LOCUS       NM_001033336            5729 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ATP-binding cassette, sub-family C member 4 (Abcc4),
            transcript variant 1, mRNA.
ACCESSION   NM_001033336 XM_887318 XM_908208
VERSION     NM_001033336.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5729)
  AUTHORS   Ranjit,S., Wang,Y., Zhu,J., Cheepala,S.B., Schuetz,E.G., Cho,W.J.,
            Xu,B., Robinson,C.G., Wu,G., Naren,A.P. and Schuetz,J.D.
  TITLE     ABCC4 impacts megakaryopoiesis and protects megakaryocytes against
            6-mercaptopurine induced cytotoxicity
  JOURNAL   Drug Resist Updat 72, 101017 (2024)
   PUBMED   37988981
  REMARK    GeneRIF: ABCC4 impacts megakaryopoiesis and protects megakaryocytes
            against 6-mercaptopurine induced cytotoxicity.
REFERENCE   2  (bases 1 to 5729)
  AUTHORS   Yerushalmi,G.M., Shuraki,B., Yung,Y., Maman,E., Baum,M.,
            Hennebold,J.D., Adashi,E.Y. and Hourvitz,A.
  TITLE     ABCC4 is a PGE2 efflux transporter in the ovarian follicle: A
            mediator of ovulation and a potential non-hormonal contraceptive
            target
  JOURNAL   FASEB J 37 (4), e22858 (2023)
   PUBMED   36943419
  REMARK    GeneRIF: ABCC4 is a PGE2 efflux transporter in the ovarian
            follicle: A mediator of ovulation and a potential non-hormonal
            contraceptive target.
REFERENCE   3  (bases 1 to 5729)
  AUTHORS   Belleville-Rolland,T., Leuci,A., Mansour,A., Decouture,B.,
            Martin,F., Poirault-Chassac,S., Rouaud,M., Guerineau,H., Dizier,B.,
            Pidard,D., Gaussem,P. and Bachelot-Loza,C.
  TITLE     Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation
            of the cAMP Pathway in Blood Platelets
  JOURNAL   Thromb Haemost 121 (12), 1628-1636 (2021)
   PUBMED   33851387
  REMARK    GeneRIF: Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent
            Regulation of the cAMP Pathway in Blood Platelets.
REFERENCE   4  (bases 1 to 5729)
  AUTHORS   Donepudi,A.C., Lee,Y., Lee,J.Y., Schuetz,J.D. and Manautou,J.E.
  TITLE     Multidrug resistance-associated protein 4 (Mrp4) is a novel genetic
            factor in the pathogenesis of obesity and diabetes
  JOURNAL   FASEB J 35 (2), e21304 (2021)
   PUBMED   33417247
REFERENCE   5  (bases 1 to 5729)
  AUTHORS   Chatterjee,S., Mukherjee,S., Sankara Sivaprasad,L.V.J., Naik,T.,
            Gautam,S.S., Murali,B.V., Hadambar,A.A., Gunti,G.R.,
            Kuchibhotla,V., Deyati,A., Basavanthappa,S., Ramarao,M.,
            Mariappan,T.T., Zinker,B.A., Zhang,Y., Sinz,M. and Shen,H.
  TITLE     Transporter Activity Changes in Nonalcoholic Steatohepatitis:
            Assessment with Plasma Coproporphyrin I and III
  JOURNAL   J Pharmacol Exp Ther 376 (1), 29-39 (2021)
   PUBMED   33127749
  REMARK    GeneRIF: Transporter Activity Changes in Nonalcoholic
            Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
REFERENCE   6  (bases 1 to 5729)
  AUTHORS   Assem,M., Schuetz,E.G., Leggas,M., Sun,D., Yasuda,K., Reid,G.,
            Zelcer,N., Adachi,M., Strom,S., Evans,R.M., Moore,D.D., Borst,P.
            and Schuetz,J.D.
  TITLE     Interactions between hepatic Mrp4 and Sult2a as revealed by the
            constitutive androstane receptor and Mrp4 knockout mice
  JOURNAL   J Biol Chem 279 (21), 22250-22257 (2004)
   PUBMED   15004017
  REMARK    GeneRIF: and Sult2a1 participate in an integrated pathway mediating
            elimination of sulfated steroid and bile acid metabolites from the
            liver
REFERENCE   7  (bases 1 to 5729)
  AUTHORS   Rius,M., Nies,A.T., Hummel-Eisenbeiss,J., Jedlitschky,G. and
            Keppler,D.
  TITLE     Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4)
            localized to the basolateral hepatocyte membrane
  JOURNAL   Hepatology 38 (2), 374-384 (2003)
   PUBMED   12883481
  REMARK    GeneRIF: abcc4 can mediate the efflux of reduced glutathione from
            hepatocytes into blood by cotransport with monoanionic bile salts.
REFERENCE   8  (bases 1 to 5729)
  AUTHORS   Lamba,J.K., Adachi,M., Sun,D., Tammur,J., Schuetz,E.G.,
            Allikmets,R. and Schuetz,J.D.
  TITLE     Nonsense mediated decay downregulates conserved alternatively
            spliced ABCC4 transcripts bearing nonsense codons
  JOURNAL   Hum Mol Genet 12 (2), 99-109 (2003)
   PUBMED   12499391
REFERENCE   9  (bases 1 to 5729)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5729)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167668.1, AK157723.1, AC154419.2 and CT025694.11.
            
            On Aug 8, 2009 this sequence version replaced NM_001033336.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157723.1, BC150822.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC167668.1         99534-99547         c
            15-2220             AK157723.1         2-2207
            2221-2221           AC154419.2         67483-67483
            2222-5461           AK157723.1         2209-5448
            5462-5462           CT025694.11        124176-124176       c
            5463-5729           AK157723.1         5450-5716
FEATURES             Location/Qualifiers
     source          1..5729
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 62.24 cM"
     gene            1..5729
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /note="ATP-binding cassette, sub-family C member 4"
                     /db_xref="GeneID:239273"
                     /db_xref="MGI:MGI:2443111"
     exon            1..184
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..4088
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     multidrug resistance-associated protein 4; ATP-binding
                     cassette, sub-family C (CFTR/MRP), member 4"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 4
                     isoform 1"
                     /protein_id="NP_001028508.2"
                     /db_xref="CCDS:CCDS27335.1"
                     /db_xref="GeneID:239273"
                     /db_xref="MGI:MGI:2443111"
                     /translation="MLPVHTEVKPNPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDM
                     FSVLPEDRSKHLGEELQRYWDKELLRAKKDSRKPSLTKAIIKCYWKSYLILGIFTLIE
                     EGTRVVQPLFLGKIIEYFEKYDPDDSVALHTAYGYAAVLSMCTLILAILHHLYFYHVQ
                     CAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAG
                     PLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLFSSLRSKTAAFTDARIRTM
                     NEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYLRGMNMASFFIANKVILFV
                     TFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKNFLLL
                     DELPQRKAHVPSDGKAIVHVQDFTAFWDKALDSPTLQGLSFIARPGELLAVVGPVGAG
                     KSSLLSAVLGELPPASGLVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVI
                     KACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVD
                     AEVGKHLFQLCICQALHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSG
                     VDFGSLLKKENEEAEPSTAPGTPTLRKRTFSEASIWSQQSSRPSLKDGAPEGQDAENT
                     QAVQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNMVGQVFYVLQDWWLSHWAN
                     KQGALNNTRNANGNITETLDLSWYLGIYAGLTAVTVLFGIARSLLVFYILVNASQTLH
                     NRMFESILKAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAV
                     AAAVIPWILIPLVPLSVVFLVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTI
                     RAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAIFVIVVAFGSLVLAK
                     TLNAGQVGLALSYALTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWECKKR
                     PPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISAL
                     FRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEEL
                     WRALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKNNRILIIDEAT
                     ANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLL
                     QNPESLFYKMVQQLGKGEAAALTETAKQVYFRRNYPDITFTSPAVMNTSNGQPSALTI
                     FETAL"
     exon            185..295
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            296..416
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            417..641
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            642..731
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            732..895
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1021
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1271
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1373
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1463
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1655
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1750
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1837
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1934
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2144
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2285
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2323
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2418
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2565
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2645
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2796
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2916
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3027
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3128
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3320
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3321..3476
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3566
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..3739
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3845
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..3980
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3981..5729
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5284..5289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /note="hexamer: AATAAA"
     polyA_site      5303
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /note="major polyA site"
     regulatory      5628..5633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
                     /note="hexamer: ATTAAA"
     polyA_site      5649
                     /gene="Abcc4"
                     /gene_synonym="ABCC4-N1; D630049P08Rik; MOATB; MRP4"
ORIGIN      
        1 ggttcccgga agccgctgct tgcctgcgag gctccggccg aggccggagc tcgagcatcc
       61 tcacccgcgc ttcccggagc cgccgcccgg ccgcgcgcac cgcgggcgag atgctgccgg
      121 tgcacaccga ggtgaaaccc aacccgctgc aggacgccaa cctctgctcg cgcgtgttct
      181 tctggtggct caacccgctg tttaaaactg gtcataagcg gagactggaa gaagatgaca
      241 tgttctcagt gcttccagaa gatcgctcaa agcacctcgg agaggagctt caacggtact
      301 gggataaaga acttctgcga gccaagaagg actcgaggaa gccctcctta acaaaggcaa
      361 tcataaagtg ttactggaag tcttacctga ttttgggaat ttttacgtta attgaggagg
      421 gcactcgagt agttcagccc ttatttttag ggaaaattat tgaatatttt gagaagtatg
      481 accccgacga ctcggtggct ttgcatacag cttatggcta cgcagcagtg ctgtccatgt
      541 gcacgctcat cctggccata ctacatcatt tgtacttcta ccacgtgcag tgcgccggga
      601 tgaggctgcg ggttgccatg tgccacatga tttaccggaa ggcactccgg ttaagtaact
      661 cggccatggg gaagacaacc acaggccaga tagttaacct gctgtccaac gacgtgaaca
      721 aattcgacca agtgacaatc ttcttgcact ttctgtgggc agggccgctg caggccatcg
      781 cggtaaccgt cctcctctgg gtggagatag gaatctcctg cctggcgggc ttggccgttc
      841 tggttattct tctgcctctg caaagctgca tcgggaagct gttctcgtca ctgcggagta
      901 aaactgcggc tttcacggat gccaggatcc ggaccatgaa tgaagtcata acaggcatga
      961 ggataataaa gatgtatgcg tgggagaaat cgtttgctga cctcattgcc aatctgagaa
     1021 agaaggagat ttccaagatt ctgggcagct cctacctcag agggatgaac atggcgtcgt
     1081 ttttcatcgc aaacaaagtc atcctgttcg tgaccttcac tagctacgtg ctgcttggca
     1141 atgagattac agctagccac gtgtttgtgg ccatgactct gtacggtgcc gttcggttga
     1201 cagtcaccct cttcttcccg tcagccattg agagagggtc agaggccatc gtcagcattc
     1261 ggaggatcaa gaactttctg ttactcgatg aactaccaca gcgcaaagcc catgtaccat
     1321 ctgatggcaa agccattgtc cacgtgcaag atttcaccgc tttctgggac aaggcactag
     1381 acagtccaac cctgcaaggt ctttccttta ttgccaggcc tggtgagttg ttagccgtgg
     1441 ttggcccagt tggagcaggc aagtcgtcgc tgttgagcgc agtgctgggt gagctgcctc
     1501 ctgccagcgg gctggtcagc gtgcacggga ggatcgccta cgtttctcag cagccctggg
     1561 tgttctcggg caccgtgagg agcaatattt tatttgggaa gaaatatgag aaggagcgat
     1621 atgagaaagt gatcaaggcc tgtgctctga agaaggacct gcagcttctg gaggacgggg
     1681 atctgacggt tataggagac cggggagcca cgctgagtgg aggccagaaa gctcgggtga
     1741 acctggcacg ggccgtctac caggacgccg acatctacct ccttgatgat ccgctcagcg
     1801 ctgtcgatgc agaagtgggc aagcacctgt tccaactgtg tatctgtcag gcgttgcacg
     1861 agaagatcac cattttagtg actcaccagt tacagtacct caaagctgca agccacatcc
     1921 tcatactcaa agatggtgag atggtgcaga aggggactta cacggagttt ctgaaatctg
     1981 gtgtagattt tggctccctg ttaaagaaag aaaacgagga agcagagccc tccacagccc
     2041 caggaacccc gacactcagg aaacgaacct tctccgaggc ctcaatttgg tctcagcagt
     2101 catccagacc ctcgttgaaa gacggggccc cagagggcca agacgcagag aacacgcagg
     2161 cagtgcaacc cgaggagagc cgttcggaag ggagaatcgg cttcaaggcc tacaagaatt
     2221 acttctcggc gggcgcatcc tggttcttca tcattttcct tgtgctgctt aacatggtgg
     2281 gccaggtttt ctatgttctt caggactggt ggctttccca ctgggcgaac aagcaaggtg
     2341 cactgaacaa caccagaaat gcgaatggaa atataacgga gaccctagac ctcagctggt
     2401 acttaggaat ttacgcaggt ctaactgcgg tcaccgtcct ttttggcata gcgagatccc
     2461 tactggtgtt ctatatcctt gtgaacgctt cccagacttt gcacaacagg atgtttgagt
     2521 ccatactgaa ggctcccgtg ttgttcttcg acagaaatcc aatcgggagg attttaaatc
     2581 gtttctccaa agacatcgga cacatggatg atttgcttcc cctgacgttc ctggacttca
     2641 tccagacgtt gctcctcgtc gtaagtgtga tcgctgtggc cgcggccgtg atcccttgga
     2701 tcctcatacc attggttccg ctctcagtcg tcttcctggt tcttcggaga tacttcttag
     2761 agacgtcacg ggatgtcaag cgcctggaat ccacaacacg gagcccggta ttctcccatt
     2821 tatcgtcctc cctccaggga ctctggacca tccgggctta caaagctgag gagaggtgtc
     2881 aggagctgtt tgatgcacac caggacttgc attcagaggc ttggttcttg ttcctgacga
     2941 catcgagatg gttcgctgtg cgtctggacg ccatctgcgc catctttgta atcgtcgttg
     3001 ccttcgggtc ccttgttctg gcgaagactt tgaatgctgg gcaggttggc ctggccttgt
     3061 cctacgccct cacactcatg gggatgttcc agtggtctgt gcgacagagc gccgaagtag
     3121 agaatatgat gatttcagtg gagagagtga ttgagtacac ggacctagag aaggaggcgc
     3181 cttgggagtg caagaagcgc ccacccccag gctggcccca cgagggagtc atcgtcttcg
     3241 acaatgtgaa cttcacctac agcttagatg ggcctctggt tctgaagcac ctgactgcgc
     3301 tcatcaagtc cagggaaaag gttggaattg tgggcagaac cggagctggg aaaagctccc
     3361 tcatctcggc cctcttcagg ctgtcagaac ccgaggggaa aatctggatc gataagatct
     3421 tgacaaccga aattgggctt cacgacttaa ggaagaaaat gtcaatcata ccacaggaac
     3481 ctgttctgtt cactggaacc atgaggaaaa acctggaccc cttcaatgag cacacggacg
     3541 aggagctgtg gagggccttg gaggaggtac aacttaaaga ggccattgaa gatcttcctg
     3601 gaaaaatgga tactgaatta gcagaatctg gatccaattt cagtgttgga cagagacagt
     3661 tagtgtgcct tgcaagggcc attctaaaga ataaccgaat actgatcatt gatgaagcaa
     3721 ctgcaaatgt ggacccaaga acggatgagt taatacaaca gaagatccgg gagaagtttg
     3781 cccagtgcac agtgctcacc attgctcaca gactgaacac catcattgac agtgacaaga
     3841 taatggtttt ggattcagga agactgaaag aatatgatga gccgtatgtc ttgctgcaga
     3901 atccagagag cctcttttac aagatggttc agcaactggg caagggcgaa gccgctgccc
     3961 tcaccgaaac agcaaaacag gtatacttca gacggaatta cccagatatt acattcacca
     4021 gccccgcggt tatgaacacc tccaatggac agccctcggc cttaacaata tttgaaacag
     4081 cattgtgacc accaggacat catcgtaaag tctgtcttga aggtgttccc caccccgccc
     4141 aggggcttgc acttggagga ctacagcaca cctggtttcc tttctttctg ccacagatcc
     4201 ttcacagacg agagactgtt gtctttggat ttttccctcc gactttactc tgtgatttca
     4261 ggttctaaca acatggcctg tcgttttatt ttaaaagttc ctgctgttct ttacaaatcc
     4321 agttctgagg tgcaggccac caacagcagc gtctaccagg ttttgtgcct taacagtctc
     4381 aagggctgaa gcccattcat tttataagct gtcaccatgg gctgctgctt cctcttgcct
     4441 taaaagtaca ctctccaggt gtgtcaggga ctctgtttac ttgaagactg tgtgcagttg
     4501 ccagttcgtc tccctgctgt ctttgagcta ggactcataa tttccctaca aaggtctctg
     4561 gttaaaatag aataggtaga attaacaaga accacaacaa caaccccccc aaaaaataat
     4621 ccatataatt taagtatatt gctggagaga gactatccca ccacctatac atctacaaag
     4681 atatatgtct aaagttggaa aatcaacttc tgctttctca gaatgggaga ccgagcgcag
     4741 gttaggcacc cctccccctt gcatctgtga gtccctctgg gcggctcgtg tactgatcgg
     4801 atctgtgagt ccctctgggc ggctcgtgta ctgatcggat cggcaccatg acacttcccc
     4861 tagactgtga ctcccaaatg cataatatta atctcatttg gcttctggtt tacagaaggt
     4921 aaagctccta ttggctgtga gccgttggtg aaatcctttc acatcgacac caaaagctct
     4981 ccccagctag tgaaaacctg aacatcgtta gagtcaccga ctttacatgc tcagaatgct
     5041 gtgcacaagc cacgctttct aaagcccatc cagattagtt tagctctgac cactaatggc
     5101 aggtcttaag gaccttgtga ttagtcaatc aacaaaccac aacacttcct aggacctgtt
     5161 gtactccgtg taactatagg tctgaatatt ttctgggtgg tggtggcaag ggtctatgtc
     5221 agggttcaag ttactaaagg ttttactgtc ataatttaaa ggggactctt cacgacccgt
     5281 cacaataaac cattctcaag ttatctatgt gtgtgtgtat atatatctca ggtttttaga
     5341 ctggttgaca gaacaaagcc tgttttaaca gtggaacctt aaagagcaca cctacaccaa
     5401 accaccaaaa ccacgccgag cacagtgact gtttgactct tggtattcag aagtctgtaa
     5461 tgaatgtaat tatgtttagg ccagtaaatg atgtagattc gtcctttatt ggtagtcgca
     5521 gttgatattt caagagagtg agatgccatg ctgacaatat taagatctat ttgaatattt
     5581 agaaatgtct tactgtatat atgtttatgt ttatttggtc cttagagatt aaaagcggtc
     5641 atacaagtat gttcctattt catttctatt tttcacacca tcacaggaca aaccaaagtc
     5701 aactgaaata aatgacagtt tccatcccc
//
