LOCUS       NP_660250                307 aa            linear   ROD 30-APR-2024
DEFINITION  sn-1-specific diacylglycerol lipase ABHD11 isoform 1 [Mus
            musculus].
ACCESSION   NP_660250
VERSION     NP_660250.1
DBSOURCE    REFSEQ: accession NM_145215.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 307)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 307)
  AUTHORS   Escoubet,J., Kenigsberg,M., Derock,M., Yaligara,V., Bock,M.D.,
            Roche,S., Massey,F., de Foucauld,H., Bettembourg,C., Olivier,A.,
            Berthemy,A., Capdevielle,J., Legoux,R., Perret,E., Buzy,A.,
            Chardenot,P., Destelle,V., Leroy,A., Cahours,C., Teixeira,S.,
            Juvet,P., Gauthier,P., Leguet,M., Rocheteau-Beaujouan,L.,
            Chatoux,M.A., Deshayes,W., Clement,M., Kabiri,M., Orsini,C.,
            Mikol,V., Didier,M. and Guillemot,J.C.
  TITLE     ABHD11, a new diacylglycerol lipase involved in weight gain
            regulation
  JOURNAL   PLoS One 15 (6), e0234780 (2020)
   PUBMED   32579589
  REMARK    GeneRIF: ABHD11, a new diacylglycerol lipase involved in weight
            gain regulation.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 307)
  AUTHORS   Francelle,L., Galvan,L., Gaillard,M.C., Petit,F., Bernay,B.,
            Guillermier,M., Bonvento,G., Dufour,N., Elalouf,J.M., Hantraye,P.,
            Deglon,N., de Chaldee,M. and Brouillet,E.
  TITLE     Striatal long noncoding RNA Abhd11os is neuroprotective against an
            N-terminal fragment of mutant huntingtin in vivo
  JOURNAL   Neurobiol Aging 36 (3), 1601 (2015)
   PUBMED   25619660
  REMARK    GeneRIF: loss lncRNA Abhd11os likely contribute to striatal
            vulnerability in HD and lncRNA may play crucial roles in
            neurodegenerative diseases.
REFERENCE   4  (residues 1 to 307)
  AUTHORS   Shen,W.J., Patel,S., Yu,Z., Jue,D. and Kraemer,F.B.
  TITLE     Effects of rosiglitazone and high fat diet on lipase/esterase
            expression in adipose tissue
  JOURNAL   Biochim Biophys Acta 1771 (2), 177-184 (2007)
   PUBMED   17215164
REFERENCE   5  (residues 1 to 307)
  AUTHORS   Merla,G., Ucla,C., Guipponi,M. and Reymond,A.
  TITLE     Identification of additional transcripts in the Williams-Beuren
            syndrome critical region
  JOURNAL   Hum Genet 110 (5), 429-438 (2002)
   PUBMED   12073013
REFERENCE   6  (residues 1 to 307)
  AUTHORS   DeSilva,U., Elnitski,L., Idol,J.R., Doyle,J.L., Gan,W.,
            Thomas,J.W., Schwartz,S., Dietrich,N.L., Beckstrom-Sternberg,S.M.,
            McDowell,J.C., Blakesley,R.W., Bouffard,G.G., Thomas,P.J.,
            Touchman,J.W., Miller,W. and Green,E.D.
  TITLE     Generation and comparative analysis of approximately 3.3 Mb of
            mouse genomic sequence orthologous to the region of human
            chromosome 7q11.23 implicated in Williams syndrome
  JOURNAL   Genome Res 12 (1), 3-15 (2002)
   PUBMED   11779826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084109.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF412033.1, BC069866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.94 cM"
     Protein         1..307
                     /product="sn-1-specific diacylglycerol lipase ABHD11
                     isoform 1"
                     /EC_number="3.1.1.116"
                     /note="Williams Beuren syndrome chromosome region 21;
                     Williams-Beuren syndrome chromosomal region 21 protein
                     homolog; abhydrolase domain-containing protein 11;
                     Williams-Beuren syndrome critical region 21; alpha/beta
                     hydrolase domain-containing protein 11; protein ABHD11;
                     sn-1-specific diacylglycerol lipase ABHD11"
                     /calculated_mol_wt=29751
     transit_peptide 1..34
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q8K4F5.1)"
                     /calculated_mol_wt=3828
     mat_peptide     35..307
                     /product="sn-1-specific diacylglycerol lipase ABHD11.
                     /evidence=ECO:0000255. /id=PRO_0000281004"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4F5.1)"
                     /calculated_mol_wt=29751
     Region          61..307
                     /region_name="PRK10673"
                     /note="esterase"
                     /db_xref="CDD:182637"
     CDS             1..307
                     /gene="Abhd11"
                     /gene_synonym="1110054D16Rik; A630008N09Rik; Wbscr21"
                     /coded_by="NM_145215.2:414..1337"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19730.1"
                     /db_xref="GeneID:68758"
                     /db_xref="MGI:MGI:1916008"
ORIGIN      
        1 mlrwarawrv prgvlgassp rrlavpvtfc ssrssgqena dlrplplsyn lldgdatlpa
       61 ivflhglfgs ktnfnslaka mvqrtgrrvl tvdarnhgds phspdasyea msqdlqgllp
      121 qlglvpcvlv ghsmggktam llalqrpdvv erlvvvdisp vgttpgshig afiaamkave
      181 ipekvphsqa rkladkqlss vvkeagirqf lltnlvevgg rfswrlnldt laqhldkimt
      241 fpqqrepysg ptlfllggns tyvqpshhse irrlfpqaqi qtvpnaghwv hsdkpqdfmd
      301 avtsfla
//
