LOCUS       NP_033723                666 aa            linear   ROD 27-APR-2025
DEFINITION  ATP-binding cassette sub-family G member 1 [Mus musculus].
ACCESSION   NP_033723
VERSION     NP_033723.1
DBSOURCE    REFSEQ: accession NM_009593.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 666)
  AUTHORS   Dahik,V.D., Kc,P., Materne,C., Reydellet,C., Lhomme,M.,
            Cruciani-Guglielmacci,C., Denom,J., Bun,E., Ponnaiah,M.,
            Deknuydt,F., Frisdal,E., Hardy,L.M., Durand,H., Guillas,I.,
            Lesnik,P., Gudelj,I., Lauc,G., Guerin,M., Kontush,A., Soprani,A.,
            Magnan,C., Diedisheim,M., Bluteau,O., Venteclef,N. and Le Goff,W.
  TITLE     ABCG1 orchestrates adipose tissue macrophage plasticity and insulin
            resistance in obesity by rewiring saturated fatty acid pools
  JOURNAL   Sci Transl Med 16 (777), eadi6682 (2024)
   PUBMED   39661702
REFERENCE   2  (residues 1 to 666)
  AUTHORS   Kloosterman,D.J., Erbani,J., Boon,M., Farber,M., Handgraaf,S.M.,
            Ando-Kuri,M., Sanchez-Lopez,E., Fontein,B., Mertz,M., Nieuwland,M.,
            Liu,N.Q., Forn-Cuni,G., van der Wel,N.N., Grootemaat,A.E.,
            Reinalda,L., van Kasteren,S.I., de Wit,E., Ruffell,B.,
            Snaar-Jagalska,E., Petrecca,K., Brandsma,D., Kros,A., Giera,M. and
            Akkari,L.
  TITLE     Macrophage-mediated myelin recycling fuels brain cancer malignancy
  JOURNAL   Cell 187 (19), 5336-5356 (2024)
   PUBMED   39137777
REFERENCE   3  (residues 1 to 666)
  AUTHORS   Terao,R., Lee,T.J., Colasanti,J., Pfeifer,C.W., Lin,J.B.,
            Santeford,A., Hase,K., Yamaguchi,S., Du,D., Sohn,B.S., Sasaki,Y.,
            Yoshida,M. and Apte,R.S.
  TITLE     LXR/CD38 activation drives cholesterol-induced macrophage
            senescence and neurodegeneration via NAD+ depletion
  JOURNAL   Cell Rep 43 (5), 114102 (2024)
   PUBMED   38636518
REFERENCE   4  (residues 1 to 666)
  AUTHORS   Yalcinkaya,M., Liu,W., Xiao,T., Abramowicz,S., Wang,R., Wang,N.,
            Westerterp,M. and Tall,A.R.
  TITLE     Cholesterol trafficking to the ER leads to the activation of
            CaMKII/JNK/NLRP3 and promotes atherosclerosis
  JOURNAL   J Lipid Res 65 (4), 100534 (2024)
   PUBMED   38522750
REFERENCE   5  (residues 1 to 666)
  AUTHORS   Liimatta,J., Curschellas,E., Altinkilic,E.M., Naamneh Elzenaty,R.,
            Augsburger,P., du Toit,T., Voegel,C.D., Breault,D.T., Fluck,C.E.
            and Pignatti,E.
  TITLE     Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis
  JOURNAL   Endocrinology 165 (3) (2024)
   PUBMED   38301271
  REMARK    GeneRIF: Adrenal Abcg1 Controls Cholesterol Flux and
            Steroidogenesis.
REFERENCE   6  (residues 1 to 666)
  AUTHORS   Lorkowski,S., Rust,S., Engel,T., Jung,E., Tegelkamp,K.,
            Galinski,E.A., Assmann,G. and Cullen,P.
  TITLE     Genomic sequence and structure of the human ABCG1 (ABC8) gene
  JOURNAL   Biochem Biophys Res Commun 280 (1), 121-131 (2001)
   PUBMED   11162488
REFERENCE   7  (residues 1 to 666)
  AUTHORS   Venkateswaran,A., Repa,J.J., Lobaccaro,J.M., Bronson,A.,
            Mangelsdorf,D.J. and Edwards,P.A.
  TITLE     Human white/murine ABC8 mRNA levels are highly induced in
            lipid-loaded macrophages. A transcriptional role for specific
            oxysterols
  JOURNAL   J Biol Chem 275 (19), 14700-14707 (2000)
   PUBMED   10799558
REFERENCE   8  (residues 1 to 666)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (residues 1 to 666)
  AUTHORS   Croop,J.M., Tiller,G.E., Fletcher,J.A., Lux,M.L., Raab,E.,
            Goldenson,D., Son,D., Arciniegas,S. and Wu,R.L.
  TITLE     Isolation and characterization of a mammalian homolog of the
            Drosophila white gene
  JOURNAL   Gene 185 (1), 77-85 (1997)
   PUBMED   9034316
REFERENCE   10 (residues 1 to 666)
  AUTHORS   Savary,S., Denizot,F., Luciani,M., Mattei,M. and Chimini,G.
  TITLE     Molecular cloning of a mammalian ABC transporter homologous to
            Drosophila white gene
  JOURNAL   Mamm Genome 7 (9), 673-676 (1996)
   PUBMED   8703120
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY296839.1, AK037433.1,
            AF323659.1, CV558133.1, CO431055.1 and AC167247.2.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the White subfamily. The human protein is
            involved in macrophage cholesterol efflux and may regulate cellular
            lipid homeostasis in other cell types. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF323659.1, U34920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.8 cM"
     Protein         1..666
                     /product="ATP-binding cassette sub-family G member 1"
                     /note="ATP-binding cassette 8; white protein homolog;
                     ATP-binding cassette transporter 8; ATP-binding cassette,
                     sub-family G (WHITE), member 1"
                     /calculated_mol_wt=73902
     Region          60..666
                     /region_name="3a01204"
                     /note="The Eye Pigment Precursor Transporter (EPP) Family
                     protein; TIGR00955"
                     /db_xref="CDD:273361"
     Site            415..433
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64343.1)"
     Site            445..465
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64343.1)"
     Site            495..513
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64343.1)"
     Site            522..543
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64343.1)"
     Site            556..574
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64343.1)"
     Site            638..657
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64343.1)"
     CDS             1..666
                     /gene="Abcg1"
                     /gene_synonym="Abc8; White"
                     /coded_by="NM_009593.2:122..2122"
                     /db_xref="CCDS:CCDS28602.1"
                     /db_xref="GeneID:11307"
                     /db_xref="MGI:MGI:107704"
ORIGIN      
        1 maclmaafsv gtamnassys aamtepksvc vsvdevvssn vdevetdlln ghlkkvdnnf
       61 teaqrfsslp rraavniefk dlsysvpegp wwkkkgyktl lkgisgkfns gelvaimgps
      121 gagkstlmni lagyretgmk gavlingmpr dlrcfrkvsc yimqddmllp hltvqeammv
      181 sahlklqekd egrremvkei ltalgllpca ntrtgslsgg qrkrlaiale lvnnppvmff
      241 deptsgldsa scfqvvslmk glaqggrsiv ctihqpsakl felfdqlyvl sqgqcvyrgk
      301 vsnlvpylrd lglncptyhn padfvmevas geygdqnsrl vravregmcd adykrdlggd
      361 tdvnpflwhr paeedsasme gchsfsascl tqfcilfkrt flsimrdsvl thlritshig
      421 iglligllyl gigneakkvl snsgflffsm lflmfaalmp tvltfplems vflrehlnyw
      481 yslkayylak tmadvpfqim fpvaycsivy wmtsqpsdav rfvlfaalgt mtslvaqslg
      541 lligaastsl qvatfvgpvt aipvllfsgf fvsfdtipay lqwmsyisyv rygfegvils
      601 iygldredlh cdiaetchfq kseailreld venaklyldf ivlgiffisl rliayfvlry
      661 kiraer
//
