LOCUS       NM_008992               2527 bp    mRNA    linear   ROD 27-JUN-2023
DEFINITION  Mus musculus ATP-binding cassette, sub-family D member 4 (Abcd4),
            mRNA.
ACCESSION   NM_008992
VERSION     NM_008992.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2527)
  AUTHORS   Kitai K, Kawaguchi K, Tomohiro T, Morita M, So T and Imanaka T.
  TITLE     The lysosomal protein ABCD4 can transport vitamin B12 across
            liposomal membranes in vitro
  JOURNAL   J Biol Chem 296, 100654 (2021)
   PUBMED   33845046
REFERENCE   2  (bases 1 to 2527)
  AUTHORS   Elsen GE, Hodge RD, Bedogni F, Daza RA, Nelson BR, Shiba N, Reiner
            SL and Hevner RF.
  TITLE     The protomap is propagated to cortical plate neurons through an
            Eomes-dependent intermediate map
  JOURNAL   Proc Natl Acad Sci U S A 110 (10), 4081-4086 (2013)
   PUBMED   23431145
REFERENCE   3  (bases 1 to 2527)
  AUTHORS   Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S
            and Russo T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   4  (bases 1 to 2527)
  AUTHORS   Kashiwayama Y, Seki M, Yasui A, Murasaki Y, Morita M, Yamashita Y,
            Sakaguchi M, Tanaka Y and Imanaka T.
  TITLE     70-kDa peroxisomal membrane protein related protein (P70R/ABCD4)
            localizes to endoplasmic reticulum not peroxisomes, and
            NH2-terminal hydrophobic property determines the subcellular
            localization of ABC subfamily D proteins
  JOURNAL   Exp Cell Res 315 (2), 190-205 (2009)
   PUBMED   19010322
  REMARK    GeneRIF: P70R resides in the ER but not the peroxisomal membranes,
            and the hydrophobic property of NH(2)-terminal region determines
            the subcellular localization of ABC subfamily D proteins.
REFERENCE   5  (bases 1 to 2527)
  AUTHORS   Kennell JA, Richards NW, Schaner PE and Gumucio DL.
  TITLE     cDNA cloning, chromosomal localization and evolutionary analysis of
            mouse vacuolar ATPase subunit D, Atp6m
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 337-341 (2001)
   PUBMED   11435709
REFERENCE   6  (bases 1 to 2527)
  AUTHORS   Schriml LM and Dean M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   7  (bases 1 to 2527)
  AUTHORS   Berger J, Albet S, Bentejac M, Netik A, Holzinger A, Roscher AA,
            Bugaut M and Forss-Petter S.
  TITLE     The four murine peroxisomal ABC-transporter genes differ in
            constitutive, inducible and developmental expression
  JOURNAL   Eur J Biochem 265 (2), 719-727 (1999)
   PUBMED   10504404
REFERENCE   8  (bases 1 to 2527)
  AUTHORS   Holzinger A, Muntau A, Mayerhofer P, Kammerer S, Albet S, Bugaut M
            and Roscher AA.
  TITLE     The mouse gene encoding the peroxisomal membrane protein 1-like
            protein (PXMP1-L): cDNA cloning, genomic organization and
            comparative expression studies
  JOURNAL   FEBS Lett 433 (1-2), 179-183 (1998)
   PUBMED   9738957
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110564.7, BB636710.1 and
            AJ001166.1.
            
            [WARNING] On Jul 5, 2023 this sequence was replaced by NM_008992.3.
            
            On Apr 1, 2009 this sequence version replaced NM_008992.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ALD subfamily, which is
            involved in peroxisomal import of fatty acids and/or fatty
            acyl-CoAs in the organelle. All known peroxisomal ABC transporters
            are half transporters which require a partner half transporter
            molecule to form a functional homodimeric or heterodimeric
            transporter. The function of this peroxisomal membrane protein is
            unknown. However, it is speculated that the human protein may
            function as a heterodimer for another peroxisomal ABC transporter
            and, therefore, may modify the adrenoleukodystrophy phenotype. It
            may also play a role in the process of peroxisome biogenesis.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ001166.1, SRR13948564.2843454.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC110564.7         205472-205554       c
            84-405              BB636710.1         2-323
            406-2315            AJ001166.1         310-2219
            2316-2527           AC110564.7         190619-190830       c
FEATURES             Location/Qualifiers
     source          1..2527
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.3 cM"
     gene            1..2527
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /note="ATP-binding cassette, sub-family D member 4"
                     /db_xref="GeneID:19300"
                     /db_xref="MGI:MGI:1349217"
     exon            1..184
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1967
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /EC_number="7.6.2.8"
                     /note="peroxisomal membrane protein, 70 kDa-related;
                     PMP70-related protein; PMP69; PXMP1-L; peroxisomal
                     membrane protein 69; ATP-binding cassette, sub-family D
                     (ALD), member 4"
                     /codon_start=1
                     /product="lysosomal cobalamin transporter ABCD4"
                     /protein_id="NP_033018.2"
                     /db_xref="CCDS:CCDS26047.1"
                     /db_xref="GeneID:19300"
                     /db_xref="MGI:MGI:1349217"
                     /translation="MAVPGPTARAGARPRLDLQLVQRFVRIQKVFFPSWSSQNVLMFM
                     TLLCVTLLEQLVIYQVGLIPSQYYGVLGNKDLDGFKALTLLAVTLIVLNSTLKSFDQF
                     TCNLLYVSWRKDLTEHLHHLYFRARVYYTLNVLRDDIDNPDQRISQDVERFCRQLSSV
                     TSKLIISPFTLTYYTYQCFQSTGWLGPVSIFGYFIVGTMVNKTLMGPIVTKLVQQEKL
                     EGDFRFKHMQIRVNAEPAAFYRAGLVEHMRTDRRLQRLLQTQRELMSRELWLYIGINT
                     FDYLGSILSYVVIAIPIFSGVYGDLSPTELSTLVSKNAFVCIYLISCFTQLIDLSTTL
                     SDVAGYTHRIGELQEALLDMSRKSQDCEALGESEWDLDKTPGCPTTEPSDTAFLLDRV
                     SILAPSSDKPLIKDLSLKICEGQSLLITGNTGTGKTSLLRVLGGLWEGMKGSVQMLAD
                     FGPHGVLFLPQKPFFTDGTLREQVIYPLKEIYPDSGSADDERIVRFLELAGLSSLVAR
                     TGGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEAESELYRIG
                     QQLGMTFISVGHRPSLEKFHSWVLRLHGGGSWELTRIKLE"
     exon            185..303
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            304..431
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            432..571
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            572..688
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            689..814
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            815..865
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            866..960
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1082
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1174
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1264
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1473
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1565
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1602
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1652
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1705
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1782
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1898
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2527
                     /gene="Abcd4"
                     /gene_synonym="P69r; P70R; Pxmp1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggagccgt cttctctatc tagcgcgtct ctgtggtcgc cagagtccca cccctttcct
       61 cctagggcgg ggccccgagc tctgaggact ctgcccgggg aggacaccgg gcttgctcgg
      121 tcgcctcgtc gcttgcatcc cgggtcatgg cggtcccggg acccacggcc cgagctggtg
      181 ccaggcccag attagatctg caacttgtcc agaggttcgt gaggatacag aaggttttct
      241 ttccttcttg gtcatcacag aatgtcttaa tgttcatgac gctcttgtgc gtgaccctcc
      301 tggagcaact ggtgatctac caagttggct tgatccccag tcagtattat ggagtcttgg
      361 gaaacaaaga cctggatgga tttaaggcac tgaccttgct ggccgtgaca cttattgtcc
      421 tcaactccac cctgaagagc tttgaccagt tcacctgcaa cctgctgtac gtgagctgga
      481 ggaaggacct cacggagcac ctgcaccacc tgtacttccg ggcccgcgtg tactacaccc
      541 tcaacgtgct gcgggacgac attgataatc cggaccagcg aatcagccag gatgtggagc
      601 gattctgccg ccagctcagc agcgtgacca gcaagctgat catttccccc ttcactctta
      661 cctactacac ttaccagtgc ttccaaagca caggctggct cgggcctgtg agcatctttg
      721 gatatttcat cgtggggacc atggtgaaca aaactttgat ggggcccatc gtgacgaagc
      781 tggtgcagca ggagaagctg gagggggatt ttaggttcaa gcacatgcag attcgagtga
      841 atgcagagcc tgcggctttc tatagagctg ggctcgtcga gcacatgagg acagaccgca
      901 ggctgcagag actccttcag acccagagag agctgatgtc cagggagctc tggctgtaca
      961 ttggtatcaa cacctttgac tatctgggca gcatcctgag ttatgtcgtc atcgctatcc
     1021 ccattttcag tggggtctat ggagatttga gccccacaga gcttagcacc ctggtcagca
     1081 agaatgcctt tgtgtgcatc tacctcatca gctgcttcac ccagctcatt gacctgtcca
     1141 ccacactctc ggatgttgcc ggttacacac acaggattgg agagcttcag gaggccctgc
     1201 tggacatgtc ccgaaaatca caagactgtg aagccctagg cgagagtgag tgggacttgg
     1261 acaaaacccc agggtgtcca acaacagagc catcagacac agcttttctg ctcgatcggg
     1321 tttccatatt ggccccctcc tctgacaagc ccctgatcaa ggacttgagc ttgaagatct
     1381 gtgaggggca gagtctgctc atcacaggca acacgggcac tggcaagacc tccctgctgc
     1441 gggtgctggg aggcctgtgg gagggcatga aaggctcagt gcagatgctg gctgattttg
     1501 ggccccacgg ggtgctgttc ctgcctcaga agccattctt cactgatggg acacttcggg
     1561 agcaggtgat atatcccctg aaggagatct accctgactc aggttctgcg gacgatgaga
     1621 ggattgtgag gttcttggaa ttggcaggcc tgtccagctt ggtggcaagg actggaggtc
     1681 tggaccagca ggtggattgg aactggtatg atgtcctgtc cccaggggag atgcaaagac
     1741 tctccttcgc ccgtctcttc tacctgcagc ccaagtatgc agtgctcgat gaagccacca
     1801 gtgccctgac agaggaagca gagagtgagc tctaccgaat tggtcagcaa ctggggatga
     1861 catttatcag cgtgggacat cgtcccagcc ttgagaagtt tcactcctgg gttctgagac
     1921 tccacggagg aggaagctgg gagctgacta gaatcaaact ggaatgaagg caagcatgca
     1981 ggttcatctg agcagcggag ctccggggcc tgcggtgccc acagacaagg aagcccgatg
     2041 agccgggaag gagccacaga ttcacctgag gtcctacaca ggagccctag cagcctctag
     2101 ccctgcccac gggtggcgct acagggaaca ctgagtctcc ccagcgctgc tcccatgact
     2161 tcttacttca gatgacgttt gctgctgaaa aacggaatga actgtaagac gtgaagggcc
     2221 agggtgagaa aactatcgga ctcaagaact ggtgatgccg ggcggcggcg cacgccttta
     2281 atcccagcac ttgggaggca gaggcaggcg gatttctgag ttcgaagcca gcctggtcta
     2341 cagagtgagt tccaggacag ccagggctat acagagaaac cctgtctcga aaaaaaaaaa
     2401 aaaaagaaag aaaaagaaaa ctggtgacat ttcacaatga tagcctttta aaaaaaactt
     2461 taataaccat ttaaaattta taacttttta aaaaagaata aatattaaaa atatggtttt
     2521 tcttcta
//
