LOCUS       NM_177678               3570 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus actin-binding LIM protein 2 (Ablim2), transcript
            variant 3, mRNA.
ACCESSION   NM_177678
VERSION     NM_177678.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3570)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3570)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   3  (bases 1 to 3570)
  AUTHORS   Barrientos,T., Frank,D., Kuwahara,K., Bezprozvannaya,S.,
            Pipes,G.C., Bassel-Duby,R., Richardson,J.A., Katus,H.A., Olson,E.N.
            and Frey,N.
  TITLE     Two novel members of the ABLIM protein family, ABLIM-2 and -3,
            associate with STARS and directly bind F-actin
  JOURNAL   J Biol Chem 282 (11), 8393-8403 (2007)
   PUBMED   17194709
  REMARK    GeneRIF: ABLIM-2 and -3 associate with STARS and directly bind
            F-actin
REFERENCE   4  (bases 1 to 3570)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   5  (bases 1 to 3570)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   6  (bases 1 to 3570)
  AUTHORS   Klimov,E., Rud'ko,O., Rakhmanaliev,E. and Sulimova,G.
  TITLE     Genomic organisation and tissue specific expression of ABLIM2 gene
            in human, mouse and rat
  JOURNAL   Biochim Biophys Acta 1730 (1), 1-9 (2005)
   PUBMED   16005990
  REMARK    GeneRIF: The highest expression of both isoforms was observed in
            rat brain and eye and in mouse embryos. ABLIM2 protein was
            necessary for the normal functioning of neurons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141898.3, AK046243.1 and AK046879.1.
            
            On Apr 25, 2010 this sequence version replaced NM_177678.6.
            
            Transcript Variant: This variant (3) lacks two alternate exons,
            compared to variant 1. The resulting isoform (3) lacks two internal
            segments, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046243.1, AJ748602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC141898.3         58625-58768
            145-185             AK046243.1         96-136
            186-186             AK046879.1         135-135
            187-3200            AK046243.1         138-3151
            3201-3570           AC141898.3         185355-185724
FEATURES             Location/Qualifiers
     source          1..3570
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 18.75 cM"
     gene            1..3570
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /note="actin-binding LIM protein 2"
                     /db_xref="GeneID:231148"
                     /db_xref="MGI:MGI:2385758"
     exon            1..181
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2010
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /note="isoform 3 is encoded by transcript variant 3;
                     abLIM-2; actin-binding LIM protein family member 2"
                     /codon_start=1
                     /product="actin-binding LIM protein 2 isoform 3"
                     /protein_id="NP_808346.3"
                     /db_xref="CCDS:CCDS19235.1"
                     /db_xref="GeneID:231148"
                     /db_xref="MGI:MGI:2385758"
                     /translation="MSAVSQPQAAHAPLEKPASTAILCNTCGNVCKGEVLRVQNKYFH
                     IRCFVCKACGCDLAEGGFFVRQGEHICTRDYQRLYGTRCFSCDRFIEGEVVSALGKTY
                     HPDCFVCAVCRLPFPPGDRVTFNGKECMCQKCSPPTLLGNSAHVAQGLRSCGGCGLEI
                     KNGQALVALDKHWHLGCFKCKTCGKLLNAEYISKDGLPYCEADYHSKFGIRCDGCEKY
                     ITGRVLEAGEKHYHPSCALCVRCGQMFSEGEEMYLQGSSIWHPACRQAARTEDKSKET
                     RTSSESIVSVPASSTSGSPSRVIYAKLGDEILDYRDLAALPKNKAIYNIDRPDMISYS
                     PYISHSAVGDRQSYGEGDQDDRSYKQCRTSSPSSAGSVSLGHYTPTSRSPQHYSRPGS
                     ESGRSTPSLSVHSDSRPPSSTYQQAPRHFHVPDTGVKDNIYRKPPIYKQHAARRLDVE
                     DSSFDQDSRKKTTWLLLKGDADTRTNSPDLDSQSLSLSSGTDQEPLQRMAGDSLYSRF
                     PYSKPDTLPGPRKDGLDLRNANLAPCGADPDASWGTREYKIYPYDSLIVTNRIRVKLP
                     KDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKKALLF"
     exon            182..325
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            326..509
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            510..625
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            626..752
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            753..846
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            847..934
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            935..993
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1071
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1221
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1342
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1444
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1498
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1551
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1690
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1752
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1807
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1815
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1896
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..3570
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3543..3548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /note="hexamer: AATAAA"
     polyA_site      3564
                     /gene="Ablim2"
                     /gene_synonym="C230091L11"
                     /note="major polyA site"
ORIGIN      
        1 aaaggggcgg ggcgggagcc ccgagctgcg gtggcgctgc gggcagcggg tactgtgtgc
       61 gccgagccgc tggcctcaag cgtgctgagg atcctgccag cgccgcacct gcccgcccgg
      121 tcctcgggct gtcgcagcgc ggggaccacc ctactgggag ctgccgctga catgagcgca
      181 gtgtcgcagc cccaggctgc tcatgcccca ctggagaagc cggccagcac tgcgatcctg
      241 tgtaatacct gtgggaatgt gtgcaaggga gaggtgctgc gtgtgcagaa caagtacttc
      301 cacatcaggt gctttgtgtg caaagcgtgt ggctgtgacc tggctgaggg tggcttcttc
      361 gtgaggcagg gtgagcacat ttgcacacgt gactaccagc ggctctatgg cactcgctgc
      421 ttcagctgtg accgcttcat tgaaggcgaa gtggtgtcgg cgcttgggaa gacctaccac
      481 cctgactgct tcgtgtgtgc tgtctgcagg ctgccctttc ctcctgggga ccgtgtgacc
      541 ttcaacggga aggagtgtat gtgccagaag tgttccccac ccacattgct gggcaacagt
      601 gctcacgtgg cccagggcct ccggagttgt gggggctgtg gcttagaaat caagaatggc
      661 caggccctgg tggctttgga caagcactgg cacctgggat gcttcaagtg caagacttgt
      721 gggaaactcc tcaatgcaga gtacatcagc aaggacgggc tgccctactg cgaggctgat
      781 tatcacagca agtttggcat ccgctgcgac ggctgtgaga agtacatcac gggccgggtg
      841 ctagaggccg gagagaagca ctaccaccct tcatgtgcgc tatgcgtcag gtgcggccag
      901 atgttctcag agggcgagga gatgtacctg caaggctcct ccatctggca tccggcatgt
      961 cgacaggcag ccaggactga agacaagagc aaggaaacca ggacttcttc ggagagcatt
     1021 gtctccgtgc ctgcctccag cacgtcaggg tccccgagcc gtgtgatcta cgcaaagctt
     1081 ggcgatgaga tcctggacta cagggacttg gctgctcttc ccaaaaacaa agcgatctac
     1141 aacatcgacc gccccgacat gatctcctat tcgccctaca ttagccactc ggccgtgggg
     1201 gacaggcaga gctatggcga gggggatcag gatgatcggt cctacaagca gtgcaggacc
     1261 tccagcccca gctctgccgg ctcagtcagc ctcggacact acaccccaac ctcacggtca
     1321 ccccagcact acagtcgtcc aggcagcgaa agtggccgta gcaccccgag tctctcagtg
     1381 cactccgaca gcagacctcc ttcctctacc taccagcagg ctccgagaca cttccacgtc
     1441 ccagacactg gcgtaaaaga taacatctat aggaaacccc ctatctacaa acagcacgct
     1501 gccaggcgat tggacgtgga ggacagcagc tttgaccagg acagcaggaa gaagacaacc
     1561 tggctgcttc tcaaggggga tgcagacacc agaactaact ctccagacct ggacagtcag
     1621 tcgctgtccc tcagcagcgg gactgaccag gaacctctcc aaagaatggc aggggacagc
     1681 ctctactcac gctttcctta ttccaaacct gacactcttc caggacccag gaaggatggc
     1741 ctggacctcc ggaatgccaa cctggcccct tgtggagcag acccggatgc cagctggggc
     1801 acgcgagagt ataagatata tccctatgat tccctcatcg taacaaaccg aattcgtgtg
     1861 aaactgccca aagacgtgga ccggacacgg ctggagagac acctatcacc tgaggagttc
     1921 caagaagtgt ttgggatgag catcgaggag tttgaccgcc tggccctgtg gaagaggaat
     1981 gacctcaaga agaaagcctt gctgttctga cagctgccaa catcttacca ggagcctgct
     2041 gggggggcag ggctgaagga ccccaccagt cccctgaaaa tcccctcctg caccttgctc
     2101 tgcttctctg tgtcagtagg gcaggcaggg tgcctgcagg aggcagggtg gggccaggcc
     2161 ctgaggagca tccagcaggc atggtccctt gtatagcaag gatgctcttg cctgtagttt
     2221 agggccaggt gccagcttga cccactcctt cccgccacaa ctgggcatca gggcagtgtt
     2281 gcagccagct atcctaggag atagggacag agcagtcagc cagcccagca cctttccggg
     2341 gcacctggtg tgcccacacc tgtgctaggc actggggcac agagtgtctg ggacgtgagt
     2401 gaaagacttg tcaggggcag actctgacac agcaggaatg gtaagtgtga gacttctcgg
     2461 agcgtgagga ggtaccaagt agccttgcag actgaggcag gggagccagg ccaaagtctg
     2521 cgaggcagtg ggacggaggt tttctacagt tattgtgata gatcttttat ggggaatgaa
     2581 tgttgacctg acagggtgcc ccccgctaat gctctgtgta ttgtgcccct cttccagatc
     2641 acccccttag ttgcctaaat gatatctttc aagttacaca gaagttttta ttttattaaa
     2701 aagtatcgct tccttacaca tatgaagaca tatatgcaga gtttagtttt acggtccctg
     2761 agaaggggac cgcctccgcc ttacaactcc ccaccccact cccaccgtgc aggcctctgt
     2821 gcttccagtc ctccgcgctc ctcacagaca ggagccggtc tgtttccctt cgtccctgct
     2881 cctttgtatg tgtcacacag acagcctcaa agacactcac tcgctcgctc agcagtgccg
     2941 tttgtaaata catgtgaaat gtatccatct ccttttccct ctgtcatttt cccaagtcgc
     3001 taagagaaga gcgccccctg atggccaaat ccctagaata aaggtttccc cactgtggcc
     3061 tagtctcaca tcaacctgac cagtcttccc agtaaagaca ctcactgtag ccctccacca
     3121 cataaaacac gcatgcccag gaagcatgct gtcacgtgac acagccattg actgcagcgg
     3181 cagagatgga cagctagagg cggtgcctcc tccaacctgg gtgtctagaa gtgggggcta
     3241 actggggccc tggtagcggg tatggaagag cacccctgct gcagaatggg tggacactgt
     3301 ggtcctgggt gactctagct gtcccctcct ctgggttgcc ctcactttct cacatcccgg
     3361 gacatgtgtt gagtctcatt ttgtgctggg gttctcacca gcctggctgg gccgtggagg
     3421 ggaacttttg gtacttaatc tgcttcctgc cacttagcag tctggacctg cgcaactgga
     3481 aaacccccac ctcctcactc atgaggtgtc atgtcatgtc tgatccctgg gacacctggg
     3541 aaaataaatg gtgacacact gtaacttgcg
//
