LOCUS       NM_025341               2247 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus abhydrolase domain containing 6 (Abhd6), transcript
            variant 1, mRNA.
ACCESSION   NM_025341
VERSION     NM_025341.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2247)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2247)
  AUTHORS   Wei,M., Yang,L., Su,F., Liu,Y., Zhao,X., Luo,L., Sun,X., Liu,S.,
            Dong,Z., Zhang,Y., Shi,Y.S., Liang,J. and Zhang,C.
  TITLE     ABHD6 drives endocytosis of AMPA receptors to regulate synaptic
            plasticity and learning flexibility
  JOURNAL   Prog Neurobiol 233, 102559 (2024)
   PUBMED   38159878
  REMARK    GeneRIF: ABHD6 drives endocytosis of AMPA receptors to regulate
            synaptic plasticity and learning flexibility.
REFERENCE   3  (bases 1 to 2247)
  AUTHORS   Poursharifi,P., Schmitt,C., Chenier,I., Leung,Y.H., Oppong,A.K.,
            Bai,Y., Klein,L.L., Al-Mass,A., Lussier,R., Abu-Farha,M.,
            Abubaker,J., Al-Mulla,F., Peyot,M.L., Madiraju,S.R.M. and
            Prentki,M.
  TITLE     ABHD6 suppression promotes anti-inflammatory polarization of
            adipose tissue macrophages via 2-monoacylglycerol/PPAR signaling in
            obese mice
  JOURNAL   Mol Metab 78, 101822 (2023)
   PUBMED   37838014
  REMARK    GeneRIF: ABHD6 suppression promotes anti-inflammatory polarization
            of adipose tissue macrophages via 2-monoacylglycerol/PPAR signaling
            in obese mice.
REFERENCE   4  (bases 1 to 2247)
  AUTHORS   Westenbroek,R., Kaplan,J., Viray,K. and Stella,N.
  TITLE     The serine hydrolase ABHD6 controls survival and thermally induced
            seizures in a mouse model of Dravet syndrome
  JOURNAL   Neurobiol Dis 180, 106099 (2023)
   PUBMED   36990366
  REMARK    GeneRIF: The serine hydrolase ABHD6 controls survival and thermally
            induced seizures in a mouse model of Dravet syndrome.
REFERENCE   5  (bases 1 to 2247)
  AUTHORS   Deng,L., Viray,K., Singh,S., Cravatt,B. and Stella,N.
  TITLE     ABHD6 Controls Amphetamine-Stimulated Hyperlocomotion: Involvement
            of CB1 Receptors
  JOURNAL   Cannabis Cannabinoid Res 7 (2), 188-198 (2022)
   PUBMED   34705543
REFERENCE   6  (bases 1 to 2247)
  AUTHORS   Siegmund,S.V., Wojtalla,A., Schlosser,M., Zimmer,A. and Singer,M.V.
  TITLE     Fatty acid amide hydrolase but not monoacyl glycerol lipase
            controls cell death induced by the endocannabinoid 2-arachidonoyl
            glycerol in hepatic cell populations
  JOURNAL   Biochem Biophys Res Commun 437 (1), 48-54 (2013)
   PUBMED   23806692
  REMARK    GeneRIF: FAAH but not monoacyl glycerol lipase exerts important
            protective actions against 2-arachidonoyl glycerol-induced cellular
            damage.
REFERENCE   7  (bases 1 to 2247)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   8  (bases 1 to 2247)
  AUTHORS   Marrs,W.R., Horne,E.A., Ortega-Gutierrez,S., Cisneros,J.A., Xu,C.,
            Lin,Y.H., Muccioli,G.G., Lopez-Rodriguez,M.L. and Stella,N.
  TITLE     Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid
            amide hydrolase increases endocannabinoid levels in neurons
  JOURNAL   J Biol Chem 286 (33), 28723-28728 (2011)
   PUBMED   21665953
  REMARK    GeneRIF: Dual inhibition of alpha/beta-hydrolase domain 6 and fatty
            acid amide hydrolase increases endocannabinoid levels in neurons.
REFERENCE   9  (bases 1 to 2247)
  AUTHORS   Marrs,W.R., Blankman,J.L., Horne,E.A., Thomazeau,A., Lin,Y.H.,
            Coy,J., Bodor,A.L., Muccioli,G.G., Hu,S.S., Woodruff,G., Fung,S.,
            Lafourcade,M., Alexander,J.P., Long,J.Z., Li,W., Xu,C., Moller,T.,
            Mackie,K., Manzoni,O.J., Cravatt,B.F. and Stella,N.
  TITLE     The serine hydrolase ABHD6 controls the accumulation and efficacy
            of 2-AG at cannabinoid receptors
  JOURNAL   Nat Neurosci 13 (8), 951-957 (2010)
   PUBMED   20657592
  REMARK    GeneRIF: ABHD6 is a rate-limiting step of 2-AG signaling
REFERENCE   10 (bases 1 to 2247)
  AUTHORS   Blankman,J.L., Simon,G.M. and Cravatt,B.F.
  TITLE     A comprehensive profile of brain enzymes that hydrolyze the
            endocannabinoid 2-arachidonoylglycerol
  JOURNAL   Chem Biol 14 (12), 1347-1356 (2007)
   PUBMED   18096503
  REMARK    GeneRIF: Data reveal that 85% of brain 2-arachidonoylglycerol
            hydrolase activity can be ascribed to monoacylglycerol
            lipase(MAGL), and the remaining 15% is catalyzed by ABHD6 and
            ABHD12.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139029.10, BY253400.1, CX239001.1, AA261636.1, AK168782.1 and
            BQ176347.1.
            
            On Sep 8, 2016 this sequence version replaced NM_025341.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090076.1, BC027011.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC139029.10        106294-106302
            10-404              BY253400.1         1-395
            405-800             CX239001.1         381-776
            801-1085            AA261636.1         202-486
            1086-2142           AK168782.1         904-1960
            2143-2241           BQ176347.1         18-116              c
            2242-2247           AC139029.10        160171-160176
FEATURES             Location/Qualifiers
     source          1..2247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 4.69 cM"
     gene            1..2247
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /note="abhydrolase domain containing 6"
                     /db_xref="GeneID:66082"
                     /db_xref="MGI:MGI:1913332"
     exon            1..76
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            77..229
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1121
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /EC_number="3.1.1.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     monoacylglycerol lipase ABHD6; 2-arachidonoylglycerol
                     hydrolase"
                     /codon_start=1
                     /product="monoacylglycerol lipase ABHD6 isoform 1"
                     /protein_id="NP_079617.2"
                     /db_xref="CCDS:CCDS26808.1"
                     /db_xref="GeneID:66082"
                     /db_xref="MGI:MGI:1913332"
                     /translation="MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRR
                     TLGMQVRYAHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVC
                     VDMPGHEGTTRSSLDDLSIVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAY
                     YPSDVCSLSLVCPAGLQYSTDNPFVQRLKELEESAAIQKIPLIPSTPEEMSEMLQLCS
                     YVRFKVPQQILQGLVDVRIPHNSFYRKLFLEIVNEKSRYSLHENMDKIKVPTQIIWGK
                     QDQVLDVSGADILAKSISNSQVEVLENCGHSVVMERPRKTAKLIVDFLASVHNTDNKK
                     LN"
     exon            230..386
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            387..500
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            501..633
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            634..791
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            792..846
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            847..947
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            948..2247
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1487..1492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1505
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /note="major polyA site"
     regulatory      2014..2019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2035
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
     regulatory      2120..2125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2144
                     /gene="Abhd6"
                     /gene_synonym="0610041D24Rik"
ORIGIN      
        1 cgagagcgag agtgcgcagg tgcggggacc tgggactgga gggcggcgaa cgggcagcag
       61 gaccgcggtc actgagcctc tgcaggtgtc aacaaggctc aaggagcagg atggatctcg
      121 atgtggttaa catgtttgtg attgcgggtg ggaccctggc cattccaatc ctggcatttg
      181 ttgcgtcttt cctcctgtgg ccttcagcac tgataagaat ctattattgg tactggcgga
      241 ggacactggg catgcaagtt cgctacgcac accatgagga ctatcagttc tgttactcct
      301 tccggggcag gccaggacac aagccatcca tccttatgct ccatggattc tccgcacaca
      361 aggacatgtg gctcagcgtg gtcaagttcc ttccgaagaa cctgcacttg gtctgtgtgg
      421 acatgcctgg gcatgaaggc accacccgct cctccctgga tgacctgtcc atagtggggc
      481 aagttaaaag gatacatcag tttgtagaat gccttaagct gaacaaaaag ccctttcacc
      541 ttataggcac ctccatgggt ggccacgtgg ctggagtata tgccgcttac tacccatctg
      601 atgtctgcag cctgtctctc gtgtgtcctg ctggcctgca gtactcaact gacaatcctt
      661 ttgtacaacg gctcaaagag ctggaggagt cagctgccat tcagaagatt cccttgatcc
      721 catccacccc ggaagagatg agtgagatgc tgcagctctg ctcctatgtc cgcttcaagg
      781 tgccccagca gatccttcaa ggtcttgtcg atgttcgcat tcctcataac agcttctacc
      841 ggaaattgtt tttggaaatc gtcaatgaga aatccagata ctctctgcat gagaatatgg
      901 acaagatcaa ggtcccgaca cagatcattt gggggaaaca agaccaggtg cttgatgtgt
      961 ccggggcaga catattagcc aagtcaatct ctaactccca ggtagaggtt ctggaaaact
     1021 gtggccattc ggtagtgatg gagagaccga ggaagacagc caagctcatt gtcgactttt
     1081 tagcttctgt gcataacaca gacaacaaga agctgaactg aggctgttgc cacagcttgc
     1141 attgtgcaca cagcatctgc tcccatcccc aaaacctgac acagtaacca ctctcaggga
     1201 tcctgcccca aatgctgtct gagcaccaac agccctgagg aagccagttg cctatcccag
     1261 tatccttggt tccacagagc atcaggggcc acaagaaact ctccaggatc ctttttttca
     1321 aaatagaaac ctaaatggaa caaacaaaca aaaaaaaaac aaataaaaaa atctagccat
     1381 gaagcctacc agaagtcttc aagttcatgt cactgagaag ccagtgctag gcagccaccc
     1441 tggaccacga gcaccacgga cactttcttt aagacattcc tcatacatta aacatcatct
     1501 atttccgttg ttgttgttgc ttccgatgta tcctctgcat ggtcagtggc ttcttctaca
     1561 ggagctttag tcatttactg aaaactcttg tttagagcta agtcaagttt tacatatagg
     1621 ccacgtgtga atgcagctgc ccgttaaccc aagaccaggg aagagacagc gaactgtgga
     1681 agaggtttct gcctcgaggc ctgatacaca ggaggctgag gcagaaggat ccaaggtcaa
     1741 ggcctgccag acaggtacag agtgagttca aggccagcct gagctactga ctgagaagag
     1801 aaaatgtttc tacctttttt gatgtagaaa tgtacatggg gggtggggtg gggcattgct
     1861 ccacctcggt cagccctaag aattgaccaa gagggagaac atacagactg atgagtttgg
     1921 gcacccacag atcagatgca tctgaccaac cacagaagaa cacctgactg ggaaggtgct
     1981 ctaggaatga tttacaactt tagaaatagg actaataaag caataatgtg ctagacttct
     2041 gtctaatcag actggagggt cacaccaagc agctcatggg catcttttct attctgctgt
     2101 tctactgaaa acccttggaa gtaaaatacc ggtttgttaa tgaattctgt gaattcagtg
     2161 aacaatagtg tgattgaaaa aaaatagtcc aaacagctgt aaaagagacc acaataatgt
     2221 gaaataaatt tactaagtct aggctgg
//
