LOCUS       NM_007435               3664 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ATP-binding cassette, sub-family D member 1 (Abcd1),
            mRNA.
ACCESSION   NM_007435 XM_973209 XM_973256 XM_973299 XM_973333 XM_973373
            XM_973409
VERSION     NM_007435.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3664)
  AUTHORS   Rondeau,V., Berman,J.M., Ling,T., O'Brien,C., Culp-Hill,R.,
            Reisz,J.A., Wunderlich,M., Chueh,Y., Jimenez-Camacho,K.E.,
            Sexton,C., Carter,K.M., Stillwell,C., St-Germain,J., Yendi,D.,
            Gupta,A., Shi,M., Bourdine,A., Paralkar,V.R., Jahangiri,S.,
            Hope,K.J., Tikhonova,A.N., Arruda,A., Minden,M.D., Raught,B.,
            D'Alessandro,A. and Jones,C.L.
  TITLE     Spermidine metabolism regulates leukemia stem and progenitor cell
            function through KAT7 expression in patient-derived mouse models
  JOURNAL   Sci Transl Med 16 (766), eadn1285 (2024)
   PUBMED   39321266
REFERENCE   2  (bases 1 to 3664)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3664)
  AUTHORS   Fujitani,N., Akashi,T., Saito,M., Morita,M., So,T. and Oka,K.
  TITLE     Increased neurotoxicity of high-density lipoprotein secreted from
            murine reactive astrocytes deficient in a peroxisomal
            very-long-chain fatty acid transporter Abcd1
  JOURNAL   J Inherit Metab Dis 47 (2), 289-301 (2024)
   PUBMED   38146202
  REMARK    GeneRIF: Increased neurotoxicity of high-density lipoprotein
            secreted from murine reactive astrocytes deficient in a peroxisomal
            very-long-chain fatty acid transporter Abcd1.
REFERENCE   4  (bases 1 to 3664)
  AUTHORS   Gong,Y., Laheji,F., Berenson,A., Li,Y., Moser,A., Qian,A.,
            Frosch,M., Sadjadi,R., Hahn,R., Maguire,C.A. and Eichler,F.
  TITLE     Role of Basal Forebrain Neurons in Adrenomyeloneuropathy in Mice
            and Humans
  JOURNAL   Ann Neurol 95 (3), 442-458 (2024)
   PUBMED   38062617
REFERENCE   5  (bases 1 to 3664)
  AUTHORS   Buda,A., Forss-Petter,S., Hua,R., Jaspers,Y., Lassnig,M.,
            Waidhofer-Sollner,P., Kemp,S., Kim,P., Weinhofer,I. and Berger,J.
  TITLE     ABCD1 Transporter Deficiency Results in Altered Cholesterol
            Homeostasis
  JOURNAL   Biomolecules 13 (9), 1333 (2023)
   PUBMED   37759733
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3664)
  AUTHORS   Bassett,D.E. Jr., Boguski,M.S., Spencer,F., Reeves,R., Kim,S.,
            Weaver,T. and Hieter,P.
  TITLE     Genome cross-referencing and XREFdb: implications for the
            identification and analysis of genes mutated in human disease
  JOURNAL   Nat Genet 15 (4), 339-344 (1997)
   PUBMED   9090377
REFERENCE   7  (bases 1 to 3664)
  AUTHORS   Kobayashi,T., Shinnoh,N., Kondo,A. and Yamada,T.
  TITLE     Adrenoleukodystrophy protein-deficient mice represent abnormality
            of very long chain fatty acid metabolism
  JOURNAL   Biochem Biophys Res Commun 232 (3), 631-636 (1997)
   PUBMED   9126326
REFERENCE   8  (bases 1 to 3664)
  AUTHORS   Fouquet,F., Zhou,J.M., Ralston,E., Murray,K., Troalen,F., Magal,E.,
            Robain,O., Dubois-Dalcq,M. and Aubourg,P.
  TITLE     Expression of the adrenoleukodystrophy protein in the human and
            mouse central nervous system
  JOURNAL   Neurobiol Dis 3 (4), 271-285 (1997)
   PUBMED   9173925
REFERENCE   9  (bases 1 to 3664)
  AUTHORS   Kennedy,M.A., Rowland,S.A., Miller,A.L., Morris,C.M., Neville,L.A.,
            Dodd,A., Fifield,W.J. and Love,D.R.
  TITLE     Structure and location of the murine adrenoleukodystrophy gene
  JOURNAL   Genomics 32 (3), 395-400 (1996)
   PUBMED   8838803
REFERENCE   10 (bases 1 to 3664)
  AUTHORS   Sarde,C.O., Thomas,J., Sadoulet,H., Garnier,J.M. and Mandel,J.L.
  TITLE     cDNA sequence of Aldgh, the mouse homolog of the X-linked
            adrenoleukodystrophy gene
  JOURNAL   Mamm Genome 5 (12), 810-813 (1994)
   PUBMED   7894167
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL805924.5 and BC079840.1.
            
            On Feb 25, 2016 this sequence version replaced NM_007435.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the ALD subfamily, which is
            involved in peroxisomal import of fatty acids and/or fatty
            acyl-CoAs in the organelle. All known peroxisomal ABC transporters
            are half transporters which require a partner half transporter
            molecule to form a functional homodimeric or heterodimeric
            transporter. This peroxisomal membrane protein is likely involved
            in the peroxisomal transport or catabolism of very long chain fatty
            acids. Defects in the human gene have been identified as the
            underlying cause of adrenoleukodystrophy, an X-chromosome
            recessively inherited demyelinating disorder of the nervous system.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079840.1, Z33637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AL805924.5         203489-203600
            113-3664            BC079840.1         1-3552
FEATURES             Location/Qualifiers
     source          1..3664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.39 cM"
     gene            1..3664
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /note="ATP-binding cassette, sub-family D member 1"
                     /db_xref="GeneID:11666"
                     /db_xref="MGI:MGI:1349215"
     exon            1..1334
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..2645
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /EC_number="7.6.2.4"
                     /note="adrenoleukodystrophy protein; X-linked
                     adrenoleukodystrophy (ALD) gene homolog; ATP-binding
                     cassette, sub-family D (ALD), member 1"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family D member 1"
                     /protein_id="NP_031461.1"
                     /db_xref="CCDS:CCDS30210.1"
                     /db_xref="GeneID:11666"
                     /db_xref="MGI:MGI:1349215"
                     /translation="MPVLSTPRPSRVTTLKRTAVVLALTAYGVHKIYPLVRQCLTPAR
                     GPQVPAGEPTQEASGATATKAGMNRVFLQRLLALLRLLFPRVLCRETGLLALHSAALV
                     SRTFLSVYVARLDGRLARCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLAL
                     SFRSRLVAHAYGLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKP
                     LLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRK
                     GELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYVMLEQFL
                     MKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVSERTEAFTIARNLL
                     TAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVKHCRFKRTGDLEEAQAGPGVM
                     VQSGVHVEGPLKIQGQVVDVEQGIICENIPIITPTGEVVVASLNIRVEEGMHLLITGP
                     NGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSAEDM
                     RRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPK
                     YALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFE
                     KLDSAARLSLTEEKQRLEQQLAGIPKMQGRLQELRQILGEAAAPVQPLVPGVPT"
     exon            1335..1515
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1658
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1827
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1922
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2068
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2214
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2299
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2425
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..3648
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3625..3630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /note="hexamer: AGTAAA"
     polyA_site      3648
                     /gene="Abcd1"
                     /gene_synonym="Ald; Aldgh; ALDP"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtagacg ctgtcgttac tgccgggctg ctcagcggac aaacacgcct ggtgccccgg
       61 ggaggggcgt cacggggggt ggggggggag gagcagtaag aggagggagg tggaaggaaa
      121 gacacagcct ctctccttaa gacctctcga ggctctgacc tcaggggcta aggggacagt
      181 ctgtagaggg aagccagttc ctccacccgg gctgcctgaa gaggccacga ccctggagga
      241 ttctaaccca accgatccag gggccccagc accaccgcga gggcctaaag caacagtctc
      301 agggatcact tcaaggtttc cagttgccta gacaacgagc cctgggtcag agcaacaacc
      361 cttccaggat ctgtctgcaa ctgtagcctc aggcagcagt tccagccctc agcctgctca
      421 ccagtccagg tgacatgccg gtgctctcca ctccccggcc ctcacgggtg accacgctga
      481 agcgcacagc tgtggtcctg gccctcacag cctatggagt ccacaaaatc taccctctag
      541 tacggcagtg tctgactcct gccagaggtc ctcaggtgcc agctggggag cccactcaag
      601 aggcctctgg agccaccgca accaaggctg gcatgaaccg ggtattcctg cagcggctct
      661 tggcgctcct gaggctgctg ttcccccgag tcttgtgccg ggaaacaggg ctgctggccc
      721 tgcattctgc tgccctggta agccgaactt tcctgtctgt gtatgttgcc cgcctggacg
      781 gcagactggc ccgctgcatt gtacgtaagg acccgcgggc ctttagctgg caactgctgc
      841 agtggctcct catcgccctt cctgccactt tcatcaacag tgccatccgc tacctagagg
      901 gccagctggc tctttctttc cgaagccgtc tagtagctca tgcctatgga ctctacttct
      961 cccaacagac ttactaccga gtaagcaaca tggatggacg acttcgaaac cctgatcagt
     1021 ctctgacaga ggatgtggta gcctttgctg cctctgtagc ccacctttat tccaacctga
     1081 ccaagccact cctggatgtg gctgtgacct cctacactct ccttcgagct gcccgatccc
     1141 gaggagctgg cacagcctgg ccctcagcca tcgctggcct ggtggtgttc ctcacagcca
     1201 acgtgcttcg agccttctct cccaagtttg gggagctagt ggcagaggag gcacggcgaa
     1261 agggggaact gcgctacatg cactctcgag tggtggccaa ctcagaggaa attgccttct
     1321 acgggggcca tgaggtggaa ctggcactac tacagcactc ctatcaagac ctagcttcac
     1381 agatcaacct catcctgctt gagcgcctat ggtatgtcat gctggaacag ttcctcatga
     1441 aatatgtgtg gagtgcatct ggcctgctca tggtagctgt ccccatcatc acagccactg
     1501 gctatgcaga gtcagactca gaagccatga agaaggcagc cttggaaatg aaggaagagg
     1561 agctggttag tgagcgtaca gaagctttca ccattgcccg aaacctcctc acagctgctg
     1621 cagatgccac cgaaaggatc atgtcatctt ataaggaggt gacagagctg gctggctaca
     1681 cagccagggt gtacgagatg ttccaggtat ttgaagatgt caaacactgt cgttttaaga
     1741 ggacaggaga tctagaggag gctcaggctg ggcctggggt catggtacag tctggtgtcc
     1801 atgtagaggg gcccctgaag atccaaggcc aagttgtgga tgtggagcag gggatcatct
     1861 gtgagaacat ccctatcatc acacccactg gagaggtggt ggtggccagc ctcaacatca
     1921 gggtggagga aggcatgcac ctgctcatca caggccccaa tggctgtggc aagagttctc
     1981 tgttccgaat cctaggtgga ctctggccca catacagtgg tgtactctat aagcccccac
     2041 cccagcgcat gttctatatc cctcagaggc cctacatgtc cgtgggctcc ttgcgtgacc
     2101 aagtgatcta tcccgactct gcggaagaca tgcggaggaa gggctgctcg gagcagcagc
     2161 tggaagcaat cctgggcatc gtgcatctcc gccacatcct gcaacgggag ggaggttggg
     2221 aggcagtgtg tgactggaag gacgtcctgt ctggaggtga gaagcagagg attggtatgg
     2281 cgcgcatgtt ctaccacagg cccaagtacg ccctcctgga tgagtgcact agtgccgtga
     2341 gcattgatgt ggaaggcaag atcttccaag cagccaaaga tgctggtatc gcactgctct
     2401 ccatcaccca tcgaccctcc ctatggaagt accacacaca cttgctgcag tttgatgggg
     2461 aaggaggctg gaagtttgag aagctggatt ctgctgcccg cctgagcctg actgaagaga
     2521 agcagcgcct ggagcagcaa ctggcgggca tccccaagat gcaggggcgc cttcaggagc
     2581 tccgccagat ccttggcgaa gctgcagctc cagttcaacc cctggtccca ggagtcccca
     2641 cttgactggg gaccttatcc ccagctccca cccttctcca ggctctcgga tcacatgaag
     2701 gaagctcctc ccctccccca ttgccctgca tgccttaccc ctcccaagcc tcctagccaa
     2761 ttacctgcat tccctgaaga ccccactctg ggacaggtag atatgaatgg ggacacactg
     2821 cattccacct tcactctggg ttctgctcca ggaactctgc cctgttcagg gcagtgtgtc
     2881 ttttactttt ccctggggag ggatggaggg tttggaagtc cccagtcctg actctatacc
     2941 agtatggctg agccatagga agtaagcagg agctgcctcc cttactgcca gcagccagaa
     3001 tgtgtggcaa ccctggtagt tgtgggttac atccctgccg aaacccaaat ccttgtcatt
     3061 gttttgatcc atccctttgt tgccatcccc ttgtgtgacc agccaatgcc cctgtcccac
     3121 aggatacccc ctgccatgaa aacagcctaa tggggcccag gattagacag ggcccaaagt
     3181 gtgcccttcc ccatggttac ccaagaagga cagagttcct cctgagccat gaagagaata
     3241 tagccctggc cctcccactc ctccacctct acaacctaat ttattggact cccagtttat
     3301 agttgtctaa attgccaaca tgagtaccct gccagcacag gaggtgactg ggtggtccct
     3361 tcaatctacc cagtctctgg tgccaaacct ggcccttcac cagcctatac tgccagttgc
     3421 cactgggggt gccctctgcc agctaggcag aagtgagggc accatgttcc cagctcagtg
     3481 ccaaagaggg gtcacaggag gtgctgtgtc tgctaaacca gccctcacca agagggagac
     3541 gcccccacac acacacccta ctgccattgt gtgcctttcc tgggccttca gccctccagc
     3601 tggggtaccc ccctcagtcc tctcagtaaa aacctctgga aagtacaaaa aaaaaaaaaa
     3661 aaaa
//
