LOCUS       NM_011510               4931 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family C member 8 (Abcc8),
            transcript variant 1, mRNA.
ACCESSION   NM_011510 NM_177891 XM_284300
VERSION     NM_011510.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4931)
  AUTHORS   Ortiz,J.A., Ghazalli,N., Lopez,K., Rawson,J., McCown,E.M., Oh,E.,
            Irimia,J.M., Jou,K., Mares,J., Chen,M.H., Wu,X., Zook,H.N.,
            Quijano,J.C., Erdem,N., Lizarraga,A., Kandeel,F., Fueger,P.T.,
            Thurmond,D.C. and Ku,H.T.
  TITLE     Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is
            Required for the Development of Islets and for beta-Cell Function
            During Aging
  JOURNAL   Diabetes 73 (9), 1447-1461 (2024)
   PUBMED   38905124
REFERENCE   2  (bases 1 to 4931)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4931)
  AUTHORS   Osipovich,A.B., Zhou,F.Y., Chong,J.J., Trinh,L.T., Cottam,M.A.,
            Shrestha,S., Cartailler,J.P. and Magnuson,M.A.
  TITLE     Deletion of Ascl1 in pancreatic beta-cells improves insulin
            secretion, promotes parasympathetic innervation, and attenuates
            dedifferentiation during metabolic stress
  JOURNAL   Mol Metab 78, 101811 (2023)
   PUBMED   37769990
REFERENCE   4  (bases 1 to 4931)
  AUTHORS   Peterson,S.M., Juliana,C.A., Hu,C.F., Chai,J., Holliday,C.,
            Chan,K.Y., Lujan Hernandez,A.G., Challocombe,Z., Wang,L., Han,Z.,
            Haas,N., Stafford,R., Axelrod,F., Yuan,T.Z., De Leon,D.D. and
            Sato,A.K.
  TITLE     Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist
            Antibody for Treatment of Hyperinsulinism
  JOURNAL   Diabetes 72 (9), 1320-1329 (2023)
   PUBMED   37358194
REFERENCE   5  (bases 1 to 4931)
  AUTHORS   Cummings,J., Wu,Y.L., Dixon,C.E., Henchir,J., Simard,J.M.,
            Panigrahy,A., Kochanek,P.M., Jha,R.M. and Aneja,R.K.
  TITLE     Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced
            axonal injury, cytotoxic edema and cognitive dysfunction vs.
            wild-type in a cecal ligation and puncture model of sepsis
  JOURNAL   J Neuroinflammation 20 (1), 12 (2023)
   PUBMED   36681815
  REMARK    GeneRIF: Abcc8 (sulfonylurea receptor-1) knockout mice exhibit
            reduced axonal injury, cytotoxic edema and cognitive dysfunction
            vs. wild-type in a cecal ligation and puncture model of sepsis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4931)
  AUTHORS   Hernandez-Sanchez,C., Wood,T.L. and LeRoith,D.
  TITLE     Developmental and tissue-specific sulfonylurea receptor gene
            expression
  JOURNAL   Endocrinology 138 (2), 705-711 (1997)
   PUBMED   9003005
REFERENCE   7  (bases 1 to 4931)
  AUTHORS   Isomoto,S., Kondo,C., Yamada,M., Matsumoto,S., Higashiguchi,O.,
            Horio,Y., Matsuzawa,Y. and Kurachi,Y.
  TITLE     A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth
            muscle type ATP-sensitive K+ channel
  JOURNAL   J Biol Chem 271 (40), 24321-24324 (1996)
   PUBMED   8798681
REFERENCE   8  (bases 1 to 4931)
  AUTHORS   Chung,W.K., Goldberg-Berman,J., Power-Kehoe,L. and Leibel,R.L.
  TITLE     Molecular mapping of the tubby (tub) mutation on mouse chromosome 7
  JOURNAL   Genomics 32 (2), 210-217 (1996)
   PUBMED   8833147
REFERENCE   9  (bases 1 to 4931)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P. 4th, Namba,N., Inazawa,J.,
            Gonzalez,G., Aguilar-Bryan,L., Seino,S. and Bryan,J.
  TITLE     Reconstitution of IKATP: an inward rectifier subunit plus the
            sulfonylurea receptor
  JOURNAL   Science 270 (5239), 1166-1170 (1995)
   PUBMED   7502040
REFERENCE   10 (bases 1 to 4931)
  AUTHORS   Aguilar-Bryan,L., Nichols,C.G., Wechsler,S.W., Clement,J.P. 4th,
            Boyd,A.E. 3rd, Gonzalez,G., Herrera-Sosa,H., Nguy,K., Bryan,J. and
            Nelson,D.A.
  TITLE     Cloning of the beta cell high-affinity sulfonylurea receptor: a
            regulator of insulin secretion
  JOURNAL   Science 268 (5209), 423-426 (1995)
   PUBMED   7716547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120135.7 and AC115036.10.
            
            On Mar 28, 2022 this sequence version replaced NM_011510.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AC120135.7         62051-62266
            217-358             AC120135.7         63485-63626
            359-480             AC120135.7         66587-66708
            481-647             AC120135.7         72078-72244
            648-890             AC120135.7         74933-75175
            891-1079            AC120135.7         75961-76149
            1080-1244           AC120135.7         84797-84961
            1245-1400           AC120135.7         87496-87651
            1401-1535           AC120135.7         90398-90532
            1536-1698           AC120135.7         91179-91341
            1699-1739           AC120135.7         102563-102603
            1740-1885           AC120135.7         103964-104109
            1886-1991           AC120135.7         105099-105204
            1992-2108           AC120135.7         105344-105460
            2109-2184           AC120135.7         105831-105906
            2185-2290           AC120135.7         106482-106587
            2291-2341           AC120135.7         115251-115301
            2342-2380           AC120135.7         117187-117225
            2381-2479           AC120135.7         118077-118175
            2480-2564           AC120135.7         119126-119210
            2565-2645           AC120135.7         119879-119959
            2646-2783           AC120135.7         121556-121693
            2784-2909           AC120135.7         122987-123112
            2910-3009           AC120135.7         123999-124098
            3010-3251           AC120135.7         124655-124896
            3252-3418           AC120135.7         124996-125162
            3419-3488           AC120135.7         126225-126294
            3489-3646           AC120135.7         126969-127126
            3647-3739           AC120135.7         128911-129003
            3740-3842           AC115036.10        188-290
            3843-3956           AC115036.10        965-1078
            3957-4077           AC115036.10        1396-1516
            4078-4208           AC115036.10        1617-1747
            4209-4287           AC115036.10        2515-2593
            4288-4396           AC115036.10        2771-2879
            4397-4500           AC115036.10        3143-3246
            4501-4634           AC115036.10        3889-4022
            4635-4697           AC115036.10        4305-4367
            4698-4931           AC115036.10        5070-5303
FEATURES             Location/Qualifiers
     source          1..4931
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.66 cM"
     gene            1..4931
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /note="ATP-binding cassette, sub-family C member 8"
                     /db_xref="GeneID:20927"
                     /db_xref="MGI:MGI:1352629"
     exon            1..216
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..4835
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sulfonylurea receptor; ATP-binding cassette, sub-family C
                     (CFTR/MRP), member 8"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 8
                     isoform 1"
                     /protein_id="NP_035640.2"
                     /db_xref="CCDS:CCDS21275.1"
                     /db_xref="GeneID:20927"
                     /db_xref="MGI:MGI:1352629"
                     /translation="MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITF
                     PILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESR
                     HLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKFYDH
                     AIGFSQLRFCLTGLLVILYGMLLLVEINVIRVRRYIFFKTPREVKPPEDLQDLGVRFL
                     QPFVNLLSKGTYWWMNAFIKTAHRKPIDLRAIGKLPIAMRALTNYQRLCAAFDAQARK
                     DTQSQQGARAIWRALCHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVF
                     QPKTQFLGVYFVSSQEFLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQ
                     TKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVI
                     LLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKL
                     LKLYAWENIFCSRVEMTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFF
                     KESDFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQC
                     APREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQRLTPSMDGDADNFCVQII
                     GGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWN
                     SSLPDSEGEDPRYCLRTSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFES
                     PFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNV
                     VFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTI
                     QREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGL
                     LLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGVLLLSLLVFSQLLKH
                     MVLVAIDYWLAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVT
                     SVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTL
                     ECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQL
                     PLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIG
                     ACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKR
                     IHTLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPG
                     QKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPV
                     LFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQ
                     LFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSA
                     DLVMVLKRGAILEFDKPEKLLSQKDSVFASFVRADK"
     exon            217..358
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..480
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..647
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..890
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1079
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1244
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1400
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1535
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1698
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1739
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1885
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1991
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2108
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2184
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2290
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2341
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2380
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2479
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2564
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2645
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2783
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2909
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3009
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3251
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3252..3418
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3488
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..3646
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3739
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3842
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3843..3956
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4077
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4208
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4209..4287
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4396
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4397..4500
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..4634
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4635..4697
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4698..4931
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4908..4913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /note="hexamer: AATAAA"
     polyA_site      4931
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /note="major polyA site"
ORIGIN      
        1 agggtgctgc gaggaacaga ggcgcgggag gcgcgcggag ccagagcaga gcccgtgcgc
       61 gcgccaccat gcccttggcc ttctgcggca ccgagaacca ctcggccgcc taccgggtgg
      121 accaaggtgt cctcaacaac ggctgcttcg tggacgcgct caacgtagtg ccacatgtct
      181 tcctgctctt catcacattc cccatcctct tcatcggatg gggcagccag agctccaagg
      241 tacacattca ccatagcacc tggctccatt tccctggcca caacctgcgc tggatcctta
      301 ccttcatgct gctctttgtc ctggtgtgtg agatcgctga gggtatcctg tctgatgggg
      361 tgacagaatc ccgccacctc catttgtaca tgccagctgg gatggctttc atggctgcca
      421 tcacctctgt ggtctactat cacaacattg agacctctaa cttccccaag ctgctgatcg
      481 ctctgcttat ctactggacc ttggccttca tcactaagac catcaagttc gtcaagttct
      541 acgaccacgc catcggcttc tctcagctgc gcttctgcct cacggggctt ctggtgatcc
      601 tctacgggat gctgctgctg gtggagatca atgtcatccg ggtgcggagg tacatcttct
      661 tcaagacgcc aagggaagtg aagccccctg aggacctgca ggacctgggg gtgcgctttc
      721 tgcagccctt cgtgaatctg ctgtcaaagg ggacctactg gtggatgaat gccttcatca
      781 agactgccca caggaagccc atcgacctgc gggccatcgg gaagctgccc atcgccatga
      841 gagccctcac caactatcag cgactctgcg cggccttcga tgcccaggcg cggaaagaca
      901 cgcagagcca gcagggcgcc cgggccatct ggagggctct ctgccatgcc tttgggagac
      961 gcctggtcct cagcagcaca ttccgtatcc tggctgacct gctgggcttt gctggaccgc
     1021 tctgcatctt tgggatcgtg gaccacctcg ggaaggagaa ccatgtcttc cagcccaaga
     1081 cacagtttct tggggtttac tttgtctcgt cccaagagtt cctgggcaac gcctatgtct
     1141 tggctgtact tctgttcctg gccctcctgc tgcaaaggac gttcctgcaa gcctcgtact
     1201 acgtcgccat tgaaactggg attaacctga gaggggcgat ccagaccaag atttacaata
     1261 agatcatgca cttgtctact tccaacctgt caatggggga gatgacggct gggcagatct
     1321 gcaacctggt ggccatcgac acaaatcagc tcatgtggtt tttcttctta tgcccaaacc
     1381 tctgggctat gccagtacag atcattgtgg gcgtgatcct cctctactac atccttgggg
     1441 tcagtgcctt gattggagca gctgtcatca ttctgctggc tcctgtacag tactttgtgg
     1501 ccaccaagct ctcccaggca cagcggagca ccctggaata ttccaatgaa aggctgaagc
     1561 agaccaacga gatgctccgg ggcatcaaac tgctcaaact gtacgcgtgg gagaacatct
     1621 tctgctcgag ggtggagatg acgcgcagga aggaaatgac cagcctcaga gccttcgctg
     1681 tctacacctc catctccatc ttcatgaaca cagctatccc cattgctgcc gtcctcatta
     1741 cctttgtggg ccacgtcagc ttcttcaaag agtcagactt ctcaccctcg gtggcctttg
     1801 cctctctctc tctcttccac atcctggtca caccgctgtt cctgctgtct agtgtggttc
     1861 ggtccaccgt caaggcccta gtgagtgtgc aaaagctgag tgagttcctg tccagtgcag
     1921 agatccgtga ggaacagtgt gccccccgag agcctgcacc ccaaggccaa gcgggcaagt
     1981 accaggcggt gcccctcaag gttgtgaacc gcaagcgccc agcccgggaa gaggttcggg
     2041 acctcttggg cccactgcag aggctgaccc ccagcatgga tggagatgct gacaacttct
     2101 gtgtccagat catcggaggc ttcttcacct ggacccctga tggaatcccc accctgtcca
     2161 acatcaccat ccgtatcccc cgaggccagc tgaccatgat tgtggggcag gtgggctgcg
     2221 gcaagtcctc gctccttctg gccaccctgg gggagatgca gagggtctcc ggggccgtct
     2281 tctggaacag cagccttcca gacagcgagg gagaagaccc caggtattgc ctcaggacaa
     2341 gcaacccaga gcgggagaca gcagccgact cggatgccag gagcagaggc cccgtagcct
     2401 acgcatctca gaaaccatgg ctgctaaatg ccacggtgga ggagaacatc accttcgaga
     2461 gtcccttcaa taagcaaagg tacaagatgg tcatcgaagc ctgctccctg cagccagaca
     2521 tagacatctt accccatgga gaccagactc agattgggga acggggcatc aacttgtctg
     2581 gtggtcagcg tcagcgaatc agtgtagccc gagccctcta ccagcacacc aatgttgtct
     2641 tcttggatga ccctttctca gctctggatg tccatctgag cgaccacctg atgcaggctg
     2701 gcatccttga gctgctccgg gatgacaaga ggacagtggt cttggtgacc cacaagctac
     2761 agtacctgcc tcatgcagac tggatcattg ctatgaagga tggcaccatt cagagggagg
     2821 ggacgctcaa ggacttccag aggtctgagt gccagctctt tgagcattgg aagaccctca
     2881 tgaacaggca agaccaagag ctggagaagg agacagtcat ggagaggaaa gccccagaac
     2941 cgtctcaggg cctgccccgt gccatgtcct caagagatgg ccttctgctg gatgaggacg
     3001 aggaggaaga ggaggcggcc gagagcgagg aagatgacaa cttatcttcg gtgctgcatc
     3061 agcgagccaa gatcccatgg cgggcctgca ctaagtattt gtcctctgcc ggcgtcctgc
     3121 tcttgtccct gcttgtcttc tcccagctac tcaagcacat ggtcttggtg gccattgatt
     3181 actggctggc caagtggacg gacagtgccc tggtcctgag ccctgctgcc aggaactgct
     3241 ccctcagcca ggaatgcgcc ctggaccagt ctgtctatgc catggtattc accgtgctct
     3301 gcagcctggg aattgcactg tgccttgtca cctctgtcac tgtggagtgg acaggactga
     3361 aggtggccaa gaggctgcac cgcagcctgc tcaatcgcat catcctggcc cccatgaggt
     3421 tctttgagac cacgcccctg gggagtatcc tgaacagatt ttcatctgac tgtaacacca
     3481 ttgaccagca catcccatcc acgctggagt gtctgagccg atccactcta ctctgtgtct
     3541 ccgccttgac tgtcatctcc tacgtcacac ctgtgttcct cgtggccctc ttacccctag
     3601 ctgtggtgtg ctacttcatc cagaaatact tccgagtggc gtccagggac ctgcagcagc
     3661 tggatgacac aacgcagctc cctctgctct cacactttgc tgaaaccgtg gaaggactca
     3721 ccaccatccg tgccttcagg tacgaggccc ggttccagca gaagctcctg gagtacacgg
     3781 actccaacaa catcgcctcc ctcttcctca cggcagccaa caggtggcta gaagtccgca
     3841 tggagtacat tggagcatgc gtggtactca tcgcagccgc cacctccatc tccaactccc
     3901 tgcacaggga gctctctgct ggtctggtgg gcctgggcct cacctacgcc ttgatggtct
     3961 ccaactacct caactggatg gtgaggaacc tggcagacat ggagatccaa ttgggggctg
     4021 tgaagcgcat ccacacactc ctgaaaactg aggcagagag ctatgagggg ctcctagcac
     4081 cgtcattgat ccccaagaac tggccagacc aagggaagat tcaaattcaa aacctgagtg
     4141 tgcgctatga cagctccctg aagcccgtgc tgaagcacgt caatgccctc atcgccccag
     4201 gacagaagat cgggatctgc ggccgcacag gcagtgggaa gtcctccttc tctctcgcct
     4261 ttttccgaat ggtggacatg ttcgaagggc gcatcatcat tgatggcatc gacatcgcca
     4321 agctgccgct gcacacgctc cgttcacgcc tctccatcat cctacaggac cctgtcctct
     4381 tcagcggcac catcagattc aacctggacc cagagaagaa atgctcagac agcacactct
     4441 gggaggctct ggagatcgcc cagctgaagc tggtggtgaa ggcactgcca ggaggcctgg
     4501 atgccatcat cacagaagga ggggagaatt ttagtcaagg tcagaggcag ctgttctgcc
     4561 tggctcgggc cttcgtgaga aagaccagca tcttcatcat ggacgaagca actgcctcca
     4621 ttgacatggc tacggaaaac atcctccaga aggtggtgat gacagccttc gcagaccgca
     4681 ctgtggtcac catcgcgcac cgcgtacaca ccatcctgag tgcagacctc gtgatggtcc
     4741 tgaagagggg agccatcctg gagtttgaca aaccggagaa gcttctgagc cagaaggaca
     4801 gcgtcttcgc ctccttcgtc cgcgcggaca aatgactctg ccagcgccag cgtgccgccc
     4861 cgcacctcac ttgcttgcct agtgtttcgt actgtaaatc acttgtaaat aaagaaatta
     4921 attctttgct a
//
