LOCUS       NM_011994               5743 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family D member 2 (Abcd2),
            transcript variant 1, mRNA.
ACCESSION   NM_011994
VERSION     NM_011994.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5743)
  AUTHORS   Nemeth,C.L., Gk,O., Tomlinson,S.N., Sharma,A., Moser,A.B.,
            Kannan,S., Kannan,R.M. and Fatemi,A.
  TITLE     Targeted Brain Delivery of Dendrimer-4-Phenylbutyrate Ameliorates
            Neurological Deficits in a Long-Term ABCD1-Deficient Mouse Model of
            X-Linked Adrenoleukodystrophy
  JOURNAL   Neurotherapeutics 20 (1), 272-283 (2023)
   PUBMED   36207570
  REMARK    GeneRIF: Targeted Brain Delivery of Dendrimer-4-Phenylbutyrate
            Ameliorates Neurological Deficits in a Long-Term ABCD1-Deficient
            Mouse Model of X-Linked Adrenoleukodystrophy.
REFERENCE   2  (bases 1 to 5743)
  AUTHORS   Gong,Y., Laheji,F., Berenson,A., Qian,A., Park,S.O., Kok,R.,
            Selig,M., Hahn,R., Sadjadi,R., Kemp,S. and Eichler,F.
  TITLE     Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical
            Allodynia
  JOURNAL   Cells 11 (11), 1842 (2022)
   PUBMED   35681537
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5743)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5743)
  AUTHORS   Raas,Q., Gondcaille,C., Hamon,Y., Leoni,V., Caccia,C.,
            Menetrier,F., Lizard,G., Trompier,D. and Savary,S.
  TITLE     CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2
            cells: novel microglial models for X-linked Adrenoleukodystrophy
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1864 (5), 704-714 (2019)
   PUBMED   30769094
  REMARK    GeneRIF: Combined absence of ABCD1 and ABCD2 proteins resulted in
            the accumulation of very long-chain fatty acids in murine BV-2
            cells.
REFERENCE   5  (bases 1 to 5743)
  AUTHORS   Ranea-Robles,P., Launay,N., Ruiz,M., Calingasan,N.Y., Dumont,M.,
            Naudi,A., Portero-Otin,M., Pamplona,R., Ferrer,I., Beal,M.F.,
            Fourcade,S. and Pujol,A.
  TITLE     Aberrant regulation of the GSK-3beta/NRF2 axis unveils a novel
            therapy for adrenoleukodystrophy
  JOURNAL   EMBO Mol Med 10 (8) (2018)
   PUBMED   29997171
REFERENCE   6  (bases 1 to 5743)
  AUTHORS   Netik,A., Forss-Petter,S., Holzinger,A., Molzer,B., Unterrainer,G.
            and Berger,J.
  TITLE     Adrenoleukodystrophy-related protein can compensate functionally
            for adrenoleukodystrophy protein deficiency (X-ALD): implications
            for therapy
  JOURNAL   Hum Mol Genet 8 (5), 907-913 (1999)
   PUBMED   10196381
REFERENCE   7  (bases 1 to 5743)
  AUTHORS   Broccardo,C., Troffer-Charlier,N., Savary,S., Mandel,J.L. and
            Chimini,G.
  TITLE     Exon organisation of the mouse gene encoding the
            Adrenoleukodystrophy related protein (ALDRP)
  JOURNAL   Eur J Hum Genet 6 (6), 638-641 (1998)
   PUBMED   9887385
REFERENCE   8  (bases 1 to 5743)
  AUTHORS   Savary,S., Troffer-Charlier,N., Gyapay,G., Mattei,M.G. and
            Chimini,G.
  TITLE     Chromosomal localization of the adrenoleukodystrophy-related gene
            in man and mice
  JOURNAL   Eur J Hum Genet 5 (2), 99-101 (1997)
   PUBMED   9195160
REFERENCE   9  (bases 1 to 5743)
  AUTHORS   Lamartine,J., Seri,M., Cinti,R., Heitzmann,F., Creaven,M.,
            Radomski,N., Jost,E., Lenoir,G.M., Romeo,G. and Sylla,B.S.
  TITLE     Molecular cloning and mapping of a human cDNA (PA2G4) that encodes
            a protein highly homologous to the mouse cell cycle protein p38-2G4
  JOURNAL   Cytogenet Cell Genet 78 (1), 31-35 (1997)
   PUBMED   9345902
REFERENCE   10 (bases 1 to 5743)
  AUTHORS   Lombard-Platet,G., Savary,S., Sarde,C.O., Mandel,J.L. and
            Chimini,G.
  TITLE     A close relative of the adrenoleukodystrophy (ALD) gene codes for a
            peroxisomal protein with a specific expression pattern
  JOURNAL   Proc Natl Acad Sci U S A 93 (3), 1265-1269 (1996)
   PUBMED   8577752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113102.8.
            
            On Sep 7, 2022 this sequence version replaced NM_011994.3.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ALD subfamily, which is
            involved in peroxisomal import of fatty acids and/or fatty
            acyl-CoAs in the organelle. All known peroxisomal ABC transporters
            are half transporters which require a partner half transporter
            molecule to form a functional homodimeric or heterodimeric
            transporter. The function of this peroxisomal membrane protein is
            unknown; however this protein is speculated to function as a
            dimerization partner of Abcd1 and/or other peroxisomal ABC
            transporters. Mutations in the human gene have been observed in
            patients with adrenoleukodystrophy, a severe demyelinating disease.
            This gene has been identified as a candidate for a modifier gene,
            accounting for the extreme variation among adrenoleukodystrophy
            phenotypes. This gene is also a candidate for a complement group of
            Zellweger syndrome, a genetically heterogeneous disorder of
            peroxisomal biogenesis. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161027.1, AK082588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1141              AC113102.8         21052-22192
            1142-1322           AC113102.8         23847-24027
            1323-1444           AC113102.8         30060-30181
            1445-1610           AC113102.8         33621-33786
            1611-1705           AC113102.8         34537-34631
            1706-1851           AC113102.8         38126-38271
            1852-1997           AC113102.8         49663-49808
            1998-2082           AC113102.8         53674-53758
            2083-2208           AC113102.8         61082-61207
            2209-5743           AC113102.8         63657-67191
FEATURES             Location/Qualifiers
     source          1..5743
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 46.0 cM"
     gene            1..5743
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /note="ATP-binding cassette, sub-family D member 2"
                     /db_xref="GeneID:26874"
                     /db_xref="MGI:MGI:1349467"
     exon            1..1141
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2428
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adrenoleukodystrophy-related protein; adrenoleukodystrophy
                     related; ATP-binding cassette, sub-family D (ALD), member
                     2"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family D member 2
                     isoform 1"
                     /protein_id="NP_036124.2"
                     /db_xref="CCDS:CCDS27760.1"
                     /db_xref="GeneID:26874"
                     /db_xref="MGI:MGI:1349467"
                     /translation="MIHMLNAAAYRVKWTRSGAAKRAACLVAAAYALKTLYPIIGKRL
                     KQPGHRKAKAEAYSPAENREILHCTEIICKKPAPGLNAAFFKQLLELRKILFPKLVTT
                     ETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPRTFIIKLIKWLMIAIPATFV
                     NSAIRYLECKLALAFRTRLVDHAYETYFANQTYYKVINMDGRLANPDQSLTEDIMMFS
                     QSVAHLYSNLTKPILDVILTSYTLIRTATSRGASPIGPTLLAGLVVYATAKVLKACSP
                     KFGSLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKCYKALAYQMNLIL
                     SKRLWYIMIEQFLMKYVWSSCGLIMVAIPIITATGFADGDLEDGPKQAMVSDRTEAFT
                     TARNLLASGADAIERIMSSYKEITELAGYTARVYNMFWVFDEVKRGIYKRTVTQEPEN
                     HSKRGGNLELPLSDTLAIKGTVIDVDHGIICENVPIITPAGEVVASRLNFKVEEGMHL
                     LITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPD
                     SADDMREKGYTDQDLERILHSVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMF
                     YHKPKYALLDECTSAVSIDVEGKIFQAAIGAGISLLSITHRPSLWKYHTHLLQFDGEG
                     GWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNELCKILGEDSVLKTIQTAEKT
                     S"
     exon            1142..1322
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1444
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1610
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1705
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1851
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1997
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2082
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2208
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..5743
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4000..4005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /note="hexamer: AACAAG"
     polyA_site      4017
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /note="major polyA site"
     regulatory      5522..5527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /note="hexamer: AATAAA"
     polyA_site      5539
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
     regulatory      5721..5726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /note="hexamer: ATTAAA"
     polyA_site      5743
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
ORIGIN      
        1 gctgagggac tcgcccccgg aggatgcggt ggagtttgtg ctttgctgca tccgtcactg
       61 aagaacaaaa taagagtaaa ggagacaagc tgcagagcat gggaggctgt ggggtcttct
      121 gaaacctttg ctgggctttc cgcggagcat gagcttttaa aacgaattct tttcaaagaa
      181 acccatttgt gtagctggaa aaatgataca catgctaaat gcagcagcct atcgggtgaa
      241 atggaccaga tccggtgctg ctaaaagggc tgcctgcctg gtggctgcgg catatgctct
      301 gaaaaccctc tatcccatca ttggcaagcg tttaaagcag cctggccaca ggaaggcaaa
      361 agcagaagct tactcgcctg cagagaacag agaaatactg cattgcacgg agatcatctg
      421 taaaaaacct gcgccgggac taaatgcagc ttttttcaaa cagctactag aacttcggaa
      481 aatcctcttt ccaaaacttg tgaccactga aacggggtgg ctctgcctcc actcggtggc
      541 tctaatctca agaacatttc tctctattta tgtggctggt ctggatggga aaatcgtgaa
      601 aagcatcgtg gaaaagaagc ctcggacttt catcatcaaa ttaatcaagt ggcttatgat
      661 tgctatccct gctacctttg tcaacagtgc tatcaggtac ctggaatgca aactggcatt
      721 ggcctttaga actcgcttag tagaccatgc ctatgagacc tatttcgcaa atcagactta
      781 ttataaggtg ataaatatgg atgggaggct ggcaaaccct gaccagtctc ttaccgaaga
      841 cattatgatg ttctcgcaat ctgtggctca cctgtattcc aaccttacca aacctatttt
      901 agatgtcatt ctaacctcct atactctcat ccggacagct acatccagag gagcaagccc
      961 tatagggccc accctgttag caggacttgt cgtgtatgcc actgctaaag tactgaaagc
     1021 ttgctcgccc aaatttggtt cgctggtggc tgaagaagcc cacaggaaag gctacctgcg
     1081 gtatgtccac tcccgaatca tagccaatgt agaagaaatt gccttctaca gaggacataa
     1141 ggtagaaatg aagcagctgc agaaatgtta caaggcttta gcttaccaga tgaacctgat
     1201 tttatccaaa cgtttatggt acatcatgat agaacaattc ttgatgaagt atgtgtggag
     1261 cagctgtgga ctaattatgg tggctatacc cattatcact gcaacgggct ttgcagatgg
     1321 tgatctggag gatggtccaa agcaggctat ggttagcgat cggacagagg ccttcaccac
     1381 tgcccggaac ttactggcct ctggagctga tgcaattgaa aggattatgt cttcatacaa
     1441 agagatcact gaactagcag gttatactgc tagagtatac aatatgttct gggtcttcga
     1501 tgaagtgaag agaggcattt ataagagaac tgtcactcag gaacctgaaa accatagcaa
     1561 gcgtggaggt aacctggaac tacccctcag cgacaccctg gccatcaaag gaacagttat
     1621 tgatgtggat catggaatca tttgtgaaaa tgttcccata attacaccag cgggcgaagt
     1681 ggtggcttcc aggctaaact tcaaagtgga agaagggatg catctcttga taactggtcc
     1741 caacggttgt gggaaaagct ctctcttcag aatcttaagc gggctgtggc ctgtgtatga
     1801 aggagtcctt tataaaccgc ctccccaaca tatgttctat attccacaga ggccatacat
     1861 gtctcttgga agtctccggg atcaagtaat ttaccctgac tcagcggatg acatgcgtga
     1921 gaaaggttac actgaccaag acctagaacg catcctgcac agcgtgcacc tctaccacat
     1981 agttcaaaga gaaggaggat gggatgcagt catggactgg aaagatgtcc tttccggagg
     2041 ggagaagcag agaatgggca tggcgcggat gttttaccat aaaccgaagt atgcattgct
     2101 ggatgaatgt accagtgccg tgagcatcga cgttgaagga aagatatttc aggctgctat
     2161 tggggctggg atttccctac tctccataac acacaggcct tctctgtgga aataccacac
     2221 tcatctatta caattcgatg gcgaaggagg ctggcgcttt gaacagttgg acactgctat
     2281 ccgtttaacg ttgagtgagg aaaagcaaaa gttggagtcg cagctcgctg gaattcccaa
     2341 aatgcaacag agactcaacg aactatgcaa aattctgggg gaagactcgg tgctgaaaac
     2401 aatccaaact gcagaaaaga catcctaatt tatcttgaca tgttttcagt taccttctag
     2461 gtgaagcctc agagactctc tctttactgc atgcagtatg ttaagctaag tgcagagaaa
     2521 gcaagccggc aaaaaaaaag tattttgtat gattttagca tcgaggaaat atatgaagac
     2581 ttttcaaaca aacaaacaaa aaaagcaaac aaattagttg agattagtca tgacttcagt
     2641 tagtgcccag tgaaaagcta actcacctgt aaagcaggac tttctaggac taggagaaag
     2701 tggcctgagg ttcttcatgt aggagaatgc cccaaaacaa agcagcaaag gcaccaggag
     2761 gactgatgtc agctgtgcag aattaggact ttgagggttc tttcagccca gttaacaagg
     2821 acaataggtg caacacctgg aatccataat cagcattgct aggggccaag tcaaactgtg
     2881 tacaaaataa caggcgtttt gatacataat ttcagtctga aaaaaaagtg cattttaatg
     2941 acagtggttg aaaagaagca tggctggaca agtataaagt actgtattta aatttttcat
     3001 actttcagca tcttgataca gataccaaaa attaacacga ataaaaagtg tatttgctta
     3061 aaaacaagcc cttttgtttt ttaaaaagag aattacccat acggaagagg aggatcctaa
     3121 caatgcttgt tctggctgtt gcttgactct gcagtgctat ctggtacaat ttctacccag
     3181 aaatattgct tgttttgtgc ccacaaaaaa gcattttaga aacttgattg ctgtcctaag
     3241 tttccttgat cctggaaatc acagttatgt tcttatactc tgcctttgaa gcaatctttt
     3301 aaggcataca agttttttgt tcctttttct tctgagaaaa aagacactca gatttacttt
     3361 agtcacatga tttatttgga aagagctgta gagatcaata gaggtcttgt gaccccctga
     3421 ttcagtgctt tcatcactac tgacccttaa atttaactgg gatataatgt caatttaaaa
     3481 attatgtgag ccaagcagtg gtggcgcaca cctttaatcc cagcactcag gaggcagagg
     3541 caggcggatt tctgagttcg agaccagtct ggtctacaaa gtgagttcca ggacagccag
     3601 ggctacacag agaaaccctg tctcgggaaa aataaaatta tgtgggccag gtaaatgtct
     3661 agaaatggaa ttgtaggcaa agcagggcat aaggaaaaaa tttaagtaga tgaataaata
     3721 tttttaaggc atggaggaat ggcagttgct tctcttgcag gggtcccgag ttctattgcc
     3781 agcatcacat ggtggctcag aactgtgtct aattccagtt ccagggaatc tgacaccctc
     3841 ttctggactt caggagccct gcatgcatga agtcctcata catacatgca gacaaaacat
     3901 tcttaacatt aaaaagtcaa taaatctgaa agatagtaag gatattgaaa ttggcaatgt
     3961 tgatgttatt atcacttatt actgtttgca agaaataaaa acaagtcgca aatgcaatgg
     4021 tcatcagtct ttgacttaaa atcaatcaag aacgacatca caccacagcc tatgtatatc
     4081 cacccaatgc tgaagtgtct gcagtatcgg cactcagaag ggcagtgaat tgaagcttca
     4141 tactactgaa catgacgaga gaaaacccta tatgagtacg tcatatgaaa tagagctcat
     4201 ctgaagtaca gagccataac tgatgcttta atctcatcct ctctcaggct atggtgaggt
     4261 atgtaaaaac ctgagatgaa tagttctagg ggcataagat tttgtttatg tatttaggca
     4321 gcactttagc cgacgctaac ttgcaataga ctgtttggaa gacagactac ctggaagtca
     4381 ctcacagtga ttgttgtaag aaattaccac atttccacat tttaaattcc ccaaattgta
     4441 tgtaatttga gttaccaata aatgtaccca ccttacatga agcaatacaa tatgaggtcc
     4501 cagtcagtac tttttaattt gtctgttact actacttctt actaaaaatg tgggggaaga
     4561 attaaatatt ttgtttagta aaagtataga accagaaatt gacacttgat ttttttaaaa
     4621 aaacaattca ctaatcttta acaaccatgt tagcagctac ccaggttatt tgataaaggg
     4681 gaaacatttg aagcaaatgt cttacattag ctctgaaagg cacaagagga aaattcaaag
     4741 ttcacatttg aaattatgct ttttcacaac ttaaaattaa accacgtaag acatgatatc
     4801 ttacattttt aagctttgca aaggatgcca acatcaaaac tagatttgta attagacctt
     4861 atttaataga tttttaccaa tgagctgagg tgaaataaat aaaactcatt acacagtggt
     4921 ttaaagatgt ctgaaattct atacttaaaa tctagtcgtg aaatttaaat ggtaaaggtt
     4981 tcaggacaaa ctatctgttt tccagtagct ttttggtgac tactgatttt ctgaattact
     5041 ttttctgaga ccaaataccc tctgtcttag agggagaatg tgatgtgaat ttgtgttgtg
     5101 tacaatccga ctctttccaa actggcccca caggagaccg gagctgatat tctcacaggc
     5161 atccttgtga gaacataaag accactgaga aatatcttct atgactagga caaagaataa
     5221 caaggaaaat gaagtatagc tccggctatc aaactactta tcttttcctt agaaaaggcg
     5281 tacatttgtg gagcttgatt actttggggg gatagctcat aacctgcatt gtgacatcct
     5341 atttctgcag catgctgtgg tatgccaagc atgagtctga cgccgtgttc accctaaaat
     5401 cctcttgaat cacaaggctg acgatcttac ttgaaaacca acccgattta ccctatgttt
     5461 acacaggaag ggttttccct tcgatagtta atttgacttt tgtcccaaat tttggtgtgt
     5521 caataaaagt aaaaacaaat gtattggttt tttttttcct tcggggcatt aattccaagt
     5581 agaagcgtgt atttgtgaga gatgtagctt atctccatgt ttggaatagg tctttgactg
     5641 tgtaagccaa aagagcttgt tatacattgg aaccctgagg aagttatgcg ctttaagaca
     5701 tgataaatgc ggcaacagat attaaattat ttgtttaaag aga
//
