LOCUS       NM_172511               2860 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus abhydrolase domain containing 10 (Abhd10), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_172511
VERSION     NM_172511.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2860)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2860)
  AUTHORS   Li,T.Z., Bai,C.Y., Wu,B., Zhang,C.Y., Wang,W.T., Shi,T.W. and
            Zhou,J.
  CONSRTM   SIRIGULENG
  TITLE     The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis
            in alcoholic liver disease
  JOURNAL   Commun Biol 6 (1), 682 (2023)
   PUBMED   37400491
  REMARK    GeneRIF: The Elk-3 target Abhd10 ameliorates hepatotoxic injury and
            fibrosis in alcoholic liver disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2860)
  AUTHORS   Liao,B., Dong,S., Xu,Z., Gao,F., Zhang,S. and Liang,R.
  TITLE     MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell
            apoptosis in myocardial infarction
  JOURNAL   Biol Direct 17 (1), 20 (2022)
   PUBMED   35978367
  REMARK    GeneRIF: MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell
            apoptosis in myocardial infarction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2860)
  AUTHORS   Cao,Y., Qiu,T., Kathayat,R.S., Azizi,S.A., Thorne,A.K., Ahn,D.,
            Fukata,Y., Fukata,M., Rice,P.A. and Dickinson,B.C.
  TITLE     ABHD10 is an S-depalmitoylase affecting redox homeostasis through
            peroxiredoxin-5
  JOURNAL   Nat Chem Biol 15 (12), 1232-1240 (2019)
   PUBMED   31740833
REFERENCE   5  (bases 1 to 2860)
  AUTHORS   Iwamura,A., Fukami,T., Higuchi,R., Nakajima,M. and Yokoi,T.
  TITLE     Human alpha/beta hydrolase domain containing 10 (ABHD10) is
            responsible enzyme for deglucuronidation of mycophenolic acid
            acyl-glucuronide in liver
  JOURNAL   J Biol Chem 287 (12), 9240-9249 (2012)
   PUBMED   22294686
  REMARK    GeneRIF: identification of human ABHD10, which is responsible for
            AcMPAG deglucuronidation in the liver
REFERENCE   6  (bases 1 to 2860)
  AUTHORS   Li,Q., Vande Velde,C., Israelson,A., Xie,J., Bailey,A.O.,
            Dong,M.Q., Chun,S.J., Roy,T., Winer,L., Yates,J.R., Capaldi,R.A.,
            Cleveland,D.W. and Miller,T.M.
  TITLE     ALS-linked mutant superoxide dismutase 1 (SOD1) alters
            mitochondrial protein composition and decreases protein import
  JOURNAL   Proc Natl Acad Sci U S A 107 (49), 21146-21151 (2010)
   PUBMED   21078990
  REMARK    GeneRIF: mitochondrial localization of rat Abhd10
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY281009.1, AK052670.1,
            BC027656.1, AC166572.1 and BQ175828.1.
            
            On Jan 10, 2013 this sequence version replaced NM_172511.3.
            
            Summary: This gene encodes a mitochondrially-localized enzyme that
            acts as a hydrolase. The encoded protein removes glucuronide from
            mycophenolic acid acyl-glucuronide. There are two pseudogenes for
            this gene on chromosome 8. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052670.1, SRR9219382.130321.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 21078990; reported by
                                                  MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BY281009.1         1-51
            52-863              AK052670.1         1-812
            864-1222            BC027656.1         279-637
            1223-2176           AK052670.1         1172-2125
            2177-2200           AC166572.1         73244-73267
            2201-2733           BQ175828.1         129-661             c
            2734-2860           BQ175828.1         1-127               c
FEATURES             Location/Qualifiers
     source          1..2860
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 30.04 cM"
     gene            1..2860
                     /gene="Abhd10"
                     /note="abhydrolase domain containing 10"
                     /db_xref="GeneID:213012"
                     /db_xref="MGI:MGI:2442422"
     exon            1..179
                     /gene="Abhd10"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..958
                     /gene="Abhd10"
                     /EC_number="3.1.2.22"
                     /EC_number="3.1.1.93"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; abhydrolase domain-containing protein 10,
                     mitochondrial; alpha/beta hydrolase domain-containing
                     protein 10, mitochondrial; mycophenolic acid
                     acyl-glucuronide esterase, mitochondrial; acyl-protein
                     thioesterase ABHD10; palmitoyl-protein thioesterase
                     ABHD10, mitochondrial"
                     /codon_start=1
                     /product="palmitoyl-protein thioesterase ABHD10,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_766099.3"
                     /db_xref="CCDS:CCDS28201.1"
                     /db_xref="GeneID:213012"
                     /db_xref="MGI:MGI:2442422"
                     /translation="MAAWAPCRRWGWAAVSFGRHPGLSASLARKPPRAWWLSACRQKA
                     SLSFLNRSELPNLAYKRLKGKTPGIIFIPGYLSNMNGIKAVAVEEFCKSLGHAFIRFD
                     YSGIGSSDGNLAECTVGKWRKDVLSILDDVAEGPQILVGSSLGGWLMLHAAIARPEKV
                     IALIGIATAADGLVTQYHALPVETQKEIEMKGEWTLPSRYNKEGYFRIPYSFIKEAEH
                     HCLLHSPIPVTCPVRLLHGMKDEIVPWQRSLQVADRIVSPDVDVILRKQGDHRMKEKA
                     DIHLLICTIDDLIDKLSTVVP"
     exon            180..363
                     /gene="Abhd10"
                     /inference="alignment:Splign:2.1.0"
     exon            364..475
                     /gene="Abhd10"
                     /inference="alignment:Splign:2.1.0"
     exon            476..613
                     /gene="Abhd10"
                     /inference="alignment:Splign:2.1.0"
     exon            614..2848
                     /gene="Abhd10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1172..1177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd10"
                     /note="hexamer: ATTAAA"
     polyA_site      1199
                     /gene="Abhd10"
                     /note="major polyA site"
     regulatory      2828..2833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abhd10"
                     /note="hexamer: AATAAA"
     polyA_site      2848
                     /gene="Abhd10"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgtgacc tcgggaccgc gcgacctgcg cgcgtctgta gcgggcgcag gggcagctgg
       61 gaagatggcg gcctgggccc cttgtcggag gtggggctgg gcggctgtgt ccttcggccg
      121 gcacccgggc ctgagcgcgt cactagctcg gaagccccca cgggcatggt ggctctcagc
      181 ttgcagacaa aaggcatcac tttctttcct taaccgatca gaacttccaa acctggctta
      241 taagaggtta aaaggcaaaa ccccaggaat tatcttcatc cctggctatc tttctaacat
      301 gaatggtata aaggcagtag cagttgagga gttttgcaaa tctctaggtc acgcctttat
      361 aaggtttgac tactcaggga ttggaagttc agatggtaac ttagcagagt gcacagtggg
      421 gaaatggaga aaggatgtcc tttccatact tgatgacgta gctgaaggac cgcagatact
      481 ggttggatcc agtcttggtg gatggctcat gctgcatgct gcaattgcac ggccggaaaa
      541 agtcatagct cttattggta tagctactgc tgcagatgga ttggtgacac aatatcatgc
      601 acttcctgtt gagactcaaa aggaaataga aatgaaaggt gagtggacct tgccatctag
      661 atacaacaag gaaggctatt tcagaatccc gtacagtttc attaaagaag cggagcatca
      721 ctgcttgttg catagcccca tccctgtgac ctgccctgta cgcttgctcc acggcatgaa
      781 ggatgaaata gttccttggc agagatccct gcaggtcgcg gaccgaatag tcagcccaga
      841 tgtagatgtc atcctccgga aacaaggtga tcacaggatg aaggagaaag cagatattca
      901 tctgcttatt tgtactattg atgacttgat tgacaagctt tcaactgtag ttccgtagaa
      961 tcacatttgt agctggaatg ccctccagtg catccagaag attgaaagtg tggtagtaaa
     1021 tcaaagaccc ggatacttca gggttttccc tcttgtagtt tgtaaatatc ggatacgtat
     1081 ttatttaatg atgtctttgc acaaatacac aaattgtgac caaagtatta gctgctcttt
     1141 ggaaattttt gtcctccttt tatattttcc cattaaagta gcacctattt tttattaaag
     1201 agatgtttgc ctttcttaca tacactttag ctgtgccagc tatagttgtg ttcctttcta
     1261 caataaagct tgaatatttt gggttttgtc tggtaccatt atatatggaa gtttgtaaaa
     1321 ttctgatttt aaaatgtagt tcacaaaata gaggaagatg tttattcaag taaatatgaa
     1381 atgattcaaa aaatgtctga agcataataa agttggaaaa gtgagggtgc catgctatat
     1441 ttaaaactaa aattactgtt tttttaaagg ttatgtttta ttgtgatgta aaagatactt
     1501 ctaaattttg aattgtcatt cttatgggaa tcttccagat tttttatttt tttaagttta
     1561 tatgtaaaat aatgggtaat accacgtcca acacttaact tcattttatc gttgtacctc
     1621 acttgcacag atcttgtcgc tctgctgtgt ttcactctct ctgcttcccc ctacaccctt
     1681 tctcccctca gtccccttct gcttccacac catgtctcta tatagagaaa acagatactg
     1741 cttccttccc caccatgctc ccctaatgtc ctttagagcc ttctctgcag tctactttca
     1801 ccagccatgc aatatatgtg tagttaaatc tgtactgtac atatgagaga aaacactttg
     1861 catatctaat ctgtttctct ttacataatc tcagttccac cattttcctg caaacatgct
     1921 ctatagttaa atggtattca tctaatgata tagtgttttt atatagcggt tggttagact
     1981 aaagaggaag atgatctttc cgcattaacc ctgctttggg gaatacgatt agactggcat
     2041 aagtgcaaat agatgggtag gtaccatttt agtttaagtg gcagaagggt agagtcagta
     2101 aggaaacatg aaatactagt gtaaggtgtg atttttaata actactgagg tattaatatt
     2161 tattagcctt tatattaaat tgtggtttgc ttttttttac ttattaattt tggctagact
     2221 ttagccctca ttgattatat ctatattaac atgccaacat aactcatgag tatgtgttga
     2281 agagttaatt tttatcgcat aaatgagagt cggcagacaa taaacctggt tgaaaggaca
     2341 gtttaaaaaa acacagtatt tatagccaat gaagaaaagg gcaataaaat ttttgtgcag
     2401 gaaagtgttg cagctggttg gcagattatc ctgagaaaag taccttatga gttggctttt
     2461 gtctgggaac gtgggtctca aggactccca ctatggccag aactgagcat agtagctcac
     2521 tgtgcttgca tgaactctct gcaaacactg gcttatgctg aaccccactt tcttcccagg
     2581 tgcccagagt gttgatatat gtggagcagc gactccctct gagtggtcca gtaaacccct
     2641 tggcaccgac tcttagcaag ctttcttgca gatggtatca catgagctgt tagagctcct
     2701 tgctggagac ccagtttctg cctctgtgac tccagtgtgg attcttggaa gcttaccccc
     2761 agtttccctg ggcttcaccc catgtgcctt tttcctttgc tcactctgct ttggatccgt
     2821 tcactctaat aaatcagtag tgaaagaaaa aaaaaaaaaa
//
