LOCUS       NM_026180               3684 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATP binding cassette subfamily G member 8 (Abcg8),
            transcript variant 1, mRNA.
ACCESSION   NM_026180 XM_985210
VERSION     NM_026180.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3684)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3684)
  AUTHORS   Wulfridge,P., Davidovich,A., Salvador,A.C., Manno,G.C.,
            Tryggvadottir,R., Idrizi,A., Huda,M.N., Bennett,B.J., Adams,L.G.,
            Hansen,K.D., Threadgill,D.W. and Feinberg,A.P.
  TITLE     Precision pharmacological reversal of strain-specific diet-induced
            metabolic syndrome in mice informed by epigenetic and
            transcriptional regulation
  JOURNAL   PLoS Genet 19 (10), e1010997 (2023)
   PUBMED   37871105
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3684)
  AUTHORS   Matsuo,M., Ogata,Y., Yamanashi,Y. and Takada,T.
  TITLE     ABCG5 and ABCG8 Are Involved in Vitamin K Transport
  JOURNAL   Nutrients 15 (4), 998 (2023)
   PUBMED   36839356
  REMARK    GeneRIF: ABCG5 and ABCG8 Are Involved in Vitamin K Transport.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3684)
  AUTHORS   Baumgartner,S., Lutjohann,D., Husche,C., Kerksiek,A., Groen,A.K.,
            Mensink,R.P. and Plat,J.
  TITLE     Plasma oxyphytosterols most likely originate from hepatic oxidation
            and subsequent spill-over in the circulation
  JOURNAL   J Steroid Biochem Mol Biol 216, 106039 (2022)
   PUBMED   34861389
REFERENCE   5  (bases 1 to 3684)
  AUTHORS   Antoine,T., Le May,C., Margier,M., Halimi,C., Nowicki,M.,
            Defoort,C., Svilar,L. and Reboul,E.
  TITLE     The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and
            Contributes to its Efflux from the Intestine
  JOURNAL   Mol Nutr Food Res 65 (21), e2100617 (2021)
   PUBMED   34510707
  REMARK    GeneRIF: The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption
            Rate and Contributes to its Efflux from the Intestine.
REFERENCE   6  (bases 1 to 3684)
  AUTHORS   Remaley,A.T., Bark,S., Walts,A.D., Freeman,L., Shulenin,S.,
            Annilo,T., Elgin,E., Rhodes,H.E., Joyce,C., Dean,M.,
            Santamarina-Fojo,S. and Brewer,H.B. Jr.
  TITLE     Comparative genome analysis of potential regulatory elements in the
            ABCG5-ABCG8 gene cluster
  JOURNAL   Biochem Biophys Res Commun 295 (2), 276-282 (2002)
   PUBMED   12150943
REFERENCE   7  (bases 1 to 3684)
  AUTHORS   Repa,J.J., Berge,K.E., Pomajzl,C., Richardson,J.A., Hobbs,H. and
            Mangelsdorf,D.J.
  TITLE     Regulation of ATP-binding cassette sterol transporters ABCG5 and
            ABCG8 by the liver X receptors alpha and beta
  JOURNAL   J Biol Chem 277 (21), 18793-18800 (2002)
   PUBMED   11901146
  REMARK    GeneRIF: regulation by liver X receptors alpha and beta
REFERENCE   8  (bases 1 to 3684)
  AUTHORS   Lu,K., Lee,M.H., Yu,H., Zhou,Y., Sandell,S.A., Salen,G. and
            Patel,S.B.
  TITLE     Molecular cloning, genomic organization, genetic variations, and
            characterization of murine sterolin genes Abcg5 and Abcg8
  JOURNAL   J Lipid Res 43 (4), 565-578 (2002)
   PUBMED   11907139
  REMARK    GeneRIF: Alternatively spliced forms for Abcg8 were identified,
            resulting from a CAG repeat at the intron 1 splice-acceptor site,
            causing a deletion of a glutamine
REFERENCE   9  (bases 1 to 3684)
  AUTHORS   Lu,K., Lee,M.H., Hazard,S., Brooks-Wilson,A., Hidaka,H., Kojima,H.,
            Ose,L., Stalenhoef,A.F., Mietinnen,T., Bjorkhem,I., Bruckert,E.,
            Pandya,A., Brewer,H.B. Jr., Salen,G., Dean,M., Srivastava,A. and
            Patel,S.B.
  TITLE     Two genes that map to the STSL locus cause sitosterolemia: genomic
            structure and spectrum of mutations involving sterolin-1 and
            sterolin-2, encoded by ABCG5 and ABCG8, respectively
  JOURNAL   Am J Hum Genet 69 (2), 278-290 (2001)
   PUBMED   11452359
REFERENCE   10 (bases 1 to 3684)
  AUTHORS   Berge,K.E., Tian,H., Graf,G.A., Yu,L., Grishin,N.V., Schultz,J.,
            Kwiterovich,P., Shan,B., Barnes,R. and Hobbs,H.H.
  TITLE     Accumulation of dietary cholesterol in sitosterolemia caused by
            mutations in adjacent ABC transporters
  JOURNAL   Science 290 (5497), 1771-1775 (2000)
   PUBMED   11099417
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165360.3, AK004871.1 and AF324495.1.
            
            On Oct 26, 2013 this sequence version replaced NM_026180.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF324495.1, AK004871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC165360.3         104734-104777
            45-3666             AK004871.1         2-3623
            3667-3684           AF324495.1         3657-3674
FEATURES             Location/Qualifiers
     source          1..3684
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 55.02 cM"
     gene            1..3684
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /note="ATP binding cassette subfamily G member 8"
                     /db_xref="GeneID:67470"
                     /db_xref="MGI:MGI:1914720"
     exon            1..174
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2133
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-binding cassette sub-family G member 8; sterolin 2;
                     ATP-binding cassette, sub-family G (WHITE), member 8"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family G member 8
                     isoform 1"
                     /protein_id="NP_080456.1"
                     /db_xref="CCDS:CCDS29002.1"
                     /db_xref="GeneID:67470"
                     /db_xref="MGI:MGI:1914720"
                     /translation="MAEKTKEETQLWNGTVLQDASQGLQDSLFSSESDNSLYFTYSGQ
                     SNTLEVRDLTYQVDIASQVPWFEQLAQFKIPWRSHSSQDSCELGIRNLSFKVRSGQML
                     AIIGSSGCGRASLLDVITGRGHGGKMKSGQIWINGQPSTPQLVRKCVAHVRQHDQLLP
                     NLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGVSGGE
                     RRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVTTLSRLAKGNRLVLISLHQPRSD
                     IFRLFDLVLLMTSGTPIYLGAAQQMVQYFTSIGHPCPRYSNPADFYVDLTSIDRRSKE
                     REVATVEKAQSLAALFLEKVQGFDDFLWKAEAKELNTSTHTVSLTLTQDTDCGTAVEL
                     PGMIEQFSTLIRRQISNDFRDLPTLLIHGSEACLMSLIIGFLYYGHGAKQLSFMDTAA
                     LLFMIGALIPFNVILDVVSKCHSERSMLYYELEDGLYTAGPYFFAKILGELPEHCAYV
                     IIYAMPIYWLTNLRPVPELFLLHFLLVWLVVFCCRTMALAASAMLPTFHMSSFFCNAL
                     YNSFYLTAGFMINLDNLWIVPAWISKLSFLRWCFSGLMQIQFNGHLYTTQIGNFTFSI
                     LGDTMISAMDLNSHPLYAIYLIVIGISYGFLFLYYLSLKLIKQKSIQDW"
     exon            175..279
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..436
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            437..675
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..808
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1078
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1241
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1322
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1522
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1599
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1867
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1995
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..3667
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3648..3653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /note="hexamer: AATAAA"
     polyA_site      3667
                     /gene="Abcg8"
                     /gene_synonym="1300003C16Rik; sterolin-2"
                     /note="major polyA site"
ORIGIN      
        1 gggagaaagg ctggcacaga ggagggctca ggtgccccag ctctaaggag caaagacaga
       61 gagagcccaa cagcagggga ggccacacaa agggcacaaa cagcactggt catggctgag
      121 aaaaccaaag aagagaccca gctgtggaat gggactgtac ttcaggatgc ttcgcagggc
      181 ctccaggaca gcttgttctc ctcggaaagt gacaacagtc tgtacttcac ctacagtggt
      241 cagtccaaca ctctggaggt cagagatctc acctaccagg tggacatcgc ctctcaggtg
      301 ccttggtttg agcagctggc tcagttcaag ataccctgga ggtctcatag cagccaagac
      361 tcctgtgagc tgggcatccg aaatctaagc ttcaaagtga ggagtggaca gatgctggcc
      421 atcataggga gctcaggctg cgggagagcc tcactactcg acgtgatcac aggcagaggc
      481 cacggtggca agatgaaatc aggacaaatt tggataaatg ggcaacccag tacgcctcag
      541 ctggtgagga agtgcgttgc gcatgtgcgg cagcatgacc aactgctgcc caacctgacc
      601 gtcagagaga ccctggcttt cattgcccag atgcgcctgc ccaggacctt ctcccaggcc
      661 cagcgtgaca aacgggtgga agacgtaatc gccgagctgc ggctgcggca gtgcgccaac
      721 accagagtgg gcaacacgta tgtacgtggg gtgtccgggg gtgagcgccg acgagtgagc
      781 attggggtgc agctcctgtg gaacccagga atcctcattc tggatgaacc cacttctggc
      841 ctcgacagct tcacagccca caatctggtg acaaccttgt cccgcctggc caagggcaac
      901 aggctggtgc tcatctccct ccaccagcct cgctctgaca tcttcaggct atttgacctg
      961 gtccttctga tgacatctgg cacccctatc tacctggggg cggcgcagca aatggtgcag
     1021 tacttcacat ccattggcca cccttgtcct cgctatagca accctgcgga cttctacgtg
     1081 gacttgacca gcatcgacag acgcagcaaa gaacgggagg tggccaccgt ggagaaggca
     1141 cagtctcttg cagccctgtt cctagaaaaa gtacaaggct ttgatgactt tctgtggaaa
     1201 gctgaggcaa aggaactcaa cacaagcacc cacacagtca gcctgaccct cacacaggac
     1261 actgactgtg ggactgctgt tgagctgccc gggatgatag agcagttttc caccctgatc
     1321 cgtcgtcaga tttccaatga cttccgggac ctgcccacgc tgctcattca tgggtcggaa
     1381 gcctgcctga tgtccctcat cattggcttc ctttactacg gccatggggc caagcagctc
     1441 tccttcatgg acacagcagc cctcctcttc atgatagggg cgctcattcc tttcaatgtc
     1501 atcctggatg tcgtctccaa atgtcactcg gagaggtcaa tgctgtacta tgagctggaa
     1561 gacgggctgt acactgctgg tccttatttc tttgccaaga tcctaggaga attgccggag
     1621 cactgtgcct acgtcatcat ctacgcgatg cccatctact ggctgacaaa cctgcggccc
     1681 gtgcctgagc tcttccttct acacttcctg ctcgtgtggt tggtggtctt ctgctgcagg
     1741 accatggccc tggctgcctc tgccatgctg cccaccttcc acatgtcctc cttcttctgc
     1801 aatgccctct acaactcctt ctaccttact gccggcttca tgataaactt ggacaacctg
     1861 tggatagtgc ctgcatggat ctccaagctg tcgttcctcc ggtggtgctt ctcggggctg
     1921 atgcagattc aatttaatgg acacctttac accacacaaa tcggcaactt caccttctcc
     1981 atcctcggag acacgatgat cagtgccatg gacctgaact cgcatccact ctatgcgatc
     2041 tacctcattg tcatcggcat cagctacggc ttcctgttcc tgtactatct atccttgaag
     2101 ctcatcaaac agaagtcaat tcaagactgg tgatactcag ccttgctctc actggcggga
     2161 cccttttccc ggggctggcc accccaggag gagccggact ggggacaagg ctcacacaga
     2221 tctctcaggc agcagccacc tcttagtgct gcagtggcac aggtcagcca caggatggca
     2281 gtagaataaa gacagttgag aggtgtttct gctcccaggc ccaggcttgt gatgggagag
     2341 agagaaacca ggtacgttgc tcatgcattt tatatcttta aataaacaac ccagtatgga
     2401 atgggaacca attatatatg aattgagtag ctaggctatg cagaaatttc tggaatcctg
     2461 agaggatagt ggtttatagc aaagtgttta actttctctt ctaccattct cacactgtta
     2521 agccactccc aatacaaagg gcgacctaaa acaaactagc aaaatgtttt tcgcttatct
     2581 ctgcgtggat tcatggactc caacccccaa agttggacag ctgagagtta attgagcatt
     2641 taatcaacgg gtacggtata aaatatgatg tgtggctatt gtcatttatt cttggagcaa
     2701 cccactgatg tgagcagcat cctgttattt cggtgaggac acggtggcaa agacaaatcc
     2761 agttgtctca gcttacaaag tgttttgtga tggaatcaaa aagacccttg ggcgttacag
     2821 agcaaaacgc caggcccgag atgcctctag aaacagtttg cagagtctgt gtgagctcag
     2881 ccaggcctca gagttgcatc cccctagcca gggctcagga tcggctttca cagtggccag
     2941 agatgcgctg cttgctgcac atccagattg cgtgcttcat gcctgtgtca aggaacccca
     3001 cccccacccc tggcccccca ccccgggccc ccgacccaaa gcatggagct gggaggggct
     3061 tgctcccaga ggaaaactcg tctggaatga aaagaaccag cggggagagt gtttgaggcc
     3121 aggagaggtg ttctccactg gttctccagg tcctgattgg tccatgacgt cagtgaatgc
     3181 tgatgaggta ggcaaaatcc caggcctgcc cagatccgtg gactcagcat cctgtgttca
     3241 gaccccagtg tgagcagcag ctccacagca tccactggcc tcagggagtc cacacagccc
     3301 tgttgccacc atccattgca tagatgtcac acaagagcca cagggccctc atgcagagca
     3361 gagtcaaaag caccctccga ttgcttcttt cagtttggaa gagctagctc ttcagtgccc
     3421 gctggcttta tagggtagct tttaatttgg atttatctgg gggcatttct cagttaaatc
     3481 ctggctgggt cagaatatcc aggaatgaaa ttggtttttc cctagtgtgt cccatcaggc
     3541 ggcacacggt tggctcccag ttgctgcgtg ctgttgactc tgattgcctg acagaaggca
     3601 cgtctgctgg acccctccac gttcctcggt tccctctttt cataattaat aaagcttttg
     3661 gataccaaaa aaaaaaaaaa aaaa
//
