LOCUS       NM_018811               2903 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus abhydrolase domain containing 2 (Abhd2), mRNA.
ACCESSION   NM_018811
VERSION     NM_018811.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2903)
  AUTHORS   Lv,M.Y., Jin,L.L., Sang,X.Q., Shi,W.C., Qiang,L.X., Lin,Q.Y. and
            Jin,S.D.
  TITLE     Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via
            TGF-beta
  JOURNAL   Int J Chron Obstruct Pulmon Dis 19, 33-50 (2024)
   PUBMED   38197032
  REMARK    GeneRIF: Abhd2, a Candidate Gene Regulating Airway Remodeling in
            COPD via TGF-beta.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2903)
  AUTHORS   Qiang,L., Li,X., Li,Q., Bo,H., Liu,Y., Lv,M., Chen,X., Ju,H.,
            Sang,X., Li,Z. and Jin,S.
  TITLE     ABHD2 deficiency aggravates ovalbumin-induced airway remodeling
            through the PI3K/Akt pathway in an animal model of chronic asthma
  JOURNAL   Pol J Vet Sci 26 (4), 635-646 (2023)
   PUBMED   38088307
  REMARK    GeneRIF: ABHD2 deficiency aggravates ovalbumin-induced airway
            remodeling through the PI3K/Akt pathway in an animal model of
            chronic asthma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2903)
  AUTHORS   Price,T.R., Stapleton,D.S., Schueler,K.L., Norris,M.K., Parks,B.W.,
            Yandell,B.S., Churchill,G.A., Holland,W.L., Keller,M.P. and
            Attie,A.D.
  TITLE     Lipidomic QTL in Diversity Outbred mice identifies a novel function
            for alpha/beta hydrolase domain 2 (Abhd2) as an enzyme that
            metabolizes phosphatidylcholine and cardiolipin
  JOURNAL   PLoS Genet 19 (7), e1010713 (2023)
   PUBMED   37523383
  REMARK    GeneRIF: Lipidomic QTL in Diversity Outbred mice identifies a novel
            function for alpha/beta hydrolase domain 2 (Abhd2) as an enzyme
            that metabolizes phosphatidylcholine and cardiolipin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2903)
  AUTHORS   Bjorkgren,I., Mendoza,S., Chung,D.H., Haoui,M., Petersen,N.T. and
            Lishko,P.V.
  TITLE     The epithelial potassium channel Kir7.1 is stimulated by
            progesterone
  JOURNAL   J Gen Physiol 153 (10) (2021)
   PUBMED   34387656
REFERENCE   5  (bases 1 to 2903)
  AUTHORS   Bjorkgren,I., Chung,D.H., Mendoza,S., Gabelev-Khasin,L.,
            Petersen,N.T., Modzelewski,A., He,L. and Lishko,P.V.
  TITLE     Alpha/Beta Hydrolase Domain-Containing Protein 2 Regulates the
            Rhythm of Follicular Maturation and Estrous Stages of the Female
            Reproductive Cycle
  JOURNAL   Front Cell Dev Biol 9, 710864 (2021)
   PUBMED   34568325
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2903)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   7  (bases 1 to 2903)
  AUTHORS   Jin,S., Zhao,G., Li,Z., Nishimoto,Y., Isohama,Y., Shen,J., Ito,T.,
            Takeya,M., Araki,K., He,P. and Yamamura,K.
  TITLE     Age-related pulmonary emphysema in mice lacking alpha/beta
            hydrolase domain containing 2 gene
  JOURNAL   Biochem Biophys Res Commun 380 (2), 419-424 (2009)
   PUBMED   19250629
  REMARK    GeneRIF: These findings suggest that derangement in alveolar
            phospholipid metabolism can induce emphysema, and that Abhd2 plays
            a critical role in maintaining lung structural integrity.
REFERENCE   8  (bases 1 to 2903)
  AUTHORS   Miyata,K., Oike,Y., Hoshii,T., Maekawa,H., Ogawa,H., Suda,T.,
            Araki,K. and Yamamura,K.
  TITLE     Increase of smooth muscle cell migration and of intimal hyperplasia
            in mice lacking the alpha/beta hydrolase domain containing 2 gene
  JOURNAL   Biochem Biophys Res Commun 329 (1), 296-304 (2005)
   PUBMED   15721306
REFERENCE   9  (bases 1 to 2903)
  AUTHORS   Edgar,A.J. and Polak,J.M.
  TITLE     Cloning and tissue distribution of three murine alpha/beta
            hydrolase fold protein cDNAs
  JOURNAL   Biochem Biophys Res Commun 292 (3), 617-625 (2002)
   PUBMED   11922611
  REMARK    GeneRIF: LABH-2 protein is a member of a novel family of membrane
            bound enzymes whose function has yet to be determined; highest
            expression level in the testis
REFERENCE   10 (bases 1 to 2903)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC160464.3.
            
            On Apr 28, 2007 this sequence version replaced NM_018811.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF546701.1, AK139526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC160464.3         139084-139157       c
            75-174              AC160464.3         117816-117915       c
            175-374             AC160464.3         115216-115415       c
            375-550             AC160464.3         88779-88954         c
            551-718             AC160464.3         86822-86989         c
            719-902             AC160464.3         63980-64163         c
            903-995             AC160464.3         61580-61672         c
            996-1106            AC160464.3         58323-58433         c
            1107-1176           AC160464.3         56552-56621         c
            1177-1261           AC160464.3         54274-54358         c
            1262-2903           AC160464.3         50822-52463         c
FEATURES             Location/Qualifiers
     source          1..2903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 44.96 cM"
     gene            1..2903
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /note="abhydrolase domain containing 2"
                     /db_xref="GeneID:54608"
                     /db_xref="MGI:MGI:1914344"
     exon            1..74
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /inference="alignment:Splign:2.1.0"
     exon            75..174
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /inference="alignment:Splign:2.1.0"
     exon            175..374
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1458
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /EC_number="3.1.1.79"
                     /EC_number="3.1.1.23"
                     /EC_number="3.1.1.6"
                     /note="lung alpha/beta hydrolase 2; alpha/beta hydrolase
                     fold protein; abhydrolase domain-containing protein 2;
                     mmLABH2; 2-arachidonoylglycerol hydrolase; acetylesterase;
                     triacylglycerol lipase"
                     /codon_start=1
                     /product="monoacylglycerol lipase ABHD2"
                     /protein_id="NP_061281.3"
                     /db_xref="CCDS:CCDS21380.1"
                     /db_xref="GeneID:54608"
                     /db_xref="MGI:MGI:1914344"
                     /translation="MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDL
                     YFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFIT
                     MSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVL
                     NHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKRTYPQTQLVVVGFSLGGNIVCKYLG
                     ETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALF
                     GDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIY
                     VPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTW
                     MDKLVVEYANAICQWERNKSQCSDTEQMEAELE"
     exon            375..550
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..718
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..902
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..995
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1106
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1176
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1261
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..2903
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1706
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /note="major polyA site"
     regulatory      1960..1965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
                     /note="hexamer: AACAAA"
     polyA_site      1985
                     /gene="Abhd2"
                     /gene_synonym="2210009N18Rik; Labh-2; LABH2"
ORIGIN      
        1 agcgcagccg gcagctgcgg agctgcggga accggactcc gggcgggttg gactgctgga
       61 gtcaatgaga gaagctttta ggttaatttg aatataagat cagatctgat tggcccacct
      121 ggacacccct tcaaggaaag cccgtattct ccgagagagg aataagcgac atagatcaag
      181 atgaatgcca tgctagagac ccccgagctc cccgccgtgt ttgatggggt gaagctggct
      241 gccgtagctg ccgttctcta cgtcatcgtg cggtgtttga acctgaagag ccctactgcc
      301 cctcctgacc tctacttcca ggactccggg ctctcacgtt tcctgctcaa atcctgtcct
      361 cttctgacca aagaatacat tccaccactg atctggggga aaagcggaca tatccagaca
      421 gccttgtatg ggaagatggg gagggtgagg tcaccacacc cttacgggca ccgcaagttc
      481 atcaccatgt cggatggtgc cacttctacc ttcgacctct tcgagcccct ggctgagcac
      541 tgtgttggag atgacatcac catggtcatc tgtcctggaa ttgccaacca cagcgagaag
      601 cagtatatcc gaaccttcgt tgactatgcc cagaaaaatg gctaccggtg cgcagtgcta
      661 aaccacctgg gagccctccc caacattgag ctgacctccc cacgaatgtt cacctatggc
      721 tgcacgtggg aatttggagc catggtgaac tacatcaaga ggacatatcc ccagacccag
      781 ctggtcgtcg tgggcttcag cctgggtggt aacatcgtgt gcaaatactt gggggagacg
      841 caggcaaacc aggaaaaggt cctgtgctgt gtcagtgtgt gccaggggta cagcgcactg
      901 agggcccagg agaccttcat gcagtgggac cagtgccgca ggttctacaa cttcctcatg
      961 gccgacaaca tgaagaagat catcctgtct cacagacaag ctctctttgg agaccacgtt
     1021 aagaaacccc agagcctgga ggacacggac ttgagccggc tgtacacagc aacatccctg
     1081 atgcagattg atgacaatgt gatgagaaag ttccatggct ataattccct gaaggaatac
     1141 tatgaggaag agagctgcat gaggtacctg cacaggatat atgtgcctct catgctggtt
     1201 aatgcagctg acgacccctt ggtgcacgaa agccttctaa ccattccaaa gtctctctca
     1261 gagaaacggg agaatgtcat gttcgtgctg cctctgcatg ggggccacct gggcttcttc
     1321 gagggctccg tgctgttccc cgagccgctg acatggatgg ataagctggt agtggagtat
     1381 gccaatgcca tttgccaatg ggaaaggaat aagtcccagt gctcagacac ggagcagatg
     1441 gaggccgagt tggaatgagg tctctggact cggcgtgctc cagcggccct cctctggaac
     1501 ccacgtccct ttgacggctg tttcaggtct cccagtgacc tggatctgac ctcataccat
     1561 cagtgggggg ttacccatca tgcaacctgt ctcaagtagg cggctctccc tgggagctcc
     1621 aggctatttt tgtgcttagt tacgggtttt ctccattgca tcgttagcca tggtgacaag
     1681 ctacaagatt ctcacccttc tgtccagttt cagtatctga ttgctttcac gctggttaac
     1741 atctagtttt cctagtaagg agcgagtctg aactatagtt ttgctttgcc aatcaaaggc
     1801 cttttcctga gaacagtgaa ggatatacgt cactctgtga tggatgtatg cgccgtacta
     1861 gagtccccac caagaagtca gcatccctcg tgctgaagaa attactcagc ttgggagtct
     1921 gagaacctgg gccttcctgg gcctgagttt tgcctgtgaa acaaaggaaa ttctctgaat
     1981 caaaagccga gttttccttc tccttgtctc ctcagacacc tctgtctctg tcttgctgct
     2041 gctgagagtt gcatggggca cttgtctaaa aattcagcct cccagatccc tcccctcgga
     2101 gccgctgacg cagtgggctt gggaagggct ctggggattt taatttttga caagtgcccc
     2161 agggaattct catcatccag caaaccgagg gaaataccgt actactatgc ctttaagtta
     2221 gaaagatctt ggtggctcat ttaattgaca ttcctaagcc acagtgtccc tctgctccca
     2281 gagacctcca aagcagcaag gcctgttgta tggctgcctt tgtgtgatcc ccctaaaagg
     2341 gagaagacat tggagctgaa ccctgtctct gcttctccct ggctgtatga ctctggataa
     2401 gtccctctgg acttgactct cttcctctgt taagtagggg gttggaccag gtagatggca
     2461 gagatgccca tcggttcatc cttccagggt tgcctgggac tccgcctccc aggttgagca
     2521 tgcaagcgcc attaattgca tttttcccct tccccatttc atagaaagat ttgagagtct
     2581 tactcactct cttgtaattt tactttttca ccccagttct acccaatgtc taattgatac
     2641 caaacaaccc aaaagttgga tgggagtttg aagaaatgta tttgcagcta agagaaggga
     2701 gtgttctttt gaagttggtt tgtacttaaa tagcctctgc atgttgtctg ttggatagat
     2761 ctttctgaaa tgtcttctca agcggacttc tcactctagg gtccaagtgc tccacttctg
     2821 gaacgttgtg gtacttgagt ccctaagaac ctgcactttg aaaagtatgc agttgctgtc
     2881 cagaattgaa tgagacgatg agt
//
