LOCUS       NM_009593               5821 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus ATP binding cassette subfamily G member 1 (Abcg1),
            mRNA.
ACCESSION   NM_009593
VERSION     NM_009593.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5821)
  AUTHORS   Dahik,V.D., Kc,P., Materne,C., Reydellet,C., Lhomme,M.,
            Cruciani-Guglielmacci,C., Denom,J., Bun,E., Ponnaiah,M.,
            Deknuydt,F., Frisdal,E., Hardy,L.M., Durand,H., Guillas,I.,
            Lesnik,P., Gudelj,I., Lauc,G., Guerin,M., Kontush,A., Soprani,A.,
            Magnan,C., Diedisheim,M., Bluteau,O., Venteclef,N. and Le Goff,W.
  TITLE     ABCG1 orchestrates adipose tissue macrophage plasticity and insulin
            resistance in obesity by rewiring saturated fatty acid pools
  JOURNAL   Sci Transl Med 16 (777), eadi6682 (2024)
   PUBMED   39661702
REFERENCE   2  (bases 1 to 5821)
  AUTHORS   Kloosterman,D.J., Erbani,J., Boon,M., Farber,M., Handgraaf,S.M.,
            Ando-Kuri,M., Sanchez-Lopez,E., Fontein,B., Mertz,M., Nieuwland,M.,
            Liu,N.Q., Forn-Cuni,G., van der Wel,N.N., Grootemaat,A.E.,
            Reinalda,L., van Kasteren,S.I., de Wit,E., Ruffell,B.,
            Snaar-Jagalska,E., Petrecca,K., Brandsma,D., Kros,A., Giera,M. and
            Akkari,L.
  TITLE     Macrophage-mediated myelin recycling fuels brain cancer malignancy
  JOURNAL   Cell 187 (19), 5336-5356 (2024)
   PUBMED   39137777
REFERENCE   3  (bases 1 to 5821)
  AUTHORS   Terao,R., Lee,T.J., Colasanti,J., Pfeifer,C.W., Lin,J.B.,
            Santeford,A., Hase,K., Yamaguchi,S., Du,D., Sohn,B.S., Sasaki,Y.,
            Yoshida,M. and Apte,R.S.
  TITLE     LXR/CD38 activation drives cholesterol-induced macrophage
            senescence and neurodegeneration via NAD+ depletion
  JOURNAL   Cell Rep 43 (5), 114102 (2024)
   PUBMED   38636518
REFERENCE   4  (bases 1 to 5821)
  AUTHORS   Yalcinkaya,M., Liu,W., Xiao,T., Abramowicz,S., Wang,R., Wang,N.,
            Westerterp,M. and Tall,A.R.
  TITLE     Cholesterol trafficking to the ER leads to the activation of
            CaMKII/JNK/NLRP3 and promotes atherosclerosis
  JOURNAL   J Lipid Res 65 (4), 100534 (2024)
   PUBMED   38522750
REFERENCE   5  (bases 1 to 5821)
  AUTHORS   Liimatta,J., Curschellas,E., Altinkilic,E.M., Naamneh Elzenaty,R.,
            Augsburger,P., du Toit,T., Voegel,C.D., Breault,D.T., Fluck,C.E.
            and Pignatti,E.
  TITLE     Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis
  JOURNAL   Endocrinology 165 (3) (2024)
   PUBMED   38301271
  REMARK    GeneRIF: Adrenal Abcg1 Controls Cholesterol Flux and
            Steroidogenesis.
REFERENCE   6  (bases 1 to 5821)
  AUTHORS   Lorkowski,S., Rust,S., Engel,T., Jung,E., Tegelkamp,K.,
            Galinski,E.A., Assmann,G. and Cullen,P.
  TITLE     Genomic sequence and structure of the human ABCG1 (ABC8) gene
  JOURNAL   Biochem Biophys Res Commun 280 (1), 121-131 (2001)
   PUBMED   11162488
REFERENCE   7  (bases 1 to 5821)
  AUTHORS   Venkateswaran,A., Repa,J.J., Lobaccaro,J.M., Bronson,A.,
            Mangelsdorf,D.J. and Edwards,P.A.
  TITLE     Human white/murine ABC8 mRNA levels are highly induced in
            lipid-loaded macrophages. A transcriptional role for specific
            oxysterols
  JOURNAL   J Biol Chem 275 (19), 14700-14707 (2000)
   PUBMED   10799558
REFERENCE   8  (bases 1 to 5821)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (bases 1 to 5821)
  AUTHORS   Croop,J.M., Tiller,G.E., Fletcher,J.A., Lux,M.L., Raab,E.,
            Goldenson,D., Son,D., Arciniegas,S. and Wu,R.L.
  TITLE     Isolation and characterization of a mammalian homolog of the
            Drosophila white gene
  JOURNAL   Gene 185 (1), 77-85 (1997)
   PUBMED   9034316
REFERENCE   10 (bases 1 to 5821)
  AUTHORS   Savary,S., Denizot,F., Luciani,M., Mattei,M. and Chimini,G.
  TITLE     Molecular cloning of a mammalian ABC transporter homologous to
            Drosophila white gene
  JOURNAL   Mamm Genome 7 (9), 673-676 (1996)
   PUBMED   8703120
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY296839.1, AK037433.1,
            AF323659.1, CV558133.1, CO431055.1 and AC167247.2.
            
            On Oct 31, 2007 this sequence version replaced NM_009593.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the White subfamily. The human protein is
            involved in macrophage cholesterol efflux and may regulate cellular
            lipid homeostasis in other cell types. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF323659.1, U34920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-372               BY296839.1         2-373
            373-709             AK037433.1         293-629
            710-1422            AF323659.1         706-1418
            1423-1774           CV558133.1         234-585
            1775-1999           AF323659.1         1771-1995
            2000-2337           CO431055.1         245-582
            2338-5821           AC167247.2         97010-100493        c
FEATURES             Location/Qualifiers
     source          1..5821
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.8 cM"
     gene            1..5821
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /note="ATP binding cassette subfamily G member 1"
                     /db_xref="GeneID:11307"
                     /db_xref="MGI:MGI:107704"
     exon            1..163
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2122
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /note="ATP-binding cassette 8; white protein homolog;
                     ATP-binding cassette transporter 8; ATP-binding cassette,
                     sub-family G (WHITE), member 1"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family G member 1"
                     /protein_id="NP_033723.1"
                     /db_xref="CCDS:CCDS28602.1"
                     /db_xref="GeneID:11307"
                     /db_xref="MGI:MGI:107704"
                     /translation="MACLMAAFSVGTAMNASSYSAAMTEPKSVCVSVDEVVSSNVDEV
                     ETDLLNGHLKKVDNNFTEAQRFSSLPRRAAVNIEFKDLSYSVPEGPWWKKKGYKTLLK
                     GISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGMPRDLRCFRKVSC
                     YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLPCANTRTGSLS
                     GGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIVCTIHQP
                     SAKLFELFDQLYVLSQGQCVYRGKVSNLVPYLRDLGLNCPTYHNPADFVMEVASGEYG
                     DQNSRLVRAVREGMCDADYKRDLGGDTDVNPFLWHRPAEEDSASMEGCHSFSASCLTQ
                     FCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSM
                     LFLMFAALMPTVLTFPLEMSVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSI
                     VYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLL
                     FSGFFVSFDTIPAYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIAETCHFQKSEA
                     ILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER"
     exon            164..407
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            408..525
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            526..658
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            659..709
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            710..855
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            856..979
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1094
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1243
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1345
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1514
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1615
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1774
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1893
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..5821
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3592..3597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /note="hexamer: ATTAAA"
     polyA_site      3614
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /note="major polyA site"
     regulatory      5800..5805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /note="hexamer: AATAAA"
     polyA_site      5821
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
ORIGIN      
        1 agtcggaacc cgcgcagagc gccgcggagg agcaggagca agcgcagcct cgttcctgca
       61 acctcgtccc cgccgcccgc agacttgtct ccactgccgc tgccgccgcc gcccccgggg
      121 catggcctgt ctgatggccg ctttctcggt cggcaccgcc atgaatgcca gcagctactc
      181 tgccgcaatg acggagccca agtccgtgtg cgtgtcagtg gacgaggtcg tgtccagcaa
      241 cgtggatgag gttgagacag acctgctcaa tgggcacctg aagaaggtgg acaacaactt
      301 cacagaggcc cagcgctttt cctcccttcc gcggagggcg gccgtgaaca tcgaattcaa
      361 ggacctttcc tactctgtac ccgaggggcc ctggtggaag aagaaaggat acaagaccct
      421 tttgaaaggg atctctggga aattcaacag tggagagctg gtggccatca tgggtccttc
      481 tggagctggg aagtccacac tcatgaatat tctggcagga tacagggaga ctggcatgaa
      541 aggggcagtc cttatcaatg gaatgccccg ggacctgcgc tgcttccgga aggtctcctg
      601 ctacatcatg caggacgaca tgctgctgcc tcacctcact gttcaggagg ccatgatggt
      661 gtccgcgcat ctgaagctgc aggagaagga tgaaggcaga cgagagatgg tcaaagagat
      721 cctgacagcc ctgggcttgc tgccctgtgc caacacacgc acggggagcc tctcaggcgg
      781 ccagcggaaa cgcctggcca ttgccctgga gctggtcaac aacccgcctg tcatgttctt
      841 tgatgagccc accagtggcc tggacagcgc ctcctgcttc caagtggtgt ctctgatgaa
      901 aggactggcc cagggtggcc gctccatcgt ctgtaccatc caccagccca gtgccaagct
      961 ctttgagctc tttgaccagc tttatgtcct aagtcaagga caatgcgtat acaggggaaa
     1021 ggtctccaat ctcgtgccgt atctgaggga tctgggtctg aactgcccta cctaccacaa
     1081 cccagcagac tttgtcatgg aagtggcatc aggggagtac ggggatcaga acagtcgcct
     1141 ggtgagagcc gtgcgagagg gcatgtgtga cgctgactat aagagagacc tcgggggcga
     1201 caccgatgtg aacccgtttc tttggcaccg gcctgctgaa gaggactccg cctccatgga
     1261 aggttgccat agcttctcgg ccagctgcct cacccagttc tgcatcctct tcaagaggac
     1321 cttcctcagc atcatgcggg actcggtcct gacacatctg cgaatcacct cgcacattgg
     1381 gatcggcctg ctcattggcc tgctgtacct ggggattggg aacgaagcca agaaggtcct
     1441 gagcaactcc ggcttcctgt tcttctccat gctgttcctc atgtttgctg ccctcatgcc
     1501 caccgttctg acctttcccc tggagatgag tgttttcctc cgggagcacc tgaactactg
     1561 gtacagcctg aaggcctact acctggcaaa gaccatggcc gatgtcccct ttcagatcat
     1621 gttccctgtg gcctactgca gtatcgtata ctggatgacg tcccagccgt cggacgctgt
     1681 gcgttttgtg ctgttcgctg ctctgggtac catgacatcg ctggtggccc agtccttagg
     1741 cctactgatt ggagctgcat ccacatccct gcaggttgcg acatttgtgg gtcccgtgac
     1801 agccatcccc gtcctgctct tctccggatt ctttgtcagc tttgacacca tcccagccta
     1861 cctgcagtgg atgtcctaca tctcctatgt cagatacggc tttgaggggg tcatcctgtc
     1921 catctacggc ttggaccgag aagacctgca ctgcgacatc gcggagacat gccacttcca
     1981 gaagtcagag gccatcctgc gggagctgga cgtggagaat gcgaagctgt acctggattt
     2041 catcgtcctg ggcatcttct tcatctccct gcggctcatc gcctatttcg tcctcagata
     2101 caaaatccgg gctgagaggt aaaaaccgcc tccaagccag caacgaggca aagcagacat
     2161 tgtgaccaag ggcactgctg ggaggtagca gcgcacctgc tcctggtgac acagactctc
     2221 ccaacccaac ctggaggcca cgcaagtctg acgatgacca gtgttgagcg cctctgcccg
     2281 ccgggttgaa actgttcgtt tccttttcta actaggaaga tgtaggacgg ttgggttttt
     2341 tttttctttt tttttttttt tttttttaga tgtgggattc aaaatacaac tggcatagaa
     2401 tgccatcctg tgctccagct ggggacagtg gcttcctccc ggagtccagg acacactggc
     2461 cccggatgag gagtgttagc cgagttggtc cccagagagg tggatatctt ggggagaagg
     2521 tccacaccta gcgggcgcag aggccacctg aggaccatct tctcttaagg tctcagcctt
     2581 ctaaagttcc tctcatttct gatgaagtca ctttccgagc caaagtcgat aaatttcatt
     2641 cacttcgaga gattgtatct ttttagtact tcttgaggga cttattcagg gtaaaagatg
     2701 tgttttgctt agaaacagaa gagtccaacc gagtcaccaa ggaggcctca caaataaaac
     2761 cagagaaggt caaatgcagg ctccgggtga gggagacacc acaccagctg cgctggggca
     2821 gcagggacta acgcaacgca atgcaacgca atgcagacag tgctggggta cttggcaggc
     2881 tcctcccaga cttcctttct catgtgcttc ttagcttaaa actcttccta gttttccagc
     2941 cactttcatt ttgcccaaga aatactcgat ccaccttgtg gatgtttaaa gacccatttc
     3001 ccctttcttc atgaatcaca ttaactacct ccaccgagcc tgggaagccg gcctggggac
     3061 atatcgggtg tatccctcca acttgagggg agccgtgggg tgtcaaggat gggcaggccg
     3121 gctgagtgga aggggaggtg ccatggatgt ccccgttaag aaaatgcagc tgctcgcctc
     3181 ttccagagca ccaccatcta aggtcagcct cctacaaaag tctctatttt tgagggtagg
     3241 tcagtttaac ccctgtgagc ctcagtttcc ccacctgtaa gtaattgcac tagatcatgt
     3301 cttgacaggt cctgagattc ctcggctgtg gccttgatgc tttcgtatct tatctgtaga
     3361 gaatgataag ggtccgaatt ttacttaccg catggataat gtgctttgga actctttaga
     3421 gattcttttt attttttaca ctcctagatc ttttttatag agaacacaca attgaaatgc
     3481 atattatgat gtaattttcg gtttgcttgt tctatacaaa cacggccttg ccttctagac
     3541 tcagctttta accagggaca cgattcgcct ttataaaaaa aaaaagtctt cattaaaaaa
     3601 gaaaacacca aaaaggtctt catttaattt caagataatt aggcatggcg tccagagagg
     3661 aactggctgc tattagctgt gaagtctgag ctgaaaagaa tgggtgttgg gtggacaaac
     3721 ctcagtccgg cacttgatgg ggttggtgcc aaagaaccca ttccatccat gtccgcacgc
     3781 atgtcttgac atggtgggtc atgcccggca ggctctgtct cctcggagag ctgtgtgctg
     3841 tcagtcacag gcagggtggt ccatgtttca ctctggaagg gttcctcagc ctctggaggg
     3901 attctttcct gtccaggttt ctcctagacc ctgagacctg cttgtcactc accctatgta
     3961 agtgagagtg ccgtgggatc cttccacggg gcggagtctg agctcaggat acaagagctg
     4021 ccaggctggt gcaggacagg gtatcctggg aagttgataa aggatgttga ccagaacagg
     4081 cgaggggtca gaggtcaccc agcattgctc aagctctgca gactcgagga aggctgacag
     4141 ccatcctagg ggactctgca cccttgtccc ttatccactg tccatagggg ccatggtgtg
     4201 tggttctacc tttccccata catagcccga atcccagaga tgctgcctgg atttctagac
     4261 cattcccttt tcttcttctt cttcccattg gtcttagtca tggtaggaga taccgggaag
     4321 tgtgcgccta cctgccacgg acgttaaagt cagacttccc ttgcagttgg gttccctaga
     4381 aggtgagttc cttcagttga aaggaaggat tgcattgggt ttaaggctac accacctcct
     4441 cctgttggct gataaaataa aagtcctcac gtaaaaaaca acagcccaag gacagaattt
     4501 acagggcttt gtcagagaga ggcctgtggg gccgtgtcag attgaggctc agaaaaggct
     4561 gagcataagg gtggggctgc tagcctctgt ctaccccttt ctttgtccac cccccacccc
     4621 cacccccacc ccagtctctc ctgcctcctc ttctaccctt tgtccagaga gagttaaact
     4681 ctctggtgtt acttctaggg agtaggggat gaatcagcga atgttgcaca cagtaggggc
     4741 aagaatcttt cttcttcacc tggaggtgga gagaggcacc cattagaacc agaaaatgga
     4801 acatgaagct tagaatttct gagaaaccca aacccaaggc agggggcaga caatatctgc
     4861 aaagcagaaa atacccaagt gtgcccctga caacagaaaa acagactgaa ggcaaacacc
     4921 ttcccttggg aagtgtctgg gcacagtgca atcccttctg gcttctccat ctagtagtca
     4981 cccatcaaac cttcattgat ctgattttcc ccctgttcca ggccccgagg ccagggaaga
     5041 caccttcctt ttgggcttac tttcatgggc agctactctc tctttctcta ggtagcattg
     5101 gggcgggaag gggctggcaa gatactgagg gccatcagag cccctgtcag acatctgagt
     5161 ccctgctttc tggcttttcc agcagtcatt gtgcaaacat aaaatgcaac tcgggtgcag
     5221 tggctatcta ctccgtcagt tgctctacca ctcaaagaga aggcggaggg gagtagccag
     5281 tctgctctct gtcccctgag ggatttacat cccaagagcc cattatgaat gcctttagcc
     5341 tacccagagg ccagccttgc ttgcatctca gtgggggtgg ccccgttctt tcctagacag
     5401 cactagtggg ccaccaccgg tcagacgcac tggtgtctgt gtacttcggg aatgtttatc
     5461 tgtgattttg cacatgcact ctcgtgcacg ttgtgcacat gagcacgtgg gcaggcccac
     5521 tcacgcgcat gtccaatagg gttattctgt agcttttcct tcatgtcagt agcccagcgg
     5581 cctccaagtc cttcccagtc acctttactc caaggaggaa agagaaaatt catccacgcc
     5641 tacagcgcaa gagacgaaag tctcttatgg ctattgttga atacgaacta aaggagaatg
     5701 agaatgtgac agacagacaa acggaaccca gcagggggag ctcgaggagc agactgtgtt
     5761 aatataaaaa gttagatact tggaagaaat aaaactgcta ataaaatatt ttatataaaa
     5821 a
//
