LOCUS       NP_035640               1588 aa            linear   ROD 12-NOV-2024
DEFINITION  ATP-binding cassette sub-family C member 8 isoform 1 [Mus
            musculus].
ACCESSION   NP_035640 NP_808559 XP_284300
VERSION     NP_035640.2
DBSOURCE    REFSEQ: accession NM_011510.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1588)
  AUTHORS   Ortiz,J.A., Ghazalli,N., Lopez,K., Rawson,J., McCown,E.M., Oh,E.,
            Irimia,J.M., Jou,K., Mares,J., Chen,M.H., Wu,X., Zook,H.N.,
            Quijano,J.C., Erdem,N., Lizarraga,A., Kandeel,F., Fueger,P.T.,
            Thurmond,D.C. and Ku,H.T.
  TITLE     Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is
            Required for the Development of Islets and for beta-Cell Function
            During Aging
  JOURNAL   Diabetes 73 (9), 1447-1461 (2024)
   PUBMED   38905124
REFERENCE   2  (residues 1 to 1588)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 1588)
  AUTHORS   Osipovich,A.B., Zhou,F.Y., Chong,J.J., Trinh,L.T., Cottam,M.A.,
            Shrestha,S., Cartailler,J.P. and Magnuson,M.A.
  TITLE     Deletion of Ascl1 in pancreatic beta-cells improves insulin
            secretion, promotes parasympathetic innervation, and attenuates
            dedifferentiation during metabolic stress
  JOURNAL   Mol Metab 78, 101811 (2023)
   PUBMED   37769990
REFERENCE   4  (residues 1 to 1588)
  AUTHORS   Peterson,S.M., Juliana,C.A., Hu,C.F., Chai,J., Holliday,C.,
            Chan,K.Y., Lujan Hernandez,A.G., Challocombe,Z., Wang,L., Han,Z.,
            Haas,N., Stafford,R., Axelrod,F., Yuan,T.Z., De Leon,D.D. and
            Sato,A.K.
  TITLE     Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist
            Antibody for Treatment of Hyperinsulinism
  JOURNAL   Diabetes 72 (9), 1320-1329 (2023)
   PUBMED   37358194
REFERENCE   5  (residues 1 to 1588)
  AUTHORS   Cummings,J., Wu,Y.L., Dixon,C.E., Henchir,J., Simard,J.M.,
            Panigrahy,A., Kochanek,P.M., Jha,R.M. and Aneja,R.K.
  TITLE     Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced
            axonal injury, cytotoxic edema and cognitive dysfunction vs.
            wild-type in a cecal ligation and puncture model of sepsis
  JOURNAL   J Neuroinflammation 20 (1), 12 (2023)
   PUBMED   36681815
  REMARK    GeneRIF: Abcc8 (sulfonylurea receptor-1) knockout mice exhibit
            reduced axonal injury, cytotoxic edema and cognitive dysfunction
            vs. wild-type in a cecal ligation and puncture model of sepsis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1588)
  AUTHORS   Hernandez-Sanchez,C., Wood,T.L. and LeRoith,D.
  TITLE     Developmental and tissue-specific sulfonylurea receptor gene
            expression
  JOURNAL   Endocrinology 138 (2), 705-711 (1997)
   PUBMED   9003005
REFERENCE   7  (residues 1 to 1588)
  AUTHORS   Isomoto,S., Kondo,C., Yamada,M., Matsumoto,S., Higashiguchi,O.,
            Horio,Y., Matsuzawa,Y. and Kurachi,Y.
  TITLE     A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth
            muscle type ATP-sensitive K+ channel
  JOURNAL   J Biol Chem 271 (40), 24321-24324 (1996)
   PUBMED   8798681
REFERENCE   8  (residues 1 to 1588)
  AUTHORS   Chung,W.K., Goldberg-Berman,J., Power-Kehoe,L. and Leibel,R.L.
  TITLE     Molecular mapping of the tubby (tub) mutation on mouse chromosome 7
  JOURNAL   Genomics 32 (2), 210-217 (1996)
   PUBMED   8833147
REFERENCE   9  (residues 1 to 1588)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P. 4th, Namba,N., Inazawa,J.,
            Gonzalez,G., Aguilar-Bryan,L., Seino,S. and Bryan,J.
  TITLE     Reconstitution of IKATP: an inward rectifier subunit plus the
            sulfonylurea receptor
  JOURNAL   Science 270 (5239), 1166-1170 (1995)
   PUBMED   7502040
REFERENCE   10 (residues 1 to 1588)
  AUTHORS   Aguilar-Bryan,L., Nichols,C.G., Wechsler,S.W., Clement,J.P. 4th,
            Boyd,A.E. 3rd, Gonzalez,G., Herrera-Sosa,H., Nguy,K., Bryan,J. and
            Nelson,D.A.
  TITLE     Cloning of the beta cell high-affinity sulfonylurea receptor: a
            regulator of insulin secretion
  JOURNAL   Science 268 (5209), 423-426 (1995)
   PUBMED   7716547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120135.7 and AC115036.10.
            
            On or before Apr 6, 2005 this sequence version replaced
            NP_808559.1, NP_035640.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1588
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.66 cM"
     Protein         1..1588
                     /product="ATP-binding cassette sub-family C member 8
                     isoform 1"
                     /note="sulfonylurea receptor; ATP-binding cassette,
                     sub-family C (CFTR/MRP), member 8"
                     /calculated_mol_wt=177940
     Region          224..1585
                     /region_name="MRP_assoc_pro"
                     /note="multi drug resistance-associated protein (MRP);
                     TIGR00957"
                     /db_xref="CDD:188098"
     CDS             1..1588
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /coded_by="NM_011510.4:69..4835"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS21275.1"
                     /db_xref="GeneID:20927"
                     /db_xref="MGI:MGI:1352629"
ORIGIN      
        1 mplafcgten hsaayrvdqg vlnngcfvda lnvvphvfll fitfpilfig wgsqsskvhi
       61 hhstwlhfpg hnlrwiltfm llfvlvceia egilsdgvte srhlhlympa gmafmaaits
      121 vvyyhniets nfpklliall iywtlafitk tikfvkfydh aigfsqlrfc ltgllvilyg
      181 mlllveinvi rvrryiffkt prevkppedl qdlgvrflqp fvnllskgty wwmnafikta
      241 hrkpidlrai gklpiamral tnyqrlcaaf daqarkdtqs qqgaraiwra lchafgrrlv
      301 lsstfrilad llgfagplci fgivdhlgke nhvfqpktqf lgvyfvssqe flgnayvlav
      361 llflalllqr tflqasyyva ietginlrga iqtkiynkim hlstsnlsmg emtagqicnl
      421 vaidtnqlmw ffflcpnlwa mpvqiivgvi llyyilgvsa ligaaviill apvqyfvatk
      481 lsqaqrstle ysnerlkqtn emlrgikllk lyawenifcs rvemtrrkem tslrafavyt
      541 sisifmntai piaavlitfv ghvsffkesd fspsvafasl slfhilvtpl fllssvvrst
      601 vkalvsvqkl seflssaeir eeqcaprepa pqgqagkyqa vplkvvnrkr pareevrdll
      661 gplqrltpsm dgdadnfcvq iiggfftwtp dgiptlsnit iriprgqltm ivgqvgcgks
      721 slllatlgem qrvsgavfwn sslpdseged pryclrtsnp eretaadsda rsrgpvayas
      781 qkpwllnatv eenitfespf nkqrykmvie acslqpdidi lphgdqtqig erginlsggq
      841 rqrisvaral yqhtnvvfld dpfsaldvhl sdhlmqagil ellrddkrtv vlvthklqyl
      901 phadwiiamk dgtiqregtl kdfqrsecql fehwktlmnr qdqeleketv merkapepsq
      961 glpramssrd gllldedeee eeaaeseedd nlssvlhqra kipwractky lssagvllls
     1021 llvfsqllkh mvlvaidywl akwtdsalvl spaarncsls qecaldqsvy amvftvlcsl
     1081 gialclvtsv tvewtglkva krlhrsllnr iilapmrffe ttplgsilnr fssdcntidq
     1141 hipstlecls rstllcvsal tvisyvtpvf lvallplavv cyfiqkyfrv asrdlqqldd
     1201 ttqlpllshf aetvegltti rafryearfq qklleytdsn niaslfltaa nrwlevrmey
     1261 igacvvliaa atsisnslhr elsaglvglg ltyalmvsny lnwmvrnlad meiqlgavkr
     1321 ihtllkteae syegllapsl ipknwpdqgk iqiqnlsvry dsslkpvlkh vnaliapgqk
     1381 igicgrtgsg kssfslaffr mvdmfegrii idgidiaklp lhtlrsrlsi ilqdpvlfsg
     1441 tirfnldpek kcsdstlwea leiaqlklvv kalpggldai iteggenfsq gqrqlfclar
     1501 afvrktsifi mdeatasidm atenilqkvv mtafadrtvv tiahrvhtil sadlvmvlkr
     1561 gailefdkpe kllsqkdsvf asfvradk
//
