LOCUS       NM_138955               3626 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATP binding cassette subfamily G member 4 (Abcg4),
            mRNA.
ACCESSION   NM_138955 XM_989152 XM_989173 XM_989206 XM_989235 XM_989268
            XM_989296 XM_989324
VERSION     NM_138955.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3626)
  AUTHORS   Fong,V., Kanuri,B., Traubert,O., Lui,M. and Patel,S.B.
  TITLE     Behavioral and Metabolic Effects of ABCG4 KO in the APPswe,Ind (J9)
            Mouse Model of Alzheimer's Disease
  JOURNAL   J Mol Neurosci 74 (2), 49 (2024)
   PUBMED   38668787
  REMARK    GeneRIF: Behavioral and Metabolic Effects of ABCG4 KO in the
            APP[swe,Ind] (J9) Mouse Model of Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3626)
  AUTHORS   Dodacki,A., Wortman,M., Saubamea,B., Chasseigneaux,S., Nicolic,S.,
            Prince,N., Lochus,M., Raveu,A.L., Decleves,X., Scherrmann,J.M.,
            Patel,S.B. and Bourasset,F.
  TITLE     Expression and function of Abcg4 in the mouse blood-brain barrier:
            role in restricting the brain entry of amyloid-beta peptide
  JOURNAL   Sci Rep 7 (1), 13393 (2017)
   PUBMED   29042617
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3626)
  AUTHORS   Murphy,A.J., Bijl,N., Yvan-Charvet,L., Welch,C.B., Bhagwat,N.,
            Reheman,A., Wang,Y., Shaw,J.A., Levine,R.L., Ni,H., Tall,A.R. and
            Wang,N.
  TITLE     Cholesterol efflux in megakaryocyte progenitors suppresses platelet
            production and thrombocytosis
  JOURNAL   Nat Med 19 (5), 586-594 (2013)
   PUBMED   23584088
  REMARK    GeneRIF: transplantation of bone marrow deficient in ABCG4, a
            transporter of unknown function, into Ldlr(-/-) mice resulted in
            thrombocytosis, accelerated thrombosis and atherosclerosis
REFERENCE   4  (bases 1 to 3626)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   5  (bases 1 to 3626)
  AUTHORS   Bojanic,D.D., Tarr,P.T., Gale,G.D., Smith,D.J., Bok,D., Chen,B.,
            Nusinowitz,S., Lovgren-Sandblom,A., Bjorkhem,I. and Edwards,P.A.
  TITLE     Differential expression and function of ABCG1 and ABCG4 during
            development and aging
  JOURNAL   J Lipid Res 51 (1), 169-181 (2010)
   PUBMED   19633360
  REMARK    GeneRIF: The loss of ABCG1 and/or ABCG4 from the CNS results in
            changes in metabolic pathways and in behavior.
REFERENCE   6  (bases 1 to 3626)
  AUTHORS   Wang,N., Lan,D., Chen,W., Matsuura,F. and Tall,A.R.
  TITLE     ATP-binding cassette transporters G1 and G4 mediate cellular
            cholesterol efflux to high-density lipoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (26), 9774-9779 (2004)
   PUBMED   15210959
  REMARK    GeneRIF: ABCG1 and ABCG4 promote cholesterol efflux from cells to
            HDL
REFERENCE   7  (bases 1 to 3626)
  AUTHORS   Oldfield,S., Lowry,C., Ruddick,J. and Lightman,S.
  TITLE     ABCG4: a novel human white family ABC-transporter expressed in the
            brain and eye
  JOURNAL   Biochim Biophys Acta 1591 (1-3), 175-179 (2002)
   PUBMED   12183068
REFERENCE   8  (bases 1 to 3626)
  AUTHORS   Kameya,S., Hawes,N.L., Chang,B., Heckenlively,J.R., Naggert,J.K.
            and Nishina,P.M.
  TITLE     Mfrp, a gene encoding a frizzled related protein, is mutated in the
            mouse retinal degeneration 6
  JOURNAL   Hum Mol Genet 11 (16), 1879-1886 (2002)
   PUBMED   12140190
REFERENCE   9  (bases 1 to 3626)
  AUTHORS   Yoshikawa,M., Yabuuchi,H., Kuroiwa,A., Ikegami,Y., Sai,Y.,
            Tamai,I., Tsuji,A., Matsuda,Y., Yoshida,H. and Ishikawa,T.
  TITLE     Molecular and cytogenetic characterization of the mouse ATP-binding
            cassette transporter Abcg4
  JOURNAL   Gene 293 (1-2), 67-75 (2002)
   PUBMED   12137944
REFERENCE   10 (bases 1 to 3626)
  AUTHORS   Annilo,T., Tammur,J., Hutchinson,A., Rzhetsky,A., Dean,M. and
            Allikmets,R.
  TITLE     Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4
  JOURNAL   Cytogenet Cell Genet 94 (3-4), 196-201 (2001)
   PUBMED   11856881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124577.5.
            
            On Apr 11, 2007 this sequence version replaced NM_138955.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043147.1, AK157317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               AC124577.5         178361-178591       c
            232-481             AC124577.5         177563-177812       c
            482-599             AC124577.5         172151-172268       c
            600-732             AC124577.5         171906-172038       c
            733-783             AC124577.5         171744-171794       c
            784-929             AC124577.5         171429-171574       c
            930-1053            AC124577.5         169882-170005       c
            1054-1168           AC124577.5         169650-169764       c
            1169-1311           AC124577.5         169319-169461       c
            1312-1410           AC124577.5         168379-168477       c
            1411-1579           AC124577.5         168005-168173       c
            1580-1680           AC124577.5         167805-167905       c
            1681-1839           AC124577.5         165597-165755       c
            1840-1958           AC124577.5         165363-165481       c
            1959-3626           AC124577.5         163537-165204       c
FEATURES             Location/Qualifiers
     source          1..3626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..3626
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /note="ATP binding cassette subfamily G member 4"
                     /db_xref="GeneID:192663"
                     /db_xref="MGI:MGI:1890594"
     exon            1..231
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            232..481
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            482..599
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            600..732
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            733..783
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            784..929
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1053
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1168
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1311
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1410
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1579
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1680
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1839
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1958
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..3626
                     /gene="Abcg4"
                     /gene_synonym="6430517O04Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcctttctg acccgagccc tgccttcctc tactgcccgc cctggcctag ccccgccccg
       61 gcccgggcca ccgggacagg gagccggggc gcgggtgccg cagccagagg caggtgaaga
      121 gagccggagt gtccacctcc cgcgccgcaa cgctgagcat ccgggtcgaa catcccggtt
      181 gagcatctct gctgagcatc cttgcgtcgc agcggccgga gacgcgtcaa ggccggctgc
      241 gtgatggcgg agaaggcatt ggaggccgtg ggctgtggac tgggccctgg ggctgtggcc
      301 atggctgtga cactggagga cggggcagag ccccctgtgc tgaccacgca cctaaagaag
      361 gtggagaacc atatcacaga agcacagcgc ttctctcacc tgcccaagcg ctctgctgtg
      421 gacatcgagt tcgtggaact gtcctattcc gtgcgggagg ggccctgctg gcgcaaacgg
      481 ggttacaaga ccctcctcaa gtgcctgtct ggtaagttct gtcgccgaga gctgattggc
      541 atcatgggcc cctctggggc tggcaagtcc acattcatga acatcttggc agggtacagg
      601 gagtcgggga tgaaggggca gatcctggtt aacgggaggc cgcgcgagct gaggaccttc
      661 cgcaagatgt cctgctacat catgcaggat gacatgctac tgcctcacct cacagtcctg
      721 gaggccatga tggtctctgc caacctgaag ctgagtgaga agcaagaggt gaagaaggaa
      781 ctggtgacag agatcctgac agccctggga ctgatgtcct gctctcacac gaggacagct
      841 ctgctctctg gagggcagag gaagcgcctg gccattgctc tggaactggt caacaacccg
      901 cctgtcatgt tctttgatga gcctaccagc ggtctagaca gcgcttcttg tttccaagtg
      961 gtgtccctca tgaagtccct ggcccatggg ggccgcaccg tcatctgcac catccaccag
     1021 cccagtgcca agctctttga gatgtttgac aagctctaca tcctgagcca ggggcaatgc
     1081 atcttcaagg gcgtggttac caacctgatt ccctatctga aggggcttgg cttgcactgt
     1141 cccacctacc acaaccccgc tgacttcatc attgaggtgg cctctggaga gtatggagac
     1201 ctgaacccca tgctgttcag ggctgtgcag aatggccttt gcaccatggc cgagaagaag
     1261 agcagccctg ggaagaatga gctccctgcc cactgcccca cttgccctcc ggagctggat
     1321 cctattgaaa gccacacatt tgccaccagc accctaaccc agttctgcat cctcttcagg
     1381 aggactttct tgtccatcct cagggacacg gtcctgaccc acttgcggtt catgtcacat
     1441 gtgttgatcg gcgtcctcat tggcctcctc tacctgcaca ttggcgatga tgccagcaaa
     1501 gtcttcaaca acaccggctt cctcttcttt tccatgctct tcctcatgtt tgcagccctc
     1561 atgccgaccg tgctcacctt tcccttagag atggcggtct tcatgaggga gcacttgaac
     1621 tactggtata ctctcaaagc ctattacttg gccaagacca tggctgatgt gcccttccag
     1681 gtggtatgcc cagtggtgta ctgcagcatc gtgtactgga tgacaggcca gccagccgag
     1741 accagccgct tcctgctctt ctcagccttg gccatagcca ccgccttagt tgcccagtct
     1801 ttgggactct tgattggcgc tgcctctacc tccttgcagg tggccacttt tgtgggccca
     1861 gtgactgcca tccctgtcct cttgttctcc ggcttcttcg tcagtttcaa gaccatcccc
     1921 acttacttgc aatggagctc ctacctctcc tatgttaggt atggctttga gggtctgatc
     1981 ctgaccatct atggtatgga gcgaggacac ctgacctgct tagatgaaca gtgcccattc
     2041 cgggacccac aaatcatttt gcgtgagctg gatgtagagg aggccaaact ctacatggac
     2101 ttcctggtcc tgggcatttt cttccttgcc ctgcggctgc tggcatacct tgtgctccgg
     2161 taccgggtca agtctgagag atagagcctg gctcctacct cttctgggca ggaaggcccc
     2221 agttccagcc ctttggggct gttttaaact tgtacttggg cattggttgc tggtgcagct
     2281 gccctcctct ccctcggctg ctactcaggc tggctggctg tgggctgtgt ctcccagtct
     2341 cagccccgga ggtagggctc cagccctccc gtcaaggcca ggagtcttcc caagttgatg
     2401 cagttggtag cttcttccct actgtctcca acacctgcat gcaaagactg ctgggaggtt
     2461 gctgccctcc tctgcggaaa gcaccctcct ctgttgtttg cctgggagct ccacgttctc
     2521 taggccttga cttacaagtg atcagattga ctcccctctg gggtccccgc cacactctgc
     2581 tatcaggttg gagtcccagg gctgggccct ggtggggtct ccagggagtc ccatcatgga
     2641 cattgaatgg agcaaggagg gactctggaa gcttcctcct ctttctcttt ccctcccaac
     2701 acccactttg gctaatttgg actatctgtt gggacagaag ccgggctttc tgtctgggcc
     2761 accactccca atcctggaga ttggagagag cataggatgt cccggcccct tccctaagcc
     2821 ttcggtctgg atagacctca acatcacctc tgcaataatg tctgtgtcac tctcccatcg
     2881 gccacaggac ctggagaatg cactttattc tggggggtga ggcggggaag cccccatcct
     2941 ccttccttgc tgctcctggg gctcagttcc acaggctcct ttcctctcca gaatcacatc
     3001 acaggcacac aaaggccgcc aggcaatctc agccctacac aggcaccatc ccttgtggct
     3061 cagaggaaga gtggccgtgg cagggagcag tcccaacgtc ctcctgcaga atcccacttt
     3121 ggaggctaag aatgagactg gtgtgaccca gtatgactcc aggctcggca ggtgtctatc
     3181 tcccagtctt ccctccctct tgagcccggg gtggcgctgg ccttctggag gtcagaaccc
     3241 aacaagcaca agaatgggca tagctggcct cggccactgc tcccccatgg ccctcctttt
     3301 gtgccccaag ctgacactca ctcacctgcc cctcctccag ctgcctgctg ctcactcaaa
     3361 cttctgttca catgtattca tcttccggtc agcagctggt tcctggacat cagagcggcg
     3421 gggcctggac atcaggtggc agacacacct gtctatcttc ttggtgggtc caggatcatc
     3481 ctatatctgg tttctcctcc tccaggactc tttccccagt ccctgtgctc actcctctgt
     3541 atctgcccca ggttcttctc attacacaga gaccagttgt atttgtggga tttcacccat
     3601 tattaataaa acctatattt atacag
//
