LOCUS       NM_026179               3148 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus abhydrolase domain containing 5 (Abhd5), transcript
            variant 1, mRNA.
ACCESSION   NM_026179
VERSION     NM_026179.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3148)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3148)
  AUTHORS   Kulminskaya,N., Rodriguez Gamez,C.F., Hofer,P., Cerk,I.K.,
            Dubey,N., Viertlmayr,R., Sagmeister,T., Pavkov-Keller,T.,
            Zechner,R. and Oberer,M.
  TITLE     Unmasking crucial residues in adipose triglyceride lipase for
            coactivation with comparative gene identification-58
  JOURNAL   J Lipid Res 65 (1), 100491 (2024)
   PUBMED   38135254
  REMARK    GeneRIF: Unmasking crucial residues in adipose triglyceride lipase
            for coactivation with comparative gene identification-58.
            Erratum:[J Lipid Res. 2024 Aug;65(8):100613. doi:
            10.1016/j.jlr.2024.100613.. PMID: 39128381]
REFERENCE   3  (bases 1 to 3148)
  AUTHORS   Huang,M., Zhang,Y., Park,J., Chowdhury,K., Xu,J., Lu,A., Wang,L.,
            Zhang,W., Ekser,B., Yu,L. and Dong,X.C.
  TITLE     ATG14 plays a critical role in hepatic lipid droplet homeostasis
  JOURNAL   Metabolism 148, 155693 (2023)
   PUBMED   37741434
REFERENCE   4  (bases 1 to 3148)
  AUTHORS   Bricola,R.S., Cordeiro,A.V., Crisol,B.M., Braga,R.R., de Melo,D.G.,
            Rocha,M.B., Gaspar,R.C., Nakandakari,S.C.B.R., Silva,V.R.R.,
            Anaruma,C.P., Katashima,C.K., Canciglieri,R.D.S., Munoz,V.R.,
            Pavan,I.C.B., Pinto,A.P., Simabuco,F.M., Silva,A.S.R.D.,
            Moura,L.P., Pauli,J.R., Cintra,D.E. and Ropelle,E.R.
  TITLE     Aging reduces ABHD5 protein content in the adipose tissue of mice:
            The reversal effect of exercise
  JOURNAL   Cell Biochem Funct 41 (1), 128-137 (2023)
   PUBMED   36515301
  REMARK    GeneRIF: Aging reduces ABHD5 protein content in the adipose tissue
            of mice: The reversal effect of exercise.
REFERENCE   5  (bases 1 to 3148)
  AUTHORS   Kato,A., Ito,M., Sanaki,T., Okuda,T., Tsuchiya,N., Yoshimoto,R. and
            Yukioka,H.
  TITLE     Acsl1 is essential for skin barrier function through the activation
            of linoleic acid and biosynthesis of omega-O-acylceramide in mice
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1867 (2), 159085 (2022)
   PUBMED   34813948
REFERENCE   6  (bases 1 to 3148)
  AUTHORS   Yamaguchi,T., Omatsu,N., Morimoto,E., Nakashima,H., Ueno,K.,
            Tanaka,T., Satouchi,K., Hirose,F. and Osumi,T.
  TITLE     CGI-58 facilitates lipolysis on lipid droplets but is not involved
            in the vesiculation of lipid droplets caused by hormonal
            stimulation
  JOURNAL   J Lipid Res 48 (5), 1078-1089 (2007)
   PUBMED   17308334
  REMARK    GeneRIF: CGI-58 facilitates lipolysis in cooperation with perilipin
            and other factors, including lipases
REFERENCE   7  (bases 1 to 3148)
  AUTHORS   Schweiger,M., Schreiber,R., Haemmerle,G., Lass,A., Fledelius,C.,
            Jacobsen,P., Tornqvist,H., Zechner,R. and Zimmermann,R.
  TITLE     Adipose triglyceride lipase and hormone-sensitive lipase are the
            major enzymes in adipose tissue triacylglycerol catabolism
  JOURNAL   J Biol Chem 281 (52), 40236-40241 (2006)
   PUBMED   17074755
REFERENCE   8  (bases 1 to 3148)
  AUTHORS   Lass,A., Zimmermann,R., Haemmerle,G., Riederer,M., Schoiswohl,G.,
            Schweiger,M., Kienesberger,P., Strauss,J.G., Gorkiewicz,G. and
            Zechner,R.
  TITLE     Adipose triglyceride lipase-mediated lipolysis of cellular fat
            stores is activated by CGI-58 and defective in Chanarin-Dorfman
            Syndrome
  JOURNAL   Cell Metab 3 (5), 309-319 (2006)
   PUBMED   16679289
  REMARK    GeneRIF: CGI-58 interacts with adipose triglyceride lipase,
            stimulating its TG hydrolase activity up to 20-fold
REFERENCE   9  (bases 1 to 3148)
  AUTHORS   Subramanian,V., Rothenberg,A., Gomez,C., Cohen,A.W., Garcia,A.,
            Bhattacharyya,S., Shapiro,L., Dolios,G., Wang,R., Lisanti,M.P. and
            Brasaemle,D.L.
  TITLE     Perilipin A mediates the reversible binding of CGI-58 to lipid
            droplets in 3T3-L1 adipocytes
  JOURNAL   J Biol Chem 279 (40), 42062-42071 (2004)
   PUBMED   15292255
  REMARK    GeneRIF: CGI-58 binds to perilipin A-coated lipid droplets in a
            manner that is dependent upon the metabolic status of the adipocyte
            and the activity of cAMP-dependent protein kinase
REFERENCE   10 (bases 1 to 3148)
  AUTHORS   Yamaguchi,T., Omatsu,N., Matsushita,S. and Osumi,T.
  TITLE     CGI-58 interacts with perilipin and is localized to lipid droplets.
            Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman
            syndrome
  JOURNAL   J Biol Chem 279 (29), 30490-30497 (2004)
   PUBMED   15136565
  REMARK    GeneRIF: CGI-58 interacts with perilipin and is localized to lipid
            droplets
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN840045.1, AK004873.1 and AK050377.1.
            
            On Feb 23, 2006 this sequence version replaced NM_026179.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050377.1, SRR1660815.251802.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               CN840045.1         12-127
            117-1960            AK004873.1         3-1846
            1961-3148           AK050377.1         1846-3033
FEATURES             Location/Qualifiers
     source          1..3148
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 73.03 cM"
     gene            1..3148
                     /gene="Abhd5"
                     /gene_synonym="1300003D03Rik; 2010002J10Rik; CGI-58;
                     IECN5; NCIE2"
                     /note="abhydrolase domain containing 5"
                     /db_xref="GeneID:67469"
                     /db_xref="MGI:MGI:1914719"
     exon            1..224
                     /gene="Abhd5"
                     /gene_synonym="1300003D03Rik; 2010002J10Rik; CGI-58;
                     IECN5; NCIE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1227
                     /gene="Abhd5"
                     /gene_synonym="1300003D03Rik; 2010002J10Rik; CGI-58;
                     IECN5; NCIE2"
                     /EC_number="2.3.1.51"
                     /note="isoform 1 is encoded by transcript variant 1;
                     1-acylglycerol-3-phosphate O-acyltransferase ABHD5; lipid
                     droplet-binding protein CGI-58; abhydrolase
                     domain-containing protein 5"
                     /codon_start=1
                     /product="1-acylglycerol-3-phosphate O-acyltransferase
                     ABHD5 isoform 1"
                     /protein_id="NP_080455.1"
                     /db_xref="CCDS:CCDS23646.1"
                     /db_xref="GeneID:67469"
                     /db_xref="MGI:MGI:1914719"
                     /translation="MKAMAAEEEVDSADAGGGSGWLTGWLPTWCPTSTSHLKEAEEKM
                     LKCVPCTYKKEPVRISNGNRIWTLMFSHNISSKTPLVLLHGFGGGLGLWALNFEDLST
                     DRPVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCALRLDKMILLGHNLGGFL
                     AAAYSLKYPSRVSHLILVEPWGFPERPDLADQERPIPVWIRALGAALTPFNPLAGLRI
                     AGPFGLSLVQRLRPDFKRKYSSMFEDDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAK
                     RPMLQRIGGLHPDIPVSVIFGARSCIDGNSGTSIQSLRPKSYVKTIAILGAGHYVYAD
                     QPEEFNQKVKEICHTVD"
     exon            225..310
                     /gene="Abhd5"
                     /gene_synonym="1300003D03Rik; 2010002J10Rik; CGI-58;
                     IECN5; NCIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            311..683
                     /gene="Abhd5"
                     /gene_synonym="1300003D03Rik; 2010002J10Rik; CGI-58;
                     IECN5; NCIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..838
                     /gene="Abhd5"
                     /gene_synonym="1300003D03Rik; 2010002J10Rik; CGI-58;
                     IECN5; NCIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..950
                     /gene="Abhd5"
                     /gene_synonym="1300003D03Rik; 2010002J10Rik; CGI-58;
                     IECN5; NCIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1137
                     /gene="Abhd5"
                     /gene_synonym="1300003D03Rik; 2010002J10Rik; CGI-58;
                     IECN5; NCIE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..3148
                     /gene="Abhd5"
                     /gene_synonym="1300003D03Rik; 2010002J10Rik; CGI-58;
                     IECN5; NCIE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3128..3133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd5"
                     /gene_synonym="1300003D03Rik; 2010002J10Rik; CGI-58;
                     IECN5; NCIE2"
                     /note="putative"
     polyA_site      3148
                     /gene="Abhd5"
                     /gene_synonym="1300003D03Rik; 2010002J10Rik; CGI-58;
                     IECN5; NCIE2"
                     /note="putative"
ORIGIN      
        1 gccgctggga cgccgagcct gcggtggcgc ggccgcgccc tcggatcgtc ccagcgggcg
       61 gacgacgcat gcgcgggcgg tgcggtctta agggcggccg cggcccgggg ccgcccagtc
      121 ggcctgtcag ccggcttcga ggtgtgtccc tgcgcttgcg cggcggcggt gatgaaagcg
      181 atggcggcgg aggaggaggt ggactcggca gacgccggtg gagggtcagg atggctgaca
      241 gggtggcttc ctacctggtg tcccacatct acatcacacc ttaaagaagc tgaagagaaa
      301 atgttaaaat gtgtcccctg cacttacaag aaagagcctg tgcgcatatc caatggaaac
      361 agaatatgga cgctgatgtt ctctcacaac atttctagta agacgccact tgtcctcctt
      421 catggttttg gaggaggtct tggactttgg gccctgaatt ttgaagatct aagcaccgat
      481 aggcctgtct atgcctttga cctattgggc ttcggaagaa gtagtagacc taggtttgac
      541 agtgatgcgg aagaagtgga gaatcagttt gtggaatcca ttgaagagtg gagatgtgcc
      601 ctcaggttgg acaaaatgat cttgcttgga cacaacctgg gagggttctt ggctgccgct
      661 tactcactga agtacccatc aagggttagt cacctcattt tagtagagcc atggggtttt
      721 cctgagcgac cagatcttgc tgatcaagag agaccaattc cagtttggat cagggcccta
      781 ggggcagcat tgactccctt taaccccttg gctggcctca ggattgcagg accttttggg
      841 ttaagtctag tgcagcgttt gaggcctgat ttcaagcgga agtactcctc tatgtttgaa
      901 gatgacacgg tgacagagta catctaccac tgtaatgtac aaaccccaag tggtgagaca
      961 gctttcaaaa acatgacgat tccttatggg tgggccaaac ggccaatgct tcagcggata
     1021 ggtggcttgc atcctgacat tccagtttca gtgatctttg gagcccgatc ctgcatagat
     1081 ggcaactctg gaaccagcat ccagtcactg cgaccgaagt cctacgtgaa gacaattgcc
     1141 atcctcgggg cggggcatta tgtgtatgca gatcagccag aagaattcaa ccagaaagtc
     1201 aaggagatct gccacacagt agactgagca cacagaacca tgcagcaccc gtgacgggtg
     1261 ccgttcatga gcaatcccca cagcccgagg acccccgcag tctcctggac tggactctgc
     1321 agctttccac atttaaacca accagtgcct tctagaagaa tggctttcct ttctcctaca
     1381 cagaattaaa atataggaga gtctcccaat ttaataatcg ccttaaataa aggttgtcct
     1441 tctgatgtac tgaaaaattg tgatttttca gctgagactt ttctcaattt cacctaactg
     1501 cttgttaggt gtttggtgtt gcagtccgta tgccagtgta cctagtccat atgccagtgt
     1561 acctagtcca tatgccagtg tacctagcga cttctgggcc tgtggtgtta ggtgttggga
     1621 agctgcactt tattttcctt gcatgtattt actgtctcta acaactaaca tagttaaccc
     1681 aagtattttt atgtaaaaag atttcaattt agaatacttc atttttgaga tggagtttag
     1741 aatatttcat tttgaaatgg aacgaaaggg ttaggttttg atgtaaaaga caggagtcaa
     1801 tcactagcgt taactttcct tgttttcctg ttttatgatc aaggccgtgt ttcagcattt
     1861 taaatgtgtt ccatggtgac atagtgctta cagcaacgca gttcctgggg cccttctgtg
     1921 tgtaatctac agggttctat gagaacatat gcatagactc agccattcaa gtgctgagta
     1981 gcccgaacct gaaacctgtc ccctttcctt ccagtattcc caggacccag gatctaggtc
     2041 ccctcacttg cagggatgtt aacactgttg cctatcggga aaccaagtcc cactgtgttc
     2101 tcatgagcaa ccagcttaca tggtgcttaa actggattgc attttaccac taacatttaa
     2161 aactatgtgg tgctgttacg tctcatggcg ccagaaatga gatagaactt gtggttattt
     2221 ttattgaata ttatgttaat ctaaccactt atatacttga agtaaaatta tgaaaaaaat
     2281 ctattatgtt gtttgaactg tttggcagaa accaccattg gatttataac tttctgacag
     2341 tgttaaagtg agagacaatt tgaaactatg aaaaagctcc atggaatagc tggatgctga
     2401 gaaagccttc tgtctagaga acagagaaca aagagcattg ttaccaacat tgtttgtcca
     2461 ggagaaaagc agattacaca aataaaacct cgacctcaca aatcacgact cgatgacttg
     2521 agctattaca tttttagtga ctagtcagga aatttttttg aaaatataaa attatatcac
     2581 atgtaattaa ctgccagcaa gattagctcc atactttagg agaccgtgaa aatcatattg
     2641 aagcgggaca aagcagcctc ccagcgaccc tttatctgac tcatttaacg cattaggtta
     2701 gtgcaaggag ccaccgtgag accaaaagtg cttgttctca ccaccttgag aataaaaata
     2761 gcctttttcc ccctttatag ttagtgttgt gggtggccag atccacactt gagagtggta
     2821 gaacatttgt gcaggactct tacttggcag tcaccagcct cagtcttttg ttcaccaaag
     2881 aaaaaaaatt ctgcacaaga aaccggtctg cccaaagaaa ctgacttccc cactgagctg
     2941 ctttgcttta ctggaaacct gtgaagcttc ctaaacatta aaatttccat ggtgtgtgca
     3001 gtgattgttg taaaggttga agtagtaaag tttataatct gcaaattctt gagaacagtg
     3061 gttgctaaac atctttcttg taaacgatct cttaactatc attggtcttt gctaagttat
     3121 tttacagaat aaactcgaca gtgctagc
//
