LOCUS       NM_009595              10714 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ABL proto-oncogene 2, non-receptor tyrosine kinase
            (Abl2), transcript variant 2, mRNA.
ACCESSION   NM_009595 XM_136360
VERSION     NM_009595.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10714)
  AUTHORS   Yao,X., Chen,R., Chen,H., Koleske,A. and Xiao,X.
  TITLE     Impact of Abl2/Arg deficiency on anxiety and depressive behaviors
            in mice
  JOURNAL   Behav Brain Res 468, 115022 (2024)
   PUBMED   38697301
  REMARK    GeneRIF: Impact of Abl2/Arg deficiency on anxiety and depressive
            behaviors in mice.
REFERENCE   2  (bases 1 to 10714)
  AUTHORS   Miao,Y. and Liu,J.
  TITLE     Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma
            correlates with ABL2 inhibition and PI3K/AKT pathway inactivation
  JOURNAL   Clin Transl Oncol 26 (2), 398-413 (2024)
   PUBMED   37479901
  REMARK    GeneRIF: Tumor-suppressive action of miR-30a-5p in lung
            adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway
            inactivation.
REFERENCE   3  (bases 1 to 10714)
  AUTHORS   Ullah,I., Barrie,U., Kernen,R.M., Mamula,E.T., Khuong,F.T.H.,
            Booshehri,L.M., Rhodes,E.L., Bradford,J.M., Datta,A. and
            Wetzel,D.M.
  TITLE     Src- and Abl-family kinases activate spleen tyrosine kinase to
            maximize phagocytosis and Leishmania infection
  JOURNAL   J Cell Sci 136 (14) (2023)
   PUBMED   37357611
REFERENCE   4  (bases 1 to 10714)
  AUTHORS   Xiao,Z., Liu,S., Li,Z., Cui,J., Wang,H., Wang,Z., Ren,Q., Xia,L.,
            Wang,Z. and Li,Y.
  TITLE     The Maternal Microbiome Programs the m6A Epitranscriptome of the
            Mouse Fetal Brain and Intestine
  JOURNAL   Front Cell Dev Biol 10, 882994 (2022)
   PUBMED   35874829
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10714)
  AUTHORS   Amado-Azevedo,J., van Stalborch,A.D., Valent,E.T., Nawaz,K., van
            Bezu,J., Eringa,E.C., Hoevenaars,F.P.M., De Cuyper,I.M.,
            Hordijk,P.L., van Hinsbergh,V.W.M., van Nieuw Amerongen,G.P.,
            Aman,J. and Margadant,C.
  TITLE     Depletion of Arg/Abl2 improves endothelial cell adhesion and
            prevents vascular leak during inflammation
  JOURNAL   Angiogenesis 24 (3), 677-693 (2021)
   PUBMED   33770321
  REMARK    GeneRIF: Depletion of Arg/Abl2 improves endothelial cell adhesion
            and prevents vascular leak during inflammation.
            Erratum:[Angiogenesis. 2022 Feb;25(1):145. doi:
            10.1007/s10456-021-09808-3.. PMID: 34370151]
REFERENCE   6  (bases 1 to 10714)
  AUTHORS   Williams,R.K., Jiang,G.S. and Holmes,K.V.
  TITLE     Receptor for mouse hepatitis virus is a member of the
            carcinoembryonic antigen family of glycoproteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (13), 5533-5536 (1991)
   PUBMED   1648219
REFERENCE   7  (bases 1 to 10714)
  AUTHORS   Craft,C.M., Lolley,R.N., Seldin,M.F. and Lee,R.H.
  TITLE     Rat pineal gland phosducin: cDNA isolation, nucleotide sequence,
            and chromosomal assignment in the mouse
  JOURNAL   Genomics 10 (2), 400-409 (1991)
   PUBMED   2071146
REFERENCE   8  (bases 1 to 10714)
  AUTHORS   Moseley,W.S. and Seldin,M.F.
  TITLE     Definition of mouse chromosome 1 and 3 gene linkage groups that are
            conserved on human chromosome 1: evidence that a conserved linkage
            group spans the centromere of human chromosome 1
  JOURNAL   Genomics 5 (4), 899-905 (1989)
   PUBMED   2574151
REFERENCE   9  (bases 1 to 10714)
  AUTHORS   Kingsmore,S.F., Vik,D.P., Kurtz,C.B., Leroy,P., Tack,B.F.,
            Weis,J.H. and Seldin,M.F.
  TITLE     Genetic organization of complement receptor-related genes in the
            mouse
  JOURNAL   J Exp Med 169 (4), 1479-1484 (1989)
   PUBMED   2564419
REFERENCE   10 (bases 1 to 10714)
  AUTHORS   Seldin,M.F. and Kruh,G.D.
  TITLE     Mapping of Abll within a conserved linkage group on distal mouse
            chromosome 1 syntenic with human chromosome 1 using an
            interspecific cross
  JOURNAL   Genomics 4 (2), 221-223 (1989)
   PUBMED   2567701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ171655.1, BC137771.1 and AC145078.2.
            
            On Oct 22, 2008 this sequence version replaced NM_009595.2.
            
            Transcript Variant: This variant (2) encodes the longer isoform (b,
            also known as 1BLCTL).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ084361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               CJ171655.1         1-200
            201-2324            BC137771.1         1-2124
            2325-10714          AC145078.2         62900-71289
FEATURES             Location/Qualifiers
     source          1..10714
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 67.71 cM"
     gene            1..10714
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /note="ABL proto-oncogene 2, non-receptor tyrosine kinase"
                     /db_xref="GeneID:11352"
                     /db_xref="MGI:MGI:87860"
     exon            1..419
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..3811
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /EC_number="2.7.10.2"
                     /note="isoform b is encoded by transcript variant 2;
                     tyrosine-protein kinase ABL2; Abelson-related gene
                     protein; tyrosine kinase ARG; abelson murine leukemia
                     viral oncogene homolog 2; tyrosine-protein kinase ARG;
                     Abelson tyrosine-protein kinase 2; v-abl Abelson murine
                     leukemia viral oncogene homolog 2 (arg, Abelson-related
                     gene); v-abl Abelson murine leukemia viral oncogene 2
                     (arg, Abelson-related gene)"
                     /codon_start=1
                     /product="tyrosine-protein kinase ABL2 isoform b"
                     /protein_id="NP_033725.2"
                     /db_xref="CCDS:CCDS15393.1"
                     /db_xref="GeneID:11352"
                     /db_xref="MGI:MGI:87860"
                     /translation="MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTADA
                     GFNVFTQHDHFASCVEDGFEGDKTGGSSPEVLHRPFGCDAESQALNEAIRWSSKENLL
                     GATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSN
                     YITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVY
                     HYRINTTTDSKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP
                     IHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
                     VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLLYMATQ
                     ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIK
                     WTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPE
                     GCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRTASSSSVV
                     PYLPRLPLLPSKTRTLRKQGENKENLDGGLDAAESLASSSAPAGFIRSTQASSGSPAL
                     PRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHK
                     KYELTGNFSPVASLQHADGFSVAPSQQEPNLVPAKCYGGSFAQRNLCADDDSGGGGGS
                     GTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDR
                     MAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEEGAAPARERPKAKLLP
                     RGATALPLRAPDPAITESDSPGVGVAGVAAAPKGKERNGGTRLGVAGVPEDGEQLGWS
                     SPAKAVAVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDK
                     DRPRRVKPKCAPPPPPVMRLLQHPSTCSDPEEEPTAPPAGQHTPETQEGGKKAAPGPM
                     PSSGKPGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA
                     LLECADLLSSAITEPVPNSQLVDTGHQLLDYCSGYVDSIPQTRNKFAFREAVSKLELS
                     LQELQVSSTAAGVPGTNPVLNNLLSCVQEISDVVQR"
     exon            420..482
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /inference="alignment:Splign:2.1.0"
     exon            483..653
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /inference="alignment:Splign:2.1.0"
     exon            654..949
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1222
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1307
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1485
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1670
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1823
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1913
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2087
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..10714
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10617..10622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /note="hexamer: AATAAA"
     polyA_site      10660
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
                     /note="major polyA site"
     polyA_site      10663
                     /gene="Abl2"
                     /gene_synonym="Abll; Arg"
ORIGIN      
        1 tgtgctcggt ggtttaaaga tggcggcggc ggctggggcg aggagccgcc ggagggggag
       61 ggagaaggag agtctgtgag tcgctgggag gcagcgcggc agcggctccg aggagtccgc
      121 gtgggagccg ccggcaactc cggcccagag ggcctgggct tgggccggag agaccggagc
      181 ggcgccagga gctccggagg ccggagcaga ggaggaatgt gagcaagggt cggcgggggc
      241 gcgggagtac gcgagcggcg ggatggggca gcaggtgggc cgcgtcgggg aggctccggg
      301 gctccagcag ccgcagccgc gcgggatccg gggcagcagc gcagccaggc cctcgggccg
      361 caggcgggac ccggcggggc gtaccgcaga cgccggcttc aacgtcttca cccagcacga
      421 tcactttgcc agctgtgtgg aggatggatt tgagggagac aagactggag gcagtagtcc
      481 agaagttttg caccgcccgt ttggctgtga tgctgaatct caggcactga atgaagcgat
      541 caggtggagc tccaaggaga acttgctggg agccactgag agtgacccta atctctttgt
      601 tgcactttat gactttgtgg caagtggtga taacacactc agtatcacta aaggtgaaaa
      661 gctgcgagtc cttggttata accagaatgg cgagtggagt gaagttcgct ccaagaatgg
      721 acagggttgg gtgccaagca actacatcac tccagttaat agcctggaga aacattcctg
      781 gtaccacgga cctgtatccc gcagcgcagc agagtatctc ctcagcagcc taatcaatgg
      841 cagcttcctg gttcgagaga gtgagagcag ccctgggcag ctgtccatct ctctcaggta
      901 tgagggacgt gtgtatcact acaggatcaa taccaccaca gacagcaagg tgtacgtgac
      961 agctgagagc cgctttagca ccttggcaga gcttgttcac caccactcca cagttgctga
     1021 tgggctagtg accacgctgc actacccagc accgaagtgc aacaagccaa ccgtctatgg
     1081 cgtgtctcct atccatgaca agtgggaaat ggaacggaca gatatcacca tgaagcacaa
     1141 acttgggggc ggtcagtacg gagaggttta cgttggcgtc tggaagaagt acagccttac
     1201 agtggctgtg aaaacactga aggaagacac catggaggtg gaggagttcc tgaaggaagc
     1261 tgcagtgatg aaggagatca agcatcctaa cttagtacaa ctgctaggtg tgtgtaccct
     1321 ggagccaccg ttttacattg tgactgaata catgccgtat gggaacctgc ttgactatct
     1381 ccgggagtgc agccgagagg aggtgaccgc cgtcgtgtta ctttacatgg ccacccagat
     1441 ctcctctgcc atggagtact tggagaagaa gaacttcatc catagagatc ttgctgcccg
     1501 gaactgccta gtgggcgaga accatgtggt gaaagtggcc gactttggtt taagtagact
     1561 gatgactgga gatacctaca ctgctcatgc tggagccaaa tttcctatta aatggacagc
     1621 acccgagagt ctggcctaca ataccttttc aattaaatct gacgtttggg cgtttggagt
     1681 actgttgtgg gaaattgcta catatggaat gtcaccatat ccaggtattg acctatctca
     1741 agtctatgac ctactggaaa aaggatatcg aatggaacag cctgagggat gcccccctaa
     1801 agtgtatgaa cttatgagag catgctggaa gtggagccct gctgacaggc cctcttttgc
     1861 tgaaacccat caagcttttg aaacaatgtt ccatgactcc agcatctctg aagaggtagc
     1921 tgaggagctt gggagaacgg cctcctcctc ctctgtggtt ccatacctgc ctcggttacc
     1981 gctgcttcct tccaagacga ggaccctgag gaagcagggg gagaacaaag agaacctaga
     2041 tgggggcctt gatgccgccg agagcctggc ctccagctca gcaccagcag ggttcattag
     2101 aagcacacag gcctccagtg ggtccccagc tctgcctcga aagcaaagag ataagtcgcc
     2161 cagcagcctc ttagaagatg ccaaagagac atgctttacc agggatagga aggggggctt
     2221 cttcagctcc ttcatgaaaa agaggaacgc ccccacgccc ccgaagcgca gcagctcctt
     2281 tcgagaaatg gagaatcagc cccacaagaa atatgaactc acgggtaact tctcacctgt
     2341 tgcttctcta cagcatgctg atgggttctc tgtcgctccc agccagcaag agccgaatct
     2401 ggtgccagcc aagtgctatg gggggagctt tgcacagagg aacctctgtg ctgatgatga
     2461 cagtggtggg ggtgggggca gtggcactgc tgggggcggg tggtctggta tcacaggctt
     2521 ctttacacct cgattaatca aaaagacact gggcttgcga gcaggtaagc ccacagccag
     2581 tgatgacact tcgaagcctt ttccaaggtc caactctaca tcttccatgt cctcagggct
     2641 tccagagcag gataggatgg caatgaccct tcccaggaac tgccagaggt ccaaactcca
     2701 gctggaaagg acagtgtcca cctcttctca accagaagag aatgtggaca gggctaatga
     2761 catgcttcca aaaaaatctg aggaaggtgc tgctccagcc agggagagac caaaagccaa
     2821 actattgccc agaggagcca cagctcttcc cttgagagcc cctgatccag ccatcacaga
     2881 gagtgactct ccgggggtag gggtggctgg agtggcagct gcccccaaag gcaaggaaag
     2941 gaatggtggg acgcgacttg gagtcgctgg agtccccgag gatggagagc agctaggctg
     3001 gtcttctcca gccaaggctg tagctgtcct cccaaccact cacaaccaca aagtgccagt
     3061 ccttatctct cccactctga aacacactcc agctgatgtg cagctcattg gcacagactc
     3121 tcaggggaac aaattcaagc tcttatctga gcatcaggtc acatcctctg gagacaagga
     3181 ccgaccccgt cgggtaaaac caaagtgtgc cccacccccc ccaccagtga tgagactact
     3241 gcagcatccg tccacatgct cagaccccga ggaagagccg actgccccac ctgcaggaca
     3301 gcacactcca gagacccagg agggaggaaa aaaggcagct ccaggcccaa tgcccagtag
     3361 tgggaaacct gggaggccag tcatgcctcc acctcaagtg cctttgccca catcttccat
     3421 ctcaccggcc aaaatggcca atggcacagc aggtactaag gtggccctga ggaaaaccaa
     3481 acaggcagct gagaaaatct cagctgacaa aatcagcaaa gaggccctgc tggagtgtgc
     3541 cgacctactg tccagtgcaa tcacggaacc tgtgcccaac agccaactgg tggacactgg
     3601 gcaccagctg ctcgactact gctcagggta tgtggacagc atccctcaga ctcgcaacaa
     3661 gtttgccttc cgagaggctg tgagcaaact ggaacttagc ttacaggagc tgcaggtgtc
     3721 ttccacagct gctggtgtgc ctgggacaaa ccccgtcctt aataacttat tgtcgtgtgt
     3781 acaggaaatt agcgatgtgg tgcagaggta gccatcgtcg gctgagtggg gaaatgcaca
     3841 cattctgagg ggaaagggaa agggactcgt tttcctgtgt tctcgttctc aaaaagtgaa
     3901 agactgatac ttgagtgtgt ttatgtgaag tacctcaggt ccctgagttc tcacgtttac
     3961 agggtcatct caaaacagca gaaaggaagt cacagaagta gataaaaagt cagtgtggtg
     4021 gagcagggca gtgcgggcag ggttggaaag tgcactggga gattagggag cctcgtgtat
     4081 acatcatagg aaggcatagc ccgccctctc tgcggtggcc tgtgccgccc accgcccacc
     4141 gttgggctgc tctcagttgt gctgtactgc gaaacaggcc ttgacttggc cagtcctggg
     4201 ggttatcacg tttcagttta ctgcaaatct ggggagcggg agaaagcagt gtgggggatg
     4261 tagcaggaga tgttttattc gagactagtg gaagtggctg ttggccttgc ttccgtggtc
     4321 attgctgttg tagcaagaac tgcacattag attaccagac tactccactg ggagacatgg
     4381 cctttccatc tgctttgcac tatttaccac ggctgtgtca gttggtgcag aaagtacaca
     4441 gtgcagcgga agtttagtca gacagacacc tccaggctct cgtactgact agcagtcact
     4501 tctcccactc ttttggaatg ttacttgcta gtgggccagt atccacctgt agcttgttgg
     4561 tggctgtctg taagccatgg gcatagggca gtctctcttc cttcattcct ggcagcatac
     4621 cgggcattac ccagcatcga tgttgaaaat agtgctcact acaggtgccc ctgatcactg
     4681 acacaatggc cacttgagca gctacacata ctctgcactt aatgagaata ccaagcagat
     4741 gtcgtacctt tctgaaaggg gctggccaca tggctgcttg tacctttccc tccttgcagc
     4801 cctctggctg gctgtaggga gccgtgtcca ctgagggctc gcctccacag gatctcgtgt
     4861 tctttgtctt tgctcccaga ccatccctaa gcccttgttg cacttggagt ttgtgttggg
     4921 aatattcttt atttattttc tcctttcatc tctatttcag tgtgcataat agaaggagtg
     4981 ggttattttc agggagcacc agttaggccc agagccctca gggtttaacc tgagagttgg
     5041 ttttgccttt gagaaatgcc actcccctcc cctgattaca gtcatggaag ctattagagt
     5101 aacatgggat agaaccgtag caggctgcac attacttatg gttttggtgt tgtgtctaat
     5161 tctagtttct gggttttttt ttcaaagaga gccaatacaa aatatggtga tgtttctttt
     5221 tccaaaggaa tattaatgta ggaagatgag aattgcgcac taagcagtgt tttcttcctg
     5281 gctcattgat ccacgccgtc aagtcgctgc cccgtcttct gatctcttaa ttgaaggcac
     5341 tagcccacat tcccaagcgg gttttgcaga cttaatatac cactcccgct gagaggctct
     5401 ctgggaagct cttaatgtta acttaatgtt gttgggtcgc ttttcattct ctttgctgaa
     5461 tcacaaataa gaaactttga actgccagaa tcgggccaga accctaaggg gaaactattt
     5521 taagtcgcat ttggcatcct taaccaagaa agaaattaaa ttttcaatta gaaaaaggaa
     5581 atttggatgc ctgtcactgc tgctttagtg aaagctcagg gtgagccgag gcctggggta
     5641 aaggacccag ccctgcagtg gcagcatgtt ccctcagctg cagcctgaca gccaggctcc
     5701 aggttcatgc ccctggagtc acggaagagg attccctcca ccttggtggc cactgttctg
     5761 cacatcggat gcacgcataa acttgaattt attctagcag ttaacttagt tagatggggc
     5821 agaggaagtg aaaacttgag ggcattatta atgctgcttt tagcgtatgt cccttgccgt
     5881 ggtgggatgt cttaatggat ggtggttgtt ttgggtttgg gtctcgtttt tgtttgtttg
     5941 ttattggttt tcccttcaga gttctgaaaa caagcaagta gtgttcttca aaacactgct
     6001 gagtctcttg gctgcctgct tttctttctc tgaggccctg agtcatgtct cactcaagcg
     6061 tctgccctgc tcacacagca tcactaaatc catgagctga actgactgtc ctctcctcat
     6121 gacgcatgag cggtgtcctt tacagggatt gaggcctcgg gccacagagg cactgtcaac
     6181 ttgctgtgga agaattattt acgtttgtct tgcatctacc tgcaagggac cagcttaaaa
     6241 gggggggggg gggacacaaa ataaaaggtt agaatctaaa tcagagaaaa ctgcttttag
     6301 aagcgaaaaa tgtaattaat tatgtagcct aaaaacaaag cagatggcga gagagaaggc
     6361 tctggcaact cctaaagccg tttgtcctgg gcagaccttt gcactgtgac agcttgctta
     6421 ctctcattac aagtcccgtg acttcagttg gctctcctgc cttcagatgc agtgctttgt
     6481 attgaatata gccaaattct gctttacggg gaacttggtt gttgtcgttt aagctttggg
     6541 tacaattata tttcacattt ccaggtgatt tccatcatgc tgttcagaaa gaaaggcctt
     6601 aaaattggcc ttttgtattt tgcagtgaga tggactaaat tgaacataat ataccaagct
     6661 gtgatctggc atgtaagaaa ctgatttggt cattttcaag atgcccttcg taaaaggtca
     6721 tcatagtgga ttggagacta gtttccggcc tcattttaag gtttcattta taaatgttcc
     6781 tacttaaatc ctccttagca gacaattggc tggtaaaatc attttctgtt aatgaagaca
     6841 gtggttttta agttaggggt acagcattac cgatagtgtg aggccatgtt tataggctgt
     6901 agctcaggtg cctggggcag tgaccaccta ggatgttaat tgctagtatg agctcctaac
     6961 ctgggagcac acaaacatcc tctagagatt tttaaaggaa aactgatgaa ttagccccgc
     7021 tttgatggaa tccctggtgg gatgagagac tagctagcat gcttcccaag atcttctcca
     7081 ggtttcaaac actccccgct ctctgaacac tgtgcacagc agaggagacg ggagagtact
     7141 gttgtcacta gttcatatct tggagcagct aatggcaaag ctggggctag aattcaggag
     7201 tcctgacatt tggcatctct ccacagcctg ctgccttgtg agatgccgag ctagacaatc
     7261 agtgtgcatg gtgctgcaca cttctaaagc acaggctctg gcaggcctgg ccagggaggg
     7321 cttggatgtt tggtaatggc agtgtagctg gacaagcctt tagtagaact ccgctctgaa
     7381 gagaacttag cactgttctt ctagacctca ggcacacata gagatctgca ctttgtagtt
     7441 gaagaatacc agcttgagtt gtttaaaaac aagaaggaaa aaaaaaaaca aactagtcct
     7501 acactctttt ttgttcaaaa agcaatgtgt tgttcagtgt cattttaatg catgtgaggt
     7561 agtgtatctg aaagcacctt gagaaatcaa atgcattcac tgtaaagctg aattgcgaat
     7621 gtgtgtagag gatgagctga cctggacctg gagctagagg ctcaccctct gctgtggttt
     7681 gttgcagaca taggtccgac actgctaaat gtgcatggga agacacggcg ctgtttgcta
     7741 acagtttaga gctgagcagc ttcaggaaat taggggccaa gtctttggtt taattctcat
     7801 ctttaagaag tagtcaagtg gtggcgtgca atccagcagt gaagaggcta aggcaagaga
     7861 gtctcaggtt ctagaccagc ctcggcctca ggagatgcaa aggaggaata gattactccc
     7921 ggtggagcca gcagcttttc caggcccttg actggaagat gaagaccccc ttcctcttga
     7981 gcagtcctct gctacatgct cggcttttgg tgtggtagga gcagactcat ctcctgttta
     8041 tgttgacact ttcttttaaa aactaatgtc ttggggtggg gggaaagttg ggggtagaag
     8101 actgatgtac ttggagaatt tctagaattt tctcccagtt ataaatgaca gtgactcctt
     8161 taaaagaaga gtagctgagc ttaactcacc tgttagatta tcatgtattc caaaaaatca
     8221 tgtggaggtg gcctgcgtag agcggcactc tagtctcttc ccctgccccg ccttttctac
     8281 ctttgctagt gatgccctgt tcattgggct gtatcttcag gggagttggt attgggttga
     8341 cagagtcatc tttatttctg ttctcaatga tctgtgtcat caccttgcat gcattaactt
     8401 gcttcatttg aatctgacat acatctttat gccctcagca tctgctatgg ccagtacttt
     8461 ctgtatttct tgtcagctgc tttagcttgg tcaagcctgg tagcttagtt ctttggattt
     8521 tgtaggcatg cagaggccta gagcaaggca gttcctaggg aacctgtgct cagactgccg
     8581 gaggcagcct aagggtgcct atggctccca tgctgccgtc acctctgagg cagagaggcg
     8641 agaccttggg atggtcctaa cacttggtct actcctaagt cttatgcata gagttccagt
     8701 tttccagctt aggactcagg agtgcttgga gtggtggttg ttcctgttac ctgtgctgat
     8761 gagcccagca cagtgaccca acttcagtgc tgttgcctgt gatcctgtta ctacggaggc
     8821 tggctcagct caccctgctc cactgccatg tgtttgtgtt ccatcttgac taggtaatga
     8881 taactcttct tttagactag ctccccaggt gcctcaggag gaccctggat ggagtctggg
     8941 cagtttatct tgataagaaa ctgacagaag ccttgattag aaactgacag aagccgttta
     9001 atcccagcac ttgggaggca gaggcagagg caggtggatt tctgagttcg aggccagcct
     9061 ggtctacaga atgagttcca ggacagccag ggctacacag agaaaccctg tctcgggggg
     9121 gaaaaaaaag gaaaggaaaa ggaaagaaac tgacagaagt catcttcaga gatttgtacc
     9181 atcaaagatg agttcctgag tattactggg agaaatactt gcctgctggg ctgttcataa
     9241 ctattgaact agagctcaaa gtccgttgct tcagactctc cattcatctc tctgcacact
     9301 ggcagattgc tgccgtgctt tctccatcct atgtgatgtg ctgagggaag aaggtccttc
     9361 tggaccagcc tccgcctcca ctcacacttc ctttgctcca tgtatgccta taaatttgag
     9421 actgtttacc cctcctagat aataataatc tttatttccc tggtgcggac aaacaagaac
     9481 acagtagcag aaccctgcac actgagtgga tctgcaaagt tgccatctaa ggataaaata
     9541 ggcccacttg tcctcggacc atagcatctt gagaagaata gggctgtgtg gggtcctgag
     9601 ttattcacct gttttgagag cttggacccc agccctttag aacatggagg aggcacagtc
     9661 agatgctagc aaggtggtga aaggaaatac aaagagttct gtgggtggag cttgctcgct
     9721 tgcttaggtt tgtttctgag ttcctgaata gcgctttaac atcttgtttt tagcgacctt
     9781 ataatttagg actagtggga cttcataaaa atgtcacata cctgagttcc cagttttcag
     9841 cagatataaa gtggcacatc tcttgttgag tcaggggaca ctgcaggggc tgtagtgctc
     9901 caggatcctt agttcccaag ttgtctttgg ttgctttaag acccatgctg tgttgtgaat
     9961 gacaagaatg ctgatggtca gggccacggg aacctgcttg cttgatctcg gtggccagct
    10021 tcctttatgc cacttgaact ccatcctgag aagtgtttgc tgagaccttg agaaatgacc
    10081 ttcaggaaca tgaggattca gaaacctccc tgtagctcct tatcacctct ctctgagggc
    10141 agaggcagtg gctggtgagc accctgcaca cacacacacc ccttccttgt agaccctgca
    10201 cttcttctcg tttgcaatct gattctgtaa tgactatcag tggaattgcc cgactttgtg
    10261 tttgcttgat aaaagtaaat ttgaacattt tgtgatggtt gatagaactt tgtcctaaaa
    10321 cttgctaatt cagactcttt aaaactctaa tgtttatacc aaaggttaca ctgcaggcgt
    10381 aggtggtaca cagagggtga ctccctagag tgggcactgt gtgcattgct aaggggacac
    10441 agtgcccagt gagaccatat gggattttac taaacacgtc agtcatgggt cacactacca
    10501 ctgttgtcaa gtatttgttc ttaattgtta ttgtaatata ttttcgattg tttttctaat
    10561 ttaattctct ctgttgtctg actgtgaact gctaacagtg ttaaaaactt gatgtaaata
    10621 aacgatgccc ctggcaggga ctgtttcctg ccatgtctca caaggtttgc aagttgtgtt
    10681 ttgttctaaa taaaagctga aatgatttat aggc
//
