LOCUS       NM_145215               1493 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus abhydrolase domain containing 11 (Abhd11), transcript
            variant 1, mRNA.
ACCESSION   NM_145215
VERSION     NM_145215.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1493)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1493)
  AUTHORS   Escoubet,J., Kenigsberg,M., Derock,M., Yaligara,V., Bock,M.D.,
            Roche,S., Massey,F., de Foucauld,H., Bettembourg,C., Olivier,A.,
            Berthemy,A., Capdevielle,J., Legoux,R., Perret,E., Buzy,A.,
            Chardenot,P., Destelle,V., Leroy,A., Cahours,C., Teixeira,S.,
            Juvet,P., Gauthier,P., Leguet,M., Rocheteau-Beaujouan,L.,
            Chatoux,M.A., Deshayes,W., Clement,M., Kabiri,M., Orsini,C.,
            Mikol,V., Didier,M. and Guillemot,J.C.
  TITLE     ABHD11, a new diacylglycerol lipase involved in weight gain
            regulation
  JOURNAL   PLoS One 15 (6), e0234780 (2020)
   PUBMED   32579589
  REMARK    GeneRIF: ABHD11, a new diacylglycerol lipase involved in weight
            gain regulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1493)
  AUTHORS   Francelle,L., Galvan,L., Gaillard,M.C., Petit,F., Bernay,B.,
            Guillermier,M., Bonvento,G., Dufour,N., Elalouf,J.M., Hantraye,P.,
            Deglon,N., de Chaldee,M. and Brouillet,E.
  TITLE     Striatal long noncoding RNA Abhd11os is neuroprotective against an
            N-terminal fragment of mutant huntingtin in vivo
  JOURNAL   Neurobiol Aging 36 (3), 1601 (2015)
   PUBMED   25619660
  REMARK    GeneRIF: loss lncRNA Abhd11os likely contribute to striatal
            vulnerability in HD and lncRNA may play crucial roles in
            neurodegenerative diseases.
REFERENCE   4  (bases 1 to 1493)
  AUTHORS   Shen,W.J., Patel,S., Yu,Z., Jue,D. and Kraemer,F.B.
  TITLE     Effects of rosiglitazone and high fat diet on lipase/esterase
            expression in adipose tissue
  JOURNAL   Biochim Biophys Acta 1771 (2), 177-184 (2007)
   PUBMED   17215164
REFERENCE   5  (bases 1 to 1493)
  AUTHORS   Merla,G., Ucla,C., Guipponi,M. and Reymond,A.
  TITLE     Identification of additional transcripts in the Williams-Beuren
            syndrome critical region
  JOURNAL   Hum Genet 110 (5), 429-438 (2002)
   PUBMED   12073013
REFERENCE   6  (bases 1 to 1493)
  AUTHORS   DeSilva,U., Elnitski,L., Idol,J.R., Doyle,J.L., Gan,W.,
            Thomas,J.W., Schwartz,S., Dietrich,N.L., Beckstrom-Sternberg,S.M.,
            McDowell,J.C., Blakesley,R.W., Bouffard,G.G., Thomas,P.J.,
            Touchman,J.W., Miller,W. and Green,E.D.
  TITLE     Generation and comparative analysis of approximately 3.3 Mb of
            mouse genomic sequence orthologous to the region of human
            chromosome 7q11.23 implicated in Williams syndrome
  JOURNAL   Genome Res 12 (1), 3-15 (2002)
   PUBMED   11779826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084109.2.
            
            On Jun 24, 2010 this sequence version replaced NM_145215.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF412033.1, BC069866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-541               AC084109.2         56301-56841
            542-677             AC084109.2         56984-57119
            678-851             AC084109.2         57889-58062
            852-1022            AC084109.2         58212-58382
            1023-1204           AC084109.2         58486-58667
            1205-1493           AC084109.2         58889-59177
FEATURES             Location/Qualifiers
     source          1..1493
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.94 cM"
     gene            1..1493
                     /gene="Abhd11"
                     /gene_synonym="1110054D16Rik; A630008N09Rik; Wbscr21"
                     /note="abhydrolase domain containing 11"
                     /db_xref="GeneID:68758"
                     /db_xref="MGI:MGI:1916008"
     exon            1..541
                     /gene="Abhd11"
                     /gene_synonym="1110054D16Rik; A630008N09Rik; Wbscr21"
                     /inference="alignment:Splign:2.1.0"
     CDS             414..1337
                     /gene="Abhd11"
                     /gene_synonym="1110054D16Rik; A630008N09Rik; Wbscr21"
                     /EC_number="3.1.1.116"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Williams Beuren syndrome chromosome region 21;
                     Williams-Beuren syndrome chromosomal region 21 protein
                     homolog; abhydrolase domain-containing protein 11;
                     Williams-Beuren syndrome critical region 21; alpha/beta
                     hydrolase domain-containing protein 11; protein ABHD11;
                     sn-1-specific diacylglycerol lipase ABHD11"
                     /codon_start=1
                     /product="sn-1-specific diacylglycerol lipase ABHD11
                     isoform 1"
                     /protein_id="NP_660250.1"
                     /db_xref="CCDS:CCDS19730.1"
                     /db_xref="GeneID:68758"
                     /db_xref="MGI:MGI:1916008"
                     /translation="MLRWARAWRVPRGVLGASSPRRLAVPVTFCSSRSSGQENADLRP
                     LPLSYNLLDGDATLPAIVFLHGLFGSKTNFNSLAKAMVQRTGRRVLTVDARNHGDSPH
                     SPDASYEAMSQDLQGLLPQLGLVPCVLVGHSMGGKTAMLLALQRPDVVERLVVVDISP
                     VGTTPGSHIGAFIAAMKAVEIPEKVPHSQARKLADKQLSSVVKEAGIRQFLLTNLVEV
                     GGRFSWRLNLDTLAQHLDKIMTFPQQREPYSGPTLFLLGGNSTYVQPSHHSEIRRLFP
                     QAQIQTVPNAGHWVHSDKPQDFMDAVTSFLA"
     exon            542..677
                     /gene="Abhd11"
                     /gene_synonym="1110054D16Rik; A630008N09Rik; Wbscr21"
                     /inference="alignment:Splign:2.1.0"
     exon            678..851
                     /gene="Abhd11"
                     /gene_synonym="1110054D16Rik; A630008N09Rik; Wbscr21"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1022
                     /gene="Abhd11"
                     /gene_synonym="1110054D16Rik; A630008N09Rik; Wbscr21"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1204
                     /gene="Abhd11"
                     /gene_synonym="1110054D16Rik; A630008N09Rik; Wbscr21"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1493
                     /gene="Abhd11"
                     /gene_synonym="1110054D16Rik; A630008N09Rik; Wbscr21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1467..1472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd11"
                     /gene_synonym="1110054D16Rik; A630008N09Rik; Wbscr21"
                     /note="hexamer: AATAAA"
     polyA_site      1488
                     /gene="Abhd11"
                     /gene_synonym="1110054D16Rik; A630008N09Rik; Wbscr21"
                     /note="major polyA site"
ORIGIN      
        1 aggagggacc agtcccacgt agcgcttccc tggtcctggt cgggaactgg tctctaagcg
       61 gctcacagcg tctgtaggaa ttgcgtagtg gcgcaagggg gcagggctag cgctgtatgg
      121 ctacgcccag cctgttacca agccagctag tcctacagac caggctcaaa gtggctgcag
      181 gaaatgtgta acgtgcaagg gctggggtcg tctagcggct gcgtccaaga agcttctgct
      241 ttgggagggg gctgaactga ctccgggaat acattagacc acgtggccta aagtggcgcc
      301 tcgatggggg gggggcgggg gaaaaggcgg agccctagtt ggaatagaca gggctctgaa
      361 aggcggagcg tgcgcaggac agccctagga agcacacttt gcgggctgtg ggcatgctcc
      421 gctgggcgcg agcgtggagg gtcccccgtg gggtactcgg tgcctcctct cccaggcgtt
      481 tggcggttcc tgtcacgttc tgtagcagcc gcagtagtgg ccaagaaaac gccgatctga
      541 ggccgctgcc gctgtcttat aatcttctag atggagacgc gacactccca gccatcgtct
      601 ttttgcatgg gctcttcggc agcaaaacca acttcaactc cctcgccaag gcaatggttc
      661 agaggactgg ccggagggtg ctgacggtgg atgcccggaa ccacggtgac agcccccaca
      721 gtccagacgc aagctatgag gccatgagtc aggaccttca gggcctcctt ccacagctgg
      781 gtctggtgcc ctgcgtcctc gttggccaca gcatgggagg aaagacagcc atgctcctgg
      841 cactgcagag gccagatgtt gtggaacgat tggttgttgt agacataagc ccggtaggaa
      901 ccacacctgg atcacacatt ggagccttca tagcagccat gaaggctgtt gagatcccag
      961 agaaggtgcc gcactcccaa gcccgaaaac tggcggataa gcagcttagt tcggttgtca
     1021 aggaagcggg cattcggcag ttcctgctca ctaacctggt agaggtgggt gggcgattct
     1081 cctggagact gaacttggat acgttagctc agcacttgga caagataatg acctttcctc
     1141 agcaacgtga accctactcg gggccaactc tcttcctgct tggtggaaat tctacatatg
     1201 tacaacccag ccaccactca gagattaggc gactcttccc tcaagcccag attcagaccg
     1261 tgcctaacgc tggccactgg gtccacagcg acaaacccca agacttcatg gatgctgtca
     1321 ccagcttctt ggcttaagaa gtagctcctt ggaagagcag ccaggggact ctaggcttgg
     1381 gatctgtgcc atcttgcttc tgcacagaaa aactcagggg cacggagagg gtccaggagt
     1441 acagaagtgg cccaacactt ttaatgaata aagacagttc ccctttaagc cct
//
