LOCUS       NM_001110271            1378 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus abhydrolase domain containing 14A (Abhd14a),
            transcript variant 1, mRNA.
ACCESSION   NM_001110271
VERSION     NM_001110271.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1378)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1378)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1378)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Abhd14a is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   4  (bases 1 to 1378)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   5  (bases 1 to 1378)
  AUTHORS   Hoshino,J., Aruga,J., Ishiguro,A. and Mikoshiba,K.
  TITLE     Dorz1, a novel gene expressed in differentiating cerebellar granule
            neurons, is down-regulated in Zic1-deficient mouse
  JOURNAL   Brain Res Mol Brain Res 120 (1), 57-64 (2003)
   PUBMED   14667578
  REMARK    GeneRIF: The expression of Dorz1 in the developing cerebellum
            peaked at embryonic day 17.5, and at that stage Dorz1 transcripts
            were detected in cerebellar granule neuron precursors where Zic1
            expression is enhanced.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151729.6.
            
            On May 15, 2019 this sequence version replaced NM_001110271.1.
            
            Transcript Variant: This variant (1) encodes isoform a. Variants 1,
            4 and 6 encode the same protein (isoform a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.193207.1, AK003653.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC151729.6         152564-152711       c
            149-457             AC151729.6         150559-150867       c
            458-674             AC151729.6         149123-149339       c
            675-790             AC151729.6         148860-148975       c
            791-1026            AC151729.6         145654-145889       c
            1027-1378           AC151729.6         145086-145437       c
FEATURES             Location/Qualifiers
     source          1..1378
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.51 cM"
     gene            1..1378
                     /gene="Abhd14a"
                     /gene_synonym="1110013B16Rik; Dorz1"
                     /note="abhydrolase domain containing 14A"
                     /db_xref="GeneID:68644"
                     /db_xref="MGI:MGI:1915894"
     exon            1..148
                     /gene="Abhd14a"
                     /gene_synonym="1110013B16Rik; Dorz1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..457
                     /gene="Abhd14a"
                     /gene_synonym="1110013B16Rik; Dorz1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..674
                     /gene="Abhd14a"
                     /gene_synonym="1110013B16Rik; Dorz1"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..1209
                     /gene="Abhd14a"
                     /gene_synonym="1110013B16Rik; Dorz1"
                     /note="isoform a is encoded by transcript variant 1;
                     downregulated in Zic1 deficient cerebellum; abhydrolase
                     domain-containing protein 14A; alpha/beta hydrolase
                     domain-containing protein 14A; down-regulated in Zic1
                     deficient cerebellar primordium; down-regulated in
                     Zic-1-mutant protein; protein ABHD14A"
                     /codon_start=1
                     /product="protein ABHD14A isoform a"
                     /protein_id="NP_001103741.2"
                     /db_xref="GeneID:68644"
                     /db_xref="MGI:MGI:1915894"
                     /translation="MSRYQAALLGLGLLLVFLLYMGLPGPPEQTSRLWRGPNVTVLTG
                     LTRGNSRIFYREVLPIQQARRAEVVFLHGKAFNSHTWEQLGTLQLLSERGYRAVAIDL
                     PGFGNSAPSEEVSTEAGRVELLERVFQDLQVQNTVLVSPSLSGSYALPFLMQNHHQLR
                     GFVPIAPTSTRNYAQEQFGAVKTPTLILYGELDHTLARESLQQLRHLPNHSVVKLHDA
                     GHACYLHKPEAFHLALLAFLDHLP"
     exon            675..790
                     /gene="Abhd14a"
                     /gene_synonym="1110013B16Rik; Dorz1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1026
                     /gene="Abhd14a"
                     /gene_synonym="1110013B16Rik; Dorz1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1378
                     /gene="Abhd14a"
                     /gene_synonym="1110013B16Rik; Dorz1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1348..1353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd14a"
                     /gene_synonym="1110013B16Rik; Dorz1"
                     /note="hexamer: AATAAA"
     polyA_site      1378
                     /gene="Abhd14a"
                     /gene_synonym="1110013B16Rik; Dorz1"
                     /note="major polyA site"
ORIGIN      
        1 gtactgcgca agcgcgcctg ggtggctgga ctttagccgt ctggttacca aggaggctgt
       61 accacagccg ctaggctgtt tggcagttgg ttccgcctag gccgggcccc gcctcaccgg
      121 agcctttctg gtcactcctg tccacgcgtg cagtctgcat cagaacccct acagttgtct
      181 agtcttgggc acccaagttg ccatggcaac gagtgaaacc ccaccccttg accctgaaag
      241 aaggatggga cactaagagt ggtccatccg gatgttccgc ctcttgggaa agctgcactg
      301 gagacaggca gccttggctg ctccaggtta ggaggaagag tgtgctcttt ctgcacccgg
      361 ctcctgattt tctatcagca ctggaagatc tgctgaagcc cacgcacagc ctgacttcgg
      421 agctagggag tgaggcctgc agaagagttc cacagaggtt ctatggtaca gaagaaattc
      481 atgagccggt accaggcagc cctgctgggt ctaggcttgc tgctcgtgtt cctcctgtat
      541 atgggcttgc ctggcccacc cgagcagact tcgcgactct ggagaggccc taatgtcaca
      601 gtcctgactg gtctcaccag aggcaactct cgaatctttt accgagaggt gctgccaatc
      661 cagcaggcac gcagggcaga agtcgtgttt ctccatggaa aagcatttaa ttcccacaca
      721 tgggaacagc tggggacgtt gcagctactg tcagagaggg gctaccgggc tgtggccatc
      781 gaccttccag gttttgggaa ctcagcccct tcagaggagg tgagcacaga ggcaggccga
      841 gtggagttgc tggagagagt gttccaggac ctacaggtgc agaatactgt gttggtgagc
      901 ccctcgctga gtggcagcta tgccctgccc ttcttgatgc aaaaccacca ccagctacgt
      961 ggattcgtgc ccatcgcacc cacctccacc aggaattatg cacaggaaca attcggggct
     1021 gtgaagaccc caactcttat cctgtatggg gaactggacc acaccttggc tcgagagtca
     1081 cttcagcagc tccgccacct gcccaaccac tctgtggtga agctgcatga tgcaggtcat
     1141 gcctgctacc tccacaagcc agaagccttc cacctcgccc ttcttgcctt ccttgaccat
     1201 ttgccttgag tggactcacc tcccaggatc gacctcgaag agtctagacc ctctctctct
     1261 cctcttccag ggtggcagtc cctggctggg actgggggac agaggatcaa gcctagccag
     1321 gacctttgta tttcatttca caagcacaat aaagaaaagc ctttttgtct tgcctgga
//
