LOCUS       NM_015751               3813 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family E member 1 (Abce1),
            transcript variant 1, mRNA.
ACCESSION   NM_015751
VERSION     NM_015751.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3813)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3813)
  AUTHORS   Jiao,X.F., Huang,C.J., Wu,D., Zhang,J.Y., Long,Y.T., Chen,F., Li,X.
            and Huo,L.J.
  TITLE     Abce1 orchestrates M-phase entry and cytoskeleton architecture in
            mouse oocyte
  JOURNAL   Oncotarget 8 (24), 39012-39020 (2017)
   PUBMED   28380459
  REMARK    GeneRIF: our study pinpoints that Abce1 plays an important role in
            meiosis resumption, spindle integrity and chromosome alignment in
            meiotic oocytes
REFERENCE   3  (bases 1 to 3813)
  AUTHORS   Sugiyama,C., Kuramoto,N., Nagashima,R., Yoneyama,M. and Ogita,K.
  TITLE     Enhanced expression of RNase L as a novel intracellular signal
            generated by NMDA receptors in mouse cortical neurons
  JOURNAL   Neurochem Int 53 (3-4), 71-78 (2008)
   PUBMED   18585418
  REMARK    GeneRIF: Expression of RNase L is a signal generated by NMDA
            receptor in cortical neurons. RNase L expression and RNA
            degradation may be events that cause neuronal damage induced by
            NMDA receptor activation.
REFERENCE   4  (bases 1 to 3813)
  AUTHORS   Li,X.Y., Cui,X.S. and Kim,N.H.
  TITLE     Transcription profile during maternal to zygotic transition in the
            mouse embryo
  JOURNAL   Reprod Fertil Dev 18 (6), 635-645 (2006)
   PUBMED   16930510
REFERENCE   5  (bases 1 to 3813)
  AUTHORS   Wise,T.L. and Pravtcheva,D.D.
  TITLE     Oligosyndactylism mice have an inversion of chromosome 8
  JOURNAL   Genetics 168 (4), 2099-2112 (2004)
   PUBMED   15611179
REFERENCE   6  (bases 1 to 3813)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 3813)
  AUTHORS   Bisbal,C., Silhol,M., Laubenthal,H., Kaluza,T., Carnac,G.,
            Milligan,L., Le Roy,F. and Salehzada,T.
  TITLE     The 2'-5' oligoadenylate/RNase L/RNase L inhibitor pathway
            regulates both MyoD mRNA stability and muscle cell differentiation
  JOURNAL   Mol Cell Biol 20 (14), 4959-4969 (2000)
   PUBMED   10866653
REFERENCE   8  (bases 1 to 3813)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (bases 1 to 3813)
  AUTHORS   Benoit De Coignac,A., Bisbal,C., Lebleu,B. and Salehzada,T.
  TITLE     cDNA cloning and expression analysis of the murine ribonuclease L
            inhibitor
  JOURNAL   Gene 209 (1-2), 149-156 (1998)
   PUBMED   9524254
REFERENCE   10 (bases 1 to 3813)
  AUTHORS   Semsei,I. and Goto,S.
  TITLE     Expression of mRNAs of pancreatic and L type RNase inhibitors as a
            function of age in different tissues of SAMP8 and BDF1 mice
  JOURNAL   Mech Ageing Dev 97 (3), 249-261 (1997)
   PUBMED   9234238
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB651928.1, AK167370.1, CD564438.1 and AV213051.2.
            
            On Sep 8, 2006 this sequence version replaced NM_015751.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the OABP subfamily.
            Alternatively referred to as the RNase L inhibitor, this protein
            functions to block the activity of ribonuclease L. Activation of
            ribonuclease L leads to inhibition of protein synthesis in the
            2-5A/RNase L system, the central pathway for viral interferon
            action. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049299.1, AK167130.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BB651928.1         2-64
            64-2007             AK167370.1         2-1945
            2008-2366           CD564438.1         103-461
            2367-3614           AK167370.1         2305-3552
            3615-3813           AV213051.2         468-666
FEATURES             Location/Qualifiers
     source          1..3813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 37.77 cM"
     gene            1..3813
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /note="ATP-binding cassette, sub-family E member 1"
                     /db_xref="GeneID:24015"
                     /db_xref="MGI:MGI:1195458"
     exon            1..198
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            199..328
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2025
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /note="ribonuclease L (2', 5'-oligoisoadenylate
                     synthetase-dependent) inhibitor; ATP-binding cassette,
                     subfamily E, member 1; RNase L inhibitor; ATP-binding
                     cassette, sub-family E (OABP), member 1; ribonuclease 4
                     inhibitor; RNS4l (Eye)"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family E member 1"
                     /protein_id="NP_056566.2"
                     /db_xref="CCDS:CCDS22438.1"
                     /db_xref="GeneID:24015"
                     /db_xref="MGI:MGI:1195458"
                     /translation="MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQ
                     SKIAWISETLCIGCGICIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRP
                     GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKIL
                     EDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLS
                     GGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDL
                     SVLDYLSDFICCLYGVPSAYGVVTMPFSVREGINIFLDGYVPTENLRFRDASLVFKVA
                     ETANEEEVKKMCMYKYPGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRML
                     AGRLKPDEGGEVPVLNVSYKPQKISPKSTGSVRQLLHEKIRDAYTHPQFVTDVMKPLQ
                     IENIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFI
                     LHAKKTAFVVEHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEITF
                     RRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD"
     exon            329..414
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            415..512
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            513..630
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            631..768
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            769..838
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            839..935
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1025
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1147
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1369
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1429
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1488
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1599
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1742
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1865
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1977
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..3813
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3588..3593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /note="hexamer: AATAAA"
     polyA_site      3610
                     /gene="Abce1"
                     /gene_synonym="Oabp; RLI; Rnaseli; RNS41; RNS4I"
                     /note="major polyA site"
ORIGIN      
        1 aacgtcatca ctccctccag ggcgccgact ctgcgctctg tcgcgcacgc gcactatgcc
       61 ctcatgcctt gcgcgaggcg gcggctgtgc accgccatct ttgccggtgg cggtaagaac
      121 acgctgtgtg ctaagacctg acggctagcg ctgctttggc tactgcacgc cccgctgtaa
      181 ggggcccgct gtctccagaa gaactggata ttctttgtta caattatggc agacaaatta
      241 acaagaattg ctattgtcaa ccacgacaaa tgcaaaccta agaaatgtcg acaggagtgc
      301 aaaaagagtt gccctgtggt tcggatggga aaattgtgca tagaagttac accccagagc
      361 aaaatagcat ggatttctga aactctctgt attggttgtg gtatttgtat taagaaatgt
      421 ccctttggcg ccttatcaat tgtcaatttg ccaagcaact tggaaaaaga aacaacacat
      481 cgctactgtg ccaatgcctt caagcttcac aggttgccta tccctcgtcc aggtgaagtt
      541 ttgggattag ttggaactaa tggtattgga aagtcaactg cactaaaaat tttagcagga
      601 aaacaaaagc caaaccttgg aaagtatgat gatccacctg attggcaaga gattttgact
      661 tatttccgtg gatctgaatt acaaaattac tttaccaaga ttctcgaaga tgacctaaaa
      721 gccattatca aacctcaata tgtagaccaa attcccaagg ctgcaaaggg gacagtgggc
      781 tctattctgg accgaaaaga tgaaacaaag acacaggcaa ttgtatgtca gcagcttgat
      841 ttaactcacc ttaaagaacg aaatgtcgaa gatctttcag gaggagagtt gcagagattt
      901 gcttgtgctg tcgtttgcat acaaaaggct gatattttta tgtttgatga accttctagt
      961 tacctcgatg tcaagcaacg tttaaaggct gccattacga ttcgatctct aataaatcca
     1021 gatagatata tcattgtggt ggagcatgat ctaagtgtat tagactatct ctctgacttc
     1081 atctgctgtc tatatggggt accgagtgct tatggtgttg tcacgatgcc ttttagtgta
     1141 agagaaggca taaatatatt tttggatggc tatgttccaa cagagaacct gaggttcagg
     1201 gatgcgtcgc ttgtttttaa ggtagctgag acagcaaatg aagaagaagt taaaaagatg
     1261 tgcatgtata aatatcccgg gatgaagaaa aagatgggag agttcgagct agcaattgta
     1321 gctggagagt tcacggactc tgagatcatg gtgatgctgg gggagaatgg tacaggtaaa
     1381 actacattta tcagaatgct tgctggaagg cttaaaccag atgaaggagg agaagtgcca
     1441 gttctaaatg tcagttataa gccacagaaa atcagtccca aatcaacagg aagtgttcgc
     1501 cagttactgc atgaaaagat cagagatgct tacacgcatc cgcagtttgt gactgatgta
     1561 atgaagcccc tacagattga aaacatcatt gaccaagagg tacagacatt gtctggtggt
     1621 gaacttcagc gagtagcttt agctctttgt ttgggcaaac ctgctgacgt ctatttgatt
     1681 gatgaacctt ctgcatattt ggattctgag caaagattaa tggcagctcg ggtcgtcaaa
     1741 cgtttcattc tccatgcaaa gaagacagct tttgttgtag aacatgactt catcatggcc
     1801 acctatctag cagatcgcgt catcgttttt gatggtgttc catcaaagaa cacagttgca
     1861 aacagtcctc agactctttt ggctggcatg aacaaatttt tgtctcagct cgaaattaca
     1921 ttcagaagag accccaacaa ctacaggcca cgaataaata agctcaattc aatcaaggat
     1981 gtagaacaaa agaagagtgg aaactacttt ttcttggatg attagattga gtctgaactt
     2041 ataagccatt tacttactgg gatttttatc atataaaact ttaatcaggt tttatggccc
     2101 cacatactct ggagcttgaa gtatgatttt cttaatgtga catcaaaaag ccagttgtct
     2161 tgtaaattgt tgtttaagaa ctattttgtt cttaagatta aacctctgtg catactacat
     2221 gaacatggag acatttcaga ttatcagtta cctccagatt ttcacaatct acggggagat
     2281 tttcagttgt atattatatt catgtaccaa atgcttcctg gtgttgccca tctttaaaat
     2341 cttggataaa atctgtactt acctgtttgc taagtgtacc agtataacag aactgccccc
     2401 ttctaaaaag ccagtcacag acttgctgcc aaagtctgat acataagcat cagggctata
     2461 tttgctactt gtgttcagtg tgtgcttcca aggaacagtg tctgctacaa acaccattgt
     2521 tggaagatgt tgatgaccaa cttatgcatt gtttttaatg agtttttggt gcttttgaac
     2581 atctgtcaaa atttatttca gtgccctaat ttaacttttt ttttttagtt cttacattct
     2641 ataacaacat tcacagtaat gttactttta taaatatata atcactgatc aagattaggg
     2701 aggaggcatt tctgaagact atttgcttcc tgcagaacta taggcttggg ctggggagat
     2761 ggttcagtca gtaagtacaa gctgcacgct catgaggacc atatttgaga ctttagtaga
     2821 agtgaagtcc agcagatccc taaagcccac tggcctgcca gcctaacaca gtctatgagc
     2881 acattcagta gaaggtcctg tcttaaaagc taagtggaca gtaattgagg aagacactct
     2941 ggcaccaaca cacacacaca aaacccaacc gatacagtct ttatagttgg tgcctaagta
     3001 tctggatttt agggtttcgg ttttaatttt gttttgagac agcttgtcgt cctatagccc
     3061 aagctggcct caaattaggt atccaaggac aaccttgaat ttctcagccc actacctagg
     3121 cttggattac acagtgctga ggatcaaacc cagggctttg tgtgtgctag gcaagcactc
     3181 taacaactga gctacatccc cagccctaca tatttagact ccagagtctt ctgttgagca
     3241 accaaggaca acctaaaaca acttctccag tgagtgcagg gaaatagcaa tacaaagtgt
     3301 ccattgctgc agtgcatact catttgttgg atacaaagga cattatccac attttactaa
     3361 tatgccaaac tggaattatg aggaaggtgg attacaatga acagggcagg cagaacagga
     3421 aaattagaaa gtatttgaca agactttaga actttaaata ataggtctga ttaatttgca
     3481 gacaatgata gaaagtttgt tttgactgat acccattagg ctttctaaaa atgaatttat
     3541 ataatccata aatatgtatc tgttgtaaag gaacacaaag tatatggaat aaaatctccc
     3601 tttatcagtt tctgagctta ccggtgtgtg gtcattcttt ccttcactat gtacttaatc
     3661 ttgttatggg aatatactaa aatatatttg tgaatattac agatacaaag ttcatccacc
     3721 ttaatgctaa tgacaatatg tgaataagag tatttttgtg caaatgaaat ttgaaaatac
     3781 aaaatcagat attaaacttt ttttgacttc ttt
//
