LOCUS       NM_008991               3386 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family D member 3 (Abcd3),
            transcript variant 1, mRNA.
ACCESSION   NM_008991
VERSION     NM_008991.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3386)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3386)
  AUTHORS   Shim,S.M., Choi,H.R., Kwon,S.C., Kim,H.Y., Sung,K.W., Jung,E.J.,
            Mun,S.R., Bae,T.H., Kim,D.H., Son,Y.S., Jung,C.H., Lee,J.,
            Lee,M.J., Park,J.W. and Kwon,Y.T.
  TITLE     The Cys-N-degron pathway modulates pexophagy through the N-terminal
            oxidation and arginylation of ACAD10
  JOURNAL   Autophagy 19 (6), 1642-1661 (2023)
   PUBMED   36184612
REFERENCE   3  (bases 1 to 3386)
  AUTHORS   Bara,A.M., Chen,L., Ma,C., Underwood,J., Moreci,R.S., Sumigray,K.,
            Sun,T., Diao,Y., Verzi,M. and Lechler,T.
  TITLE     Maf family transcription factors are required for nutrient uptake
            in the mouse neonatal gut
  JOURNAL   Development 149 (23) (2022)
   PUBMED   36504079
REFERENCE   4  (bases 1 to 3386)
  AUTHORS   Gong,Y., Laheji,F., Berenson,A., Qian,A., Park,S.O., Kok,R.,
            Selig,M., Hahn,R., Sadjadi,R., Kemp,S. and Eichler,F.
  TITLE     Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical
            Allodynia
  JOURNAL   Cells 11 (11), 1842 (2022)
   PUBMED   35681537
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3386)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   6  (bases 1 to 3386)
  AUTHORS   Chen,N., Lu,Z., Land,M., Ayres,R. and Crane,D.I.
  TITLE     Peroxisomal membrane protein PMP68 of mouse liver: cloning of a
            cDNA encompassing the nucleotide binding fold and epitope mapping
            of monoclonal antibodies to the expressed protein
  JOURNAL   Arch Biochem Biophys 321 (2), 526-530 (1995)
   PUBMED   7544098
REFERENCE   7  (bases 1 to 3386)
  AUTHORS   Bryant,D.D. and Wilson,G.N.
  TITLE     Differential evolution and expression of murine peroxisomal
            membrane protein genes
  JOURNAL   Biochem Mol Med 55 (1), 22-30 (1995)
   PUBMED   7551822
REFERENCE   8  (bases 1 to 3386)
  AUTHORS   van Ree,J.H., Gijbels,M.J., van den Broek,W.J., Hofker,M.H. and
            Havekes,L.M.
  TITLE     Atypical xanthomatosis in apolipoprotein E-deficient mice after
            cholesterol feeding
  JOURNAL   Atherosclerosis 112 (2), 237-243 (1995)
   PUBMED   7772082
REFERENCE   9  (bases 1 to 3386)
  AUTHORS   Hamel,C.P., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Redmond,T.M.
  TITLE     The gene for the retinal pigment epithelium-specific protein RPE65
            is localized to human 1p31 and mouse 3
  JOURNAL   Genomics 20 (3), 509-512 (1994)
   PUBMED   8034329
REFERENCE   10 (bases 1 to 3386)
  AUTHORS   Gartner,J., Kearns,W., Rosenberg,C., Pearson,P., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Valle,D.
  TITLE     Localization of the 70-kDa peroxisomal membrane protein to human
            1p21-p22 and mouse 3
  JOURNAL   Genomics 15 (2), 412-414 (1993)
   PUBMED   8449508
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129311.6.
            
            On Jul 22, 2022 this sequence version replaced NM_008991.3.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ALD subfamily, which is
            involved in peroxisomal import of fatty acids and/or fatty
            acyl-CoAs in the organelle. All known peroxisomal ABC transporters
            are half transporters which require a partner half transporter
            molecule to form a functional homodimeric or heterodimeric
            transporter. This peroxisomal membrane protein likely plays an
            important role in peroxisome biogenesis. Mutations have been
            associated with some forms of Zellweger syndrome, a heterogeneous
            group of peroxisome assembly disorders. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004660.1, AK144060.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC129311.6         133604-133791       c
            189-225             AC129311.6         115044-115080       c
            226-324             AC129311.6         111399-111497       c
            325-413             AC129311.6         110329-110417       c
            414-483             AC129311.6         104597-104666       c
            484-581             AC129311.6         103068-103165       c
            582-705             AC129311.6         102606-102729       c
            706-762             AC129311.6         100523-100579       c
            763-905             AC129311.6         98150-98292         c
            906-975             AC129311.6         95592-95661         c
            976-1045            AC129311.6         94397-94466         c
            1046-1143           AC129311.6         94212-94309         c
            1144-1235           AC129311.6         94026-94117         c
            1236-1327           AC129311.6         92737-92828         c
            1328-1400           AC129311.6         92584-92656         c
            1401-1464           AC129311.6         90898-90961         c
            1465-1542           AC129311.6         88110-88187         c
            1543-1608           AC129311.6         87947-88012         c
            1609-1698           AC129311.6         87762-87851         c
            1699-1818           AC129311.6         87217-87336         c
            1819-1923           AC129311.6         83596-83700         c
            1924-1980           AC129311.6         80010-80066         c
            1981-3386           AC129311.6         77499-78904         c
FEATURES             Location/Qualifiers
     source          1..3386
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 52.94 cM"
     gene            1..3386
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /note="ATP-binding cassette, sub-family D member 3"
                     /db_xref="GeneID:19299"
                     /db_xref="MGI:MGI:1349216"
     exon            1..188
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2058
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal membrane protein 1; 68 kDa peroxisomal
                     membrane protein; 70 kDa peroxisomal membrane protein;
                     peroxisomal membrane protein, 70 kDa; ATP-binding
                     cassette, sub-family D (ALD), member 3"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family D member 3
                     isoform 1"
                     /protein_id="NP_033017.2"
                     /db_xref="CCDS:CCDS17806.1"
                     /db_xref="GeneID:19299"
                     /db_xref="MGI:MGI:1349216"
                     /translation="MAAFSKYLTARNTSLAGAAFLLLCLLHKRRRALGLHGKKSGKPP
                     LQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLLLIAVMLVSRTYCDVW
                     MIQNGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTR
                     YLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYI
                     FKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRYVNSRLITNS
                     EEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFIDSIIAKYVATVVGYLVVS
                     RPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARIT
                     ELMQVLKDLNHGRYERTMVSQQEKGIEGAQASPLVPGAGEIINTDNIIKFDHVPLATP
                     NGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYV
                     PQRPYMTLGTLRDQVIYPDGKEDQKKRGISDQVLKEYLDNVQLGHILEREGGWDSVQD
                     WMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVS
                     HRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS"
     exon            189..225
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            226..324
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..413
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..483
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..581
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..705
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..762
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..905
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..975
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1045
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1143
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1235
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1327
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1400
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1464
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1542
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1608
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1698
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1818
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1923
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..1980
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..3386
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3357..3362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /note="hexamer: ATTAAA"
     polyA_site      3381
                     /gene="Abcd3"
                     /gene_synonym="PMP68; PMP70; Pxmp1"
                     /note="major polyA site"
ORIGIN      
        1 agtttccccc gcggttcctg cactgaggtt gtcgccggcg cgtcccctat cccgcggctc
       61 gctcgccctg ccggtgccat ggcggccttc agcaagtact tgacggcacg gaacacctcg
      121 ctggcggggg ccgcgttcct gctgctctgc ctactccata agcggcgtcg cgccctcggc
      181 ctgcacggta agaaaagtgg aaaaccgcca ttacagaata atgagaaaga aggaaagaaa
      241 gagcgagctg tggtggacaa agtgttttta tcaaggctct cacagatcct aaaaattatg
      301 gttcctagaa cattttgtaa agagacaggc tacttgttac ttattgcggt tatgctggta
      361 tctcgaacat actgtgatgt ttggatgatt cagaatggga cgctcattga gagtggcatc
      421 attggtcgca gcagcaaaga tttcaagaga tacttattca acttcatcgc tgccatgcct
      481 cttatctctc tggttaataa cttcttgaag tatgggttaa atgagctcaa actgtgcttc
      541 cgagtcaggc tcacacggta cctctacgag gagtatctcc aagctttcac ctattataaa
      601 atgggcaacc tggataacag aatagcaaat ccagaccagc tgcttacaca ggatgtagaa
      661 aaattttgta acagtgtagt cgatctgtat tcaaatctta gtaagccatt tttagacata
      721 gttttatata ttttcaagtt aacaagtgca attggagctc agggcccggc aagcatgatg
      781 gcctacttgc ttgtttctgg gctattccta actcgactca gaagacccat tggtaagatg
      841 acaattatgg agcagaagta cgaaggagaa tacagatacg tgaattcacg gcttatcact
      901 aatagtgaag aaattgcctt ttacaatggg aataaacggg agaagcagac aatccactca
      961 gtcttccgaa aactggtgga acacctacat aatttcattt tctttcggtt ttctatgggt
     1021 ttcattgata gcatcattgc caaatatgtt gccactgtcg tcgggtacct ggttgtcagt
     1081 cgccccttcc tagatctggc acaccctcgc caccttcaca gcacacactc agagctgctg
     1141 gaggattact accaaagtgg aaggatgctt ttgagaatgt ctcaagcttt gggtcgtata
     1201 gttttggctg ggcgtgaaat gactagattg gctggtttta cggctcggat tacagaatta
     1261 atgcaagtac taaaggactt aaatcatggc agatatgaac gtacaatggt gtcacaacag
     1321 gagaagggta ttgaaggagc acaagctagt cccttggtcc ctggtgctgg agaaatcatc
     1381 aatacagaca acattataaa gtttgatcat gttcctttag caacaccaaa tggtgacatc
     1441 ttgatccaag accttagttt tgaagttcga tctggggcca acgttctgat ttgtggtcca
     1501 aacggctgtg gaaagagctc cctcttccgt gttcttggtg agttatggcc tctttttgga
     1561 gggcggctta ctaaacctga gagaggaaag ttattttatg ttcctcagcg accctatatg
     1621 accctgggaa cactgagaga ccaagtcata tatccagatg gaaaggaaga tcagaagaag
     1681 agggggatct ctgaccaggt gctgaaggag tacttggaca atgtgcagct gggtcacatc
     1741 cttgagcgag aaggcggctg ggacagtgtt caggactgga tggatgtact cagcggagga
     1801 gagaaacaaa gaatggcgat ggcaagactg ttttatcata aaccccagtt tgccattttg
     1861 gatgaatgca caagtgcggt cagtgtggat gtggaggact acatttacag ccactgtcga
     1921 aaggttggca tcaccctctt taccgtttca cacagaaagt ccctttggaa gcaccacgag
     1981 tactacctgc atatggatgg gagaggcaat tatgaattca aaaagatcac agaagataca
     2041 gttgagttcg gatcatagag accatctcaa gaacttcatt tgcttcaaaa caagataatg
     2101 aacagaatgc atttgtaaat gcaagatgca ttgtaaaata aagttaagct tgtttttttt
     2161 taaaaaaaac aaagcaacaa attgactaga tataggataa ttgaaacatg ttaaaacatt
     2221 taatattgta taggatattg ctaattgtgt atatgttggt ttaattatta attatgtact
     2281 aagaatgtcc ttattcttgt ggttaaaaaa cctgcctgaa ttaaattggg cttaaatcag
     2341 tgtaacctga ttcatcctgg gatgtaaacc atttgaagtc agctaatttg acttttatgg
     2401 ctctgtcttt ttctttcatg aagaaccctg tttaaaactg gggtcattaa ctgttctatt
     2461 ctaacaaagt agtcttgagt ttcatttctt atgccccatg gtagtgggaa ccagaccaat
     2521 cacaatgttt tattgaaaca tattccatcg ttacaggata gcgttcggta cacagtggcg
     2581 ggtttcttta gctgctgtgt ttattctcat tcctcacaca tgcctttaag tgcattggac
     2641 tccaggagag ccatttgggg tttctctagc taaacaataa atgtacctgt ctcagtccgc
     2701 tggactgagt tgttttgaag gttctcatgg tgcacagcag tgtgtatgtg gtgtacaaca
     2761 gtgtgtatgc agccgtgctt acagcctgtg gttgctacct gttgtaccag tctgaccagt
     2821 gtttggaatg ttcagacata atctcctgtg tgaagctcaa ggtcttagga ggattttgga
     2881 ttttgtgaag agatggacag tctcatcaga aatgtggttg tataatggtg agcgccacat
     2941 gagtgtagag gcactatatg acgtagtgta ctgagcatgc aacgctgctg ccgtccttgt
     3001 ctgtggtttc agtttgtaaa actgctaagc cattctcatg cacatgggtg aatgacattt
     3061 cctaggaacg gtctctgact cctggacaac tactcctgta tcggctctgg ctccccggaa
     3121 ccattagaga ctaactgttg tttccacaaa ggagggctga gagtgaacgt gatcatacgt
     3181 agttgtgaaa tcggtttgat tgagtgggct ctgaaagggg catttaatgg tcttgtttct
     3241 tcataactca caatcactgg ctaccaagat aaccctgatg tattgattcc ataaatgcat
     3301 cacattcagt tttaccatgt ctccttagca aacttgtgta cttattttct gttcagatta
     3361 aaaaaaaaaa atgataacct acagaa
//
