LOCUS       NP_766099                297 aa            linear   ROD 27-APR-2025
DEFINITION  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 1
            precursor [Mus musculus].
ACCESSION   NP_766099
VERSION     NP_766099.3
DBSOURCE    REFSEQ: accession NM_172511.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 297)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 297)
  AUTHORS   Li,T.Z., Bai,C.Y., Wu,B., Zhang,C.Y., Wang,W.T., Shi,T.W. and
            Zhou,J.
  CONSRTM   SIRIGULENG
  TITLE     The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis
            in alcoholic liver disease
  JOURNAL   Commun Biol 6 (1), 682 (2023)
   PUBMED   37400491
  REMARK    GeneRIF: The Elk-3 target Abhd10 ameliorates hepatotoxic injury and
            fibrosis in alcoholic liver disease.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 297)
  AUTHORS   Liao,B., Dong,S., Xu,Z., Gao,F., Zhang,S. and Liang,R.
  TITLE     MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell
            apoptosis in myocardial infarction
  JOURNAL   Biol Direct 17 (1), 20 (2022)
   PUBMED   35978367
  REMARK    GeneRIF: MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell
            apoptosis in myocardial infarction.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 297)
  AUTHORS   Cao,Y., Qiu,T., Kathayat,R.S., Azizi,S.A., Thorne,A.K., Ahn,D.,
            Fukata,Y., Fukata,M., Rice,P.A. and Dickinson,B.C.
  TITLE     ABHD10 is an S-depalmitoylase affecting redox homeostasis through
            peroxiredoxin-5
  JOURNAL   Nat Chem Biol 15 (12), 1232-1240 (2019)
   PUBMED   31740833
REFERENCE   5  (residues 1 to 297)
  AUTHORS   Iwamura,A., Fukami,T., Higuchi,R., Nakajima,M. and Yokoi,T.
  TITLE     Human alpha/beta hydrolase domain containing 10 (ABHD10) is
            responsible enzyme for deglucuronidation of mycophenolic acid
            acyl-glucuronide in liver
  JOURNAL   J Biol Chem 287 (12), 9240-9249 (2012)
   PUBMED   22294686
  REMARK    GeneRIF: identification of human ABHD10, which is responsible for
            AcMPAG deglucuronidation in the liver
REFERENCE   6  (residues 1 to 297)
  AUTHORS   Li,Q., Vande Velde,C., Israelson,A., Xie,J., Bailey,A.O.,
            Dong,M.Q., Chun,S.J., Roy,T., Winer,L., Yates,J.R., Capaldi,R.A.,
            Cleveland,D.W. and Miller,T.M.
  TITLE     ALS-linked mutant superoxide dismutase 1 (SOD1) alters
            mitochondrial protein composition and decreases protein import
  JOURNAL   Proc Natl Acad Sci U S A 107 (49), 21146-21151 (2010)
   PUBMED   21078990
  REMARK    GeneRIF: mitochondrial localization of rat Abhd10
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY281009.1, AK052670.1,
            BC027656.1, AC166572.1 and BQ175828.1.
            
            On Nov 21, 2009 this sequence version replaced NP_766099.2.
            
            Summary: This gene encodes a mitochondrially-localized enzyme that
            acts as a hydrolase. The encoded protein removes glucuronide from
            mycophenolic acid acyl-glucuronide. There are two pseudogenes for
            this gene on chromosome 8. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052670.1, SRR9219382.130321.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 21078990; reported by
                                                  MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 30.04 cM"
     Protein         1..297
                     /product="palmitoyl-protein thioesterase ABHD10,
                     mitochondrial isoform 1 precursor"
                     /EC_number="3.1.2.22"
                     /EC_number="3.1.1.93"
                     /note="abhydrolase domain-containing protein 10,
                     mitochondrial; alpha/beta hydrolase domain-containing
                     protein 10, mitochondrial; mycophenolic acid
                     acyl-glucuronide esterase, mitochondrial; acyl-protein
                     thioesterase ABHD10; palmitoyl-protein thioesterase
                     ABHD10, mitochondrial"
                     /calculated_mol_wt=28180
     transit_peptide 1..43
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q6PE15.1)"
                     /calculated_mol_wt=4879
     mat_peptide     44..297
                     /product="Palmitoyl-protein thioesterase ABHD10,
                     mitochondrial. /id=PRO_0000280734"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PE15.1)"
                     /calculated_mol_wt=28180
     Region          62..293
                     /region_name="YvaK"
                     /note="Esterase/lipase [Secondary metabolites
                     biosynthesis, transport and catabolism]; COG1647"
                     /db_xref="CDD:441253"
     CDS             1..297
                     /gene="Abhd10"
                     /coded_by="NM_172511.4:65..958"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS28201.1"
                     /db_xref="GeneID:213012"
                     /db_xref="MGI:MGI:2442422"
ORIGIN      
        1 maawapcrrw gwaavsfgrh pglsaslark pprawwlsac rqkaslsfln rselpnlayk
       61 rlkgktpgii fipgylsnmn gikavaveef ckslghafir fdysgigssd gnlaectvgk
      121 wrkdvlsild dvaegpqilv gsslggwlml haaiarpekv ialigiataa dglvtqyhal
      181 pvetqkeiem kgewtlpsry nkegyfripy sfikeaehhc llhspipvtc pvrllhgmkd
      241 eivpwqrslq vadrivspdv dvilrkqgdh rmkekadihl lictiddlid klstvvp
//
