        1 gagttctcct gtgtgcctga gacctggcct gtgcctaaca gcttgctgca cagacactga
       61 accatcctgg gttctgacat gaatctcaga ggaagaccga aatgcaactt ccttcacctt
      121 ggaatccttc ccttcgcagt gtttgtctta gtcttctttg gctacctgtt cctaagcttc
      181 agaagccaga acttgggtca cccaggagct gtgactagga atgcctatct gcagccaagg
      241 gtgctaaaac ccactaggaa agatgttctt gtcttgactc cttggctggc gcccatcatc
      301 tgggagggga ccttcaacat cgacatattg aatgagcagt tcaggattcg gaatactacg
      361 attggactga ctgtatttgc tatcaaaaag tatgtggtgt tccttaagct gttccttgag
      421 actgcagaac aacacttcat ggtgggacac aaggtcatct actatgtctt cactgaccgt
      481 ccagctgatg tgccacaggt gatcctgggt gcaggacggc aactggtggt gctaactgtg
      541 cgcaactata ctcgatggca ggatgtgtcc atgcacagga tggagatgat cagccacttc
      601 tcagagcgac gctttctacg tgaggtggat tacctggtgt gtgcagatgc ggacatgaag
      661 ttcagtgacc atgtgggtgt ggagattctc tcaacattct ttggcactct gcaccctggc
      721 ttctacagta gcagccgaga ggcctttacc tatgagcgcc ggccacagtc ccaggcctac
      781 atcccctggg acaggggtga cttttactac ggaggagcct tctttggggg gtcagtgcta
      841 gaagtgtacc atctcaccaa ggcctgccat gaagctatga tggaggacaa ggccaacggc
      901 attgagcctg tgtggcatga tgagagctat ttgaacaaat acctgcttta ccataagcct
      961 acaaaggtgc tgtccccaga gtatttgtgg gaccagcagc tgctgggctg gccctccatc
     1021 atgaagaagc tgagatatgt ggctgtgccc aaggaccatc aggcaatcag aaactaatag
     1081 ctaaattcct attggagagg acaggctgat agccaggtgg cactccaggc tgtgatgaaa
     1141 ctaaaaggat ttgagagcca attgtcatcc tctatcccac ctcagagtcc agcagaccca
     1201 gtatcacttg gcttaccaca cactttgagc cctggagtgg caaccacctt cagctccact
     1261 gtgtgtccct aagctccttt tactgagtga catggtagat ggagctttca gaacatgaaa
     1321 aaattcttgt catatagtta tctgggggca tgtgcatcct cactcaggct tgtctggtgc
     1381 tgggaggctg atggaggacc aggcaggagg gcaggaagca tcagcctgca gtccacagag
     1441 ggacatagtt cactcggggc agatcagcac cctgtgccca taacctctgc tcatttttgg
     1501 tttatttggg aatatctagc tatccattct agggaataaa taagtttcta cgtagtatag
     1561 gaagttttta gtttcccccc ttttgttttg aggtatttgg gattgaaccc agtgtctcgt
     1621 gaatgctatt caggcacgca gactatctta gagacacata ctgactgaac ttgatgtgtg
     1681 ctacatctac tatattttta ttgatacagt ctctagtagt tcaagctggt ttcagcctta
     1741 ctatgatggt cttatgctcc t
//
