LOCUS       NM_001358967            5740 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family D member 2 (Abcd2),
            transcript variant 2, mRNA.
ACCESSION   NM_001358967
VERSION     NM_001358967.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5740)
  AUTHORS   Nemeth,C.L., Gk,O., Tomlinson,S.N., Sharma,A., Moser,A.B.,
            Kannan,S., Kannan,R.M. and Fatemi,A.
  TITLE     Targeted Brain Delivery of Dendrimer-4-Phenylbutyrate Ameliorates
            Neurological Deficits in a Long-Term ABCD1-Deficient Mouse Model of
            X-Linked Adrenoleukodystrophy
  JOURNAL   Neurotherapeutics 20 (1), 272-283 (2023)
   PUBMED   36207570
  REMARK    GeneRIF: Targeted Brain Delivery of Dendrimer-4-Phenylbutyrate
            Ameliorates Neurological Deficits in a Long-Term ABCD1-Deficient
            Mouse Model of X-Linked Adrenoleukodystrophy.
REFERENCE   2  (bases 1 to 5740)
  AUTHORS   Gong,Y., Laheji,F., Berenson,A., Qian,A., Park,S.O., Kok,R.,
            Selig,M., Hahn,R., Sadjadi,R., Kemp,S. and Eichler,F.
  TITLE     Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical
            Allodynia
  JOURNAL   Cells 11 (11), 1842 (2022)
   PUBMED   35681537
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5740)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5740)
  AUTHORS   Raas,Q., Gondcaille,C., Hamon,Y., Leoni,V., Caccia,C.,
            Menetrier,F., Lizard,G., Trompier,D. and Savary,S.
  TITLE     CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2
            cells: novel microglial models for X-linked Adrenoleukodystrophy
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1864 (5), 704-714 (2019)
   PUBMED   30769094
  REMARK    GeneRIF: Combined absence of ABCD1 and ABCD2 proteins resulted in
            the accumulation of very long-chain fatty acids in murine BV-2
            cells.
REFERENCE   5  (bases 1 to 5740)
  AUTHORS   Ranea-Robles,P., Launay,N., Ruiz,M., Calingasan,N.Y., Dumont,M.,
            Naudi,A., Portero-Otin,M., Pamplona,R., Ferrer,I., Beal,M.F.,
            Fourcade,S. and Pujol,A.
  TITLE     Aberrant regulation of the GSK-3beta/NRF2 axis unveils a novel
            therapy for adrenoleukodystrophy
  JOURNAL   EMBO Mol Med 10 (8) (2018)
   PUBMED   29997171
REFERENCE   6  (bases 1 to 5740)
  AUTHORS   Netik,A., Forss-Petter,S., Holzinger,A., Molzer,B., Unterrainer,G.
            and Berger,J.
  TITLE     Adrenoleukodystrophy-related protein can compensate functionally
            for adrenoleukodystrophy protein deficiency (X-ALD): implications
            for therapy
  JOURNAL   Hum Mol Genet 8 (5), 907-913 (1999)
   PUBMED   10196381
REFERENCE   7  (bases 1 to 5740)
  AUTHORS   Broccardo,C., Troffer-Charlier,N., Savary,S., Mandel,J.L. and
            Chimini,G.
  TITLE     Exon organisation of the mouse gene encoding the
            Adrenoleukodystrophy related protein (ALDRP)
  JOURNAL   Eur J Hum Genet 6 (6), 638-641 (1998)
   PUBMED   9887385
REFERENCE   8  (bases 1 to 5740)
  AUTHORS   Savary,S., Troffer-Charlier,N., Gyapay,G., Mattei,M.G. and
            Chimini,G.
  TITLE     Chromosomal localization of the adrenoleukodystrophy-related gene
            in man and mice
  JOURNAL   Eur J Hum Genet 5 (2), 99-101 (1997)
   PUBMED   9195160
REFERENCE   9  (bases 1 to 5740)
  AUTHORS   Lamartine,J., Seri,M., Cinti,R., Heitzmann,F., Creaven,M.,
            Radomski,N., Jost,E., Lenoir,G.M., Romeo,G. and Sylla,B.S.
  TITLE     Molecular cloning and mapping of a human cDNA (PA2G4) that encodes
            a protein highly homologous to the mouse cell cycle protein p38-2G4
  JOURNAL   Cytogenet Cell Genet 78 (1), 31-35 (1997)
   PUBMED   9345902
REFERENCE   10 (bases 1 to 5740)
  AUTHORS   Lombard-Platet,G., Savary,S., Sarde,C.O., Mandel,J.L. and
            Chimini,G.
  TITLE     A close relative of the adrenoleukodystrophy (ALD) gene codes for a
            peroxisomal protein with a specific expression pattern
  JOURNAL   Proc Natl Acad Sci U S A 93 (3), 1265-1269 (1996)
   PUBMED   8577752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113102.8.
            
            On Sep 7, 2022 this sequence version replaced NM_001358967.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ALD subfamily, which is
            involved in peroxisomal import of fatty acids and/or fatty
            acyl-CoAs in the organelle. All known peroxisomal ABC transporters
            are half transporters which require a partner half transporter
            molecule to form a functional homodimeric or heterodimeric
            transporter. The function of this peroxisomal membrane protein is
            unknown; however this protein is speculated to function as a
            dimerization partner of Abcd1 and/or other peroxisomal ABC
            transporters. Mutations in the human gene have been observed in
            patients with adrenoleukodystrophy, a severe demyelinating disease.
            This gene has been identified as a candidate for a modifier gene,
            accounting for the extreme variation among adrenoleukodystrophy
            phenotypes. This gene is also a candidate for a complement group of
            Zellweger syndrome, a genetically heterogeneous disorder of
            peroxisomal biogenesis. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.166877.1,
                                           SRR1660813.241631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1141              AC113102.8         21052-22192
            1142-1319           AC113102.8         23847-24024
            1320-1441           AC113102.8         30060-30181
            1442-1607           AC113102.8         33621-33786
            1608-1702           AC113102.8         34537-34631
            1703-1848           AC113102.8         38126-38271
            1849-1994           AC113102.8         49663-49808
            1995-2079           AC113102.8         53674-53758
            2080-2205           AC113102.8         61082-61207
            2206-5740           AC113102.8         63657-67191
FEATURES             Location/Qualifiers
     source          1..5740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 46.0 cM"
     gene            1..5740
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /note="ATP-binding cassette, sub-family D member 2"
                     /db_xref="GeneID:26874"
                     /db_xref="MGI:MGI:1349467"
     exon            1..1141
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2425
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     adrenoleukodystrophy-related protein; adrenoleukodystrophy
                     related; ATP-binding cassette, sub-family D (ALD), member
                     2"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family D member 2
                     isoform 2"
                     /protein_id="NP_001345896.1"
                     /db_xref="GeneID:26874"
                     /db_xref="MGI:MGI:1349467"
                     /translation="MIHMLNAAAYRVKWTRSGAAKRAACLVAAAYALKTLYPIIGKRL
                     KQPGHRKAKAEAYSPAENREILHCTEIICKKPAPGLNAAFFKQLLELRKILFPKLVTT
                     ETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPRTFIIKLIKWLMIAIPATFV
                     NSAIRYLECKLALAFRTRLVDHAYETYFANQTYYKVINMDGRLANPDQSLTEDIMMFS
                     QSVAHLYSNLTKPILDVILTSYTLIRTATSRGASPIGPTLLAGLVVYATAKVLKACSP
                     KFGSLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKCYKALAYQMNLIL
                     SKRLWYIMIEQFLMKYVWSSCGLIMVAIPIITATGFADDLEDGPKQAMVSDRTEAFTT
                     ARNLLASGADAIERIMSSYKEITELAGYTARVYNMFWVFDEVKRGIYKRTVTQEPENH
                     SKRGGNLELPLSDTLAIKGTVIDVDHGIICENVPIITPAGEVVASRLNFKVEEGMHLL
                     ITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDS
                     ADDMREKGYTDQDLERILHSVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFY
                     HKPKYALLDECTSAVSIDVEGKIFQAAIGAGISLLSITHRPSLWKYHTHLLQFDGEGG
                     WRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNELCKILGEDSVLKTIQTAEKTS
                     "
     exon            1142..1319
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1441
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1607
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1702
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1848
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1994
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2079
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2205
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..5740
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3997..4002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /note="hexamer: AACAAG"
     polyA_site      4014
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /note="major polyA site"
     regulatory      5519..5524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /note="hexamer: AATAAA"
     polyA_site      5536
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
     regulatory      5718..5723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
                     /note="hexamer: ATTAAA"
     polyA_site      5740
                     /gene="Abcd2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP"
ORIGIN      
        1 gctgagggac tcgcccccgg aggatgcggt ggagtttgtg ctttgctgca tccgtcactg
       61 aagaacaaaa taagagtaaa ggagacaagc tgcagagcat gggaggctgt ggggtcttct
      121 gaaacctttg ctgggctttc cgcggagcat gagcttttaa aacgaattct tttcaaagaa
      181 acccatttgt gtagctggaa aaatgataca catgctaaat gcagcagcct atcgggtgaa
      241 atggaccaga tccggtgctg ctaaaagggc tgcctgcctg gtggctgcgg catatgctct
      301 gaaaaccctc tatcccatca ttggcaagcg tttaaagcag cctggccaca ggaaggcaaa
      361 agcagaagct tactcgcctg cagagaacag agaaatactg cattgcacgg agatcatctg
      421 taaaaaacct gcgccgggac taaatgcagc ttttttcaaa cagctactag aacttcggaa
      481 aatcctcttt ccaaaacttg tgaccactga aacggggtgg ctctgcctcc actcggtggc
      541 tctaatctca agaacatttc tctctattta tgtggctggt ctggatggga aaatcgtgaa
      601 aagcatcgtg gaaaagaagc ctcggacttt catcatcaaa ttaatcaagt ggcttatgat
      661 tgctatccct gctacctttg tcaacagtgc tatcaggtac ctggaatgca aactggcatt
      721 ggcctttaga actcgcttag tagaccatgc ctatgagacc tatttcgcaa atcagactta
      781 ttataaggtg ataaatatgg atgggaggct ggcaaaccct gaccagtctc ttaccgaaga
      841 cattatgatg ttctcgcaat ctgtggctca cctgtattcc aaccttacca aacctatttt
      901 agatgtcatt ctaacctcct atactctcat ccggacagct acatccagag gagcaagccc
      961 tatagggccc accctgttag caggacttgt cgtgtatgcc actgctaaag tactgaaagc
     1021 ttgctcgccc aaatttggtt cgctggtggc tgaagaagcc cacaggaaag gctacctgcg
     1081 gtatgtccac tcccgaatca tagccaatgt agaagaaatt gccttctaca gaggacataa
     1141 ggtagaaatg aagcagctgc agaaatgtta caaggcttta gcttaccaga tgaacctgat
     1201 tttatccaaa cgtttatggt acatcatgat agaacaattc ttgatgaagt atgtgtggag
     1261 cagctgtgga ctaattatgg tggctatacc cattatcact gcaacgggct ttgcagatga
     1321 tctggaggat ggtccaaagc aggctatggt tagcgatcgg acagaggcct tcaccactgc
     1381 ccggaactta ctggcctctg gagctgatgc aattgaaagg attatgtctt catacaaaga
     1441 gatcactgaa ctagcaggtt atactgctag agtatacaat atgttctggg tcttcgatga
     1501 agtgaagaga ggcatttata agagaactgt cactcaggaa cctgaaaacc atagcaagcg
     1561 tggaggtaac ctggaactac ccctcagcga caccctggcc atcaaaggaa cagttattga
     1621 tgtggatcat ggaatcattt gtgaaaatgt tcccataatt acaccagcgg gcgaagtggt
     1681 ggcttccagg ctaaacttca aagtggaaga agggatgcat ctcttgataa ctggtcccaa
     1741 cggttgtggg aaaagctctc tcttcagaat cttaagcggg ctgtggcctg tgtatgaagg
     1801 agtcctttat aaaccgcctc cccaacatat gttctatatt ccacagaggc catacatgtc
     1861 tcttggaagt ctccgggatc aagtaattta ccctgactca gcggatgaca tgcgtgagaa
     1921 aggttacact gaccaagacc tagaacgcat cctgcacagc gtgcacctct accacatagt
     1981 tcaaagagaa ggaggatggg atgcagtcat ggactggaaa gatgtccttt ccggagggga
     2041 gaagcagaga atgggcatgg cgcggatgtt ttaccataaa ccgaagtatg cattgctgga
     2101 tgaatgtacc agtgccgtga gcatcgacgt tgaaggaaag atatttcagg ctgctattgg
     2161 ggctgggatt tccctactct ccataacaca caggccttct ctgtggaaat accacactca
     2221 tctattacaa ttcgatggcg aaggaggctg gcgctttgaa cagttggaca ctgctatccg
     2281 tttaacgttg agtgaggaaa agcaaaagtt ggagtcgcag ctcgctggaa ttcccaaaat
     2341 gcaacagaga ctcaacgaac tatgcaaaat tctgggggaa gactcggtgc tgaaaacaat
     2401 ccaaactgca gaaaagacat cctaatttat cttgacatgt tttcagttac cttctaggtg
     2461 aagcctcaga gactctctct ttactgcatg cagtatgtta agctaagtgc agagaaagca
     2521 agccggcaaa aaaaaagtat tttgtatgat tttagcatcg aggaaatata tgaagacttt
     2581 tcaaacaaac aaacaaaaaa agcaaacaaa ttagttgaga ttagtcatga cttcagttag
     2641 tgcccagtga aaagctaact cacctgtaaa gcaggacttt ctaggactag gagaaagtgg
     2701 cctgaggttc ttcatgtagg agaatgcccc aaaacaaagc agcaaaggca ccaggaggac
     2761 tgatgtcagc tgtgcagaat taggactttg agggttcttt cagcccagtt aacaaggaca
     2821 ataggtgcaa cacctggaat ccataatcag cattgctagg ggccaagtca aactgtgtac
     2881 aaaataacag gcgttttgat acataatttc agtctgaaaa aaaagtgcat tttaatgaca
     2941 gtggttgaaa agaagcatgg ctggacaagt ataaagtact gtatttaaat ttttcatact
     3001 ttcagcatct tgatacagat accaaaaatt aacacgaata aaaagtgtat ttgcttaaaa
     3061 acaagccctt ttgtttttta aaaagagaat tacccatacg gaagaggagg atcctaacaa
     3121 tgcttgttct ggctgttgct tgactctgca gtgctatctg gtacaatttc tacccagaaa
     3181 tattgcttgt tttgtgccca caaaaaagca ttttagaaac ttgattgctg tcctaagttt
     3241 ccttgatcct ggaaatcaca gttatgttct tatactctgc ctttgaagca atcttttaag
     3301 gcatacaagt tttttgttcc tttttcttct gagaaaaaag acactcagat ttactttagt
     3361 cacatgattt atttggaaag agctgtagag atcaatagag gtcttgtgac cccctgattc
     3421 agtgctttca tcactactga cccttaaatt taactgggat ataatgtcaa tttaaaaatt
     3481 atgtgagcca agcagtggtg gcgcacacct ttaatcccag cactcaggag gcagaggcag
     3541 gcggatttct gagttcgaga ccagtctggt ctacaaagtg agttccagga cagccagggc
     3601 tacacagaga aaccctgtct cgggaaaaat aaaattatgt gggccaggta aatgtctaga
     3661 aatggaattg taggcaaagc agggcataag gaaaaaattt aagtagatga ataaatattt
     3721 ttaaggcatg gaggaatggc agttgcttct cttgcagggg tcccgagttc tattgccagc
     3781 atcacatggt ggctcagaac tgtgtctaat tccagttcca gggaatctga caccctcttc
     3841 tggacttcag gagccctgca tgcatgaagt cctcatacat acatgcagac aaaacattct
     3901 taacattaaa aagtcaataa atctgaaaga tagtaaggat attgaaattg gcaatgttga
     3961 tgttattatc acttattact gtttgcaaga aataaaaaca agtcgcaaat gcaatggtca
     4021 tcagtctttg acttaaaatc aatcaagaac gacatcacac cacagcctat gtatatccac
     4081 ccaatgctga agtgtctgca gtatcggcac tcagaagggc agtgaattga agcttcatac
     4141 tactgaacat gacgagagaa aaccctatat gagtacgtca tatgaaatag agctcatctg
     4201 aagtacagag ccataactga tgctttaatc tcatcctctc tcaggctatg gtgaggtatg
     4261 taaaaacctg agatgaatag ttctaggggc ataagatttt gtttatgtat ttaggcagca
     4321 ctttagccga cgctaacttg caatagactg tttggaagac agactacctg gaagtcactc
     4381 acagtgattg ttgtaagaaa ttaccacatt tccacatttt aaattcccca aattgtatgt
     4441 aatttgagtt accaataaat gtacccacct tacatgaagc aatacaatat gaggtcccag
     4501 tcagtacttt ttaatttgtc tgttactact acttcttact aaaaatgtgg gggaagaatt
     4561 aaatattttg tttagtaaaa gtatagaacc agaaattgac acttgatttt tttaaaaaaa
     4621 caattcacta atctttaaca accatgttag cagctaccca ggttatttga taaaggggaa
     4681 acatttgaag caaatgtctt acattagctc tgaaaggcac aagaggaaaa ttcaaagttc
     4741 acatttgaaa ttatgctttt tcacaactta aaattaaacc acgtaagaca tgatatctta
     4801 catttttaag ctttgcaaag gatgccaaca tcaaaactag atttgtaatt agaccttatt
     4861 taatagattt ttaccaatga gctgaggtga aataaataaa actcattaca cagtggttta
     4921 aagatgtctg aaattctata cttaaaatct agtcgtgaaa tttaaatggt aaaggtttca
     4981 ggacaaacta tctgttttcc agtagctttt tggtgactac tgattttctg aattactttt
     5041 tctgagacca aataccctct gtcttagagg gagaatgtga tgtgaatttg tgttgtgtac
     5101 aatccgactc tttccaaact ggccccacag gagaccggag ctgatattct cacaggcatc
     5161 cttgtgagaa cataaagacc actgagaaat atcttctatg actaggacaa agaataacaa
     5221 ggaaaatgaa gtatagctcc ggctatcaaa ctacttatct tttccttaga aaaggcgtac
     5281 atttgtggag cttgattact ttggggggat agctcataac ctgcattgtg acatcctatt
     5341 tctgcagcat gctgtggtat gccaagcatg agtctgacgc cgtgttcacc ctaaaatcct
     5401 cttgaatcac aaggctgacg atcttacttg aaaaccaacc cgatttaccc tatgtttaca
     5461 caggaagggt tttcccttcg atagttaatt tgacttttgt cccaaatttt ggtgtgtcaa
     5521 taaaagtaaa aacaaatgta ttggtttttt ttttccttcg gggcattaat tccaagtaga
     5581 agcgtgtatt tgtgagagat gtagcttatc tccatgtttg gaataggtct ttgactgtgt
     5641 aagccaaaag agcttgttat acattggaac cctgaggaag ttatgcgctt taagacatga
     5701 taaatgcggc aacagatatt aaattatttg tttaaagaga
//
