LOCUS       NM_024465               1967 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus abhydrolase domain containing 12 (Abhd12), transcript
            variant 1, mRNA.
ACCESSION   NM_024465
VERSION     NM_024465.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1967)
  AUTHORS   Khandelwal,N., Shaikh,M., Mhetre,A., Singh,S., Sajeevan,T.,
            Joshi,A., Balaji,K.N., Chakrapani,H. and Kamat,S.S.
  TITLE     Fatty acid chain length drives lysophosphatidylserine-dependent
            immunological outputs
  JOURNAL   Cell Chem Biol 28 (8), 1169-1179 (2021)
   PUBMED   33571455
REFERENCE   2  (bases 1 to 1967)
  AUTHORS   Singh,S., Joshi,A. and Kamat,S.S.
  TITLE     Mapping the Neuroanatomy of ABHD16A, ABHD12, and
            Lysophosphatidylserines Provides New Insights into the
            Pathophysiology of the Human Neurological Disorder PHARC
  JOURNAL   Biochemistry 59 (24), 2299-2311 (2020)
   PUBMED   32462874
  REMARK    GeneRIF: Mapping the Neuroanatomy of ABHD16A, ABHD12, and
            Lysophosphatidylserines Provides New Insights into the
            Pathophysiology of the Human Neurological Disorder PHARC.
REFERENCE   3  (bases 1 to 1967)
  AUTHORS   Ichu,T.A., Reed,A., Ogasawara,D., Ulanovskaya,O., Roberts,A.,
            Aguirre,C.A., Bar-Peled,L., Gao,J., Germain,J., Barbas,S.,
            Masuda,K., Conti,B., Tontonoz,P. and Cravatt,B.F.
  TITLE     ABHD12 and LPCAT3 Interplay Regulates a
            Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network
            Implicated in Neurological Disease
  JOURNAL   Biochemistry 59 (19), 1793-1799 (2020)
   PUBMED   32364701
  REMARK    GeneRIF: ABHD12 and LPCAT3 Interplay Regulates a
            Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network
            Implicated in Neurological Disease.
REFERENCE   4  (bases 1 to 1967)
  AUTHORS   Leishman,E., Mackie,K. and Bradshaw,H.B.
  TITLE     Elevated Levels of Arachidonic Acid-Derived Lipids Including
            Prostaglandins and Endocannabinoids Are Present Throughout ABHD12
            Knockout Brains: Novel Insights Into the Neurodegenerative
            Phenotype
  JOURNAL   Front Mol Neurosci 12, 142 (2019)
   PUBMED   31213981
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1967)
  AUTHORS   Kelkar,D.S., Ravikumar,G., Mehendale,N., Singh,S., Joshi,A.,
            Sharma,A.K., Mhetre,A., Rajendran,A., Chakrapani,H. and Kamat,S.S.
  TITLE     A chemical-genetic screen identifies ABHD12 as an
            oxidized-phosphatidylserine lipase
  JOURNAL   Nat Chem Biol 15 (2), 169-178 (2019)
   PUBMED   30643283
REFERENCE   6  (bases 1 to 1967)
  AUTHORS   Fiskerstrand,T., H'mida-Ben Brahim,D., Johansson,S., M'zahem,A.,
            Haukanes,B.I., Drouot,N., Zimmermann,J., Cole,A.J., Vedeler,C.,
            Bredrup,C., Assoum,M., Tazir,M., Klockgether,T., Hamri,A.,
            Steen,V.M., Boman,H., Bindoff,L.A., Koenig,M. and Knappskog,P.M.
  TITLE     Mutations in ABHD12 cause the neurodegenerative disease PHARC: An
            inborn error of endocannabinoid metabolism
  JOURNAL   Am J Hum Genet 87 (3), 410-417 (2010)
   PUBMED   20797687
  REMARK    GeneRIF: Mutations in the ABHD12 gene cause polyneuropathy, hearing
            loss, ataxia, retinitis pigmentosa, and cataract disease.
REFERENCE   7  (bases 1 to 1967)
  AUTHORS   Blankman,J.L., Simon,G.M. and Cravatt,B.F.
  TITLE     A comprehensive profile of brain enzymes that hydrolyze the
            endocannabinoid 2-arachidonoylglycerol
  JOURNAL   Chem Biol 14 (12), 1347-1356 (2007)
   PUBMED   18096503
  REMARK    GeneRIF: Data reveal that 85% of brain 2-arachidonoylglycerol
            hydrolase activity can be ascribed to monoacylglycerol
            lipase(MAGL), and the remaining 15% is catalyzed by ABHD6 and
            ABHD12.
REFERENCE   8  (bases 1 to 1967)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 1967)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
REFERENCE   10 (bases 1 to 1967)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808125.11 and AL954712.9.
            
            On Nov 2, 2007 this sequence version replaced NM_024465.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002138.1, SRR1660821.177622.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               AL808125.11        71224-71598         c
            376-500             AL808125.11        25227-25351         c
            501-606             AL808125.11        15219-15324         c
            607-726             AL808125.11        13111-13230         c
            727-757             AL808125.11        10258-10288         c
            758-803             AL808125.11        9113-9158           c
            804-933             AL808125.11        6587-6716           c
            934-971             AL808125.11        5608-5645           c
            972-1051            AL808125.11        5182-5261           c
            1052-1134           AL808125.11        4219-4301           c
            1135-1213           AL808125.11        2140-2218           c
            1214-1341           AL954712.9         64185-64312         c
            1342-1967           AL954712.9         62421-63046         c
FEATURES             Location/Qualifiers
     source          1..1967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.74 cM"
     gene            1..1967
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /note="abhydrolase domain containing 12"
                     /db_xref="GeneID:76192"
                     /db_xref="MGI:MGI:1923442"
     exon            1..375
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1381
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /EC_number="3.1.1.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     monoacylglycerol lipase ABHD12; abhydrolase
                     domain-containing protein 12; 2-arachidonoylglycerol
                     hydrolase ABHD12; oxidized phosphatidylserine lipase
                     ABHD12; lysophosphatidylserine lipase ABHD12"
                     /codon_start=1
                     /product="lysophosphatidylserine lipase ABHD12 isoform 1"
                     /protein_id="NP_077785.2"
                     /db_xref="CCDS:CCDS50742.1"
                     /db_xref="GeneID:76192"
                     /db_xref="MGI:MGI:1923442"
                     /translation="MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAG
                     KGTAEPHSASDAGMKRALGRRKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIF
                     LNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWY
                     EDALASNHAIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSER
                     GMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFT
                     NIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDP
                     VVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKS
                     EPERQH"
     exon            376..500
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            501..606
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            607..726
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            727..757
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            758..803
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            804..933
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            934..971
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1051
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1134
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1213
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1341
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1967
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1947..1952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
     polyA_site      1967
                     /gene="Abhd12"
                     /gene_synonym="1500011G07Rik; 6330583M11Rik"
ORIGIN      
        1 ggtggccgac cggcctccgg cgctggtcca tagcgggcgc cgcggcctgg ggctgggatg
       61 tgacccgcag tgggctcccg gctccgggtg gtgacggctg tgagcggcgg cgactgcagc
      121 gaggtcggcg caggcgggcg ggcgaaacca gggcgccgag agctgctgcc gacagggccg
      181 cgggatgagg aagcggaccg agcccgtcac cttggagcat gagcgctgcg ccgcctcagg
      241 ctcgtcctcc tccggctcgg ccgccgcggc gctggacgcc gactgcagct tgaagcagaa
      301 cctgcgtctg gcgggcaagg ggacggcaga gccgcacagc gcatccgacg cgggcatgaa
      361 gcgggcgctg ggcagacgaa agagcctgtg gttccgacta aggaagatac ttctctgtgt
      421 tctggggttc tacattgcca ttccatttct tgtcaaactg tgtcctggga tacaggccaa
      481 actgatattc ttaaatttcg tgagggttcc ctatttcatt gatttaaaaa aaccacagga
      541 tcaaggtttg aatcacacct gcaattacta cctccagcca gaggatgatg tgactattgg
      601 agtctggcac acaatcccct ctgtctggtg gaagaatgcc caagggaagg accagatgtg
      661 gtatgaggat gctctggctt ctaaccatgc catcatacta tacctgcatg ggaatgcagg
      721 caccagagga ggtgaccacc gtgtggagct gtacaaggtg ctgagttccc ttggctacca
      781 cgtggtcacc tttgactaca gaggttgggg tgactcagta ggaacaccat cggagcgagg
      841 catgacgtat gacgcactcc atgtttttga ctggatcaaa gcaagaagtg gtgataatcc
      901 tgtgtatatt tggggccatt cactgggcac cggagtggca acaaatctgg tacggcgcct
      961 ctgtgagcga gagacgccac cagatgccct tatattggag tctccattca caaatattcg
     1021 tgaagaagca aagagtcatc cattttcagt gatataccga tacttccctg gctttgactg
     1081 gttcttcctc gaccccatta caagcagtgg aattaaattt gcaaatgacg aaaatatgaa
     1141 gcacatctcc tgtcctctgc tcatcttgca tgccgaggat gatccagttg tgccctttca
     1201 tctcggtaga aagctataca acattgctgc accatctcgg agtttccgag acttcaaagt
     1261 ccagtttatc ccctttcact cagaccttgg ctacagacat aaatacatct acaagagccc
     1321 agagcttcca aggatactga gggaattcct agggaagtcg gaaccggaac gccagcactg
     1381 agactggccc atgaaggagc atgaagaccc accttccttc cttctcccct ggacagcagc
     1441 ctggcacccc gaagcccaga gtgccaccac ctgtggtgct caggagccca gtgcacacct
     1501 agaaagagga ctcagacaca gcgggcagag gctcctgatg gacctgtgag gaaagcccgg
     1561 tggcaggcag gtggcccccc cagccctctg gtgaccactg tatctgagct ctttttggga
     1621 aggcttatag acagcaggtg gaccccatat gctgggcata gggagcctgg gaagggctca
     1681 ggagctcagg accactccag gctctctggc accattgctt aagattcagg aaaatggttc
     1741 tttctgccct tcctagcgtt tacagaacag actccaagtg gttcagtttg tctcctacag
     1801 ctcatttacc tgcttgcctt cctcagctgt ccctgcctct cctggcatct gattacccac
     1861 agtaaggggc acctggatct gcacttcttc cattctgccc acctgtctgt cacctaacct
     1921 ggccgtagac tgagcattta tttaagaata aaatctcggt ggtggtc
//
