LOCUS       NM_030239               2998 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ATP binding cassette subfamily G member 3 (Abcg3),
            transcript variant 1, mRNA.
ACCESSION   NM_030239
VERSION     NM_030239.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2998)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2998)
  AUTHORS   Wergedal,J.E., Ackert-Bicknell,C.L., Beamer,W.G., Mohan,S.,
            Baylink,D.J. and Srivastava,A.K.
  TITLE     Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J
            intercross and a combined intercross involving NZB/B1NJ, RF/J,
            MRL/MpJ, and SJL/J mouse strains
  JOURNAL   J Lipid Res 48 (8), 1724-1734 (2007)
   PUBMED   17496333
REFERENCE   3  (bases 1 to 2998)
  AUTHORS   Olszewski,M.A., Gray,J. and Vestal,D.J.
  TITLE     In silico genomic analysis of the human and murine
            guanylate-binding protein (GBP) gene clusters
  JOURNAL   J Interferon Cytokine Res 26 (5), 328-352 (2006)
   PUBMED   16689661
REFERENCE   4  (bases 1 to 2998)
  AUTHORS   Mickley,L., Jain,P., Miyake,K., Schriml,L.M., Rao,K., Fojo,T.,
            Bates,S. and Dean,M.
  TITLE     An ATP-binding cassette gene (ABCG3) closely related to the
            multidrug transporter ABCG2 (MXR/ABCP) has an unusual ATP-binding
            domain
  JOURNAL   Mamm Genome 12 (1), 86-88 (2001)
   PUBMED   11178751
REFERENCE   5  (bases 1 to 2998)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125005.15.
            
            On Mar 28, 2023 this sequence version replaced NM_030239.2.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the White subfamily. It lacks several highly
            conserved residues found in other ATP-binding proteins; this
            suggests that this protein may not bind ATP and may require
            dimerization with another subunit to form a functional
            ATP-transporter. The function of this gene has not yet been
            determined; however, high levels of expression in the thymus and
            spleen suggest a potential role in the transport of specific
            peptides or hydrophobic compounds from lymphocytes. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051880.1, BC138772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC125005.15        24679-24812
            135-356             AC125005.15        29527-29748
            357-416             AC125005.15        31939-31998
            417-531             AC125005.15        32599-32713
            532-684             AC125005.15        33230-33382
            685-821             AC125005.15        37830-37966
            822-973             AC125005.15        39063-39214
            974-1075            AC125005.15        40532-40633
            1076-1323           AC125005.15        43684-43931
            1324-1406           AC125005.15        46102-46184
            1407-1496           AC125005.15        54188-54277
            1497-1621           AC125005.15        55720-55844
            1622-1776           AC125005.15        58885-59039
            1777-1866           AC125005.15        68130-68219
            1867-1952           AC125005.15        69093-69178
            1953-2998           AC125005.15        71258-72303
FEATURES             Location/Qualifiers
     source          1..2998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.68 cM"
     gene            1..2998
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /note="ATP binding cassette subfamily G member 3"
                     /db_xref="GeneID:27405"
                     /db_xref="MGI:MGI:1351624"
     exon            1..134
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            135..356
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2106
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-binding cassette sub-family G member 3; ATP-binding
                     cassette, sub-family G (WHITE), member 3"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family G member 3
                     isoform 1"
                     /protein_id="NP_084515.2"
                     /db_xref="CCDS:CCDS19488.1"
                     /db_xref="GeneID:27405"
                     /db_xref="MGI:MGI:1351624"
                     /translation="MASNNDPTVISMIERHLCDLPETNTSDLKTLTEEAVLSFHNISY
                     QETVQSGFPLRKKAYVIERLSNISGIMKPGLNAIMGPQDGSRSLLLDVLAARRDPRGL
                     SGDILINGKPRPANFKCTSGYVPQNDVVLGTVTVRDNLEFSAALRLPVTITRDEKRRR
                     INEVLELLHLNKEQNIKPRSKELRKRTSIAMELVTEHPILFLDDPTTGLDLRTTTDVI
                     LVLRRMSKKGRTIIFSINQPQYSIFKFFDSLTLVASGKVMFHGPAQDALEYFRSAGYN
                     YESHNNPADFFLDVINGGFSNILDTEEDGHEDDKYEELFERQYQVTGKLANMYAQSPL
                     YSETRAILDQLLGEQKLERSSAVETTCVTPFCHQLKWIICQSFKNFKGFPWVTVIQAI
                     ITVILATAVGTAFRVLKNDCIEVQMRAGLLYLLTIFQCITSVSAGELFVIDRVRFLHE
                     HTSGYYRVSSYFFGKLLAELIPRRLLPSTVFSLITYVIAGVKMSMKCFFTMICTIMVL
                     AYSASSLPLSIGAGENAVAVPTLLVTIYFVFMLFFSGLSLYSGSFLPKLSWIQYFSIP
                     HYGFRALLHNEFLGQNFCPEHNTEEVSRCHNYVICTGEEFLMIQGIDLSSWGFWENHL
                     ALVCTMIILLTITYVQLLQVKNIRNF"
     exon            357..416
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..531
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..684
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..821
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..973
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1075
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1323
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1406
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1496
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1621
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1776
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1866
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1952
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2998
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2811..2816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /note="hexamer: ATTACA"
     polyA_site      2831
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /note="major polyA site"
     regulatory      2981..2986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /note="hexamer: AATAAA"
     polyA_site      2998
                     /gene="Abcg3"
                     /gene_synonym="Abcp2; Mxr2"
                     /note="major polyA site"
ORIGIN      
        1 gctcctgacc acgaccacag aggctccaag agctctgcag agcagaagcc agagcctctt
       61 gcaccttcca aagacccgag ctgcaaatct tcctgtgcaa gtagcaacct gagcccctgc
      121 attatctcac agtggaagaa agaacctcct gagatggctt ctaataatga ccccactgta
      181 atctcaatga tagaaagaca tctttgtgac cttcctgaaa caaacaccag tgacctgaag
      241 acattgactg aagaggctgt gttgagtttt cacaacatca gttaccaaga aacagtacag
      301 agtggctttc cacttcgtaa aaaggcatat gtgatagaaa gactatcaaa catcagtggg
      361 atcatgaaac ctggcctcaa tgccattatg ggacctcagg atgggagcag atctttgttg
      421 ttagatgtct tagctgcaag gagagatccg cgtggattat caggagatat tttgataaat
      481 ggcaaacctc gacctgctaa tttcaagtgt acttctggtt atgtaccaca aaatgatgtg
      541 gtgttgggca cagtgaccgt gagagacaat ttagagttct cagcagctct tcgtctccca
      601 gtgactataa caagagatga aaagagaagg aggattaatg aggtgcttga acttctgcat
      661 ctgaataaag aacaaaatat caagcctaga tccaaagaac tcaggaaaag gaccagtata
      721 gcaatggagc tggtcactga gcatcccatt ttgttcttgg atgatcccac aactggctta
      781 gatttgagaa ctacgactga tgtcatttta gtcctgagaa ggatgtcgaa gaagggacgg
      841 accatcatct tctccatcaa tcagcctcag tactccatct tcaaattttt tgatagcctc
      901 accttagtgg cttcaggaaa agttatgttt catggacctg cacaggatgc tttggagtac
      961 ttcagatctg caggttacaa ttatgaatcg cacaacaacc ctgcagactt cttcctggat
     1021 gtcattaatg gaggtttctc taatatatta gacacagagg aagacggcca tgaagatgac
     1081 aaatatgaag agctttttga gagacagtat caagtcacag gaaaactggc caatatgtat
     1141 gcccagtccc cattatacag tgaaacaaga gccatcctgg atcaactctt gggagaacag
     1201 aagctggaga ggagctcagc cgtggagaca acatgtgtca cccctttctg ccatcagctc
     1261 aagtggatta tctgtcaatc attcaaaaat ttcaagggtt ttccatgggt cactgtgatt
     1321 caggccatta tcacagtcat attggctaca gccgtaggca ctgctttccg tgtcctaaaa
     1381 aatgattgta ttgaagtcca gatgagagct ggcctacttt acctgctcac catcttccag
     1441 tgtatcacaa gtgtgtctgc aggggagctc tttgtgattg acagggttcg ctttctacat
     1501 gagcacacca gtggatacta cagagtgtca tcctatttct ttgggaaatt gctggctgag
     1561 ctaataccca ggaggctttt gccaagtact gtattttctc taataacata tgtcatagca
     1621 ggagtaaaaa tgagtatgaa gtgtttcttc actatgatat gtaccatcat ggtgctggcc
     1681 tattctgcca gttccctgcc attgtccata ggagctgggg agaatgcagt ggctgttcca
     1741 acactgcttg tgaccatcta ctttgtgttc atgctgtttt tttcaggtct atcactatat
     1801 tctggaagct tcctgcctaa gctctcatgg attcagtact ttagcattcc tcattatgga
     1861 tttagggctc tgctgcataa tgaattcctg ggacaaaact tttgtccaga acacaacaca
     1921 gaagaagtca gtagatgcca taactatgtt atatgtactg gtgaagaatt cttgatgatc
     1981 cagggcattg atctctcatc gtggggcttc tgggagaatc acctggcttt agtttgtaca
     2041 atgattatcc tcttaacaat tacctatgtg cagttattac aggttaagaa tattagaaat
     2101 ttttagttcc tgggggagga attttctaca gttgtttaaa tagatgtgat tccaaacaat
     2161 cctctgaaca ttaataatta tactcgtgga caaatgccac tgagaggatc cctcttctgt
     2221 gaactgtgtg aatgcagaga cttatggctg ctcacagtac aaggctaagg aacacgcaaa
     2281 tgtttatctc caacagaaca cctatagcaa accctctata gcttagagca ttgtggaata
     2341 tgggagaaag agtgcaagag ccagatgatg aaaagaagga atggaaatgc agtattgtgg
     2401 tcatgaacag acatagcaac cgtggtctgt gtcccaactc cacagcttaa ctgcataaga
     2461 ctggatccct catcagcaca ggaaggaaca gaggggacct caatgatccc atccaccatt
     2521 ctgctcagct attggctact ggagagaggc agtcattgat tcacatttac actcacattt
     2581 gagcctacag gaatccagtg gaaagtctga aacccttcat cacacagaca gccctgttta
     2641 aaccctgggg gggtggtcac atgataatac caaagttgtg aaggtgagaa agacacttgt
     2701 aaagaggagt atgtcaaggg agtgtaaggg agatgagaga ggtgggacag agggggaaat
     2761 ggctgaaatg aactatatat gtatatggaa ttgtcaattt ttaaataaaa attacaaata
     2821 tacaaaaatt gtaaaaaata ataaacattg tcatttgtct tatactgtaa atcagcaata
     2881 aatatatgtt taagaaatca caaaataata agtaaaaggg tctaagccct aaacgtctac
     2941 agagatactt gctcatccct tgtgtttctg tagtgcataa aataaaaact tcaacaac
//
