LOCUS       NM_031884               2411 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus ATP binding cassette subfamily G member 5 (Abcg5),
            mRNA.
ACCESSION   NM_031884
VERSION     NM_031884.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2411)
  AUTHORS   Zhang,L., Zhang,S., Zou,W., Hu,Y., Gao,Y., Zhang,J. and Zheng,J.
  TITLE     Maternal high-fat diet regulates offspring hepatic ABCG5 expression
            and cholesterol metabolism via the gut microbiota and its derived
            butyrate
  JOURNAL   Clin Sci (Lond) 138 (17), 1039-1054 (2024)
   PUBMED   39136693
  REMARK    GeneRIF: Maternal high-fat diet regulates offspring hepatic ABCG5
            expression and cholesterol metabolism via the gut microbiota and
            its derived butyrate.
REFERENCE   2  (bases 1 to 2411)
  AUTHORS   Matsuo,M., Ogata,Y., Yamanashi,Y. and Takada,T.
  TITLE     ABCG5 and ABCG8 Are Involved in Vitamin K Transport
  JOURNAL   Nutrients 15 (4), 998 (2023)
   PUBMED   36839356
  REMARK    GeneRIF: ABCG5 and ABCG8 Are Involved in Vitamin K Transport.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2411)
  AUTHORS   Antoine,T., Le May,C., Margier,M., Halimi,C., Nowicki,M.,
            Defoort,C., Svilar,L. and Reboul,E.
  TITLE     The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and
            Contributes to its Efflux from the Intestine
  JOURNAL   Mol Nutr Food Res 65 (21), e2100617 (2021)
   PUBMED   34510707
  REMARK    GeneRIF: The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption
            Rate and Contributes to its Efflux from the Intestine.
REFERENCE   4  (bases 1 to 2411)
  AUTHORS   Mishima,Y., Sonoyama,H., Ishihara,S., Oshima,N., Moriyama,I.,
            Kawashima,K. and Kinoshita,Y.
  TITLE     Interleukin-33 delays recovery of mucosal inflammation via
            downregulation of homeostatic ABCG5/8 in the colon
  JOURNAL   Lab Invest 100 (3), 491-502 (2020)
   PUBMED   31641224
  REMARK    GeneRIF: Interleukin-33 delays recovery of mucosal inflammation via
            downregulation of homeostatic ABCG5/8 in the colon.
REFERENCE   5  (bases 1 to 2411)
  AUTHORS   Chase,T.H., Lyons,B.L., Bronson,R.T., Foreman,O., Donahue,L.R.,
            Burzenski,L.M., Gott,B., Lane,P., Harris,B., Ceglarek,U.,
            Thiery,J., Wittenburg,H., Thon,J.N., Italiano,J.E. Jr.,
            Johnson,K.R. and Shultz,L.D.
  TITLE     The mouse mutation 'thrombocytopenia and cardiomyopathy' (trac)
            disrupts Abcg5: a spontaneous single gene model for human
            hereditary phytosterolemia/sitosterolemia
  JOURNAL   Blood 115 (6), 1267-1276 (2010)
   PUBMED   19846887
  REMARK    GeneRIF: Disruption in Abcg5 gene is associated with
            thrombocytopenia and cardiomyopathy.
REFERENCE   6  (bases 1 to 2411)
  AUTHORS   Repa,J.J., Berge,K.E., Pomajzl,C., Richardson,J.A., Hobbs,H. and
            Mangelsdorf,D.J.
  TITLE     Regulation of ATP-binding cassette sterol transporters ABCG5 and
            ABCG8 by the liver X receptors alpha and beta
  JOURNAL   J Biol Chem 277 (21), 18793-18800 (2002)
   PUBMED   11901146
  REMARK    GeneRIF: regulation by liver X receptors alpha and beta
REFERENCE   7  (bases 1 to 2411)
  AUTHORS   Lu,K., Lee,M.H., Yu,H., Zhou,Y., Sandell,S.A., Salen,G. and
            Patel,S.B.
  TITLE     Molecular cloning, genomic organization, genetic variations, and
            characterization of murine sterolin genes Abcg5 and Abcg8
  JOURNAL   J Lipid Res 43 (4), 565-578 (2002)
   PUBMED   11907139
  REMARK    GeneRIF: Although a large number of polymorphic variants were
            identified, strains reported to show significant differences in
            cholesterol absorption rates did not show significant genomic
            variations in Abcg5 or Abcg8.
REFERENCE   8  (bases 1 to 2411)
  AUTHORS   Lu,K., Lee,M.H., Hazard,S., Brooks-Wilson,A., Hidaka,H., Kojima,H.,
            Ose,L., Stalenhoef,A.F., Mietinnen,T., Bjorkhem,I., Bruckert,E.,
            Pandya,A., Brewer,H.B. Jr., Salen,G., Dean,M., Srivastava,A. and
            Patel,S.B.
  TITLE     Two genes that map to the STSL locus cause sitosterolemia: genomic
            structure and spectrum of mutations involving sterolin-1 and
            sterolin-2, encoded by ABCG5 and ABCG8, respectively
  JOURNAL   Am J Hum Genet 69 (2), 278-290 (2001)
   PUBMED   11452359
REFERENCE   9  (bases 1 to 2411)
  AUTHORS   Lee,M.H., Lu,K., Hazard,S., Yu,H., Shulenin,S., Hidaka,H.,
            Kojima,H., Allikmets,R., Sakuma,N., Pegoraro,R., Srivastava,A.K.,
            Salen,G., Dean,M. and Patel,S.B.
  TITLE     Identification of a gene, ABCG5, important in the regulation of
            dietary cholesterol absorption
  JOURNAL   Nat Genet 27 (1), 79-83 (2001)
   PUBMED   11138003
REFERENCE   10 (bases 1 to 2411)
  AUTHORS   Berge,K.E., Tian,H., Graf,G.A., Yu,L., Grishin,N.V., Schultz,J.,
            Kwiterovich,P., Shan,B., Barnes,R. and Hobbs,H.H.
  TITLE     Accumulation of dietary cholesterol in sitosterolemia caused by
            mutations in adjacent ABC transporters
  JOURNAL   Science 290 (5497), 1771-1775 (2000)
   PUBMED   11099417
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF312713.2 and BB798401.1.
            
            On Nov 25, 2015 this sequence version replaced NM_031884.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the White subfamily, and functions as a
            half-transporter to limit intestinal absorption and promote biliary
            excretion of sterols. Disruption of this gene in mice results in
            thrombocytopenia, prolonged bleeding times, anemia, leukopenia,
            infertility, shortened life span and cardiomyopathy. Mice lacking
            this gene show symptoms of sitosterolemia. [provided by RefSeq, Nov
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF312713.2, AK149569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2351              AF312713.2         1-2351
            2352-2411           BB798401.1         311-370
FEATURES             Location/Qualifiers
     source          1..2411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 55.02 cM"
     gene            1..2411
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /note="ATP binding cassette subfamily G member 5"
                     /db_xref="GeneID:27409"
                     /db_xref="MGI:MGI:1351659"
     exon            1..284
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2097
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /note="sterolin 1; ATP-binding cassette, sub-family G
                     (WHITE), member 5"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family G member 5"
                     /protein_id="NP_114090.1"
                     /db_xref="CCDS:CCDS29001.1"
                     /db_xref="GeneID:27409"
                     /db_xref="MGI:MGI:1351659"
                     /translation="MGELPFLSPEGARGPHINRGSLSSLEQGSVTGTEARHSLGVLHV
                     SYSVSNRVGPWWNIKSCQQKWDRQILKDVSLYIESGQIMCILGSSGSGKTTLLDAISG
                     RLRRTGTLEGEVFVNGCELRRDQFQDCFSYVLQSDVFLSSLTVRETLRYTAMLALCRS
                     SADFYNKKVEAVMTELSLSHVADQMIGSYNFGGISSGERRRVSIAAQLLQDPKVMMLD
                     EPTTGLDCMTANQIVLLLAELARRDRIVIVTIHQPRSELFQHFDKIAILTYGELVFCG
                     TPEEMLGFFNNCGYPCPEHSNPFDFYMDLTSVDTQSREREIETYKRVQMLECAFKESD
                     IYHKILENIERARYLKTLPTVPFKTKDPPGMFGKLGVLLRRVTRNLMRNKQAVIMRLV
                     QNLIMGLFLIFYLLRVQNNTLKGAVQDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVS
                     DQESQDGLYHKWQMLLAYVLHVLPFSVIATVIFSSVCYWTLGLYPEVARFGYFSAALL
                     APHLIGEFLTLVLLGIVQNPNIVNSIVALLSISGLLIGSGFIRNIQEMPIPLKILGYF
                     TFQKYCCEILVVNEFYGLNFTCGGSNTSMLNHPMCAITQGVQFIEKTCPGATSRFTAN
                     FLILYGFIPALVILGIVIFKVRDYLISR"
     exon            285..406
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     exon            407..543
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     exon            544..642
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     exon            643..775
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     exon            776..915
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1045
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1259
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1465
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1604
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1790
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1903
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2411
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2325..2330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /note="hexamer: AATAAT"
     polyA_site      2351
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /note="major polyA site"
     regulatory      2386..2391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /note="hexamer: AATAAA"
     polyA_site      2406
                     /gene="Abcg5"
                     /gene_synonym="cmp; sterolin-1; trac"
                     /note="major polyA site"
ORIGIN      
        1 attggtgaac tgttatctca cgaggattcc agggctgggt aggatcggac agggcactcc
       61 cattggctcc tcagttaaag ctgccctgga gccggacagg ccactagaaa attcacttgc
      121 atttgcttcc tgctagccat gggtgagctg ccctttctga gtccagaggg agccagaggg
      181 cctcacatca acagagggtc tctgagctcc ctggagcaag gttcggtcac gggcacagag
      241 gctcggcaca gcttaggtgt cctgcatgtg tcctacagcg tcagcaaccg tgtcgggcct
      301 tggtggaaca tcaaatcatg ccagcagaag tgggacaggc aaatcctcaa agatgtctcc
      361 ttgtacatcg agagtggcca gattatgtgc atcttaggca gctcaggctc agggaagacc
      421 acgctgctgg acgccatctc cgggaggctg cggcgcactg ggaccctgga aggggaggtg
      481 tttgtgaatg gctgcgagct gcgcagggac cagttccaag actgcttctc ctacgtcctg
      541 cagagcgacg tttttctgag cagcctcact gtgcgcgaga cgttgcgata cacagcgatg
      601 ctggccctct gccgcagctc cgcggacttc tacaacaaga aggtagaggc agtcatgaca
      661 gagctgagcc tgagccacgt ggcggaccaa atgattggca gctataattt tgggggaatt
      721 tccagtggcg agcggcgccg agtttccatc gcagcccaac tccttcagga ccccaaggtc
      781 atgatgctag atgagccaac cacaggactg gactgcatga ctgcaaatca aattgtcctt
      841 ctcttggctg agctggctcg cagggaccga attgtgattg tcaccatcca ccagcctcgc
      901 tctgagctct tccaacactt cgacaaaatt gccatcctga cttacggaga gttggtgttc
      961 tgtggcaccc cagaggagat gcttggcttc ttcaataact gtggttaccc ctgtcctgaa
     1021 cattccaatc cctttgattt ttacatggac ttgacatcag tggacaccca aagcagagag
     1081 cgggaaatag aaacgtacaa gcgagtacag atgctggaat gtgccttcaa ggaatctgac
     1141 atctatcaca aaattctgga gaacattgaa agagcacgat acctgaaaac cttacccacg
     1201 gttcctttca aaacaaaaga tcctcctggg atgttcggca agcttggtgt cctgctgagg
     1261 cgagtaacaa gaaacttaat gaggaataag caggcagtga ttatgcgtct cgttcagaat
     1321 ctgatcatgg gcctcttcct cattttctac cttctccgcg tccagaacaa cacgctaaag
     1381 ggcgctgtgc aggaccgcgt ggggctgctc tatcagcttg tgggtgccac cccatacacc
     1441 ggcatgctca atgctgtgaa tctgtttccc atgctgagag ccgtcagcga ccaggagagt
     1501 caggatggcc tgtatcataa gtggcagatg ctgctcgcct acgtgctaca cgtcctcccc
     1561 ttcagcgtca tcgccacggt cattttcagc agtgtgtgtt attggactct gggcttgtat
     1621 cctgaagttg ccagatttgg atatttctct gctgctcttt tggcccctca cttaattgga
     1681 gaatttctaa cacttgtgct gcttggtata gtccaaaacc ctaatattgt caacagtata
     1741 gtggctctgc tcagcatctc tgggctgctt attggatctg gatttatcag aaacatacaa
     1801 gaaatgccca ttcctttaaa aatcctgggt tattttacat tccaaaaata ctgttgtgag
     1861 attctcgtgg tcaatgagtt ttacggcctg aacttcactt gtggtggatc caacacctct
     1921 atgctaaatc acccgatgtg cgccatcacc caaggggtcc agttcatcga gaaaacctgc
     1981 ccaggtgcta catccagatt cacggcaaac ttcctcatct tatatgggtt tatcccagct
     2041 ctggtcatcc taggaatagt gatttttaaa gtcagggact acctgattag cagatagtta
     2101 agatgacagg caggaaaggg ttaatgggca ggcacgccca ctgtggagca cagagaagta
     2161 ctgtctacaa ccatcaggat tccatctgcg acccttgtgt ctgacccttg tgtctatccg
     2221 gagccccaag ggcaacgaga actcacagcc ctctgctatt ccagcttgtg gggcaatgtg
     2281 gtgcttggac attgtgactg aactggtcca ataatgtaaa taataataat tcataaacct
     2341 acaggacatt agcttgacta tgtgtttttt ttctagtcac agaaaaataa acccatttaa
     2401 aaattatgtt t
//
