LOCUS       NM_001381927            2134 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus ATP binding cassette subfamily G member 2 (Junior
            blood group) (Abcg2), transcript variant 5, mRNA.
ACCESSION   NM_001381927 XM_006506148
VERSION     NM_001381927.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2134)
  AUTHORS   Li,C., Cai,Y., Chen,Y., Tong,J., Li,Y., Liu,D., Wang,Y., Li,Z.,
            Wang,Y. and Li,Q.
  TITLE     ABCG2 shields against epilepsy, relieves oxidative stress and
            apoptosis via inhibiting the ISGylation of STAT1 and mTOR
  JOURNAL   Redox Biol 75, 103262 (2024)
   PUBMED   38981367
  REMARK    GeneRIF: ABCG2 shields against epilepsy, relieves oxidative stress
            and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
REFERENCE   2  (bases 1 to 2134)
  AUTHORS   Banks,D.B., Lierz,S.L., Cannon,R.E. and Korach,K.S.
  TITLE     Nongenomic ERalpha-AMPK Signaling Regulates Sex-Dependent Bcrp
            Transport Activity at the Blood-Brain Barrier
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   38984714
  REMARK    GeneRIF: Nongenomic ERalpha-AMPK Signaling Regulates Sex-Dependent
            Bcrp Transport Activity at the Blood-Brain Barrier.
REFERENCE   3  (bases 1 to 2134)
  AUTHORS   Alvarez-Fernandez,L., Blanco-Paniagua,E., Millan-Garcia,A.,
            Velasco-Diez,M., Alvarez,A.I. and Merino,G.
  TITLE     The ABCG2 protein in vitro transports the xenobiotic thiabendazole
            and increases the appearance of its residues in milk
  JOURNAL   Environ Toxicol Pharmacol 107, 104421 (2024)
   PUBMED   38493880
  REMARK    GeneRIF: The ABCG2 protein in vitro transports the xenobiotic
            thiabendazole and increases the appearance of its residues in milk.
REFERENCE   4  (bases 1 to 2134)
  AUTHORS   Chen,C., Zhang,Z., Liu,C., Sun,P., Liu,P. and Li,X.
  TITLE     ABCG2 is an itaconate exporter that limits antibacterial innate
            immunity by alleviating TFEB-dependent lysosomal biogenesis
  JOURNAL   Cell Metab 36 (3), 498-510 (2024)
   PUBMED   38181789
  REMARK    GeneRIF: ABCG2 is an itaconate exporter that limits antibacterial
            innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
REFERENCE   5  (bases 1 to 2134)
  AUTHORS   Sun,H.L., Bian,H.G., Liu,X.M., Zhang,H., Ying,J., Yang,H., Zu,T.,
            Cui,G.Q., Liao,Y.F., Xu,M.F., Meng,X.M. and Jin,J.
  TITLE     GRP/GRPR signaling pathway aggravates hyperuricemia-induced renal
            inflammation and fibrosis via ABCG2-dependent mechanisms
  JOURNAL   Biochem Pharmacol 218, 115901 (2023)
   PUBMED   38084678
  REMARK    GeneRIF: GRP/GRPR signaling pathway aggravates
            hyperuricemia-induced renal inflammation and fibrosis via
            ABCG2-dependent mechanisms.
REFERENCE   6  (bases 1 to 2134)
  AUTHORS   Geschwind,D.H., Ou,J., Easterday,M.C., Dougherty,J.D.,
            Jackson,R.L., Chen,Z., Antoine,H., Terskikh,A., Weissman,I.L.,
            Nelson,S.F. and Kornblum,H.I.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
REFERENCE   7  (bases 1 to 2134)
  AUTHORS   Jonker,J.W., Smit,J.W., Brinkhuis,R.F., Maliepaard,M.,
            Beijnen,J.H., Schellens,J.H. and Schinkel,A.H.
  TITLE     Role of breast cancer resistance protein in the bioavailability and
            fetal penetration of topotecan
  JOURNAL   J Natl Cancer Inst 92 (20), 1651-1656 (2000)
   PUBMED   11036110
REFERENCE   8  (bases 1 to 2134)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (bases 1 to 2134)
  AUTHORS   Allen,J.D., Brinkhuis,R.F., Wijnholds,J. and Schinkel,A.H.
  TITLE     The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in
            cell lines selected for resistance to topotecan, mitoxantrone, or
            doxorubicin
  JOURNAL   Cancer Res 59 (17), 4237-4241 (1999)
   PUBMED   10485464
REFERENCE   10 (bases 1 to 2134)
  AUTHORS   Allikmets,R., Schriml,L.M., Hutchinson,A., Romano-Spica,V. and
            Dean,M.
  TITLE     A human placenta-specific ATP-binding cassette gene (ABCP) on
            chromosome 4q22 that is involved in multidrug resistance
  JOURNAL   Cancer Res 58 (23), 5337-5339 (1998)
   PUBMED   9850061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121859.2.
            
            On Apr 20, 2020 this sequence version replaced XM_006506148.4.
            
            Summary: The membrane-associated protein encoded by this gene is
            included in the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the White subfamily.
            Alternatively referred to as a breast cancer resistance protein,
            the human protein functions as a xenobiotic transporter which may
            play a major role in multi-drug resistance. This protein likely
            serves as a cellular defense mechanism in response to mitoxantrone
            and anthracycline exposure. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189679.67132.1,
                                           SRR5189682.105299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC121859.2         139842-139923       c
            83-301              AC121859.2         124613-124831       c
            302-361             AC121859.2         116796-116855       c
            362-476             AC121859.2         115911-116025       c
            477-629             AC121859.2         115213-115365       c
            630-787             AC121859.2         113430-113587       c
            788-939             AC121859.2         111131-111282       c
            940-1044            AC121859.2         108355-108459       c
            1045-1295           AC121859.2         105651-105901       c
            1296-1378           AC121859.2         102111-102193       c
            1379-1468           AC121859.2         97150-97239         c
            1469-1593           AC121859.2         96012-96136         c
            1594-1748           AC121859.2         94648-94802         c
            1749-1838           AC121859.2         90825-90914         c
            1839-1927           AC121859.2         89850-89938         c
            1928-2134           AC121859.2         88020-88226         c
FEATURES             Location/Qualifiers
     source          1..2134
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.82 cM"
     gene            1..2134
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /note="ATP binding cassette subfamily G member 2 (Junior
                     blood group)"
                     /db_xref="GeneID:26357"
                     /db_xref="MGI:MGI:1347061"
     exon            1..82
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            83..301
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2075
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /EC_number="7.6.2.2"
                     /note="mitoxantrone resistance protein 1; ATP-binding
                     cassette sub-family G member 2; breast cancer resistance
                     protein 1 homolog; urate exporter; ATP-binding cassette,
                     sub-family G (WHITE), member 2"
                     /codon_start=1
                     /product="broad substrate specificity ATP-binding cassette
                     transporter ABCG2"
                     /protein_id="NP_001368856.1"
                     /db_xref="GeneID:26357"
                     /db_xref="MGI:MGI:1347061"
                     /translation="MSSSNDHVLVPMSQRNNNGLPRMNSRAVRTLAEGDVLSFHHITY
                     RVKVKSGFLVRKTVEKEILSDINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPKGLS
                     GDVLINGAPQPAHFKCCSGYVVQDDVVMGTLTVRENLQFSAALRLPTTMKNHEKNERI
                     NTIIKELGLEKVADSKVGTQFIRGISGGERKRTSIGMELITDPSILFLDEPTTGLDSS
                     TANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGKLVFHGPAQKALEYF
                     ASAGYHCEPYNNPADFFLDVINGDSSAVMLNREEQDNEANKTEEPSKGEKPVIENLSE
                     FYINSAIYGETKAELDQLPGAQEKKGTSAFKEPVYVTSFCHQLRWIARRSFKNLLGNP
                     QASVAQLIVTVILGLIIGAIYFDLKYDAAGMQNRAGVLFFLTTNQCFSSVSAVELFVV
                     EKKLFIHEYISGYYRVSSYFFGKVMSDLLPMRFLPSVIFTCILYFMLGLKKTVDAFFI
                     MMFTLIMVAYTASSMALAIATGQSVVSVATLLMTIAFVFMMLFSGLLVNLRTIGPWLS
                     WLQYFSIPRYGFTALQYNEFLGQEFCPGFNVTDNSTCVNSYAICTGNEYLINQGIELS
                     PWGLWKNHVALACMIIIFLTIAYLKLLFLKKYS"
     exon            302..361
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..476
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..629
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..787
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..939
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1044
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1295
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1378
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1468
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1593
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1748
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1838
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1927
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2134
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /note="hexamer: ATTAAA"
     polyA_site      2134
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /note="major polyA site"
ORIGIN      
        1 agacgctcct ggcgggcgag cgtgtgcagg tctgagtgtg tgcgagttct ggcgcggctg
       61 ctgctccgcc agggaccgcg agaaaggcat aaatcctaaa gatgtcttcc agtaatgacc
      121 acgtgttagt accaatgtcg cagagaaaca acaacggcct tcctaggatg aactccagag
      181 ccgttaggac gctcgcagaa ggagatgtgt tgagttttca tcacatcacc tatcgagtga
      241 aagtaaagag tgggtttcta gtccggaaaa cagttgagaa agaaatacta tcagatatca
      301 atgggatcat gaaacctggc cttaatgcta ttctgggacc cacaggcgga ggcaagtctt
      361 cgttgctaga tgtcttagca gcaaggaaag atccaaaggg attatctgga gatgttttga
      421 taaatggagc acctcaacct gcccatttca aatgctgttc aggttatgtg gttcaagatg
      481 acgttgtgat gggcaccctg acagtgagag aaaacttaca gttctcagca gctcttcgac
      541 ttccaacaac tatgaagaat catgaaaaaa atgaacggat taacacaatc attaaagagt
      601 taggtctgga aaaagtagca gattctaagg tcggaactca gtttatccgt ggcatctctg
      661 gaggagaaag aaaaaggaca agcataggga tggagctgat cactgaccct tccatcctct
      721 tcctggatga gcccacgact ggtttggact caagcacagc gaatgctgtc cttttgctcc
      781 tgaaaaggat gtctaaacag ggtcgaacaa tcatcttctc cattcatcag cctcggtatt
      841 ccatctttaa gttgtttgac agcctcacct tactggcttc cgggaaactc gtgttccatg
      901 ggccagcaca gaaggccttg gagtactttg catcagcagg ttaccactgt gagccctaca
      961 acaaccctgc ggattttttc cttgatgtca tcaatggaga ttcttctgct gtgatgttaa
     1021 atagagagga acaagacaat gaagcaaaca agactgaaga gccttccaag ggagagaagc
     1081 cagtaataga aaatttatct gagttttata tcaactctgc catctatgga gaaacaaaag
     1141 ctgaattaga tcaacttcca ggagctcagg aaaagaaagg aacatcggcc ttcaaagagc
     1201 cagtctatgt tacctctttc tgtcaccagc tccgatggat tgccaggcgc tcatttaaaa
     1261 acttgctcgg gaaccctcaa gcttctgttg ctcagttaat tgttacagtc atactggggc
     1321 ttattattgg tgccatttac tttgatctga aatatgatgc cgctggaatg caaaatagag
     1381 ctggagtttt gtttttcctg actaccaacc agtgtttttc cagtgtgtca gctgtggagc
     1441 tgttcgtagt ggagaagaaa ctcttcatac atgagtacat cagtggatat tacagagtgt
     1501 cttcttactt ctttggaaag gtgatgtctg atttactccc catgaggttc ttgccaagtg
     1561 ttatattcac ttgtatatta tacttcatgt taggactgaa gaagacggtg gatgcttttt
     1621 tcatcatgat gtttaccctt ataatggtgg cttatacggc cagttccatg gcactggcca
     1681 tagccacagg ccaaagtgtg gtgtctgtag caacacttct catgacaatc gcttttgtat
     1741 ttatgatgct cttttctggc ctcttggtga atctcagaac cattgggcct tggctgtcct
     1801 ggcttcagta ctttagcatt cctcgatatg gcttcacagc tttgcagtat aatgaattct
     1861 tgggacaaga gttttgtcca ggattcaatg taacggacaa cagcacttgt gttaacagct
     1921 atgcaatatg tactggtaac gagtacttga taaatcaggg catcgaactg tcaccttggg
     1981 gactgtggaa gaatcatgtg gccctggctt gtatgattat tatcttcctc acaattgcct
     2041 acctgaaatt gttgtttctt aaaaagtatt cttaatttcc cctttaacgg actattaatt
     2101 gtactccaat taaatatggg cactttgatt acca
//
