LOCUS       NM_001163675            5711 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ATP-binding cassette, sub-family C member 4 (Abcc4),
            transcript variant 2, mRNA.
ACCESSION   NM_001163675
VERSION     NM_001163675.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5711)
  AUTHORS   Ranjit,S., Wang,Y., Zhu,J., Cheepala,S.B., Schuetz,E.G., Cho,W.J.,
            Xu,B., Robinson,C.G., Wu,G., Naren,A.P. and Schuetz,J.D.
  TITLE     ABCC4 impacts megakaryopoiesis and protects megakaryocytes against
            6-mercaptopurine induced cytotoxicity
  JOURNAL   Drug Resist Updat 72, 101017 (2024)
   PUBMED   37988981
  REMARK    GeneRIF: ABCC4 impacts megakaryopoiesis and protects megakaryocytes
            against 6-mercaptopurine induced cytotoxicity.
REFERENCE   2  (bases 1 to 5711)
  AUTHORS   Yerushalmi,G.M., Shuraki,B., Yung,Y., Maman,E., Baum,M.,
            Hennebold,J.D., Adashi,E.Y. and Hourvitz,A.
  TITLE     ABCC4 is a PGE2 efflux transporter in the ovarian follicle: A
            mediator of ovulation and a potential non-hormonal contraceptive
            target
  JOURNAL   FASEB J 37 (4), e22858 (2023)
   PUBMED   36943419
  REMARK    GeneRIF: ABCC4 is a PGE2 efflux transporter in the ovarian
            follicle: A mediator of ovulation and a potential non-hormonal
            contraceptive target.
REFERENCE   3  (bases 1 to 5711)
  AUTHORS   Belleville-Rolland,T., Leuci,A., Mansour,A., Decouture,B.,
            Martin,F., Poirault-Chassac,S., Rouaud,M., Guerineau,H., Dizier,B.,
            Pidard,D., Gaussem,P. and Bachelot-Loza,C.
  TITLE     Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation
            of the cAMP Pathway in Blood Platelets
  JOURNAL   Thromb Haemost 121 (12), 1628-1636 (2021)
   PUBMED   33851387
  REMARK    GeneRIF: Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent
            Regulation of the cAMP Pathway in Blood Platelets.
REFERENCE   4  (bases 1 to 5711)
  AUTHORS   Donepudi,A.C., Lee,Y., Lee,J.Y., Schuetz,J.D. and Manautou,J.E.
  TITLE     Multidrug resistance-associated protein 4 (Mrp4) is a novel genetic
            factor in the pathogenesis of obesity and diabetes
  JOURNAL   FASEB J 35 (2), e21304 (2021)
   PUBMED   33417247
REFERENCE   5  (bases 1 to 5711)
  AUTHORS   Chatterjee,S., Mukherjee,S., Sankara Sivaprasad,L.V.J., Naik,T.,
            Gautam,S.S., Murali,B.V., Hadambar,A.A., Gunti,G.R.,
            Kuchibhotla,V., Deyati,A., Basavanthappa,S., Ramarao,M.,
            Mariappan,T.T., Zinker,B.A., Zhang,Y., Sinz,M. and Shen,H.
  TITLE     Transporter Activity Changes in Nonalcoholic Steatohepatitis:
            Assessment with Plasma Coproporphyrin I and III
  JOURNAL   J Pharmacol Exp Ther 376 (1), 29-39 (2021)
   PUBMED   33127749
  REMARK    GeneRIF: Transporter Activity Changes in Nonalcoholic
            Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
REFERENCE   6  (bases 1 to 5711)
  AUTHORS   Assem,M., Schuetz,E.G., Leggas,M., Sun,D., Yasuda,K., Reid,G.,
            Zelcer,N., Adachi,M., Strom,S., Evans,R.M., Moore,D.D., Borst,P.
            and Schuetz,J.D.
  TITLE     Interactions between hepatic Mrp4 and Sult2a as revealed by the
            constitutive androstane receptor and Mrp4 knockout mice
  JOURNAL   J Biol Chem 279 (21), 22250-22257 (2004)
   PUBMED   15004017
  REMARK    GeneRIF: and Sult2a1 participate in an integrated pathway mediating
            elimination of sulfated steroid and bile acid metabolites from the
            liver
REFERENCE   7  (bases 1 to 5711)
  AUTHORS   Rius,M., Nies,A.T., Hummel-Eisenbeiss,J., Jedlitschky,G. and
            Keppler,D.
  TITLE     Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4)
            localized to the basolateral hepatocyte membrane
  JOURNAL   Hepatology 38 (2), 374-384 (2003)
   PUBMED   12883481
  REMARK    GeneRIF: abcc4 can mediate the efflux of reduced glutathione from
            hepatocytes into blood by cotransport with monoanionic bile salts.
REFERENCE   8  (bases 1 to 5711)
  AUTHORS   Lamba,J.K., Adachi,M., Sun,D., Tammur,J., Schuetz,E.G.,
            Allikmets,R. and Schuetz,J.D.
  TITLE     Nonsense mediated decay downregulates conserved alternatively
            spliced ABCC4 transcripts bearing nonsense codons
  JOURNAL   Hum Mol Genet 12 (2), 99-109 (2003)
   PUBMED   12499391
REFERENCE   9  (bases 1 to 5711)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5711)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052778.1, AC167668.1, AC154419.2, AK032802.1 and AK157723.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) has a shorter N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052778.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AK052778.1         2-26
            26-26               AC167668.1         70234-70234         c
            27-559              AK052778.1         28-560
            560-560             AC154419.2         10828-10828
            561-755             AK052778.1         562-756
            756-756             AC154419.2         33941-33941
            757-2935            AK052778.1         758-2936
            2936-3986           AK052778.1         2938-3988
            3987-5626           AK032802.1         1568-3207
            5627-5711           AK157723.1         5632-5716
FEATURES             Location/Qualifiers
     source          1..5711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 62.24 cM"
     gene            1..5711
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /note="ATP-binding cassette, sub-family C member 4"
                     /db_xref="GeneID:239273"
                     /db_xref="MGI:MGI:2443111"
     exon            1..166
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            167..277
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..4070
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     multidrug resistance-associated protein 4; ATP-binding
                     cassette, sub-family C (CFTR/MRP), member 4"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 4
                     isoform 2"
                     /protein_id="NP_001157147.1"
                     /db_xref="GeneID:239273"
                     /db_xref="MGI:MGI:2443111"
                     /translation="MFSVLPEDRSKHLGEELQRYWDKELLRAKKDSRKPSLTKAIIKC
                     YWKSYLILGIFTLIEEGTRVVQPLFLGKIIEYFEKYDPDDSVALHTAYGYAAVLSMCT
                     LILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVN
                     KFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLFSSL
                     RSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYLRGM
                     NMASFFIANKVILFVTFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGS
                     EAIVSIRRIKNFLLLDELPQRKAHVPSDGKAIVHVQDFTAFWDKALDSPTLQGLSFIA
                     RPGELLAVVGPVGAGKSSLLSAVLGELPPASGLVSVHGRIAYVSQQPWVFSGTVRSNI
                     LFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQ
                     DADIYLLDDPLSAVDAEVGKHLFQLCICQALHEKITILVTHQLQYLKAASHILILKDG
                     EMVQKGTYTEFLKSGVDFGSLLKKENEEAEPSTAPGTPTLRKRTFSEASIWSQQSSRP
                     SLKDGAPEGQDAENTQAVQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNMVGQ
                     VFYVLQDWWLSHWANKQGALNNTRNANGNITETLDLSWYLGIYAGLTAVTVLFGIARS
                     LLVFYILVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTFL
                     DFIQTLLLVVSVIAVAAAVIPWILIPLVPLSVVFLVLRRYFLETSRDVKRLESTTRSP
                     VFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICA
                     IFVIVVAFGSLVLAKTLNAGQVGLALSYALTLMGMFQWSVRQSAEVENMMISVERVIE
                     YTDLEKEAPWECKKRPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGI
                     VGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTM
                     RKNLDPFNEHTDEELWRALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLAR
                     AILKNNRILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVL
                     DSGRLKEYDEPYVLLQNPESLFYKMVQQLGKGEAAALTETAKQVYFRRNYPDITFTSP
                     AVMNTSNGQPSALTIFETAL"
     exon            278..398
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            399..623
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            624..713
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            714..877
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1003
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1253
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1355
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1445
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1637
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1732
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1819
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1916
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2126
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2267
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2305
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2400
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2547
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2627
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2778
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2898
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3009
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3110
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3302
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3458
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3548
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3721
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3827
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..3962
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3963..5711
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5266..5271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /note="hexamer: AATAAA"
     polyA_site      5285
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /note="major polyA site"
     regulatory      5610..5615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /note="hexamer: ATTAAA"
     polyA_site      5631
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
ORIGIN      
        1 atcattaggc ggttgtccga gcttaagagt ctacagcatt ctgaagtcag ctgtggaggc
       61 ttcgagacac acacacacac acacacacac acacacacac acacacacac acactcacac
      121 gtcaacactg gccacctgtg gtaggagaca gactgctctg gaggtggtgg ctcaacccgc
      181 tgtttaaaac tggtcataag cggagactgg aagaagatga catgttctca gtgcttccag
      241 aagatcgctc aaagcacctc ggagaggagc ttcaacggta ctgggataaa gaacttctgc
      301 gagccaagaa ggactcgagg aagccctcct taacaaaggc aatcataaag tgttactgga
      361 agtcttacct gattttggga atttttacgt taattgagga gggcactcga gtagttcagc
      421 ccttattttt agggaaaatt attgaatatt ttgagaagta tgaccccgac gactcggtgg
      481 ctttgcatac agcttatggc tacgcagcag tgctgtccat gtgcacgctc atcctggcca
      541 tactacatca tttgtacttc taccacgtgc agtgcgccgg gatgaggctg cgggttgcca
      601 tgtgccacat gatttaccgg aaggcactcc ggttaagtaa ctcggccatg gggaagacaa
      661 ccacaggcca gatagttaac ctgctgtcca acgacgtgaa caaattcgac caagtgacaa
      721 tcttcttgca ctttctgtgg gcagggccgc tgcaggccat cgcggtaacc gtcctcctct
      781 gggtggagat aggaatctcc tgcctggcgg gcttggccgt tctggttatt cttctgcctc
      841 tgcaaagctg catcgggaag ctgttctcgt cactgcggag taaaactgcg gctttcacgg
      901 atgccaggat ccggaccatg aatgaagtca taacaggcat gaggataata aagatgtatg
      961 cgtgggagaa atcgtttgct gacctcattg ccaatctgag aaagaaggag atttccaaga
     1021 ttctgggcag ctcctacctc agagggatga acatggcgtc gtttttcatc gcaaacaaag
     1081 tcatcctgtt cgtgaccttc actagctacg tgctgcttgg caatgagatt acagctagcc
     1141 acgtgtttgt ggccatgact ctgtacggtg ccgttcggtt gacagtcacc ctcttcttcc
     1201 cgtcagccat tgagagaggg tcagaggcca tcgtcagcat tcggaggatc aagaactttc
     1261 tgttactcga tgaactacca cagcgcaaag cccatgtacc atctgatggc aaagccattg
     1321 tccacgtgca agatttcacc gctttctggg acaaggcact agacagtcca accctgcaag
     1381 gtctttcctt tattgccagg cctggtgagt tgttagccgt ggttggccca gttggagcag
     1441 gcaagtcgtc gctgttgagc gcagtgctgg gtgagctgcc tcctgccagc gggctggtca
     1501 gcgtgcacgg gaggatcgcc tacgtttctc agcagccctg ggtgttctcg ggcaccgtga
     1561 ggagcaatat tttatttggg aagaaatatg agaaggagcg atatgagaaa gtgatcaagg
     1621 cctgtgctct gaagaaggac ctgcagcttc tggaggacgg ggatctgacg gttataggag
     1681 accggggagc cacgctgagt ggaggccaga aagctcgggt gaacctggca cgggccgtct
     1741 accaggacgc cgacatctac ctccttgatg atccgctcag cgctgtcgat gcagaagtgg
     1801 gcaagcacct gttccaactg tgtatctgtc aggcgttgca cgagaagatc accattttag
     1861 tgactcacca gttacagtac ctcaaagctg caagccacat cctcatactc aaagatggtg
     1921 agatggtgca gaaggggact tacacggagt ttctgaaatc tggtgtagat tttggctccc
     1981 tgttaaagaa agaaaacgag gaagcagagc cctccacagc cccaggaacc ccgacactca
     2041 ggaaacgaac cttctccgag gcctcaattt ggtctcagca gtcatccaga ccctcgttga
     2101 aagacggggc cccagagggc caagacgcag agaacacgca ggcagtgcaa cccgaggaga
     2161 gccgttcgga agggagaatc ggcttcaagg cctacaagaa ttacttctcg gcgggcgcat
     2221 cctggttctt catcattttc cttgtgctgc ttaacatggt gggccaggtt ttctatgttc
     2281 ttcaggactg gtggctttcc cactgggcga acaagcaagg tgcactgaac aacaccagaa
     2341 atgcgaatgg aaatataacg gagaccctag acctcagctg gtacttagga atttacgcag
     2401 gtctaactgc ggtcaccgtc ctttttggca tagcgagatc cctactggtg ttctatatcc
     2461 ttgtgaacgc ttcccagact ttgcacaaca ggatgtttga gtccatactg aaggctcccg
     2521 tgttgttctt cgacagaaat ccaatcggga ggattttaaa tcgtttctcc aaagacatcg
     2581 gacacatgga tgatttgctt cccctgacgt tcctggactt catccagacg ttgctcctcg
     2641 tcgtaagtgt gatcgctgtg gccgcggccg tgatcccttg gatcctcata ccattggttc
     2701 cgctctcagt cgtcttcctg gttcttcgga gatacttctt agagacgtca cgggatgtca
     2761 agcgcctgga atccacaaca cggagcccgg tattctccca tttatcgtcc tccctccagg
     2821 gactctggac catccgggct tacaaagctg aggagaggtg tcaggagctg tttgatgcac
     2881 accaggactt gcattcagag gcttggttct tgttcctgac gacatcgaga tggttcgctg
     2941 tgcgtctgga cgccatctgc gccatctttg taatcgtcgt tgccttcggg tcccttgttc
     3001 tggcgaagac tttgaatgct gggcaggttg gcctggcctt gtcctacgcc ctcacactca
     3061 tggggatgtt ccagtggtct gtgcgacaga gcgccgaagt agagaatatg atgatttcag
     3121 tggagagagt gattgagtac acggacctag agaaggaggc gccttgggag tgcaagaagc
     3181 gcccaccccc aggctggccc cacgagggag tcatcgtctt cgacaatgtg aacttcacct
     3241 acagcttaga tgggcctctg gttctgaagc acctgactgc gctcatcaag tccagggaaa
     3301 aggttggaat tgtgggcaga accggagctg ggaaaagctc cctcatctcg gccctcttca
     3361 ggctgtcaga acccgagggg aaaatctgga tcgataagat cttgacaacc gaaattgggc
     3421 ttcacgactt aaggaagaaa atgtcaatca taccacagga acctgttctg ttcactggaa
     3481 ccatgaggaa aaacctggac cccttcaatg agcacacgga cgaggagctg tggagggcct
     3541 tggaggaggt acaacttaaa gaggccattg aagatcttcc tggaaaaatg gatactgaat
     3601 tagcagaatc tggatccaat ttcagtgttg gacagagaca gttagtgtgc cttgcaaggg
     3661 ccattctaaa gaataaccga atactgatca ttgatgaagc aactgcaaat gtggacccaa
     3721 gaacggatga gttaatacaa cagaagatcc gggagaagtt tgcccagtgc acagtgctca
     3781 ccattgctca cagactgaac accatcattg acagtgacaa gataatggtt ttggattcag
     3841 gaagactgaa agaatatgat gagccgtatg tcttgctgca gaatccagag agcctctttt
     3901 acaagatggt tcagcaactg ggcaagggcg aagccgctgc cctcaccgaa acagcaaaac
     3961 aggtatactt cagacggaat tacccagata ttacattcac cagccccgcg gttatgaaca
     4021 cctccaatgg acagccctcg gccttaacaa tatttgaaac agcattgtga ccaccaggac
     4081 atcatcgtaa agtctgtctt gaaggtgttc cccaccccgc ccaggggctt gcacttggag
     4141 gactacagca cacctggttt cctttctttc tgccacagat ccttcacaga cgagagactg
     4201 ttgtctttgg atttttccct ccgactttac tctgtgattt caggttctaa caacatggcc
     4261 tgtcgtttta ttttaaaagt tcctgctgtt ctttacaaat ccagttctga ggtgcaggcc
     4321 accaacagca gcgtctacca ggttttgtgc cttaacagtc tcaagggctg aagcccattc
     4381 attttataag ctgtcaccat gggctgctgc ttcctcttgc cttaaaagta cactctccag
     4441 gtgtgtcagg gactctgttt acttgaagac tgtgtgcagt tgccagttcg tctccctgct
     4501 gtctttgagc taggactcat aatttcccta caaaggtctc tggttaaaat agaataggta
     4561 gaattaacaa gaaccacaac aacaaccccc ccaaaaaata atccatataa tttaagtata
     4621 ttgctggaga gagactatcc caccacctat acatctacaa agatatatgt ctaaagttgg
     4681 aaaatcaact tctgctttct cagaatggga gaccgagcgc aggttaggca cccctccccc
     4741 ttgcatctgt gagtccctct gggcggctcg tgtactgatc ggatctgtga gtccctctgg
     4801 gcggctcgtg tactgatcgg atcggcacca tgacacttcc cctagactgt gactcccaaa
     4861 tgcataatat taatctcatt tggcttctgg tttacagaag gtaaagctcc tattggctgt
     4921 gagccgttgg tgaaatcctt tcacatcgac accaaaagct ctccccagct agtgaaaacc
     4981 tgaacatcgt tagagtcacc gactttacat gctcagaatg ctgtgcacaa gccacgcttt
     5041 ctaaagccca tccagattag tttagctctg accactaatg gcaggtctta aggaccttgt
     5101 gattagtcaa tcaacaaacc acaacacttc ctaggacctg ttgtactccg tgtaactata
     5161 ggtctgaata ttttctgggt ggtggtggca agggtctatg tcagggttca agttactaaa
     5221 ggttttactg tcataattta aaggggactc ttcacgaccc gtcacaataa accattctca
     5281 agttatctat gtgtgtgtgt atatatatct caggttttta gactggttga cagaacaaag
     5341 cctgttttaa cagtggaacc ttaaagagca cacctacacc aaaccaccaa aaccacgccg
     5401 agcacagtga ctgtttgact cttggtattc agaagtctgt aatgaatgta attatgttta
     5461 ggccagtaaa tgatgtagat tcgtccttta ttggtagtcg cagttgatat ttcaagagag
     5521 tgagatgcca tgctgacaat attaagatct atttgaatat ttagaaatgt cttactgtat
     5581 atatgtttat gtttatttgg tccttagaga ttaaaagcgg tcatacaagt atgttcctat
     5641 ttcatttcta tttttcacac catcacagga caaaccaaag tcaactgaaa taaatgacag
     5701 tttccatccc c
//
