LOCUS       NM_026185               3249 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus abhydrolase domain containing 15 (Abhd15), mRNA.
ACCESSION   NM_026185
VERSION     NM_026185.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3249)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3249)
  AUTHORS   Stockli,J., Zadoorian,A., Cooke,K.C., Deshpande,V., Yau,B.,
            Herrmann,G., Kebede,M.A., Humphrey,S.J. and James,D.E.
  TITLE     ABHD15 regulates adipose tissue lipolysis and hepatic lipid
            accumulation
  JOURNAL   Mol Metab 25, 83-94 (2019)
   PUBMED   31105056
  REMARK    GeneRIF: ABHD15 protein levels were reduced in adipocytes from mice
            fed a Western diet, further implicating this protein in metabolic
            homeostasis.
            Erratum:[Mol Metab. 2021 Jun;48:101219. doi:
            10.1016/j.molmet.2021.101219.. PMID: 33775605]
REFERENCE   3  (bases 1 to 3249)
  AUTHORS   Xia,W., Pessentheiner,A.R., Hofer,D.C., Amor,M., Schreiber,R.,
            Schoiswohl,G., Eichmann,T.O., Walenta,E., Itariu,B., Prager,G.,
            Hackl,H., Stulnig,T., Kratky,D., Rulicke,T. and Bogner-Strauss,J.G.
  TITLE     Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by
            Altering PDE3B Stability and Contributes to Insulin Resistance
  JOURNAL   Cell Rep 23 (7), 1948-1961 (2018)
   PUBMED   29768196
  REMARK    GeneRIF: ABHD15 associates with and stabilizes phosphodiesterase 3B
            (PDE3B).
REFERENCE   4  (bases 1 to 3249)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3249)
  AUTHORS   Walenta,E., Pessentheiner,A.R., Pelzmann,H.J., Deutsch,A.,
            Goeritzer,M., Kratky,D., Hackl,H., Oh,D.Y., Prokesch,A. and
            Bogner-Strauss,J.G.
  TITLE     alpha/beta-hydrolase domain containing protein 15 (ABHD15)--an
            adipogenic protein protecting from apoptosis
  JOURNAL   PLoS One 8 (11), e79134 (2013)
   PUBMED   24236098
  REMARK    GeneRIF: ABHD15 is an essential component in the development of
            adipocytes as well as in apoptosis.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046590.1, AK153809.1 and CJ304668.1.
            
            On May 22, 2007 this sequence version replaced NM_026185.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153809.1, AK046590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK046590.1         2-5
            5-947               AK153809.1         2-944
            948-1715            AK046590.1         949-1716
            1716-3083           AK046590.1         1718-3085
            3084-3249           CJ304668.1         314-479
FEATURES             Location/Qualifiers
     source          1..3249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.63 cM"
     gene            1..3249
                     /gene="Abhd15"
                     /gene_synonym="1300007F04Rik"
                     /note="abhydrolase domain containing 15"
                     /db_xref="GeneID:67477"
                     /db_xref="MGI:MGI:1914727"
     exon            1..936
                     /gene="Abhd15"
                     /gene_synonym="1300007F04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1462
                     /gene="Abhd15"
                     /gene_synonym="1300007F04Rik"
                     /EC_number="3.1.1.-"
                     /note="abhydrolase domain-containing protein 15;
                     alpha/beta hydrolase domain-containing protein 15; protein
                     ABHD15"
                     /codon_start=1
                     /product="protein ABHD15 precursor"
                     /protein_id="NP_080461.3"
                     /db_xref="CCDS:CCDS36234.1"
                     /db_xref="GeneID:67477"
                     /db_xref="MGI:MGI:1914727"
                     /translation="MPPWAAALALLLAALALLLLRPWKRAVGARTSVRDHEEQEVASG
                     GPADQFSDRREALPGGCSLICKPSALAQCLLRALRRSAALEPSPRSWLSGPHLQTFCH
                     FILPVGPGPELAREYLQLADDGLVALDWVIGPCARGRRVTNPGSLPPVLLVIPNAWGR
                     LTRNVLGLCLLALERGYYPVIFHRRGHHGCPLVSPRLQPFGDPSDLKEAVTYIRFRHP
                     AAPLFAVSEGSGSALLLSYLGECGSSSYVTGAACISPVLRCREWFEAGLPWPYERGFL
                     LHQKISLSRYASALEDTVDTGKLFRSGSLREFEETLFCHTKSCPISWDTYWDLNDPLR
                     DVDEAAVPVLCICSADDPVCGPPEHTLPAELFHSNPYFFLLLSHHGGHCGFLRPEPLP
                     AWSHEVILESFRALTEFFRMEERMKGLSRRRTSFLGGRRRWGGLQKREVSPSSNLEEI
                     FNWKRSYTR"
     exon            937..3249
                     /gene="Abhd15"
                     /gene_synonym="1300007F04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1771..1776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd15"
                     /gene_synonym="1300007F04Rik"
                     /note="hexamer: CATAAA"
     polyA_site      1795
                     /gene="Abhd15"
                     /gene_synonym="1300007F04Rik"
     polyA_site      2669
                     /gene="Abhd15"
                     /gene_synonym="1300007F04Rik"
                     /note="major polyA site"
     regulatory      3024..3029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd15"
                     /gene_synonym="1300007F04Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3049
                     /gene="Abhd15"
                     /gene_synonym="1300007F04Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggacagaacg aggagcccga cgagaggaca gctccgctcc ccgcagccca gtgcctccct
       61 ccggggactg tcctgccagg ccatgcctcc gtgggcggcc gctctagcgc tgctactggc
      121 ggcgctcgcc ttgctcctcc tgcgaccctg gaagcgcgct gtcggagcgc gaacctcagt
      181 ccgggaccac gaggagcagg aggtggcgag cggaggcccc gcggatcagt tcagcgaccg
      241 gcgcgaagcg ctccccggag gctgcagcct catttgcaag ccgtcggcgc tggcccagtg
      301 cctgctgcgc gctctgcgac gctcggcggc gctggaaccc agcccccgct cctggctgtc
      361 gggaccccac ctgcaaacct tctgccactt catcctgcca gtcgggcccg ggcctgagct
      421 agcccgtgag tacctgcagc tggcagatga tgggctggtg gctctggatt gggtcatagg
      481 accttgtgcc aggggccgcc gggtcaccaa ccctgggagc ctccctccag tgctgttggt
      541 aatccccaat gcatggggac gcctcactcg caatgtactg gggctctgcc tgctcgccct
      601 ggagcgcggc tactacccgg tcatcttcca tcgccgcggc caccacggtt gcccgctagt
      661 cagccccaga ctacagcctt tcggggaccc gtccgacctc aaggaggcgg tgacttacat
      721 tcgcttccga cacccggcgg cccccctgtt cgcggtgagc gagggttcag ggtccgcgct
      781 gctgctgtcc tacttggggg agtgtggctc ctccagctat gtgactggcg ccgcctgcat
      841 ctcgccagtg ctacgctgtc gcgagtggtt cgaggctggc ttgccttggc cctatgaacg
      901 tgggttcttg ctgcaccaga aaatctctct cagcaggtat gcctccgccc tggaggacac
      961 agtggacacc ggcaagctct tcaggagtgg ctccctgcga gagtttgagg agaccctgtt
     1021 ctgtcacacc aagagttgcc ccatcagctg ggatacctac tgggatctca acgacccact
     1081 ccgggatgtg gatgaggctg cggtacccgt gctgtgcatc tgcagtgctg atgacccggt
     1141 gtgtggaccc ccagagcaca ctctgcctgc ggaactcttc cacagcaacc cgtacttctt
     1201 cctgctgctc agtcaccatg gaggccactg tggcttcctg cgccctgaac ccttgccagc
     1261 atggagccac gaggtcatct tggagtcctt cagggccctg actgaattct tccgaatgga
     1321 agagagaatg aaagggctga gcaggcgcag gacttcattt ttagggggcc ggcgtcgctg
     1381 gggaggcctg cagaagcgag aggtttcccc ttcttccaat ctggaggaga ttttcaactg
     1441 gaagcgttca tacaccaggt gaggctcgcc tggggaagcc ccttggactt gtgagaaaga
     1501 cccccacaag gtatcacagc gagggggggc ctctgtgttc ctctcttgct aactggagaa
     1561 agaacttcac cctgtgctac gctaccttga gaagagttgc cctggctcta agaaacattg
     1621 ctcagccctg ggccactatt tcctgtcatc aaagtcccaa gcagaatagc agccctggcg
     1681 aagtccatag accagagaga aattccggct cacccagctg ggagtccagg caggatgaac
     1741 ttgtgagagt caatgggtgg ttctgtccca cataaatatc atcttggtga ctctatgtct
     1801 cgagctggag ccacttggta cagaaaggac aggatgtttg tgtctctgtc ccatttccct
     1861 catgtgctct gcggttgtgg ttctgctctg acttgcatat cagcagctgg ggaagcaggc
     1921 tgtcggttgc ctagctctcc cctggctgag aagccagcag aggcaggaga tgctgggctg
     1981 aggccagggt ggaaagagct agcaagggta gaatgtgtgt gtctgtccct gcctctcatg
     2041 gtagatggaa gctctgatct aggccaggct ctcaagctgg tacagctcat ctcctaaaag
     2101 ttattttagg agtaagaggt gctattgccc agggtctaag ggttccgtta ggtcatggtt
     2161 gtggtagcca ggttaggcca gatacacaca caccttcagt tctgatcctg gagcttcctc
     2221 cagagagccg cagccagcca gatgcgttcc tcctgaaggg tgggctttct cacagtcagt
     2281 gggaagggtg gcaaccgtca caatagtctc tgatcagttt tcttctggta ctagcttctt
     2341 ctccctttcc acagccaggc aagaggtctg ggagcggagc ggagaaaacc cgagggctta
     2401 gtgaaggcaa tccaactatt tctgagtgtc tcacattaca gctttgtctg ctcaattatt
     2461 caaaagacag aagcctgttt tccgaatctg ttcactcagc cactaagtgg gcatttggtt
     2521 ttgaggaaga atgctgaagg cccaagaaca ataagccata gctcccagga tgacttacat
     2581 ggcttgggtt ggattaagcc tttacaaatc attttgatag ctggacatgg agatccgtgt
     2641 gttgttaaga ttcaaaaatc taccctgaag ttttgtttgt tatttattca tggtgcctgg
     2701 gcctcactca ctaggcaaac aaaacactct accgctgagc tatacatcca gtccataaag
     2761 ttatttttca gtttatcagt gggaaagaag tcacctgttt ctgacttaag gcagcaaaac
     2821 agttcgacag agactctcac agccaaggac aaggatagca cccaggtata ctgggacttc
     2881 catcccaggg gtggataatc tggtcctctc cagtttgggg gttggttggt tgtttgggag
     2941 ttttgctttg ttttctgcct ggcctggaac tcactatata gcccaggctg ccctcaagta
     3001 cagagctcca tcagagtact ggaattaaag gcttgtgcta gctatcccac tgagccttct
     3061 aatcttgttc ttttagatta agtaagaatc aatgaaccta gccgggcagt gatggctcat
     3121 gcctttaatc ccagcactag ggaggcagaa gcaggtggaa ttctgagttc gaggccagcc
     3181 ttgtctacaa agtgagttcc aggacagcca ggggaacaca gagaaaccct gtctcgaaaa
     3241 aacaaaaac
//
