LOCUS       NM_001363187            5019 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family C member 3 (Abcc3),
            transcript variant 1, mRNA.
ACCESSION   NM_001363187 XM_006534428
VERSION     NM_001363187.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5019)
  AUTHORS   Zhang,X., Wang,R., Wang,T., Zhang,X., Dongye,M., Wang,D., Wang,J.,
            Li,W., Wu,X., Lin,D. and Lin,H.
  TITLE     The Metabolic Reprogramming of Frem2 Mutant Mice Embryos in
            Cryptophthalmos Development
  JOURNAL   Front Cell Dev Biol 8, 625492 (2021)
   PUBMED   33490088
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5019)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   3  (bases 1 to 5019)
  AUTHORS   Tai,T., Mi,Q.Y., Ji,J.Z., Yin,Q., Pan,Y.Q., Zhang,M.R., Huang,B.B.
            and Xie,H.G.
  TITLE     Enhanced Platelet Response to Clopidogrel in Abcc3-deficient Mice
            Due to Its Increased Bioactivation
  JOURNAL   J Cardiovasc Pharmacol 68 (6), 433-440 (2016)
   PUBMED   27525577
  REMARK    GeneRIF: Abbcc3 knock-out mice have enhanced platelet response to
            clopidogrel due to increased formation of clopidogral active
            metabolite.
REFERENCE   4  (bases 1 to 5019)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5019)
  AUTHORS   Zhang,Y., Li,F., Wang,Y., Pitre,A., Fang,Z.Z., Frank,M.W.,
            Calabrese,C., Krausz,K.W., Neale,G., Frase,S., Vogel,P., Rock,C.O.,
            Gonzalez,F.J. and Schuetz,J.D.
  TITLE     Maternal bile acid transporter deficiency promotes neonatal demise
  JOURNAL   Nat Commun 6, 8186 (2015)
   PUBMED   26416771
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5019)
  AUTHORS   Belinsky,M.G., Dawson,P.A., Shchaveleva,I., Bain,L.J., Wang,R.,
            Ling,V., Chen,Z.S., Grinberg,A., Westphal,H., Klein-Szanto,A.,
            Lerro,A. and Kruh,G.D.
  TITLE     Analysis of the in vivo functions of Mrp3
  JOURNAL   Mol Pharmacol 68 (1), 160-168 (2005)
   PUBMED   15814571
REFERENCE   7  (bases 1 to 5019)
  AUTHORS   Maher,J.M., Slitt,A.L., Cherrington,N.J., Cheng,X. and
            Klaassen,C.D.
  TITLE     Tissue distribution and hepatic and renal ontogeny of the multidrug
            resistance-associated protein (Mrp) family in mice
  JOURNAL   Drug Metab Dispos 33 (7), 947-955 (2005)
   PUBMED   15802388
REFERENCE   8  (bases 1 to 5019)
  AUTHORS   McCarthy,T.C., Li,X. and Sinal,C.J.
  TITLE     Vitamin D receptor-dependent regulation of colon multidrug
            resistance-associated protein 3 gene expression by bile acids
  JOURNAL   J Biol Chem 280 (24), 23232-23242 (2005)
   PUBMED   15824121
  REMARK    GeneRIF: VDR has a role in the protection of colon cells from bile
            acid toxicity through regulation of the Mrp3 expression
REFERENCE   9  (bases 1 to 5019)
  AUTHORS   Tanaka,Y., Yoshikawa,M., Kobayashi,Y., Kuroda,M., Kaito,M.,
            Shiroi,A., Yamao,J., Fukui,H., Ishizaka,S. and Adachi,Y.
  TITLE     Expressions of hepatobiliary organic anion transporters and
            bilirubin-conjugating enzyme in differentiating embryonic stem
            cells
  JOURNAL   Biochem Biophys Res Commun 309 (2), 324-330 (2003)
   PUBMED   12951053
REFERENCE   10 (bases 1 to 5019)
  AUTHORS   Bohan,A., Chen,W.S., Denson,L.A., Held,M.A. and Boyer,J.L.
  TITLE     Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and
            Mrp3(Abcc3) reduces liver injury in obstructive cholestasis
  JOURNAL   J Biol Chem 278 (38), 36688-36698 (2003)
   PUBMED   12837754
  REMARK    GeneRIF: induction of Mrp3 plays a significant role in hepatocyte
            protection during obstructive cholestasis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645965.8.
            
            On May 11, 2018 this sequence version replaced XM_006534428.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150788.1, AK155664.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AL645965.8         75229-75348         c
            121-297             AL645965.8         57899-58075         c
            298-423             AL645965.8         57425-57550         c
            424-561             AL645965.8         57080-57217         c
            562-687             AL645965.8         56267-56392         c
            688-749             AL645965.8         55985-56046         c
            750-881             AL645965.8         55231-55362         c
            882-1070            AL645965.8         53977-54165         c
            1071-1248           AL645965.8         50799-50976         c
            1249-1410           AL645965.8         50539-50700         c
            1411-1503           AL645965.8         49948-50040         c
            1504-1707           AL645965.8         47384-47587         c
            1708-1854           AL645965.8         47131-47277         c
            1855-1942           AL645965.8         46710-46797         c
            1943-2009           AL645965.8         46400-46466         c
            2010-2136           AL645965.8         46055-46181         c
            2137-2313           AL645965.8         45791-45967         c
            2314-2481           AL645965.8         44008-44175         c
            2482-2659           AL645965.8         43530-43707         c
            2660-2774           AL645965.8         42187-42301         c
            2775-2922           AL645965.8         41885-42032         c
            2923-3130           AL645965.8         41599-41806         c
            3131-3441           AL645965.8         41110-41420         c
            3442-3641           AL645965.8         39565-39764         c
            3642-3768           AL645965.8         39331-39457         c
            3769-3870           AL645965.8         37371-37472         c
            3871-4017           AL645965.8         34438-34584         c
            4018-4176           AL645965.8         34157-34315         c
            4177-4343           AL645965.8         33294-33460         c
            4344-4538           AL645965.8         28305-28499         c
            4539-5019           AL645965.8         25653-26133         c
FEATURES             Location/Qualifiers
     source          1..5019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 58.9 cM"
     gene            1..5019
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /note="ATP-binding cassette, sub-family C member 3"
                     /db_xref="GeneID:76408"
                     /db_xref="MGI:MGI:1923658"
     exon            1..120
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..4647
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     canalicular multispecific organic anion transporter 2;
                     ATP-binding cassette protein C3; ATP-binding cassette
                     transporter; multidrug resistance-associated protein 3;
                     ATP-binding cassette, sub-family C (CFTR/MRP), member 3"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 3
                     isoform 1"
                     /protein_id="NP_001350116.1"
                     /db_xref="CCDS:CCDS88225.1"
                     /db_xref="GeneID:76408"
                     /db_xref="MGI:MGI:1923658"
                     /translation="MDRLCGSGELGSKFWDSNLSIYTNTPDLTPCFQNSLLAWVPCIY
                     LWAALPCYLFYLRHHQLGYIVLSWLSRLKTALGVLLWCVSWVDLFYSFHGLIHGSSPA
                     PVFFVTPLVVGITMLLATLLIQYERLRGVQSSGVLIIFWLLCVICAIIPFRSKILSAL
                     AEGKILDPFRFTTFYIYFALVFCALILSCFKEKPPLFSPENLDTNPCPEASAGFFSRL
                     SFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHKVVQRLLEAWQKQQNQASRSQTATAE
                     PKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLLMSACFNLIQNLLGFVNPQLLSIL
                     IRFISDPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIGVIYRKA
                     LVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPS
                     ALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPS
                     FLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEK
                     AFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFLNQNELDPQCVERKTISPGY
                     AITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEG
                     VVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQ
                     TEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGV
                     LAGKTRVLVTHGISFLPQTDFIIVLAGGQVSEMGHYSALLQHDGSFANFLRNYAPDED
                     QEDHEAALQNANEEVLLLEDTLSTHTDLTDNEPAIYEVRKQFMREMSSLSSEGEVQNR
                     TMPKKHTNSLEKEALVTKTKETGALIKEEIAETGNVKLSVYWDYAKSMGLCTTLSICL
                     LYGGQSAAAIGANVWLSAWSNDAEEHGQQNKTSVRLGVYAALGILQGLLVMLSAFTMV
                     VGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLN
                     SFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSH
                     FSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVL
                     FAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEYSKT
                     KTEAPWVVESNRAPEGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGR
                     TGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRM
                     NLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARAL
                     LRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDK
                     GVVAEFDSPVNLIAAGGIFYGMAKDAGLA"
     exon            121..297
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            298..423
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            424..561
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            562..687
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            688..749
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            750..881
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1070
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1248
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1410
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1503
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1707
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1854
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1942
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2009
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2136
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2313
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2481
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2659
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2774
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2922
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3130
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3441
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3641
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3642..3768
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..3870
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4017
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4018..4176
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4177..4343
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4344..4538
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            4539..5019
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4998..5003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /note="hexamer: AATAAA"
     polyA_site      5019
                     /gene="Abcc3"
                     /gene_synonym="1700019L09Rik; ABC31; MLP2; MOAT-D; MRP3"
                     /note="major polyA site"
ORIGIN      
        1 agaggcggtt ccggggcaga tctgctgggg ctgagctgaa ctgagattcc aagtcctgcg
       61 gtgcaccaga gccacatgga ccgcctgtgc ggctccggag agctgggctc caagttctgg
      121 gactccaacc tgtctatata taccaacact ccggacctca caccctgttt ccagaactcc
      181 ttgctggcct gggtcccctg catctacctg tgggctgcct tgccctgcta cctgttttac
      241 ctgagacacc atcagctcgg ctacatagtc ctctcatggt tatccaggct caagacggcc
      301 ctcggtgttc tgctgtggtg tgtctcatgg gtggacctgt tctattcctt ccacggcctg
      361 atccatggct catcccctgc tcctgtcttc tttgtcacac ccttggtggt ggggatcacc
      421 atgctgctgg ccactttgct aatccagtac gagcggcttc ggggggtaca gtcttcggga
      481 gtgctcatca tattctggct cctgtgtgtg atctgtgcca tcatcccctt ccgttccaag
      541 atcctctcag ctttggcaga gggtaaaatc ttggatccgt tccggttcac cactttctac
      601 atctactttg ccctggtgtt ctgtgccctc atcctgtcct gcttcaagga gaagccgcct
      661 ttgttctccc cggagaatct tgacacaaat ccttgcccag aggccagcgc tggcttcttt
      721 tcccgcttgt ctttctggtg gttcacaagg cttgccatcc ttggctaccg acgtcccctg
      781 gaggaccgtg acctctggtc tctgtctgag gaggactgct ctcacaaggt ggtacaacgg
      841 ctgctggaag catggcaaaa gcagcagaac caagcatcaa ggtcccagac ggcaacagct
      901 gagccaaaga tcccaggtga ggatgcggtc ctactgaagc cccgacccaa gtccaagcag
      961 ccttcctttc tgagggcttt ggtgagaacc ttcacctcca gcttgctcat gagtgcctgt
     1021 ttcaacctga tccagaacct actcggcttc gtcaacccac agctgctcag tatactcatc
     1081 aggtttattt ctgaccccac ggcccccacc tggtggggct tcttgctggc cggactgatg
     1141 ttcctgagct ccaccatgca gacattgatc ttacaccaat attaccactg catctttgtg
     1201 atggccttga ggctacggac tgctattata ggtgtcatct acaggaaggc tctggtcatc
     1261 accaactcag tcaaacggga gtccactgtg ggagaaatgg tcaacctcat gtcagtggat
     1321 gctcagcgct tcatggatgt ctcccctttc atcaatctgc tgtggtctgc acctttgcag
     1381 gtcatcctgg caatatactt cctctggcag atcctgggcc catcagctct ggctggagtg
     1441 gctgtgatag tcttgctgat accactcaat ggagctgtgt ccatgaagat gaagacctac
     1501 caggtaaagc aaatgaagtt caaggactcc cgcatcaagc tgatgagcga gatcctgaac
     1561 ggcatcaaag tgctcaagct gtacgcttgg gagcccagct tcttggagca ggtgaaaggg
     1621 atcaggcaga gtgaacttca gctgctccgg aagggggcct acctgcaggc catctccacc
     1681 ttcatctgga tctgcacccc atttctggtg accctgatca ccctcggagt gtacgtgtat
     1741 gtggacgaga gcaatgtact ggatgccgag aaggcctttg tgtccctgtc tttgttcaat
     1801 atcttaaaga tccccctcaa catgctgcct cagttaatca gtggactgac ccaggccagc
     1861 gtgtctctga aacggatcca ggatttcctg aaccaaaatg aacttgaccc ccaatgtgtg
     1921 gaaagaaaga ccatctcccc aggctacgcc atcaccatac acaacggcac cttcacctgg
     1981 gcccaggacc tgccgcccac cctgcacagc ctaaacattc aaatcccgaa gggggcattg
     2041 gtggctgtgg tgggacctgt gggctgtggg aagtcttctc tggtgtctgc cttactcgga
     2101 gagatggaga agctggaagg tgtggtgtct gtaaagggct ctgtggccta cgtgccccag
     2161 caggcatgga tccagaactg cacacttcag gaaaatgtgc tatttggcca acccatgaac
     2221 cccaagcgct accaacaggc tctggagaca tgtgccctgc tagctgacct agatgtgctt
     2281 cctggtgggg accagacaga gattggagag aagggtatta acctatctgg aggccagcgc
     2341 caacgggtga gtttggcccg agctgtttat agtgatgcca acattttttt gctggatgac
     2401 ccactgtcgg ctgtggactc tcatgtggcg aagcatatct tcgaccaagt gattggacca
     2461 gaaggtgtgc tggcaggcaa gactcgggtg ctggtaactc atggcatcag cttcctgccc
     2521 cagacggact ttatcattgt gcttgctggt ggacaggtgt ctgagatggg ccactactcg
     2581 gccctcctgc agcatgatgg ctcctttgcc aacttcctcc gaaactacgc accagatgaa
     2641 gaccaggagg accatgaagc agccttgcaa aatgcaaatg aggaggtact cctgctcgaa
     2701 gacacactca gcacccacac agacctgaca gacaatgagc cagccatcta cgaggtccgc
     2761 aagcagttca tgagagagat gagctccttg tcttctgaag gggaggtcca gaaccggact
     2821 atgcccaaga aacacacaaa ttcattggag aaggaggcgc tggtgacaaa gactaaggag
     2881 actggcgcat taatcaaaga ggagatagca gagacaggca atgtgaagct gagtgtgtac
     2941 tgggattatg ccaagtctat gggactctgt accacgctat ctatctgcct cctgtatggt
     3001 ggccaaagcg cagctgctat cggagccaat gtgtggctca gcgcctggag caatgatgcg
     3061 gaggaacatg gccagcagaa caagacctcc gtaaggctcg gtgtctacgc cgccctaggg
     3121 atactgcaag ggctcctggt catgctgtca gctttcacca tggtggtcgg cgcgatccag
     3181 gctgcccgcc tgctgcacga agctctgctg cacaacaaga ttcgttcccc tcagtccttc
     3241 tttgacacca cgccctcggg ccgcatcctc aaccgtttct ccaaggacat atacgtcatc
     3301 gacgaggttc tggcccccac catcctcatg ctgttgaatt ccttcttcac atccatctcc
     3361 accatcatgg tcatcgtggc cagcacgccg ctcttcatgg tggttgtctt gcccctggct
     3421 gtgctctatg gctttgtgca gcgcttctat gtggccacat cacggcagct caagcggctg
     3481 gaatccatca gccgctcacc catcttctcc cacttttcgg agacagtaac gggcaccagt
     3541 gtcattcggg cctatggccg aatccaagac ttcaaggtcc tcagtgatac taaggtggac
     3601 aacaaccaga aaagcagtta tccctacatt gcctccaatc gatggctggg ggtccacgtg
     3661 gagtttgtgg ggaactgcgt ggtgctcttt gccgcactgt ttgcagtgat cgggagaaac
     3721 agcttgaatc cagggcttgt gggtctttct gtgtcctatg ccttacaggt gaccatggct
     3781 ttgaattgga tgatacgaat gatatccgac ttggagtcta atatcatagc tgtggagaga
     3841 gtcaaggagt actctaagac caagactgag gccccctggg tggtggagag caaccgcgcc
     3901 ccggaaggct ggcccacgcg aggaatggtg gagttccgga actattcagt gcggtaccgg
     3961 cctggcctcg agttggtgct gaagaacgtg actgttcatg tgcagggtgg ggagaaggta
     4021 ggcattgtgg gccgcactgg ggctggcaaa tcttccatga ctctttgcct gttccgaatc
     4081 ctggaggccg cagagggtga gatcgtcatt gatgggctca acgtggcaca cattggcctc
     4141 cacgacctgc gctctcagct caccatcatc cctcaggacc ccatcctgtt ctcgggcacc
     4201 ctgcgtatga acttagatcc ctttggccga tactcggagg aggacatctg gagggccctg
     4261 gagctatccc acctgaacac gttcgtgagc agccagccag caggcctgga tttccagtgc
     4321 gctgagggtg gggataatct cagtgttggc cagaggcagc ttgtatgcct agcccgagcc
     4381 ctgctccgga agagccgagt cctggtttta gacgaggcca ctgctgccat tgacttggag
     4441 acggatgacc tcatccaggg caccatccgt acccagtttg aagactgcac cgtactgacc
     4501 atcgcccacc ggctcaacac aatcatggac tacaacaggg tcctggtctt ggacaaagga
     4561 gtagtagctg aatttgattc tccagtcaac ctcattgcgg ccggaggcat cttctatggg
     4621 atggccaagg atgcgggact tgcctagatg atgcattcca agggtttctt ccttgtcaga
     4681 tggactcgat ggccatgagt ggggacattt agagtttttt ttaattctgc aaattgtctc
     4741 acagtggaat gaggaaatga gttagagatc acagccagtt caaagccacg ctctgaccag
     4801 tgcctgggtc tcctggtcta gtccaccatg attcctgtac tgcagttttt aagagacctt
     4861 gctcctgcct ctacatatgc atattttcca attttttttt tttaaatgag cctttctcct
     4921 cctggaccag ggactgctag gtcagtctgt cccgggaaca gagaccctgt actggtgctg
     4981 tctgagtcca ctgatgaaat aaagctgtag tcaacagca
//
