LOCUS       NM_025659               4038 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ABI family member 3 (Abi3), transcript variant 1,
            mRNA.
ACCESSION   NM_025659
VERSION     NM_025659.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4038)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4038)
  AUTHORS   Fu,Y., Zhang,J., Liu,Q., Yang,L., Wu,Q., Yang,X., Wang,L., Ding,N.,
            Xiong,J., Gao,Y., Ma,S. and Jiang,Y.
  TITLE     Unveiling the role of ABI3 and hub senescence-related genes in
            macrophage senescence for atherosclerotic plaque progression
  JOURNAL   Inflamm Res 73 (1), 65-82 (2024)
   PUBMED   38062164
  REMARK    GeneRIF: Unveiling the role of ABI3 and hub senescence-related
            genes in macrophage senescence for atherosclerotic plaque
            progression.
REFERENCE   3  (bases 1 to 4038)
  AUTHORS   Karahan,H., Smith,D.C., Kim,B., McCord,B., Mantor,J., John,S.K.,
            Al-Amin,M.M., Dabin,L.C. and Kim,J.
  TITLE     The effect of Abi3 locus deletion on the progression of Alzheimer's
            disease-related pathologies
  JOURNAL   Front Immunol 14, 1102530 (2023)
   PUBMED   36895556
  REMARK    GeneRIF: The effect of Abi3 locus deletion on the progression of
            Alzheimer's disease-related pathologies.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4038)
  AUTHORS   Smith,D.C., Karahan,H., Wijeratne,H.R.S., Al-Amin,M., McCord,B.,
            Moon,Y. and Kim,J.
  TITLE     Deletion of the Alzheimer's disease risk gene Abi3 locus results in
            obesity and systemic metabolic disruption in mice
  JOURNAL   Front Aging Neurosci 14, 1035572 (2022)
   PUBMED   36620768
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4038)
  AUTHORS   Turner,A.K., Shaw,B.C., Simpson,J.F. and Estus,S.
  TITLE     Identification and Quantitation of Novel ABI3 Isoforms Relative to
            Alzheimer's Disease Genetics and Neuropathology
  JOURNAL   Genes (Basel) 13 (9), 1607 (2022)
   PUBMED   36140776
  REMARK    GeneRIF: Identification and Quantitation of Novel ABI3 Isoforms
            Relative to Alzheimer's Disease Genetics and Neuropathology.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4038)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 4038)
  AUTHORS   Latini,F.R., Hemerly,J.P., Freitas,B.C., Oler,G., Riggins,G.J. and
            Cerutti,J.M.
  TITLE     ABI3 ectopic expression reduces in vitro and in vivo cell growth
            properties while inducing senescence
  JOURNAL   BMC Cancer 11, 11 (2011)
   PUBMED   21223585
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4038)
  AUTHORS   Matsuda,S., Yokozaki,S., Yoshida,H., Kitagishi,Y., Shirafuji,N. and
            Okumura,N.
  TITLE     Insulin receptor substrate protein 53 (IRSp53) as a binding partner
            of antimetastasis molecule NESH, a member of Abelson interactor
            protein family
  JOURNAL   Ann Oncol 19 (7), 1356-1357 (2008)
   PUBMED   18480067
REFERENCE   9  (bases 1 to 4038)
  AUTHORS   Hirao,N., Sato,S., Gotoh,T., Maruoka,M., Suzuki,J., Matsuda,S.,
            Shishido,T. and Tani,K.
  TITLE     NESH (Abi-3) is present in the Abi/WAVE complex but does not
            promote c-Abl-mediated phosphorylation
  JOURNAL   FEBS Lett 580 (27), 6464-6470 (2006)
   PUBMED   17101133
REFERENCE   10 (bases 1 to 4038)
  AUTHORS   Ichigotani,Y., Yokozaki,S., Fukuda,Y., Hamaguchi,M. and Matsuda,S.
  TITLE     Forced expression of NESH suppresses motility and metastatic
            dissemination of malignant cells
  JOURNAL   Cancer Res 62 (8), 2215-2219 (2002)
   PUBMED   11956071
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL593858.20 and AK008928.1.
            
            On Jul 28, 2009 this sequence version replaced NM_025659.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033965.1, BC058260.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-353               AL593858.20        133774-134126       c
            354-1653            AK008928.1         76-1375
            1654-4038           AL593858.20        121759-124143       c
FEATURES             Location/Qualifiers
     source          1..4038
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..4038
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /note="ABI family member 3"
                     /db_xref="GeneID:66610"
                     /db_xref="MGI:MGI:1913860"
     exon            1..419
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1397
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /note="isoform 1 is encoded by transcript variant 1; new
                     molecule including SH3; ABI gene family, member 3"
                     /codon_start=1
                     /product="ABI gene family member 3 isoform 1"
                     /protein_id="NP_079935.1"
                     /db_xref="CCDS:CCDS25283.1"
                     /db_xref="GeneID:66610"
                     /db_xref="MGI:MGI:1913860"
                     /translation="MAELQQLQQLQEFDIPTGREALRGNHSALLRVANYCEDNYLQAT
                     DKRKALEETMAFTTQALASVAYQVGNLAGHTLRMLDLQGAALRQVEAKMSTLGQMVNM
                     HMEKVARREIGTLATVVRLPSNQKVIPPESLPSLTPYHRKPLNFACLDDIGHGVKDLS
                     TQLSRTGTLSRKSIKAPATPVSATLGRPPRIPEPVQLPAVPDGKLSAASSASSLASAG
                     SAEGASGIPQSKGQVAPATPPPPPVAPVTPPPPPLSAEVFLPPPPLEVSQPPLEAELP
                     LPPPPALEGDELGLLPPPPPGFGPDEPSWVPASYLEKVVTLYPYTRQKDNELSFSEGT
                     VICVTRRYSDGWCEGVSSEGTGFFPGNYVEPSC"
     exon            420..587
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /inference="alignment:Splign:2.1.0"
     exon            588..764
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /inference="alignment:Splign:2.1.0"
     exon            765..850
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /inference="alignment:Splign:2.1.0"
     exon            851..946
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1107
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1233
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..4038
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1699..1704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /note="hexamer: AATAAA"
     polyA_site      1722
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /note="major polyA site"
     regulatory      1956..1961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /note="hexamer: AACAAG"
     polyA_site      1979
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
     regulatory      2717..2722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /note="hexamer: AGTAAA"
     polyA_site      2741
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
     regulatory      3997..4002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
                     /note="hexamer: AATAAA"
     polyA_site      4030
                     /gene="Abi3"
                     /gene_synonym="2210414K06Rik; NESH"
ORIGIN      
        1 cagatgcccc gaccttggct tcctttgctt ggtgagattg agagaccgag cccccaacag
       61 gcccctggtt tcccccttct cctgagcagg gtacagagag gcccaggccc agggcccagg
      121 gtctgacttc ctcttgtccc ggaatgagca tgcctacccc tttacaggca ggtttgagtc
      181 tctcacgcag aggaaaccaa aagcagaggg agggaaggca gagcggccaa tcaggggcag
      241 ggtgaggctc aaaacccagc aggctcccca gggaacccca ccgaggccaa gccatggcgg
      301 agctgcagca gttacagcag ctgcaggagt ttgatatccc cacgggccgg gaggctctgc
      361 ggggcaacca cagcgccctg ctacgggtgg ccaactactg cgaggataac tacttgcagg
      421 ccacagacaa gcggaaggcg ctggaagaga cgatggcttt caccacccag gccctagcca
      481 gtgtggccta ccaagtgggt aacctggccg ggcatactct tcgaatgctg gatctacagg
      541 gtgctgccct gcggcaggta gaagccaaga tgagcacact gggccagatg gtaaacatgc
      601 atatggagaa ggtagctaga agggagatcg gcactttggc cactgttgtg cggctgccct
      661 ctaaccagaa agtcatccct cctgagagcc tgccttccct cactccctac cacagaaaac
      721 ccctcaactt tgcctgcttg gatgacattg gccacggagt caaggacttg agcacgcagc
      781 tgtcacggac cgggaccctg tctcgcaaga gcataaaggc gcctgctaca cctgtttccg
      841 ccacgctggg gagaccaccc cggatccctg agccggtgca gctcccagcc gtgccagacg
      901 gcaagctctc cgctgcctcc tctgcctctt ccttggcctc ggcaggcagt gcggaaggtg
      961 ccagtgggat cccccagtcc aagggacagg tagcgcctgc aaccccgcct cctccacctg
     1021 tagcacctgt aaccccgcct cctccaccgt tgtctgccga ggtcttcttg ccgccccctc
     1081 cgctggaggt gtcccagccc cctctggaag cagagttgcc cctgcctcct cccccagctc
     1141 tagaggggga tgaactgggg ctgctgcctc cgcccccacc aggttttgga ccagatgagc
     1201 ccagctgggt ccctgctagc tacttggaga aagtggtgac cctgtaccca tacacccggc
     1261 aaaaggacaa tgagctctcc ttctctgaag gcaccgtcat ctgtgtcact cgccgctact
     1321 cggatggctg gtgtgagggt gtcagttcag agggcactgg attcttccca gggaactatg
     1381 tggagcccag ctgctgacag cccaggatct atccctgcac caaccctgca ctgcctcggt
     1441 gggcctctcg agccccagga agccagcttc cacagtcaaa gctggactaa ggacctgtct
     1501 acctcttggg ctgtgaactg tgttcagtcc ctgctccata cagcagtggg aagagggtgg
     1561 gctagagagg ggtggtactc aggggggact gctgcagatg gcataaagaa tacaaaaaca
     1621 aacaaaccta gaaggcaagg agtttaagca ccttgcccag aggaccccca gctcatgctc
     1681 agaagatcgc cagctttgaa taaaactgct gacctcctgg tagttgctcc aaagggctag
     1741 aaggccagac agggagtgat ggaaagggaa cacggaagcc ctgcagtctg ccccagaagg
     1801 actctcaatc tcaaccctct ttactcttcc cattaggccc ctgacgtcac aagcagccat
     1861 tcgctgggct cttcacgccc tcactactta aataggactc cctgagagca gagagcacct
     1921 ctctttcatc cccccttctc actgtggcac aagagaacaa gtccctttgt cccccttcac
     1981 ctcctttatt ggtctgaaac tccagagagg ggaagggctt gggtttccct ggctctgctt
     2041 aaaaacatgg ctttctgttc cataagggca aaggggaatg caagggggga ggggtgcggg
     2101 gggggagggg acgactttgg tgaagtccct ggtctcttgc tggagtgcta ggatttttca
     2161 cactctccga ggtcagtggt cggttcttct acctcgttct accagcagga ggcggtagtt
     2221 ccttctgact ttttcttcct ttgggtgggt ggggggtgtc tggtgggcgg gggtggggtg
     2281 ggggtggaga gggggaagga agcaaggcgc agccagcgca gcggtagtgt agggttgcgt
     2341 tggctgaagc aagatcaaga cctagagctg tcttctgaga gcatcatagg tctgccgcga
     2401 ggaatctggt actggcatgc ggattggggg atcctgagtc cgtttgaaag actgggcaga
     2461 ggaggttatg cagccggtac agcagctaaa gtaagtggga gatgttcctt ctcccaactt
     2521 ccaggaaccc gttcctctca gttcgagggg cactgcctgc cttccaaggg gtgctcacct
     2581 ccctggaggg aaggcagcag agctgtgtta actgcataga tagggacggc tctgaacccc
     2641 tgctcccagc ccacaagcag actgaattcc agatatgccc ggaggagcat agcaaagcga
     2701 aaggaaagag gagggtagta aaactaggtg atcctaacca atccccagtc ccgtccctcc
     2761 tccgtcggtt gtcccgagca cccctggcag gcgatggtct tcaacacatc ttcagcacct
     2821 gttgcagatg ttggcgcaca tcggcggctg tttcccaggg caccacgtgg gcgcggaagg
     2881 agctgggctc agctttctgt gcctcctgga tgaggcggtg catggggtag ccgcggcgcg
     2941 ggaaggccac gtccccgccc gccagcagcc ccatggggca aaagtcattt gcaccatcac
     3001 ccacgtagaa gaggcgctcg aagtgcacgc cgtcgcgggc ccgctcacgc aggtattcgc
     3061 tgagcacctt gtgcttgcac atgttggccg ggcagcgcga gcagctgtgc gtgtggaagg
     3121 gccgcagcgt cagcagtccc cgcgcgtcgg gccccgacgg gttgctgagg atgcggcgga
     3181 ataaactgtg gtggccagcg gcacgcaggg cactctccac accgaaggtg ttggcatccg
     3241 aaatgagaat aacctcgaag caggagccct gtttggctat gaactgcaac aaatcgccca
     3301 tgcctggcga cagggggatg gtctcgtaga cagcgcgcag gtcccggggc cgtacaccct
     3361 gctcacccag gtacttaaag actcgttgca tgtactcatt gtagtagccc tcgcgatagg
     3421 tggcacgcag gctctcgggc agttgctggc ctggcgcggc acgcacgatc gagtcgtcgc
     3481 tgttctcgtc cacgatggtc tcatcgaagt cgaaggtgag gaggaagcga ggcgcgcccg
     3541 gcgcagccat cctgccgtcc tgggagcagg gggaagagga gcaggaggag gaggcaagcg
     3601 agaggcggcg cggcgggagc cggccaggga gaagctgatt agcgggccac agccagggtc
     3661 gctggcacat ccaagacctg aggaggaccc aaggctggtt aagcaggaga tggaaccaat
     3721 gtgctgccca caccccgccg tcccttgcct gtctctcagt taatcgtgct ggggtcgacg
     3781 caagggggcc atactagtct tgaagccaaa agcttccttg gcttcggttt ctgctgctct
     3841 cataggatcc cttaagagag gggatgactc gtcaaggatc actccttgag actcctcaac
     3901 tgggttggag gtttctggtg tcagagcaga gtagacagca gattcatgta cccaggggga
     3961 gcagcctcct tttcccgtga tccccctggg atcaagaata aatggaggag ccaggctcct
     4021 ggaaaagcca ttgacatc
//
