LOCUS       NM_134130               1903 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus abhydrolase domain containing 3 (Abhd3), mRNA.
ACCESSION   NM_134130
VERSION     NM_134130.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Lui,J.H., Nowakowski,T.J., Pollen,A.A., Javaherian,A.,
            Kriegstein,A.R. and Oldham,M.C.
  TITLE     Radial glia require PDGFD-PDGFRbeta signalling in human but not
            mouse neocortex
  JOURNAL   Nature 515 (7526), 264-268 (2014)
   PUBMED   25391964
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Long,J.Z., Cisar,J.S., Milliken,D., Niessen,S., Wang,C.,
            Trauger,S.A., Siuzdak,G. and Cravatt,B.F.
  TITLE     Metabolomics annotates ABHD3 as a physiologic regulator of
            medium-chain phospholipids
  JOURNAL   Nat Chem Biol 7 (11), 763-765 (2011)
   PUBMED   21926997
  REMARK    GeneRIF: This study descrbed a cell-based screen for enzyme
            substrate discovery and its application to identify the protein
            alpha/beta-hydrolase domain-containing 3 as a lipase that
            selectively cleaves medium-chain and oxidatively truncated
            phospholipids.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1903)
  AUTHORS   Edgar,A.J. and Polak,J.M.
  TITLE     Cloning and tissue distribution of three murine alpha/beta
            hydrolase fold protein cDNAs
  JOURNAL   Biochem Biophys Res Commun 292 (3), 617-625 (2002)
   PUBMED   11922611
  REMARK    GeneRIF: a member of a novel family of membrane bound enzymes whose
            function has yet to be determined; highest expression level in the
            liver [LABH3]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF429302.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF429302.1, AK134676.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 5.28 cM"
     gene            1..1903
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /note="abhydrolase domain containing 3"
                     /db_xref="GeneID:106861"
                     /db_xref="MGI:MGI:2147183"
     exon            1..167
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1241
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /EC_number="3.1.1.4"
                     /EC_number="3.1.1.32"
                     /note="lung alpha/beta hydrolase 3; abhydrolase
                     domain-containing protein 3; mmLABH3"
                     /codon_start=1
                     /product="phospholipase ABHD3"
                     /protein_id="NP_598891.1"
                     /db_xref="CCDS:CCDS29057.1"
                     /db_xref="GeneID:106861"
                     /db_xref="MGI:MGI:2147183"
                     /translation="MQRLAMDLRVLSRELALYLEHQVRVGFFGSGVGLSLILGFSVAY
                     ACYYLSSIAKKPQLVIGGESFSRFLQDHCPVVTETYYPTVWCWESRGQTLLRPFITSK
                     PPVQYRNELIKTADGGQISLDWFDNNNSAYYVDASTRPTILLLPGLTGTSKESYILHM
                     IHLSEELGYRCVVFNNRGVAGESLLTPRTYCCANTEDLEAVVHHVHSLYPGAPFLAAG
                     VSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESLERPLNWLLFNYYLTTCLQ
                     SSVKKHRHMFVEQIDMDQVMKAKSIREFDKRFTAVMFGYRTLDDYYTDASPNRRLKSV
                     GIPVLCLNATDDVFSPSHAIPIETAKQNPNVALVLTAYGGHIGFLEGIWPRQCTYMDR
                     VFKQFVQAMVEHGHELSNM"
     exon            168..331
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            332..514
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            515..560
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            561..673
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            674..847
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            848..896
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1062
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1887
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1868..1873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /note="hexamer: AATAAA"
     polyA_site      1887
                     /gene="Abhd3"
                     /gene_synonym="LABH3"
                     /note="major polyA site"
ORIGIN      
        1 gcactatgca gcgcctggcc atggacctgc gggtgctgtc ccgggagctg gcgctctacc
       61 tggagcacca ggttcgcgtc ggcttcttcg gctcgggcgt gggcttgtca ctgatcttgg
      121 gattcagcgt tgcctatgct tgctactacc tgagtagcat tgccaagaaa ccccagttag
      181 tgattggagg ggagagtttc agccgcttcc tacaggacca ctgtcccgtg gtgacagaaa
      241 cctattaccc gacggtctgg tgctgggaga gccgaggaca gacattgctg agacccttca
      301 tcacttccaa acccccggtg caatacagga acgaactcat taaaactgca gacggaggac
      361 agatctcact ggactggttt gataacaata acagtgcgta ctatgtggat gccagcacca
      421 gacctactat cttgctcttg cctggcctca ctggaacaag caaggaatcc tacatccttc
      481 atatgatcca tctcagtgaa gaattaggat acaggtgtgt ggtttttaat aacagaggag
      541 tagcaggaga aagtctcttg acaccacgga cttactgctg tgcgaacact gaagacttgg
      601 aggccgtcgt ccaccacgtg cacagcctgt accctggggc tccttttctg gcagcaggcg
      661 tatcaatggg aggaatgctg cttctgaatt acttgggtaa aattgggtcc aaaacccctc
      721 tgatggctgc tgcaacgttt tcggttggct ggaacacttt cgcttgctca gagtctctgg
      781 agaggccgct gaactggcta ctttttaatt actacttaac aacttgcctc cagtcatcag
      841 ttaagaagca ccggcatatg tttgtggagc agattgacat ggatcaggtc atgaaggcca
      901 agtcgatcag agagtttgat aagcggttca cggcggtcat gtttgggtac cgcacactcg
      961 atgattacta caccgatgcc agtccaaacc gcaggctgaa gtcagtggga atccctgttc
     1021 tgtgcctgaa tgctacggac gacgtgttct cacccagcca tgctatccca atagaaactg
     1081 ctaaacaaaa ccctaacgtg gctttggtcc ttacagccta tggaggccat attggttttc
     1141 tggagggaat ctggcctagg caatgcactt acatggatcg agtcttcaag caatttgtac
     1201 aggccatggt tgagcacgga catgaactct ccaacatgta gcttcttggc tgcattcagc
     1261 ctgagccact gttgttaaag cagctcagct tggagcacag gtttcaacag ctgagggtag
     1321 agctgacaag ccggcagatg ggtgaagagg tccagcatga catgcaaaac tacttcttag
     1381 ggaaacacaa caactttgta gtaagaaact aaagatagtt tagattgtta ctgtagtaga
     1441 tcttattttt cctatgcctt accaaatatg accttaaaat taagtagtcc ttatgtaaca
     1501 gaattgcact taaccaaaac tattgtgtaa aacgatttta attcctcagg gttttaattt
     1561 aggctagtat ttttaattac tcagtttagg tgacttaata atactttaat aactgttaag
     1621 agattttaat gatttgaata taagttagaa gaggggtatt catggtaaca agaaactgaa
     1681 aaggataaat tatattgttc taagtgtttc ttctgattta aaaggcaaat gcaacaatgt
     1741 tagactgact tctatatttg ctctcttctc tgataatatt aaattagggc tgatttatgt
     1801 tttataattg ttatcattta catgcttatt tttaaaatag tatttgtgaa tacatatatc
     1861 atattaaaat aaattctatc attttaaaaa aaaaaaaaaa aaa
//
