LOCUS       NM_001283046            7367 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus c-abl oncogene 1, non-receptor tyrosine kinase (Abl1),
            transcript variant 4, mRNA.
ACCESSION   NM_001283046
VERSION     NM_001283046.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7367)
  AUTHORS   Chandia-Cristi,A., Gutierrez,D.A., Dulcey,A.E., Lara,M., Vargas,L.,
            Lin,Y.H., Jimenez-Munoz,P., Larenas,G., Xu,X., Wang,A., Owens,A.,
            Dextras,C., Chen,Y., Pinto,C., Marin,T., Almarza-Salazar,H.,
            Acevedo,K., Cancino,G.I., Hu,X., Rojas,P., Ferrer,M., Southall,N.,
            Henderson,M.J., Zanlungo,S., Marugan,J.J. and Alvarez,R. A.
  TITLE     Prophylactic treatment with the c-Abl inhibitor, neurotinib,
            diminishes neuronal damage and the convulsive state in
            pilocarpine-induced mice
  JOURNAL   Cell Rep 43 (5), 114144 (2024)
   PUBMED   38656874
REFERENCE   2  (bases 1 to 7367)
  AUTHORS   Vong,K.I., Lee,S., Au,K.S., Crowley,T.B., Capra,V., Martino,J.,
            Haller,M., Araujo,C., Machado,H.R., George,R., Gerding,B.,
            James,K.N., Stanley,V., Jiang,N., Alu,K., Meave,N., Nidhiry,A.S.,
            Jiwani,F., Tang,I., Nisal,A., Jhamb,I., Patel,A., Patel,A.,
            McEvoy-Venneri,J., Barrows,C., Shen,C., Ha,Y.J., Howarth,R.,
            Strain,M., Ashley-Koch,A.E., Azam,M., Mumtaz,S., Bot,G.M.,
            Finnell,R.H., Kibar,Z., Marwan,A.I., Melikishvili,G., Meltzer,H.S.,
            Mutchinick,O.M., Stevenson,D.A., Mroczkowski,H.J., Ostrander,B.,
            Schindewolf,E., Moldenhauer,J., Zackai,E.H., Emanuel,B.S.,
            Garcia-Minaur,S., Nowakowska,B.A., Stevenson,R.E., Zaki,M.S.,
            Northrup,H., McNamara,H.K., Aldinger,K.A., Phelps,I.G., Deng,M.,
            Glass,I.A., Morrow,B., McDonald-McGinn,D.M., Sanna-Cherchi,S.,
            Lamb,D.J. and Gleeson,J.G.
  CONSRTM   Spina Bifida Sequencing Consortiumdouble dagger
  TITLE     Risk of meningomyelocele mediated by the common 22q11.2 deletion
  JOURNAL   Science 384 (6695), 584-590 (2024)
   PUBMED   38696583
REFERENCE   3  (bases 1 to 7367)
  AUTHORS   Ullah,I., Barrie,U., Kernen,R.M., Mamula,E.T., Khuong,F.T.H.,
            Booshehri,L.M., Rhodes,E.L., Bradford,J.M., Datta,A. and
            Wetzel,D.M.
  TITLE     Src- and Abl-family kinases activate spleen tyrosine kinase to
            maximize phagocytosis and Leishmania infection
  JOURNAL   J Cell Sci 136 (14) (2023)
   PUBMED   37357611
REFERENCE   4  (bases 1 to 7367)
  AUTHORS   Leon,R., Gutierrez,D.A., Pinto,C., Morales,C., de la Fuente,C.,
            Riquelme,C., Cortes,B.I., Gonzalez-Martin,A., Chamorro,D.,
            Espinosa,N., Fuentealba,P., Cancino,G.I., Zanlungo,S., Dulcey,A.E.,
            Marugan,J.J. and Alvarez Rojas,A.
  TITLE     c-Abl tyrosine kinase down-regulation as target for memory
            improvement in Alzheimer's disease
  JOURNAL   Front Aging Neurosci 15, 1180987 (2023)
   PUBMED   37358955
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7367)
  AUTHORS   Feng,L., Ding,R., Qu,X., Li,Y., Shen,T., Wang,L., Li,R., Zhang,J.,
            Ru,Y., Bu,X., Wang,Y., Li,M., Song,W., Shen,L. and Zhang,P.
  TITLE     BCR-ABL triggers a glucose-dependent survival program during
            leukemogenesis through the suppression of TXNIP
  JOURNAL   Cell Death Dis 14 (4), 287 (2023)
   PUBMED   37095099
  REMARK    GeneRIF: BCR-ABL triggers a glucose-dependent survival program
            during leukemogenesis through the suppression of TXNIP.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7367)
  AUTHORS   Pilz,A., Moseley,H., Peters,J. and Abbott,C.
  TITLE     Comparative mapping of mouse chromosome 2 and human chromosome 9q:
            the genes for gelsolin and dopamine beta-hydroxylase map to mouse
            chromosome 2
  JOURNAL   Genomics 12 (4), 715-719 (1992)
   PUBMED   1315305
REFERENCE   7  (bases 1 to 7367)
  AUTHORS   Gaskins,H.R., Prochazka,M. and Leiter,E.H.
  TITLE     Chromosomal localization of the murine stress protein gene encoding
            glucose-regulated protein 78 (BiP)
  JOURNAL   Mamm Genome 3 (12), 709-711 (1992)
   PUBMED   1362103
REFERENCE   8  (bases 1 to 7367)
  AUTHORS   Fulchignoni-Lataud,M.C., Szpirer,J., Levan,G. and Weiss,M.C.
  TITLE     Assignment of the rat genes coding for alpha 1-antitrypsin (PI),
            phosphoenolpyruvate carboxykinase (PEPCK), alcohol dehydrogenase
            (ADH), and fructose-1,6-bisphosphatase (FDP)
  JOURNAL   Mamm Genome 3 (1), 42-45 (1992)
   PUBMED   1316195
REFERENCE   9  (bases 1 to 7367)
  AUTHORS   Siracusa,L.D., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification and applications of repetitive probes for gene
            mapping in the mouse
  JOURNAL   Genetics 127 (1), 169-179 (1991)
   PUBMED   1673105
REFERENCE   10 (bases 1 to 7367)
  AUTHORS   Risser,R., Stockert,E. and Old,L.J.
  TITLE     Abelson antigen: a viral tumor antigen that is also a
            differentiation antigen of BALB/c mice
  JOURNAL   Proc Natl Acad Sci U S A 75 (8), 3918-3922 (1978)
   PUBMED   211509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929275.8.
            
            Transcript Variant: This variant (4) contains an alternate 5' exon
            compared to variant 1, and uses an alternate downstream start codon
            compared to variant 1. The resulting protein (isoform d) has a
            shorter and distinct N-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR9219383.29092.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849380, SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1406              AL929275.8         27464-28869
            1407-1611           AL929275.8         29482-29686
            1612-1785           AL929275.8         117261-117434
            1786-2081           AL929275.8         117848-118143
            2082-2354           AL929275.8         123434-123706
            2355-2439           AL929275.8         129198-129282
            2440-2617           AL929275.8         129589-129766
            2618-2802           AL929275.8         131165-131349
            2803-2955           AL929275.8         133469-133621
            2956-3045           AL929275.8         135900-135989
            3046-3210           AL929275.8         136490-136654
            3211-7367           AL929275.8         139133-143289
FEATURES             Location/Qualifiers
     source          1..7367
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.86 cM"
     gene            1..7367
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /note="c-abl oncogene 1, non-receptor tyrosine kinase"
                     /db_xref="GeneID:11350"
                     /db_xref="MGI:MGI:87859"
     exon            1..1406
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1611
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             1551..4904
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /EC_number="2.7.10.2"
                     /note="isoform d is encoded by transcript variant 4;
                     proto-oncogene tyrosine-protein kinase ABL1; p150;
                     proto-oncogene c-Abl; abelson murine leukemia viral
                     oncogene homolog 1; Abelson murine leukemia oncogene;
                     Abelson tyrosine-protein kinase 1; c-abl oncogene 1,
                     receptor tyrosine kinase; v-abl Abelson murine leukemia
                     oncogene 1; c-abl protein, type III"
                     /codon_start=1
                     /product="tyrosine-protein kinase ABL1 isoform d"
                     /protein_id="NP_001269975.1"
                     /db_xref="GeneID:11350"
                     /db_xref="MGI:MGI:87859"
                     /translation="MISFDLLSDELHLKLLVLDVEALQRPVASDFEPQGLSEAARWNS
                     KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ
                     GWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLR
                     YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPT
                     IYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE
                     FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVL
                     LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAG
                     AKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDY
                     RMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRG
                     TRGGAGSMLQAPELPTKTRTCRRAAEQKDAPDTPELLHTKGLGESDALDSEPAVSPLL
                     PRKERGPPDGSLNEDERLLPRDRKTNLFSALIKKKKKMAPTPPKRSSSFREMDGQPDR
                     RGASEDDSRELCNGPPALTSDAAEPTKSPKASNGAGVPNGAFREPGNSGFRSPHMWKK
                     SSTLTGSRLAAAEEESGMSSSKRFLRSCSASCMPHGARDTEWRSVTLPRDLPSAGKQF
                     DSSTFGGHKSEKPALPRKRTSESRSEQVAKSTAMPPPRLVKKNEEAAEEGFKDTESSP
                     GSSPPSLTPKLLRRQVTASPSSGLSHKEEATKGSASGMGTPATAEPAPPSNKVGLSKA
                     SSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEAGGP
                     TKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPSTA
                     PAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAI
                     SRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICP
                     ATASSGPAATQDFSKLLSSVKEISDIVRR"
     exon            1612..1785
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..2081
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2354
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2439
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2617
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2802
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2955
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3045
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3210
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..7367
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5362
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
     regulatory      6521..6526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6546
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /note="major polyA site"
     regulatory      7211..7216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
                     /note="hexamer: CATAAA"
     polyA_site      7235
                     /gene="Abl1"
                     /gene_synonym="Abl; c-Abl; E430008G22Rik"
ORIGIN      
        1 gtggcgcggc tcgtaatcca ttatggcggc ctcgggggtc ggtgtctctc cctgagaggc
       61 gtcggagctg gaaccgggtg ccgggtcctg cggctgagga ctcctaacgc ggcacacacc
      121 ctcactggct ggagaagccg ggttcctgga ctgagccggg catgtgactg ctcggcggcg
      181 gtggcagggg ccggtgccgg gggaggggtg tctcgggtag agacccttgg gctcggggca
      241 gctgaggcgc cgggcctcct cccctgtggc tgcctccagg ttccggaccg cgggaatcct
      301 tcgtccctcc tagtcctgct ctggctctgg gacacccaga gtggtctctg tttctcctta
      361 cctggaacac cctgtttcct gaggaggagc gtcgcccccg aataagcctc ccgcgccctg
      421 cctgggaagt ctctttctca ccccgagacc gcctttcgct cgatttcaac cccaagtttg
      481 ccacggagtc cctcattcaa accatctccc tgctgtcaag agatcttcgg ggcgtcctcc
      541 cagattgctt tcgccggcct ccgatgtcct gacttcttcc aatgtcacct acagccccct
      601 tggtcacagt gcagcccaaa actttaatgc aaaggaaaag tctggattgg tttcacaggc
      661 cttttaaaaa gcggacttaa aagttgctgg tcatgcattt cttctcggca gagtggagag
      721 caagctctcg atgagatctg tgtgacccgt gtcatttttc cggagagcag ggcagggaag
      781 tgagagcggc aggaaatttg ttacaagatg gagagacaga gataggggat tggttgactt
      841 ccacagaaaa gattgcagag aatataaaag cagctcagcc tttgcttctc gctggggagt
      901 tgaaatgact ttcagtgccg ttggcccttt tctgactttt ctgtgaatag ttttatctaa
      961 agttcccctc ttgcaaagaa agtgttcctc agctcgcaac gtagacttag attgaagaaa
     1021 cttttggcat tgcggttaca tgacttcaaa ctaattaccc tggaaaagaa ttccaggctc
     1081 ctgtttacat gtgtgaacct caaacccagc ttccctttgt catggaagtt gtctgtctgt
     1141 gattgaccca agttactgac ccaagacggt ggtgtgaagt tctgggtata tactgttgcc
     1201 tgctaacccc cacggaccat tctgaaaagt cttgaaccct cttctggaaa ggggcaccta
     1261 ttattgcttt atggggcagc agcctggaaa agttcttggg gaccaaagaa ggcctagttt
     1321 gcccgccctg cattttatca aaggggcagg gaagagggac tcatcgaggc atgggggccc
     1381 acactgcaat gtctttgtgg aacacgctgt cttcagacac cccagaagag ggcatcaggt
     1441 ctcattatgg atggttgtga gccaccatgt ggttgcgggg atttgaactc aggacctcgg
     1501 gaagagcagt cggtgctctc aacctctgag ccatctctcc agcctccgac atgatatctt
     1561 ttgaccttct cagtgatgag ctgcacttga aacttctcgt tttggatgta gaagccctgc
     1621 agaggccagt ggcatctgac tttgagcccc agggtctcag cgaagcagct cgatggaact
     1681 ccaaggaaaa ccttcttgct gggcccagtg aaaatgaccc caaccttttt gtggcactct
     1741 atgattttgt ggccagtgga gataacactc tcagcatcac taaaggtgaa aagctccggg
     1801 tcttgggtta taatcacaat ggggaatggt gtgaagccca aacgaaaaat ggccaaggat
     1861 gggtcccaag caactacatc acccccgtca acagcctgga gaaacattcc tggtatcatg
     1921 gccctgtatc tcggaatgct gctgagtatc tgctgagcag cggaatcaac ggcagcttct
     1981 tagtgcggga gagtgagagt agccctggcc agagatccat ctcgctgcgg tatgaaggga
     2041 gggtgtacca ctacaggatc aacactgcct ctgatggcaa gctgtacgtg tcctccgaga
     2101 gccgcttcaa cactctggct gagttagttc accatcactc cacggtggct gatggcctca
     2161 tcaccacact ccactaccca gctcccaagc gcaacaagcc cactatctac ggtgtgtccc
     2221 ccaactacga caagtgggaa atggagcgca ccgacatcac catgaagcac aagttgggtg
     2281 gaggccagta cggggaggtg tacgagggcg tttggaagaa gtacagcctc actgtggccg
     2341 tgaagacctt gaaggaggac accatggagg tggaggagtt cctgaaggaa gcggcggtga
     2401 tgaaggagat caaacaccct aacctggtgc agctgctagg ggtgtgtacc cgggaaccac
     2461 cattctacat aatcactgag ttcatgacct atgggaacct gctggactac ctgagggagt
     2521 gtaaccggca ggaggtgagc gccgtggtac tgctctacat ggccacacag atctcatcag
     2581 ccatggagta cttggagaag aagaacttca tccacagaga ccttgctgcc cggaactgcc
     2641 tggtagggga aaaccacttg gtgaaggtgg ctgattttgg cctgagcagg ttgatgacag
     2701 gggacaccta cacggcccat gctggagcca aattccccat caaatggacc gcacctgaga
     2761 gcctggccta caacaagttc tccatcaagt cggacgtgtg ggcatttgga gtattgctct
     2821 gggagattgc tacctatggc atgtcacctt acccgggaat tgacctgtct caggtttatg
     2881 agctgctgga aaaagactac cgcatggagc gccctgaagg ctgcccggag aaggtctacg
     2941 agctcatgcg agcatgttgg cagtggaacc cctctgaccg gccctccttt gctgaaatcc
     3001 accaagcctt tgaaaccatg ttccaggaat ccagtatctc agatgaggtg gagaaggagc
     3061 tggggaaacg aggcacgaga ggaggtgctg ggagtatgct gcaggcccca gagctgccca
     3121 ccaagaccag aacctgcagg agagcagctg agcagaaaga tgcgcctgac acccctgagc
     3181 tgctccacac gaagggcctg ggagaaagcg atgcactgga cagtgagcct gctgtatcgc
     3241 cactgcttcc tcggaaagag cgcgggcccc cagacggcag cctaaatgaa gatgagcgcc
     3301 ttctccccag agacagaaag accaacctgt tcagcgcttt gatcaagaag aagaagaaaa
     3361 tggcgccgac gccccctaag cgcagcagtt ccttccgaga gatggatggc cagccagacc
     3421 gcagaggggc tagtgaggat gacagcaggg aactctgcaa tggaccacca gctctcacct
     3481 cagacgcagc agagcctacc aagtccccaa aggccagcaa tggggctggc gtccctaatg
     3541 gagccttccg ggagccgggc aactcaggct tccgttctcc ccacatgtgg aaaaagtcca
     3601 gcacactgac cgggagccgc ctggctgctg ccgaagagga gagcggcatg agctccagta
     3661 agcgcttcct gcgttcttgt tcggcctcct gcatgcccca tggggcaagg gacacagagt
     3721 ggcggtcggt cacgctgcct cgagacctgc cgtctgctgg caagcagttt gactcatcca
     3781 cctttggagg gcacaaaagc gaaaagccag ctctgcctcg gaaacgcacc agtgagagca
     3841 ggtctgagca ggtggccaaa agcacggcga tgccccctcc ccggctggtg aagaagaacg
     3901 aggaggctgc tgaagaaggc ttcaaagaca cagaatccag ccctggctcc agccctccca
     3961 gcttgactcc caaactcctc cgcaggcagg tcactgcctc tccttcctct ggcctctctc
     4021 acaaggaaga ggccaccaag ggcagtgcct caggcatggg gactccggcc actgcagagc
     4081 cagcaccccc cagcaacaaa gtgggcctca gcaaggcctc ctctgaggag atgcgcgtaa
     4141 ggaggcacaa gcacagctcg gagtccccag ggagagacaa ggggcgactg gctaagctca
     4201 agcctgcccc gccgcctcct cctgcctgca caggaaaagc aggcaagccc gcacagagcc
     4261 ccagccaaga ggccggggag gcaggggggc ccacaaagac aaaatgcacg agtctggcta
     4321 tggatgctgt gaacactgac cccaccaagg ccggcccacc tggagaagga ctgagaaagc
     4381 ctgtgccccc atctgtgcca aagccccagt cgacggctaa gcctccaggg actcccacca
     4441 gcccggtctc caccccctcc acagcaccag ctccttcacc cctggctggg gaccagcagc
     4501 catcttctgc cgccttcatc cccctcatat caacccgtgt gtctcttagg aagacccgcc
     4561 agccgccaga gcgcattgcc agtggcacca tcaccaaggg tgtggttctg gacagtactg
     4621 aggccctgtg ccttgccatc tcccggaact cagagcagat ggccagccac agtgctgtac
     4681 tggaggctgg caagaacctg tacactttct gtgtgagcta tgtggactct atccagcaga
     4741 tgaggaacaa gtttgccttc cgtgaggcta tcaacaagct ggagagcaac ctccgagagc
     4801 tgcagatctg ccctgccaca gcctccagtg ggccagctgc cacccaagac ttcagcaagc
     4861 tgctcagctc tgtgaaggag atcagcgaca ttgtccggag gtagcagcaa ccagtgtatg
     4921 tcagcaagag atgttgcagt tcacagggct cttgtgccta taaagatggg gacaggggac
     4981 tggggagctg gcgtctttcc ccaggagctt taaagagaga caagcagagc ctgagggaga
     5041 cctggatgga gcctggtgga gttggctctt cctcctgtgt tgtgcaccag ctgccctgca
     5101 cctttcctgt ccagcccagg cgtcagccac ctctcctcac tgcctgtgga tgggtctcct
     5161 gctctgaaga ctacatctgg cctgcctggc caccaggctt ctcactcccc ggtgcctcag
     5221 acccagctcc caggtcagcc tggagtgctc ttccctgtcc ttgcagaacg acctcctctg
     5281 atggaccttc ttgtcaccaa ggcatgggag cccctgtgct tactgtacct gcacctttga
     5341 tgcttacaaa ctgtccccga gagcctgtgc tcactgtgtt ttcattggaa ggaagctgtc
     5401 gctttaaggg tcatgaggtg ctaaagccag gggcccagat gggtgggcac tggaaacagg
     5461 agctgggcag tgtggtctgt cacctgctct cagtatcttc agcagtgtgc ccggcagatc
     5521 ttggacagca agcttgagtt ttatgggtgg cagtcactgg ctggctaggc acatagccag
     5581 gccaaaccta ggcctccaag ggctccccaa aatctgaatt tctgagtagt cttcatcccc
     5641 tctcctgctc taaggtcagg tccatcctct ctggtcctta ccttgatgac aaggatccag
     5701 ccttctggtg tttttgagca tttcaaaggt ctgcatagaa aggaacagcc actaggtaca
     5761 aacaggcagg aatctgggct ctcctgagcc ctgactgctt ctcagaactg ctgcttaacc
     5821 actgagaaca gtgctcagcc cagagctcct gagagccatg cacatcacgc tggggttggg
     5881 tgtcccttgc agactcagcc aggggggcca tatcttcctc ctaaggcagg caggaccaga
     5941 gctgagcaca ggcacaggtg tgggcgactc cttgactaac ccagagccgc cagcctaggc
     6001 ctcgtgccag gctgacccaa aacagggcgc atgcctaggc cttgtaccag gctggaagac
     6061 acctccacac tccctgcttc tccactgcag gtgtgctgtg ctggccccag gcccacactg
     6121 atcacctaga tgcgggcctg gtagagatga tttcctctgg atggtcttcc atggtcctcg
     6181 tagcacctca cctcgttacc tccaaaggct gctctgcagc ccaagggagg ctgtgccaca
     6241 ctgccagcga ccttgaatag ccagacaccg ccatcccctg acactgtgct cacaaggccc
     6301 ctgctctgtt gctgccgtgg gtgccactat attttgtatt acactttgat attacactct
     6361 tttttaaaat agacttgcgc tcttataaat gacatgtaaa tagttcacca ctgtgccccc
     6421 tctggcacac caacagcatt cccctttttt ctcagtccag tacattttgt ttctgtatat
     6481 gactgttttt tgaatccaaa tctctctgta gtatttttta aataaatgtt tacagaacta
     6541 tcgacagact gcttggtctg tgattcatct ctgcaagccc tcatgtccca gcccgtgtgt
     6601 cccgagcata tcgttgccag ctgcccagct cttggcagcc tcacagcaga tggtagtgtc
     6661 ctgtgtcggg ccggaagtag gagcggctaa gcacctgaga ttcttgctgg cggagtgagt
     6721 ccctccccgg catgcctctg ccttcagccg ctcagtgctc tctctctctc atgtggcttc
     6781 gggtgccagc tgttaggctt cagtggacag tgaacaaacg cctcggcagg ctccgtggac
     6841 tatgcttcag tcactggagc tcaggcaagg atgccaaggc cacaggctgg ggtgccctgc
     6901 cactccaaca actcgccaca cagaagctct gcctcccctg gctgtcatat gtcatgcatg
     6961 ttgaagtggg tcggagttgt ccagtgaatc tagacactgg ccatcctgca ggtcttctgt
     7021 agccaatagg gtcatccttg agtggctgtc taacaggagg ttccagggac agcctccaca
     7081 gctaccactt gtgcttttgt gtgtgacatg ggcctaagag ggctcccagt ggcctcaagc
     7141 aagtactgtt tgcctgtttt ctcgatttct tgtaaggcca caggagtgag acctgtcacc
     7201 ttggcccaag cataaaatac tccatgtctc cgaaataagg tcctgatgtg tcattggaaa
     7261 cttatttctg tggctacctt tcttgtcaga cgtggtggtg cccacaaagg caggtggcct
     7321 ggcctacaga gcaagatccg gggcagtcag agggaaaccc tggcttg
//
