LOCUS       NM_011920               2493 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus ATP binding cassette subfamily G member 2 (Junior
            blood group) (Abcg2), transcript variant 1, mRNA.
ACCESSION   NM_011920
VERSION     NM_011920.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2493)
  AUTHORS   Li,C., Cai,Y., Chen,Y., Tong,J., Li,Y., Liu,D., Wang,Y., Li,Z.,
            Wang,Y. and Li,Q.
  TITLE     ABCG2 shields against epilepsy, relieves oxidative stress and
            apoptosis via inhibiting the ISGylation of STAT1 and mTOR
  JOURNAL   Redox Biol 75, 103262 (2024)
   PUBMED   38981367
  REMARK    GeneRIF: ABCG2 shields against epilepsy, relieves oxidative stress
            and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
REFERENCE   2  (bases 1 to 2493)
  AUTHORS   Banks,D.B., Lierz,S.L., Cannon,R.E. and Korach,K.S.
  TITLE     Nongenomic ERalpha-AMPK Signaling Regulates Sex-Dependent Bcrp
            Transport Activity at the Blood-Brain Barrier
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   38984714
  REMARK    GeneRIF: Nongenomic ERalpha-AMPK Signaling Regulates Sex-Dependent
            Bcrp Transport Activity at the Blood-Brain Barrier.
REFERENCE   3  (bases 1 to 2493)
  AUTHORS   Alvarez-Fernandez,L., Blanco-Paniagua,E., Millan-Garcia,A.,
            Velasco-Diez,M., Alvarez,A.I. and Merino,G.
  TITLE     The ABCG2 protein in vitro transports the xenobiotic thiabendazole
            and increases the appearance of its residues in milk
  JOURNAL   Environ Toxicol Pharmacol 107, 104421 (2024)
   PUBMED   38493880
  REMARK    GeneRIF: The ABCG2 protein in vitro transports the xenobiotic
            thiabendazole and increases the appearance of its residues in milk.
REFERENCE   4  (bases 1 to 2493)
  AUTHORS   Chen,C., Zhang,Z., Liu,C., Sun,P., Liu,P. and Li,X.
  TITLE     ABCG2 is an itaconate exporter that limits antibacterial innate
            immunity by alleviating TFEB-dependent lysosomal biogenesis
  JOURNAL   Cell Metab 36 (3), 498-510 (2024)
   PUBMED   38181789
  REMARK    GeneRIF: ABCG2 is an itaconate exporter that limits antibacterial
            innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
REFERENCE   5  (bases 1 to 2493)
  AUTHORS   Sun,H.L., Bian,H.G., Liu,X.M., Zhang,H., Ying,J., Yang,H., Zu,T.,
            Cui,G.Q., Liao,Y.F., Xu,M.F., Meng,X.M. and Jin,J.
  TITLE     GRP/GRPR signaling pathway aggravates hyperuricemia-induced renal
            inflammation and fibrosis via ABCG2-dependent mechanisms
  JOURNAL   Biochem Pharmacol 218, 115901 (2023)
   PUBMED   38084678
  REMARK    GeneRIF: GRP/GRPR signaling pathway aggravates
            hyperuricemia-induced renal inflammation and fibrosis via
            ABCG2-dependent mechanisms.
REFERENCE   6  (bases 1 to 2493)
  AUTHORS   Geschwind,D.H., Ou,J., Easterday,M.C., Dougherty,J.D.,
            Jackson,R.L., Chen,Z., Antoine,H., Terskikh,A., Weissman,I.L.,
            Nelson,S.F. and Kornblum,H.I.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
REFERENCE   7  (bases 1 to 2493)
  AUTHORS   Jonker,J.W., Smit,J.W., Brinkhuis,R.F., Maliepaard,M.,
            Beijnen,J.H., Schellens,J.H. and Schinkel,A.H.
  TITLE     Role of breast cancer resistance protein in the bioavailability and
            fetal penetration of topotecan
  JOURNAL   J Natl Cancer Inst 92 (20), 1651-1656 (2000)
   PUBMED   11036110
REFERENCE   8  (bases 1 to 2493)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (bases 1 to 2493)
  AUTHORS   Allen,J.D., Brinkhuis,R.F., Wijnholds,J. and Schinkel,A.H.
  TITLE     The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in
            cell lines selected for resistance to topotecan, mitoxantrone, or
            doxorubicin
  JOURNAL   Cancer Res 59 (17), 4237-4241 (1999)
   PUBMED   10485464
REFERENCE   10 (bases 1 to 2493)
  AUTHORS   Allikmets,R., Schriml,L.M., Hutchinson,A., Romano-Spica,V. and
            Dean,M.
  TITLE     A human placenta-specific ATP-binding cassette gene (ABCP) on
            chromosome 4q22 that is involved in multidrug resistance
  JOURNAL   Cancer Res 58 (23), 5337-5339 (1998)
   PUBMED   9850061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121855.3, CO039662.1, AC121859.2, AK087830.1, AF103875.1 and
            AI428558.1.
            
            On Jul 28, 2006 this sequence version replaced NM_011920.2.
            
            Summary: The membrane-associated protein encoded by this gene is
            included in the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the White subfamily.
            Alternatively referred to as a breast cancer resistance protein,
            the human protein functions as a xenobiotic transporter which may
            play a major role in multi-drug resistance. This protein likely
            serves as a cellular defense mechanism in response to mitoxantrone
            and anthracycline exposure. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no full-length transcript from the
            C57BL/6J reference strain was available. The extent of this
            transcript is supported by its existence in a single strain,
            C57BL/6NCrl.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053730.1, SRR7652917.858451.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-437               AC121855.3         174919-175355
            438-831             CO039662.1         226-619             c
            832-984             AC121859.2         115213-115365       c
            985-1142            AC121859.2         113430-113587       c
            1143-1294           AC121859.2         111131-111282       c
            1295-1399           AC121859.2         108355-108459       c
            1400-1650           AC121859.2         105651-105901       c
            1651-1948           AK087830.1         656-953
            1949-2103           AC121859.2         94648-94802         c
            2104-2488           AF103875.1         118-502
            2489-2493           AI428558.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..2493
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.82 cM"
     gene            1..2493
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /note="ATP binding cassette subfamily G member 2 (Junior
                     blood group)"
                     /db_xref="GeneID:26357"
                     /db_xref="MGI:MGI:1347061"
     exon            1..437
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            438..656
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..2430
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /EC_number="7.6.2.2"
                     /note="mitoxantrone resistance protein 1; ATP-binding
                     cassette sub-family G member 2; breast cancer resistance
                     protein 1 homolog; urate exporter; ATP-binding cassette,
                     sub-family G (WHITE), member 2"
                     /codon_start=1
                     /product="broad substrate specificity ATP-binding cassette
                     transporter ABCG2"
                     /protein_id="NP_036050.1"
                     /db_xref="CCDS:CCDS20195.1"
                     /db_xref="GeneID:26357"
                     /db_xref="MGI:MGI:1347061"
                     /translation="MSSSNDHVLVPMSQRNNNGLPRMNSRAVRTLAEGDVLSFHHITY
                     RVKVKSGFLVRKTVEKEILSDINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPKGLS
                     GDVLINGAPQPAHFKCCSGYVVQDDVVMGTLTVRENLQFSAALRLPTTMKNHEKNERI
                     NTIIKELGLEKVADSKVGTQFIRGISGGERKRTSIGMELITDPSILFLDEPTTGLDSS
                     TANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGKLVFHGPAQKALEYF
                     ASAGYHCEPYNNPADFFLDVINGDSSAVMLNREEQDNEANKTEEPSKGEKPVIENLSE
                     FYINSAIYGETKAELDQLPGAQEKKGTSAFKEPVYVTSFCHQLRWIARRSFKNLLGNP
                     QASVAQLIVTVILGLIIGAIYFDLKYDAAGMQNRAGVLFFLTTNQCFSSVSAVELFVV
                     EKKLFIHEYISGYYRVSSYFFGKVMSDLLPMRFLPSVIFTCILYFMLGLKKTVDAFFI
                     MMFTLIMVAYTASSMALAIATGQSVVSVATLLMTIAFVFMMLFSGLLVNLRTIGPWLS
                     WLQYFSIPRYGFTALQYNEFLGQEFCPGFNVTDNSTCVNSYAICTGNEYLINQGIELS
                     PWGLWKNHVALACMIIIFLTIAYLKLLFLKKYS"
     exon            657..716
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..831
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..984
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1142
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1294
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1399
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1650
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1733
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1823
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1948
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2103
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2193
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2282
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2491
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2464..2469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /note="hexamer: ATTAAA"
     polyA_site      2489
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /note="major polyA site"
ORIGIN      
        1 atataaaaag atctctctgt ctggatttcc tcttttccaa tctccttgcc agataagagg
       61 ggttaggttg tcttgagttg gaacccacat ttctttcttg attcaggata accagctaac
      121 agatattcac tactgtcgtc ctgaaattaa ctgaggatat tcattaattt cctggaagct
      181 agatttttga aaagtcttga ttttgcctgt ctcttgaggc aaaacttagc aactttgggg
      241 attgataaat cttctgtctt cctggtcctc tccctgcttt ttctcaactc cactgcaagc
      301 aagagtggac atactcttag ggtggctttt gtggcaggca tggatcctag ctgaactctt
      361 tctccagtgt acaacattgc tgcatctcac tgaggcctga cagttctcct tttgacacct
      421 cattacacat agcagagaaa ggcataaatc ctaaagatgt cttccagtaa tgaccacgtg
      481 ttagtaccaa tgtcgcagag aaacaacaac ggccttccta ggatgaactc cagagccgtt
      541 aggacgctcg cagaaggaga tgtgttgagt tttcatcaca tcacctatcg agtgaaagta
      601 aagagtgggt ttctagtccg gaaaacagtt gagaaagaaa tactatcaga tatcaatggg
      661 atcatgaaac ctggccttaa tgctattctg ggacccacag gcggaggcaa gtcttcgttg
      721 ctagatgtct tagcagcaag gaaagatcca aagggattat ctggagatgt tttgataaat
      781 ggagcacctc aacctgccca tttcaaatgc tgttcaggtt atgtggttca agatgacgtt
      841 gtgatgggca ccctgacagt gagagaaaac ttacagttct cagcagctct tcgacttcca
      901 acaactatga agaatcatga aaaaaatgaa cggattaaca caatcattaa agagttaggt
      961 ctggaaaaag tagcagattc taaggtcgga actcagttta tccgtggcat ctctggagga
     1021 gaaagaaaaa ggacaagcat agggatggag ctgatcactg acccttccat cctcttcctg
     1081 gatgagccca cgactggttt ggactcaagc acagcgaatg ctgtcctttt gctcctgaaa
     1141 aggatgtcta aacagggtcg aacaatcatc ttctccattc atcagcctcg gtattccatc
     1201 tttaagttgt ttgacagcct caccttactg gcttccggga aactcgtgtt ccatgggcca
     1261 gcacagaagg ccttggagta ctttgcatca gcaggttacc actgtgagcc ctacaacaac
     1321 cctgcggatt ttttccttga tgtcatcaat ggagattctt ctgctgtgat gttaaataga
     1381 gaggaacaag acaatgaagc aaacaagact gaagagcctt ccaagggaga gaagccagta
     1441 atagaaaatt tatctgagtt ttatatcaac tctgccatct atggagaaac aaaagctgaa
     1501 ttagatcaac ttccaggagc tcaggaaaag aaaggaacat cggccttcaa agagccagtc
     1561 tatgttacct ctttctgtca ccagctccga tggattgcca ggcgctcatt taaaaacttg
     1621 ctcgggaacc ctcaagcttc tgttgctcag ttaattgtta cagtcatact ggggcttatt
     1681 attggtgcca tttactttga tctgaaatat gatgccgctg gaatgcaaaa tagagctgga
     1741 gttttgtttt tcctgactac caaccagtgt ttttccagtg tgtcagctgt ggagctgttc
     1801 gtagtggaga agaaactctt catacatgag tacatcagtg gatattacag agtgtcttct
     1861 tacttctttg gaaaggtgat gtctgattta ctccccatga ggttcttgcc aagtgttata
     1921 ttcacttgta tattatactt catgttagga ctgaagaaga cggtggatgc ttttttcatc
     1981 atgatgttta cccttataat ggtggcttat acggccagtt ccatggcact ggccatagcc
     2041 acaggccaaa gtgtggtgtc tgtagcaaca cttctcatga caatcgcttt tgtatttatg
     2101 atgctctttt ctggcctctt ggtgaatctc agaaccattg ggccttggct gtcctggctt
     2161 cagtacttta gcattcctcg atatggcttc acagctttgc agtataatga attcttggga
     2221 caagagtttt gtccaggatt caatgtaacg gacaacagca cttgtgttaa cagctatgca
     2281 atatgtactg gtaacgagta cttgataaat cagggcatcg aactgtcacc ttggggactg
     2341 tggaagaatc atgtggccct ggcttgtatg attattatct tcctcacaat tgcctacctg
     2401 aaattgttgt ttcttaaaaa gtattcttaa tttccccttt aacggactat taattgtact
     2461 ccaattaaat atgggcactt tgattaccat aaa
//
