LOCUS       NM_021041               7534 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family C member 9 (Abcc9),
            transcript variant 2, mRNA.
ACCESSION   NM_021041
VERSION     NM_021041.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7534)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7534)
  AUTHORS   Gerschenfeld,G., Coulpier,F., Gresset,A., Pulh,P., Job,B.,
            Topilko,T., Siegenthaler,J., Kastriti,M.E., Brunet,I., Charnay,P.
            and Topilko,P.
  TITLE     Neural tube-associated boundary caps are a major source of mural
            cells in the skin
  JOURNAL   Elife 12, e69413 (2023)
   PUBMED   38095361
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7534)
  AUTHORS   Russell,N.X., Burra,K., Shah,R.M., Bottasso-Arias,N.,
            Mohanakrishnan,M., Snowball,J., Ediga,H.H., Madala,S.K. and
            Sinner,D.
  TITLE     Wnt signaling regulates ion channel expression to promote smooth
            muscle and cartilage formation in developing mouse trachea
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (6), L788-L802 (2023)
   PUBMED   37873566
REFERENCE   4  (bases 1 to 7534)
  AUTHORS   McClenaghan,C., Mukadam,M.A., Roeglin,J., Tryon,R.C., Grabner,M.,
            Dayal,A., Meyer,G.A. and Nichols,C.G.
  TITLE     Skeletal muscle delimited myopathy and verapamil toxicity in SUR2
            mutant mouse models of AIMS
  JOURNAL   EMBO Mol Med 15 (6), e16883 (2023)
   PUBMED   37154692
  REMARK    GeneRIF: Skeletal muscle delimited myopathy and verapamil toxicity
            in SUR2 mutant mouse models of AIMS.
REFERENCE   5  (bases 1 to 7534)
  AUTHORS   Ando,K., Tong,L., Peng,D., Vazquez-Liebanas,E., Chiyoda,H., He,L.,
            Liu,J., Kawakami,K., Mochizuki,N., Fukuhara,S., Grutzendler,J. and
            Betsholtz,C.
  TITLE     KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular
            smooth muscle development and neurovascular coupling
  JOURNAL   Dev Cell 57 (11), 1383-1399 (2022)
   PUBMED   35588738
  REMARK    GeneRIF: KCNJ8/ABCC9-containing K-ATP channel modulates brain
            vascular smooth muscle development and neurovascular coupling.
REFERENCE   6  (bases 1 to 7534)
  AUTHORS   Chutkow,W.A., Makielski,J.C., Nelson,D.J., Burant,C.F. and Fan,Z.
  TITLE     Alternative splicing of sur2 Exon 17 regulates nucleotide
            sensitivity of the ATP-sensitive potassium channel
  JOURNAL   J Biol Chem 274 (19), 13656-13665 (1999)
   PUBMED   10224138
REFERENCE   7  (bases 1 to 7534)
  AUTHORS   Yamada,M., Isomoto,S., Matsumoto,S., Kondo,C., Shindo,T., Horio,Y.
            and Kurachi,Y.
  TITLE     Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive
            but ATP-insensitive K+ channel
  JOURNAL   J Physiol 499 (Pt 3) (Pt 3), 715-720 (1997)
   PUBMED   9130167
REFERENCE   8  (bases 1 to 7534)
  AUTHORS   Isomoto,S., Kondo,C., Yamada,M., Matsumoto,S., Higashiguchi,O.,
            Horio,Y., Matsuzawa,Y. and Kurachi,Y.
  TITLE     A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth
            muscle type ATP-sensitive K+ channel
  JOURNAL   J Biol Chem 271 (40), 24321-24324 (1996)
   PUBMED   8798681
REFERENCE   9  (bases 1 to 7534)
  AUTHORS   Chutkow,W.A., Simon,M.C., Le Beau,M.M. and Burant,C.F.
  TITLE     Cloning, tissue expression, and chromosomal localization of SUR2,
            the putative drug-binding subunit of cardiac, skeletal muscle, and
            vascular KATP channels
  JOURNAL   Diabetes 45 (10), 1439-1445 (1996)
   PUBMED   8826984
REFERENCE   10 (bases 1 to 7534)
  AUTHORS   Williams,T., Yon,J., Huxley,C. and Fried,M.
  TITLE     The mouse surfeit locus contains a very tight cluster of four
            'housekeeping' genes that is conserved through evolution
  JOURNAL   Proc Natl Acad Sci U S A 85 (10), 3527-3530 (1988)
   PUBMED   2453062
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC121611.3.
            
            On Aug 8, 2022 this sequence version replaced NM_021041.2.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the MRP subfamily which is
            involved in multi-drug resistance. The human protein is thought to
            form ATP-sensitive potassium channels in cardiac, skeletal, and
            vascular and non-vascular smooth muscle. Protein structure suggests
            a role as the drug-binding channel-modulating subunit of the
            extrapancreatic ATP-sensitive potassium channels. Alternative
            splicing of this gene results in multiple transcript variants.
            [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes isoform b (also known as SUR2A or SUR2-39).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86037.2, SRR10223971.7297.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC121611.3         146905-147015       c
            112-198             AC121611.3         146558-146644       c
            199-359             AC121611.3         142420-142580       c
            360-501             AC121611.3         139218-139359       c
            502-623             AC121611.3         137522-137643       c
            624-790             AC121611.3         133705-133871       c
            791-1033            AC121611.3         131940-132182       c
            1034-1216           AC121611.3         129741-129923       c
            1217-1375           AC121611.3         127600-127758       c
            1376-1531           AC121611.3         126730-126885       c
            1532-1666           AC121611.3         123960-124094       c
            1667-1829           AC121611.3         120142-120304       c
            1830-1870           AC121611.3         117336-117376       c
            1871-2013           AC121611.3         116282-116424       c
            2014-2122           AC121611.3         109273-109381       c
            2123-2227           AC121611.3         103239-103343       c
            2228-2300           AC121611.3         101344-101416       c
            2301-2406           AC121611.3         97268-97373         c
            2407-2445           AC121611.3         92768-92806         c
            2446-2547           AC121611.3         91013-91114         c
            2548-2632           AC121611.3         90627-90711         c
            2633-2713           AC121611.3         89016-89096         c
            2714-2851           AC121611.3         84189-84326         c
            2852-2977           AC121611.3         83933-84058         c
            2978-3074           AC121611.3         77826-77922         c
            3075-3304           AC121611.3         73164-73393         c
            3305-3453           AC121611.3         72214-72362         c
            3454-3523           AC121611.3         71930-71999         c
            3524-3681           AC121611.3         70678-70835         c
            3682-3774           AC121611.3         65424-65516         c
            3775-3877           AC121611.3         59155-59257         c
            3878-3979           AC121611.3         50560-50661         c
            3980-4100           AC121611.3         49571-49691         c
            4101-4231           AC121611.3         47788-47918         c
            4232-4310           AC121611.3         46517-46595         c
            4311-4419           AC121611.3         45649-45757         c
            4420-4523           AC121611.3         43795-43898         c
            4524-4657           AC121611.3         42849-42982         c
            4658-4720           AC121611.3         39450-39512         c
            4721-4896           AC121611.3         38708-38883         c
            4897-7534           AC121611.3         32607-35244         c
FEATURES             Location/Qualifiers
     source          1..7534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 74.35 cM"
     gene            1..7534
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /note="ATP-binding cassette, sub-family C member 9"
                     /db_xref="GeneID:20928"
                     /db_xref="MGI:MGI:1352630"
     exon            1..111
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            112..198
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            199..359
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..4858
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /note="isoform b is encoded by transcript variant 2;
                     sulfonylurea-binding protein 2; ATP-binding cassette
                     transporter sub-family C member 9; sulfonylurea receptor
                     2; ATP-binding cassette, sub-family C (CFTR/MRP), member
                     9"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 9
                     isoform b"
                     /protein_id="NP_066378.1"
                     /db_xref="CCDS:CCDS39699.1"
                     /db_xref="GeneID:20928"
                     /db_xref="MGI:MGI:1352630"
                     /translation="MSLSFCGNNISSYNIYYGVLQNPCFVDALNLVPHVFLLFITFPI
                     LFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSHRASRHL
                     HLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQLGW
                     GVSDLRFCITGVMVILNGLLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQP
                     FVNLLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRAVTNYVCLKEAYEEQKKKAA
                     DHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNEKTNTTRE
                     MFPETLSSKEFLENAHVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNK
                     ILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLL
                     GSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAW
                     EHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKP
                     AEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGEDSWRAGEGTL
                     PFESCKKHTGVQSKPINRKQPGRYHLDSYEQARRLRPAETEDIAIKVTNGYFSWGSGL
                     ATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVYWNNVNESEPSFEA
                     TRSRSRYSVAYAAQKPWLLNATVEENITFGSPFNRQRYKAVTDACSLQPDIDLLPFGD
                     QTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFL
                     QDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQ
                     DQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEEDNMSTVMRLRT
                     KMPWKTCWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINHPGKADQT
                     FYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGL
                     ILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALAPLGVAFYFI
                     QKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNI
                     AYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWV
                     VRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYEN
                     NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLP
                     LHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLD
                     ATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFAD
                     RTVVTIAHRVSSIVDAGLVLVFSEGILVECDTGPNLLQHKNGLFSTLVMTNK"
     exon            360..501
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            502..623
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            624..790
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1033
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1216
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1375
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1531
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1666
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1829
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1870
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2013
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2122
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2227
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2300
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2406
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2445
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2547
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2632
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2713
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2851
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2977
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3074
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3304
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3305..3453
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..3523
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3681
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3682..3774
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3775..3877
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3878..3979
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4100
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4101..4231
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4310
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4311..4419
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4420..4523
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4524..4657
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4658..4720
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4721..4896
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4897..7534
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6249..6254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /note="hexamer: AATAAA"
     polyA_site      6269
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
     regulatory      7509..7514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /note="hexamer: AATAAA"
     polyA_site      7534
                     /gene="Abcc9"
                     /gene_synonym="Sur2; SUR2A; SUR2B"
                     /note="major polyA site"
ORIGIN      
        1 aatccactcg ccggctgctg acccgggagg aaaacttgtc gtcccatgga gtgcgtgagc
       61 tcctcggctt gctacagaga gatccccaac cactctgagg agtcactggc tgagaaattt
      121 acatcttcag acggtgggca ggctgttggt agctcaagtg caccagtagg gggactaagc
      181 cctggagcca aagccaaggt taatcaagta agaagaaatg agcctttctt tttgtgggaa
      241 caacatctcc tcctacaaca tctattatgg tgttctccaa aacccctgct ttgtggacgc
      301 actcaacctg gtcccacatg tcttcctgct gtttatcacc tttccaatac tgttcattgg
      361 atgggggagc caaagctcaa aagtgcaaat tcatcataac acgtggcttc attttcccgg
      421 acacaacctg agatggattc tgacgtttgc gctcctgttt gtgcatgttt gtgagatagc
      481 ggaaggcatc gtttcagact cgcatcgggc gtccaggcat ctccaccttt tcatgccggc
      541 tgtgatggga tttgtcgcca caacaacgtc catcgtctat tatcataaca ttgaaacatc
      601 aaatttccct aaattacttt tagctttatt cctgtactgg gtaatggcct ttattacaaa
      661 gacgataaag ttggtcaaat actggcagtt ggggtgggga gtgtcagacc tgcgcttctg
      721 catcacagga gtgatggtca tcttgaatgg gctgctgatg gctgtggaga tcaatgtcat
      781 ccgggtcaga agatatgttt tcttcatgaa tccccagaaa gtgaagcctc cggaagacct
      841 ccaggacctg ggcgtgaggt tcctccagcc atttgtgaat ttactgtcca aagctactta
      901 ctggtggatg aacacactta tcatatcagc tcacaggaaa cctatcgatc tgaaggcgat
      961 tggaaagttg ccgatagcga tgagggcggt gaccaattat gtctgcctaa aggaagccta
     1021 tgaagagcag aagaaaaagg ctgccgatca tccaaatcgg actccctcca tatggctggc
     1081 catgtacaga gcttttggga gaccaatcct gctgagcagc acattccggt acttggctga
     1141 cttgctgggg tttgctggtc ctctttgtat atctgggata gtccagcgag taaatgaaaa
     1201 gactaacaca acaagagaaa tgtttccaga gacactctca tcaaaggaat ttctggaaaa
     1261 cgcccatgtg ctggctgtcc tgcttttcct ggcccttatc ctacagagga cctttctgca
     1321 ggcttcctac tatgtgacca tagagaccgg catcaacctc cgtggggctc tgctggctat
     1381 gatatacaat aaaatccttc ggctctcgac ttctaaccta tccatgggtg agatgaccct
     1441 gggacagatc aacaacttgg ttgccataga aaccaatcag ctcatgtggt tcttgttcct
     1501 gtgtcccaat ctgtgggcca tgcctgttca gatcataatg ggggtgatcc tgctctacaa
     1561 tttgcttggg tcgagtgcac tggttggcgc tgcagtcatt gtgctccttg caccgattca
     1621 gtacttcatt gccacgaagc tggcggaggc tcagaagagc actctggatt attccaccga
     1681 gaggttgaag aagacgaatg agatactgaa gggcatcaaa ctccttaagc tgtacgcctg
     1741 ggagcacatt ttctgcaaga gcgtggagga gacacgaatg aaggagctct ccagcctcaa
     1801 aaccttcgcg ctctacacgt cactttccat cttcatgaac gcagcaattc ccatcgcagc
     1861 tgttcttgcg acatttgtga cacatgcgta cgccagtgga aacaacctga agcctgcaga
     1921 ggcctttgcc tctctgtctc tcttccacat cctcgtcaca ccgctcttcc tgctgtccac
     1981 ggtggtcaga ttcgcagtca aagccatcat cagtgttcaa aagctgaatg agtttctctt
     2041 gagcgatgag attggtgagg acagctggag ggccggggag ggcacgctgc ctttcgagtc
     2101 ctgtaagaag cacaccggag tgcaatcaaa accaataaac aggaagcagc ctggacggta
     2161 ccacctggac agctacgagc aagcacggcg cctccggccc gctgagacgg aagacattgc
     2221 cataaaggtg acaaatggat acttctcatg gggcagtggt ttagctacat tgtccaatat
     2281 tgacattcga attccaacag gtcagctaac catgattgta ggccaagtgg gttgtggaaa
     2341 atcatctctt ctccttgcca tccttggtga gatgcagacc ctggaaggaa aagtttactg
     2401 gaacaatgta aatgaatctg agccttcttt tgaagcaacc cgaagcagaa gcaggtattc
     2461 tgtggcttac gctgcccaga agccttggct cctaaatgct acagttgagg aaaatatcac
     2521 ttttggaagt cctttcaaca gacagaggta caaggctgtc accgatgcct gctctcttca
     2581 gccagacatt gatttgctac catttggaga ccaaactgaa atcggagaga ggggcatcaa
     2641 cctgagtggg ggtcagaggc agagaatctg cgtggcacgg gcactctacc aaaacaccaa
     2701 catcgtcttt ttggacgacc cattctctgc cctggacatc cacctgagcg atcatttgat
     2761 gcaggaagga atcctgaagt ttctccagga tgacaagagg acggttgttc ttgtgacgca
     2821 caaactgcag tacctgacgc acgctgactg gatcatagcc atgaaggatg gcagtgtgtt
     2881 aagggaaggg actttgaaag acattcagac caaagacgtg gagctttatg aacactggaa
     2941 aaccctcatg aatagacagg atcaagaatt agaaaaggac atggaagcag accaaacaac
     3001 actggagagg aagactctcc ggagagccat gtattcaaga gaggccaagg cacagatgga
     3061 ggatgaagat gaagaggagg aagaggagga agatgaggaa gataacatgt caacggtgat
     3121 gaggctcagg accaagatgc cctggaagac ctgctggtgg tacctcactt caggagggtt
     3181 ttttctgctc ttcctcatga tcttctccaa gcttttgaag cactcggtga ttgtggctat
     3241 agactactgg ctagctacgt ggacatccga atacagtata aaccatcctg gaaaagctga
     3301 ccagaccttc tatgtggctg ggttcagcat cctctgtgga gcaggcattt tcctttgcct
     3361 cgtcacctcc ctcaccgtgg aatggatggg cctcacagcc gccaagaacc tccaccacaa
     3421 cctcctcaat aagataattc tcgggccaat aaggttcttt gataccacac cgctggggct
     3481 gatcctcaat cggttttctg ctgatacgaa catcatcgac cagcatatcc ctccgacctt
     3541 ggagtcgctg acgcgctcca ccctgctctg cctgtctgct attgggatga tctcctatgc
     3601 tacacccgtg tttctcgtcg cccttgcgcc cctgggtgta gccttttatt tcatccagaa
     3661 atacttccgg gttgcctcta aggatctcca ggaacttgac gacagcaccc agctccccct
     3721 gctttgtcac ttctcagaaa cagctgaagg gctcaccact atccgggcct tcaggcatga
     3781 aaccagattc aagcaacgca tgctggagct gacagacacg aacaacattg cctacttatt
     3841 tctctcagca gccaacagat ggctggaggt caggacggac tatctgggag cgtgcattgt
     3901 tctgacagcc tccattgcat ccattagtgg ctcttccaac tctggactgg tgggcttggg
     3961 ccttctctat gccctcacga taaccaatta cctaaattgg gttgtaagga acttggccga
     4021 cctggaagtc cagatgggtg cagtgaagaa agtgaacagt ttcttgacta tggagtccga
     4081 gaactatgaa ggcaccatgg atccttctca agtcccagag cactggccac aggaaggcga
     4141 gatcaagatt cacgatctgt gtgtcagata tgaaaataac ctgaagcccg ttctgaaaca
     4201 tgtcaaggct tacatcaaac ccgggcagaa ggtgggcatc tgtggtcgaa ctggcagtgg
     4261 gaagtcctcc ttatccctgg ctttcttcag aatggtcgac atatttgacg gaaagatagt
     4321 cattgatggg atagacatct ccaaactgcc cttgcacacg ctccgctcca ggctgtccat
     4381 cattctccag gacccaatcc tgttcagcgg ctccatcagg tttaacctgg atcctgaatg
     4441 caagtgcaca gatgacaggc tctgggaggc tctagaaatt gcccagctga agaatatggt
     4501 caaatctctg cccggaggct tagatgccac tgtcaccgaa ggtggtgaga acttcagtgt
     4561 tggacagaga cagctgttct gcctggccag ggcctttgtt cggaagagca gtatactcat
     4621 catggatgaa gccactgctt ccatcgacat ggccacggaa aacattttgc agaaagtagt
     4681 catgacagcc tttgcggatc gcacggtcgt aaccatagct caccgtgtct cttctattgt
     4741 ggatgcaggc cttgttttag tcttttctga gggtatttta gtggagtgtg atactggtcc
     4801 aaacctgctc cagcacaaga atggcctctt ttctactttg gtgatgacca acaagtagac
     4861 cagcgtgatc tgctccgaca agtgtctcat tctctgcatc gggttcacac cattctgact
     4921 gcagacctgg ttattgtgat gaagagagga aatattttgg aatacgacac cccggaaagc
     4981 ctcttggccc aggaagatgg agtgtttgcc tcgtttgtcc gtgcagacat gtgacaggat
     5041 tgtctctcaa cagcacaagt acttcaatgc ctaccgtcgg cccacctgag cggtcttcac
     5101 ctttgccaac tttgacggat ttctgtgtgg agagttgaga tttctatttc ctgttttggt
     5161 ttaacagttt ctgagatacg tgtgttatag gttcatttac tacgatctgt ccacactcga
     5221 aaagtaggct acattaaatc atgctagcag ccttaagagg taaagccatt ggagagaagt
     5281 gtcaagcatg ggagctaaaa tgagtaatct gtgttaccac actcttagta ctatcatttt
     5341 tttttttgag acagggtttc tctgtatagc cctggctgtc ctggaactca ctctgtagac
     5401 caggctggcc tcaaactcaa aaatccacct gcctctgcct cccaagtgct gggattaaag
     5461 gcgtgcgcca ccaccaccca gctgttacca cactcttatt tggaagacta gcatgacctt
     5521 gctgttgatg tgcccatgta gcagggtaaa agaaaattca ttttctaaca aaatactcac
     5581 attcatgatc tactgtagga gaatattttc tatgcattta acattattaa tattggtttt
     5641 aacttttccc ttttaaataa tttcctgtca tcaagaagct atcacatttt tggtacctct
     5701 ataaagctaa cccttcacaa aagaaaagat caccaaaagg ggttgtatat ttgaaaacat
     5761 tatacttgta tccattttcc tctgttcaac aaagagaaag ttcaagttag cttcagtcct
     5821 tcagtgatag gcaacctagg ttttctagag tttaattctt tatcagccag gcaatgactc
     5881 tgaactctga aatgctatat tatttaggac ccaaaagaaa atggatcaat ggccttatct
     5941 gttacacata cacacacaca cacacacaca cacacacaca ttttcacagc atagcttggc
     6001 tttatgctaa tcttggcatg tgcacattcc tcagaggtac caggtattcc cagccatgca
     6061 tctctgtggg aagatagaag aatctcatgc tctgcagtta cataggtagc aagggtttat
     6121 ttttacttgg gcaaatttca gtgataggca ttgagatcat gcattcgacc atttgtcctg
     6181 ttctaattat gaagagcgta ccagaagtct gtatgatatt agtgtcatat ttcattcaaa
     6241 tgccaattaa taaagcaaag ctgactgaag ttgcctcccc tggtgttcca ccatccacag
     6301 tttctgtaac atttacccag tggacatgag cgctgctgaa tttcatataa gggtcttcac
     6361 agaaaataca tgttccttcc ccgtggttcc tgtactcatt ttaacgtgtt gtttattctg
     6421 tttcacgacc tacatacagt tcttgtgcat caggatatat caagctgcct tcatggctat
     6481 agaatgtaat gtaagaaaaa tgttcataaa tatggacaaa aatggtccag attacttagt
     6541 ttaaatagct acattttctt ctgtatctaa aacttcgtta gaagaaagta atagtattat
     6601 ttgcagaaag ccagtcgatc acagccatta ccaataagtt caacctcaaa gtacttcata
     6661 aaaatctgac caatctacta aaatactgca ggcgtgaaag gttctgttgg agctgaatgt
     6721 catgatgttt atcatccagc aagccctcct tctcacatag caacagcatc cacctacaga
     6781 agcagcccct cagtgtagcc acttcaccac cctgtgcacc ctaagtgact tttgattcct
     6841 tgaacctttt acttacttga ggtgaggaaa tgtctgataa tctgcaaaac aaaacctacc
     6901 aaatggaatc aggggcgaca tctcagtcgg tccggctggc attgcgttgc ttgggctacc
     6961 tccgatgaca gaaacgtgct tttactgtag gtaaaaccat aagaaaagaa aataatctca
     7021 attattttca gagctaaagt ttatattgat cttaccaaat caacaccaca catatttatt
     7081 ctaactataa aaagcaataa atgcaaacaa aacaaaaaag ttcatggtaa aatgacggaa
     7141 tcagcatgtg agtaaggatc gctttcctca aaggttaccc tcccaccccc gctatttctc
     7201 atgattcgtc aatatctagg ttaggtattg aaagatcttt ctaagcatct ggtactatga
     7261 tcaggaccat atcctgccca tctttgggcc cttggcacta aaacaagtga atagatccaa
     7321 gtgaataaag taatttctcc attgactttt ttttttaact gctagtcatg tggctgtaac
     7381 tatgggttgc tctttattat tccctgatat gtttattcta tttattctca gtatattaaa
     7441 tctgtttatt atgtacactg tatgtttact ctcaatagta catgagaacg tattggctta
     7501 ccttatacaa taaattagtc cttttgttta ctca
//
