LOCUS       NM_018795               4958 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family C member 6 (Abcc6),
            mRNA.
ACCESSION   NM_018795
VERSION     NM_018795.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4958)
  AUTHORS   Brampton,C., Pomozi,V., Le Corre,Y., Zoll,J., Kauffenstein,G.,
            Ma,C., Hoffmann,P.R., Martin,L. and Le Saux,O.
  TITLE     Bone Marrow-Derived ABCC6 Is an Essential Regulator of Ectopic
            Calcification In Pseudoxanthoma Elasticum
  JOURNAL   J Invest Dermatol 144 (8), 1772-1783 (2024)
   PUBMED   38367909
  REMARK    GeneRIF: Bone Marrow-Derived ABCC6 Is an Essential Regulator of
            Ectopic Calcification In Pseudoxanthoma Elasticum.
REFERENCE   2  (bases 1 to 4958)
  AUTHORS   Casemayou,A., Belliere,J., Letavernier,E., Colliou,E., El
            Hachem,H., Zarowski,J., Bazin,D., Kounde,C., Piedrafita,A.,
            Feuillet,G., Schanstra,J.P. and Faguer,S.
  TITLE     Abcc6 deficiency prevents rhabdomyolysis-induced acute kidney
            injury
  JOURNAL   Sci Rep 13 (1), 21513 (2023)
   PUBMED   38057332
  REMARK    GeneRIF: Abcc6 deficiency prevents rhabdomyolysis-induced acute
            kidney injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4958)
  AUTHORS   Jacobs,I.J. and Li,Q.
  TITLE     Novel Treatments for PXE: Targeting the Systemic and Local Drivers
            of Ectopic Calcification
  JOURNAL   Int J Mol Sci 24 (20), 15041 (2023)
   PUBMED   37894722
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4958)
  AUTHORS   Plumers,R., Lindenkamp,C., Osterhage,M.R., Knabbe,C. and Hendig,D.
  TITLE     Matrix Metalloproteinases Contribute to the Calcification Phenotype
            in Pseudoxanthoma Elasticum
  JOURNAL   Biomolecules 13 (4), 672 (2023)
   PUBMED   37189419
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4958)
  AUTHORS   Soma,K., Watanabe,K. and Izumi,M.
  TITLE     Anticalcification effects of DS-1211 in pseudoxanthoma elasticum
            mouse models and the role of tissue-nonspecific alkaline
            phosphatase in ABCC6-deficient ectopic calcification
  JOURNAL   Sci Rep 12 (1), 19852 (2022)
   PUBMED   36400944
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4958)
  AUTHORS   Ivandic,B.T., Utz,H.F., Kaczmarek,P.M., Aherrahrou,Z., Axtner,S.B.,
            Klepsch,C., Lusis,A.J. and Katus,H.A.
  TITLE     New Dyscalc loci for myocardial cell necrosis and calcification
            (dystrophic cardiac calcinosis) in mice
  JOURNAL   Physiol Genomics 6 (3), 137-144 (2001)
   PUBMED   11526197
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4958)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   8  (bases 1 to 4958)
  AUTHORS   Brunnert,S.R., Shi,S. and Chang,B.
  TITLE     Chromosomal localization of the loci responsible for dystrophic
            cardiac calcinosis in DBA/2 mice
  JOURNAL   Genomics 59 (1), 105-107 (1999)
   PUBMED   10395807
REFERENCE   9  (bases 1 to 4958)
  AUTHORS   van den Broek,F.A., Bakker,R., den Bieman,M.,
            Fielmich-Bouwman,A.X., Lemmens,A.G., van Lith,H.A., Nissen,I.,
            Ritskes-Hoitinga,J.M., van Tintelen,G. and van Zutphen,L.F.
  TITLE     Genetic analysis of dystrophic cardiac calcification in DBA/2 mice
  JOURNAL   Biochem Biophys Res Commun 253 (2), 204-208 (1998)
   PUBMED   9878516
REFERENCE   10 (bases 1 to 4958)
  AUTHORS   Ivandic,B.T., Qiao,J.H., Machleder,D., Liao,F., Drake,T.A. and
            Lusis,A.J.
  TITLE     A locus on chromosome 7 determines myocardial cell necrosis and
            calcification (dystrophic cardiac calcinosis) in mice
  JOURNAL   Proc Natl Acad Sci U S A 93 (11), 5483-5488 (1996)
   PUBMED   8643601
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC115036.10.
            
            On Apr 13, 2007 this sequence version replaced NM_018795.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the MRP subfamily which is involved in
            multi-drug resistance. The specific function of this protein is
            unknown; however, a similar rat protein has been identified as the
            major canalicular bile salt export pump of liver. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF109741.1, EF109740.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC115036.10        79545-79603
            60-242              AC115036.10        80661-80843
            243-368             AC115036.10        89165-89290
            369-497             AC115036.10        89565-89693
            498-623             AC115036.10        91141-91266
            624-685             AC115036.10        92296-92357
            686-817             AC115036.10        93317-93448
            818-997             AC115036.10        94238-94417
            998-1175            AC115036.10        95585-95762
            1176-1337           AC115036.10        97176-97337
            1338-1430           AC115036.10        100953-101045
            1431-1634           AC115036.10        104191-104394
            1635-1781           AC115036.10        104565-104711
            1782-1869           AC115036.10        107166-107253
            1870-1942           AC115036.10        108761-108833
            1943-2069           AC115036.10        110702-110828
            2070-2246           AC115036.10        111005-111181
            2247-2414           AC115036.10        113009-113176
            2415-2574           AC115036.10        114491-114650
            2575-2650           AC115036.10        117448-117523
            2651-2777           AC115036.10        119417-119543
            2778-2985           AC115036.10        120086-120293
            2986-3296           AC115036.10        123190-123500
            3297-3496           AC115036.10        124571-124770
            3497-3623           AC115036.10        126400-126526
            3624-3725           AC115036.10        127599-127700
            3726-3872           AC115036.10        128717-128863
            3873-4031           AC115036.10        129797-129955
            4032-4198           AC115036.10        130037-130203
            4199-4393           AC115036.10        132393-132587
            4394-4958           AC115036.10        132887-133451
FEATURES             Location/Qualifiers
     source          1..4958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.64 cM"
     gene            1..4958
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /note="ATP-binding cassette, sub-family C member 6"
                     /db_xref="GeneID:27421"
                     /db_xref="MGI:MGI:1351634"
     exon            1..59
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..4502
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /EC_number="7.6.2.3"
                     /note="multidrug resistance-associated protein 6;
                     ATP-binding cassette, sub-family C (CFTR/MRP), member 6"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 6"
                     /protein_id="NP_061265.2"
                     /db_xref="CCDS:CCDS21272.1"
                     /db_xref="GeneID:27421"
                     /db_xref="MGI:MGI:1351634"
                     /translation="MNRGRSMATPGEQCAGLRVWNQTEQEPAAYHLLSLCFVRAASSW
                     VPPMYLWVLGPIYLLYIHRHGRCYLRMSHLFKTKMVLGLALILLYTFNVAVPLWRIHQ
                     GVPQAPELLIHPTVWLTTMSFATFLIHMERRKGVRSSGVLFGYWLLCCILPGINTVQQ
                     ASAGNFRQEPLHHLATYLCLSLVVAELVLSCLVDQPPFFSEDSQPLNPCPEAEASFPS
                     KAMFWWASGLLWRGYKKLLGPKDLWSLGRENSSEELVSQLEREWRRSCNGLPGHKGHS
                     SVGAPETEAFLQPERSQRGPLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPKLLSLFL
                     EFMGDRNSSAWTGWLLAVLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLVYRKVL
                     VLSSGSRKSSAAGDVVNLVSVDIQRLAESIIYLNGLWLLFLWIFVCFVYLWQLLGPSA
                     LTAVAVFLSLLPLNFFITKKRGFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAF
                     LERLLHIRGQELSALKTSTLLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKA
                     FVTLTVLSILNKAQAFLPFSVHCIVQARVSFDRLAAFLCLEEVDPNGMIASNSRRSSK
                     DRISVHNGTFAWSQESPPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVE
                     GSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQKVLDACALGSDVASFPAGV
                     HTPIGEQGMNLSGGQKQRLSLARAVYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSG
                     LLQGTTRILVTHTLHVLPQADRILVLANGTIAEMGSYQDLLQRNGALVGLLDGARQPA
                     GTHDAATSDDLGGFPGGGRPTCRPDRPRPTEAAPVKGRSTSEVQMEASLDDPEATGLT
                     AEEDSVRYGRVKTTIYLSYLRAVGTPLCTYTLFLFLCQQVASFSQGYWLSLWADDPVV
                     DGRQMHAALRGWVFGLLGCLQAIGLFASMAAVFLGGARASGLLFRSLLWDVARSPIGF
                     FERTPVGNLLNRFSKETDTVDVDIPDKLRSLLTYAFGLLEVGLAVTMATPLAIVAILP
                     LMVLYAGFQSLYVATSCQLRRLESARYSSVCSHMAETFQGSLVVRAFRAQASFTAQHD
                     ALMDENQRVSFPKLVADRWLATNLELLGNGLVFVAATCAVLSKAHLSAGLVGFSVSAA
                     LQVTQTLQWVVRSWTDLENSMVAVERVQDYARIPKEAPWRLPTCAAQPLWPCGGQIEF
                     RDFGLRHRPELPLAVQGVSLKIHAGEKVGIVGRTGAGKSSLAWGLLRLQEAAEGNIWI
                     DGVPITHVGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQEHTDEGIWAALETVQLKAF
                     VTSLPGQLQYECAGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTEMQMQ
                     AALERWFTQCTVLLIAHRLRSVMDCARVLVMDEGQVAESGSPAQLLAQKGLFYRLAHE
                     SGLA"
     exon            60..242
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            243..368
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            369..497
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            498..623
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            624..685
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            686..817
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            818..997
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1175
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1337
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1430
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1634
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1781
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1869
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1942
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2069
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2246
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2414
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2574
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2650
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2777
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2985
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3296
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3496
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3623
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3725
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3726..3872
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..4031
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4032..4198
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4199..4393
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..4958
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4845..4850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /note="hexamer: AAGAAA"
     polyA_site      4871
                     /gene="Abcc6"
                     /gene_synonym="Abcc1b; DCC; dyscalc; Dyscalc1; Mrp6"
                     /note="major polyA site"
ORIGIN      
        1 gactgatgaa cagagggcgc tccatggcca cgcctggaga gcagtgcgcc ggcctgaggg
       61 tctggaacca gacagagcag gagcctgcgg cctatcactt gctcagcctg tgctttgtga
      121 gagccgccag cagctgggtg ccccccatgt acctctgggt cctcggcccc atctaccttc
      181 tctacatcca tcgccatggc cggtgctacc tccggatgtc ccacctcttc aaaaccaaaa
      241 tggtgctggg cttggccctc atccttctgt ataccttcaa cgtggccgtg cctctgtgga
      301 ggatccacca gggcgtgccc caggccccag agcttctaat tcaccctact gtgtggctca
      361 ccaccatgag ctttgccacc tttctgatcc acatggagag aaggaaggga gtccggtcat
      421 ccggggtgtt gttcgggtac tggctgctct gctgcatctt gccaggaatc aacactgtgc
      481 agcaggcctc tgcagggaac ttccgtcagg agcccctcca ccacctggcc acctacctgt
      541 gcttgtccct ggtggtggct gagctggtgc tgtcctgtct ggtggaccag ccacccttct
      601 tctcggaaga ctcccagcca ttgaatccgt gtccagaggc tgaggcctcc tttccctcca
      661 aggccatgtt ctggtgggcc tctggactgc tatggagggg ctacaaaaag ctgctgggac
      721 caaaagacct ctggtcactt gggagagaaa actcttcaga agaactcgtt tcccagctgg
      781 aaagagaatg gaggagaagc tgcaatgggc tgccagggca caaagggcac agtagtgtgg
      841 gggcccctga gacagaggcc ttcctgcagc cagagaggag tcagaggggc ccactactca
      901 gggctatctg gcgcgtgttc cggtccacct tcctgctggg gaccctcagc ctggtcatta
      961 gcgatgcctt caggtttgct gttcccaagc tcctcagtct gtttctggag ttcatgggtg
     1021 accgcaactc ctcggcgtgg acaggctggc tcctagctgt gctgatgttc gcggcagcct
     1081 gcctacagac gttgtttgaa cagcagcaca tgtacagagc caaggtcctg cagatgaggc
     1141 tgcgaacagc catcactggc ctggtgtaca gaaaggtcct ggtcctgtcc agtggttcca
     1201 gaaagtccag cgcagcaggg gacgtggtca acctggtgtc ggtggacatc cagcggctgg
     1261 ccgagagcat catctacctc aacgggctgt ggctgctctt cctgtggatc tttgtgtgct
     1321 ttgtctacct gtggcagctc cttggaccct ctgctctcac agccgttgct gtcttcctga
     1381 gcctcctccc tctgaacttc ttcatcacca agaagagggg cttccatcag gaagaacaga
     1441 tgaggcagaa ggcctccaga gcacggctca ccagctccat gctcagaact gtgagaacca
     1501 tcaagtccca cggctgggag catgccttcc tggagcgact ccttcacatc cggggccagg
     1561 agctcagcgc cctgaagacc tccaccctcc tcttctctgt gtctctcgtg tccttccaag
     1621 tgtctacatt tctggtggcg ctggtcgtgt ttgctgtcca caccctggtg gcagaggaca
     1681 atgccatgga tgcagagaag gcctttgtga cgctcacagt gctcagcatc cttaacaaag
     1741 cccaggcctt cctccccttc tctgtgcact gcatcgttca ggctcgagtg tcctttgacc
     1801 ggctggctgc cttcctgtgc ctggaagaag tagaccccaa tggcatgatc gcgagtaact
     1861 ccaggcgctc ctcgaaggat cgaatttctg tacacaatgg caccttcgct tggtcccagg
     1921 agagcccacc ctgcctgcac gggatcaacc tcaccgtgcc ccagggctgt ctgctggctg
     1981 ttgtgggtcc agtgggggct gggaagtcct ccctgctgtc tgccctgctt ggggagctgt
     2041 tgaaggtaga agggtctgtg agcattgagg gttccgtggc ttacgtgcct caggaggcct
     2101 gggtccagaa tacctctgtg gtggagaatg tgtgcttcag gcaagagctg gacctgccct
     2161 ggttgcagaa agttctagat gcctgtgcct tggggtctga tgtggccagc ttccctgcag
     2221 gagttcacac cccaataggg gagcagggca tgaatctttc tgggggccag aagcagcggc
     2281 tgagcttggc tcgggctgtg tacaaaaagg ctgccatcta cttgctggat gaccccctgg
     2341 cagcgctgga tgcccacgtc agccagcagg tcttcaaaca ggtcatcggg cccagtggat
     2401 tgctccaggg tacgactcgg atccttgtaa cacacacgct gcacgtcctg ccccaggctg
     2461 accggatcct ggtgctggcc aatgggacca tcgcagagat gggctcctac caggaccttc
     2521 tgcaaaggaa cggagccctg gtgggtcttc tggatggagc cagacagcct gcaggaacac
     2581 acgatgcagc taccagtgac gacctcggag gctttcctgg aggtgggagg cccacatgca
     2641 gaccagacag gcccaggccc acggaggcag cccctgtgaa gggcaggagc acatctgagg
     2701 tacagatgga ggcttctctg gatgaccctg aggccacagg attgacagca gaagaggata
     2761 gtgtgcgata tggccgggtg aagaccacca tatacctgag ctacctgcgg gcggtgggca
     2821 cacccctctg tacctacacc ctgttcctct tcctctgcca gcaagtggca tccttctccc
     2881 aaggctactg gctgagcctt tgggccgatg acccggttgt ggatgggcgg cagatgcatg
     2941 cagccctgcg tggctgggtc tttgggctcc ttggctgtct gcaagccatc ggactgtttg
     3001 cctccatggc tgcggtgttc ctgggtggag cccgggcctc aggcctcctt ttccggagtc
     3061 tcctgtggga cgtggctcgc tctcccatcg gcttctttga gcgcacgcca gtcgggaacc
     3121 tgctgaaccg cttttccaag gagacagaca cagtggatgt ggacatcccg gacaagctga
     3181 ggtcccttct gacctacgcc tttgggctcc tggaggtcgg cctggcagtg acgatggcca
     3241 cgcctctggc cattgtggcc atcctacctc tcatggtcct ctatgctggg tttcagagcc
     3301 tctatgtggc cacatcttgc cagctgagac gtctagagtc ggcccgctac tcatctgtgt
     3361 gttcccatat ggctgagacc ttccagggaa gtctggtggt cagggccttc cgggcccagg
     3421 catccttcac ggctcagcac gatgctctca tggatgagaa ccagagggtc agtttcccga
     3481 aactggtggc tgacaggtgg ctggctacta acctggagct tctagggaat ggcttggtat
     3541 tcgtggctgc tacatgtgct gtgctgagca aggctcacct aagtgctggc ctcgtgggct
     3601 tctcggtctc cgctgccctc caggtgacac agactctgca gtgggtggtc cgcagctgga
     3661 cagatctgga gaacagcatg gtagccgtgg agcgcgtgca ggactacgct cgcatcccca
     3721 aagaggctcc ctggaggctg cccacctgcg cagcccagcc tctctggcct tgtgggggac
     3781 agattgagtt ccgggacttt gggctcagac accgaccaga gctgcccttg gctgtgcagg
     3841 gagtgtccct gaagatccat gcaggagaga aggtgggcat cgtgggcaga acaggggccg
     3901 ggaagtcctc cctggcttgg ggcctgctgc ggcttcagga ggctgccgag ggtaatatct
     3961 ggatcgatgg ggtccctatc acccatgtgg ggctgcacac actgaggtcc cgaatcacca
     4021 tcatccctca ggaccctgtc ctgttcccag gctctctgcg gatgaacctg gacctgcttc
     4081 aggagcacac agatgaaggc atctgggcag cgctggagac agtgcagctc aaggccttcg
     4141 tgaccagcct gcctggccag ctgcaatatg agtgtgcagg ccagggagat gacctgagcg
     4201 tgggtcagaa acagctcctg tgcctggcac gagcccttct ccggaaaacc cagatcctca
     4261 tcctggacga ggcgactgcc tctgtggacc cagggacgga gatgcagatg caggcggccc
     4321 tggagcgctg gtttacacag tgtaccgtac tgcttatcgc tcaccgcctg cgctccgtga
     4381 tggactgtgc cagagtccta gtcatggatg aggggcaggt ggcagaaagt ggcagtcctg
     4441 ctcagctgct ggcccagaaa ggcctgtttt acaggctagc ccatgagtcg ggcctcgctt
     4501 gaataaggat tcttaccaac ccccgtggag ccagccatag agcctgcagt ggctggagat
     4561 gccagagact ccaatctaaa ctcctctttg ggagggagat ggcagagaaa gtgatggagt
     4621 attgggatac cagacccaga agaacccagc acgcccaggt tggcctgagc aaggccatgc
     4681 ccaccccagg ccaaagagaa tggtaactct cagcccaagc tgtctacttc aaggccacgc
     4741 ccactccagg ccaatcagat tggatgccct ggacccaggt gatggtgtgc acatattccc
     4801 taactcctta ttttgaagtc attgtagatt tcagtcacag ttttaagaaa taacacggag
     4861 agaaactgtg acccctctgc cctgtttatt ccaagggtga caccttgtcc aactctagag
     4921 catcacaccg actctgaccg actcgtcttt acaactcc
//
