LOCUS       NM_001417679            1960 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus abhydrolase domain containing 16A (Abhd16a),
            transcript variant 12, mRNA.
ACCESSION   NM_001417679
VERSION     NM_001417679.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1960)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1960)
  AUTHORS   Singh,S., Joshi,A. and Kamat,S.S.
  TITLE     Mapping the Neuroanatomy of ABHD16A, ABHD12, and
            Lysophosphatidylserines Provides New Insights into the
            Pathophysiology of the Human Neurological Disorder PHARC
  JOURNAL   Biochemistry 59 (24), 2299-2311 (2020)
   PUBMED   32462874
  REMARK    GeneRIF: Mapping the Neuroanatomy of ABHD16A, ABHD12, and
            Lysophosphatidylserines Provides New Insights into the
            Pathophysiology of the Human Neurological Disorder PHARC.
REFERENCE   3  (bases 1 to 1960)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1960)
  AUTHORS   Kamat,S.S., Camara,K., Parsons,W.H., Chen,D.H., Dix,M.M.,
            Bird,T.D., Howell,A.R. and Cravatt,B.F.
  TITLE     Immunomodulatory lysophosphatidylserines are regulated by ABHD16A
            and ABHD12 interplay
  JOURNAL   Nat Chem Biol 11 (2), 164-171 (2015)
   PUBMED   25580854
  REMARK    GeneRIF: In mouse macrophages, disruption of ABHD12 and ABHD16A
            respectively increases and decreases both lysophosphatidylserines
            and lipopolysaccharide-induced cytokine production.
REFERENCE   5  (bases 1 to 1960)
  AUTHORS   Savinainen,J.R., Patel,J.Z., Parkkari,T., Navia-Paldanius,D.,
            Marjamaa,J.J., Laitinen,T., Nevalainen,T. and Laitinen,J.T.
  TITLE     Biochemical and pharmacological characterization of the human
            lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A)
  JOURNAL   PLoS One 9 (10), e109869 (2014)
   PUBMED   25290914
  REMARK    GeneRIF: BAT5 is a genuine lipase with preference for long-chain
            unsaturated monoacylglycerols, and could in this capacity regulate
            glycerolipid metabolism in vivo as well.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1960)
  AUTHORS   Mathew,P.A., Kumar,V., Bennett,M. and Flaherty,L.
  TITLE     Identification of a recombinational breakpoint at the BAT5 locus in
            three intra-H-2 recombinant inbred mouse strains
  JOURNAL   Exp Clin Immunogenet 12 (4), 261-267 (1995)
   PUBMED   8919359
REFERENCE   7  (bases 1 to 1960)
  AUTHORS   Gasser,D.L., Sternberg,N.L., Pierce,J.C., Goldner-Sauve,A.,
            Feng,H., Haq,A.K., Spies,T., Hunt,C., Buetow,K.H. and Chaplin,D.D.
  TITLE     P1 and cosmid clones define the organization of 280 kb of the mouse
            H-2 complex containing the Cps-1 and Hsp70 loci
  JOURNAL   Immunogenetics 39 (1), 48-55 (1994)
   PUBMED   7993390
REFERENCE   8  (bases 1 to 1960)
  AUTHORS   Ikegami,H., Kawaguchi,Y., Ueda,H., Fukuda,M., Takakawa,K.,
            Fujioka,Y., Fujisawa,T., Uchida,K. and Ogihara,T.
  TITLE     MHC-linked diabetogenic gene of the NOD mouse: molecular mapping of
            the 3' boundary of the diabetogenic region
  JOURNAL   Biochem Biophys Res Commun 192 (2), 677-682 (1993)
   PUBMED   8097912
REFERENCE   9  (bases 1 to 1960)
  AUTHORS   Turner,S.K., Miller,C.L., Wettstein,P.J., Hasenkrug,K.J.,
            Stimpfling,J.H. and Carlson,G.A.
  TITLE     Meiotic recombination within the H-2K-H-2D interval:
            characterization of a panel of congenic mice, including 12 new
            strains, using DNA markers
  JOURNAL   Immunogenetics 38 (5), 332-340 (1993)
   PUBMED   8102126
REFERENCE   10 (bases 1 to 1960)
  AUTHORS   Lafuse,W.P., Lanning,D., Spies,T. and David,C.S.
  TITLE     PFGE mapping and RFLP analysis of the S/D region of the mouse H-2
            complex
  JOURNAL   Immunogenetics 36 (2), 110-116 (1992)
   PUBMED   1351875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087117.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.207478.1,
                                           SRR13422598.918690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC087117.9         197910-198073
            165-221             AC087117.9         198986-199042
            222-288             AC087117.9         199639-199705
            289-375             AC087117.9         200188-200274
            376-461             AC087117.9         202868-202953
            462-535             AC087117.9         204921-204994
            536-658             AC087117.9         205099-205221
            659-773             AC087117.9         207311-207425
            774-875             AC087117.9         207516-207617
            876-939             AC087117.9         208952-209015
            940-989             AC087117.9         209256-209305
            990-1113            AC087117.9         209579-209702
            1114-1218           AC087117.9         209859-209963
            1219-1282           AC087117.9         210159-210222
            1283-1339           AC087117.9         210445-210501
            1340-1402           AC087117.9         210587-210649
            1403-1479           AC087117.9         210763-210839
            1480-1578           AC087117.9         210915-211013
            1579-1642           AC087117.9         211092-211155
            1643-1960           AC087117.9         211287-211604
FEATURES             Location/Qualifiers
     source          1..1960
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     gene            1..1960
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /note="abhydrolase domain containing 16A"
                     /db_xref="GeneID:193742"
                     /db_xref="MGI:MGI:99476"
     exon            1..164
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1916
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /EC_number="3.1.1.23"
                     /note="isoform 9 is encoded by transcript variant 12;
                     protein BAT5; abhydrolase domain-containing protein 16A;
                     HLA-B associated transcript 5; alpha/beta hydrolase
                     domain-containing protein 16A; protein ABHD16A;
                     monoacylglycerol lipase ABHD16A; phosphatidylserine lipase
                     ABHD16A"
                     /codon_start=1
                     /product="phosphatidylserine lipase ABHD16A isoform 9"
                     /protein_id="NP_001404608.1"
                     /db_xref="GeneID:193742"
                     /db_xref="MGI:MGI:99476"
                     /translation="MAKLLSCVLGPRLYKIYRERDTDRAASSVPETPTAVPAASSSSW
                     DTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGT
                     LLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSAENKRQLANYNFDFRSWPVDF
                     HWEEPSSRKGSRGGPSRRGVALLRPEPLHRGTADTFLNRVKKLPCQITSYLVAHTLGR
                     RMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEP
                     QGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVV
                     VQFAIHRLGFQPQDIVIYAWSIGGFTATWAAMSYPDISAVILDASFDDLVPLALKVMP
                     DSWRALVTRTVRQHLNLNNSEQLCRFQGPVLLVRRTKDEIITTTVPEDIMSNRGNDLL
                     LKLLQFRYPRVMVEEGLRAVRQWLEASSQLEEASIYSRWEVEEDWCVSVLRSYQAEHG
                     PDFPWSVGEDMSADGRRQLALFLVSSGAGPGSIYTTLRPHTALHSRPSTSRCPGTSRT
                     TCRLFWKDKIGGDTRGYFCDSLHVAVYSLARGDIPSGQQSSCTFPSSMWKHLAPLIHT
                     CIK"
     exon            165..221
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            222..288
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            289..375
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            376..461
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            462..535
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            536..658
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            659..773
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            774..875
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            876..939
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            940..989
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1113
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1218
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1282
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1339
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1402
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1479
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1578
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1642
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1960
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1937..1942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /note="hexamer: AATAAA"
     polyA_site      1960
                     /gene="Abhd16a"
                     /gene_synonym="Bat-5; Bat5; D17H6S82E; mBAT5; NG26"
                     /note="major polyA site"
ORIGIN      
        1 gaggccgagg gacagcggcc cgagccgggg ctatggcgaa gctcctgagc tgcgtcctcg
       61 gcccccggct ctacaagatc taccgggaga gggacacgga ccgggccgcg tccagcgtcc
      121 ccgagactcc cactgccgtc cccgccgcct cgtccagctc ctgggatacg tattatcagc
      181 ctcgggccct ggagaaacat gcagacagca tcctggcact ggcttcagtc ttctggtcca
      241 tctcttatta ctcctctccc ttcgccttct tctacttata caggaaaggt tacttgagtt
      301 tgtccaaagt ggtgccattt tctcactatg ccgggacatt gctgctgcta cttgcagggg
      361 tggcctgcct ccgaggcatt ggccgctgga ccaaccccca gtaccgacag ttcatcacca
      421 tcttggaagc cacacatagg aaccagtctg cagaaaacaa gaggcagctg gccaactata
      481 acttcgactt caggagctgg ccagtcgact tccactggga ggagcccagc agccggaagg
      541 ggtcccgagg tggcccttcc cgcaggggtg tggccctgct tcgtccagag cctctgcacc
      601 ggggaacagc agacacgttt ctcaacaggg tcaagaagct gccctgtcag atcaccagct
      661 atctggtggc acacaccttg gggcgccgga tgctgtaccc aggctccgtg tacctgctcc
      721 agaaggccct catgcctgtg ctgctgcagg gccaggcccg actggtggaa gagtgtaatg
      781 ggcgccgtgc aaaactgctc gcctgtgatg gtaatgagat agacaccatg tttgtggacc
      841 gacgggggac agctgagccc caggggcaga agctggtcat ctgctgtgag gggaatgcag
      901 gattctatga ggtgggctgt gtctccacac ccctagaagc tggctattct gtcctgggct
      961 ggaatcatcc aggctttgca ggaagcacgg gggtaccatt cccacagaac gaggccaatg
     1021 ccatggatgt ggtggttcag tttgccatcc accgcctggg cttccagccc caggacattg
     1081 tcatctacgc ctggtccatt ggaggcttca ctgccacgtg ggcagccatg tcctacccag
     1141 acatcagtgc tgttatcctg gacgcctcct tcgatgactt ggtgcccctg gccttgaagg
     1201 tcatgccgga cagctggcga gccctggtca ccaggacggt gaggcagcat ctcaacctca
     1261 acaactcgga gcagctgtgc aggttccagg gccccgtgct gctggtccgg agaaccaagg
     1321 acgagatcat caccaccacg gtccctgagg acatcatgtc caacagaggc aatgacctcc
     1381 tgctgaagct cctgcagttc cggtaccctc gagtgatggt ggaggagggg ctcagagctg
     1441 tgaggcagtg gctggaggcc tcttcccagc tagaggaagc ctccatttac agtcgctggg
     1501 aggtggagga ggactggtgt gtgtctgtgc ttcgctccta ccaggcagag catgggcctg
     1561 atttcccctg gagtgtgggg gaggacatga gtgcagatgg acggaggcag ctggcgctgt
     1621 tcctggtgag ctcaggagct gggcccggaa gcatctacac aactttgagg ccacacactg
     1681 cactccactc ccggcccagc acttccagat gccctggcac ctctagaacc acgtgtagac
     1741 tcttctggaa ggacaagata ggaggagaca cgaggggata cttttgtgac tctcttcatg
     1801 ttgctgttta tagtctggcc cgtggggaca tcccctctgg ccaacagtcc tcctgcacgt
     1861 ttccctcatc tatgtggaag cacttagctc ccctcataca cacctgcatt aaatgaatga
     1921 tttattccta ataattaata aaaaggtatt ttttctacaa
//
