LOCUS       NM_013806               5389 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family member 2 (Abcc2),
            mRNA.
ACCESSION   NM_013806
VERSION     NM_013806.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5389)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5389)
  AUTHORS   Wang,S., Feng,R., Wang,S.S., Liu,H., Shao,C., Li,Y., Link,F.,
            Munker,S., Liebe,R., Meyer,C., Burgermeister,E., Ebert,M.,
            Dooley,S., Ding,H. and Weng,H.
  TITLE     FOXA2 prevents hyperbilirubinaemia in acute liver failure by
            maintaining apical MRP2 expression
  JOURNAL   Gut 72 (3), 549-559 (2023)
   PUBMED   35444014
  REMARK    GeneRIF: FOXA2 prevents hyperbilirubinaemia in acute liver failure
            by maintaining apical MRP2 expression.
REFERENCE   3  (bases 1 to 5389)
  AUTHORS   Beer,A.J., Hertz,D., Seemann,E., Beretta,M., Westermann,M.,
            Bauer,R., Bauer,M., Kessels,M.M. and Qualmann,B.
  TITLE     Reduced Mrp2 surface availability as PI3Kgamma-mediated hepatocytic
            dysfunction reflecting a hallmark of cholestasis in sepsis
  JOURNAL   Sci Rep 10 (1), 13110 (2020)
   PUBMED   32753644
  REMARK    GeneRIF: Reduced Mrp2 surface availability as PI3Kgamma-mediated
            hepatocytic dysfunction reflecting a hallmark of cholestasis in
            sepsis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5389)
  AUTHORS   Zukauskas,A., Mrsny,R.J., Cortes Barrantes,P., Turner,J.R.,
            Leong,J.M. and McCormick,B.A.
  TITLE     Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals
            To Control Transepithelial Neutrophil Migration during
            Streptococcus pneumoniae Lung Infection
  JOURNAL   mSphere 3 (4), e00303-18 (2018)
   PUBMED   29976647
  REMARK    GeneRIF: The authors conclude that MRP1 assists in depression of
            polymorphonuclear cell (PMN) migration by effluxing a molecule that
            inhibits the proinflammatory effects of MRP2 activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5389)
  AUTHORS   Oh,J.H., Lee,J.H., Han,D.H., Cho,S. and Lee,Y.J.
  TITLE     Circadian Clock Is Involved in Regulation of Hepatobiliary
            Transport Mediated by Multidrug Resistance-Associated Protein 2
  JOURNAL   J Pharm Sci 106 (9), 2491-2498 (2017)
   PUBMED   28479363
  REMARK    GeneRIF: Circadian oscillation of Mrp2 protein expression was
            clearly observed in the mouse liver with levels down at the light
            phase and up at the dark phase.
REFERENCE   6  (bases 1 to 5389)
  AUTHORS   Konig,J., Nies,A.T., Cui,Y., Leier,I. and Keppler,D.
  TITLE     Conjugate export pumps of the multidrug resistance protein (MRP)
            family: localization, substrate specificity, and MRP2-mediated drug
            resistance
  JOURNAL   Biochim Biophys Acta 1461 (2), 377-394 (1999)
   PUBMED   10581368
  REMARK    Review article
REFERENCE   7  (bases 1 to 5389)
  AUTHORS   Borst,P., Evers,R., Kool,M. and Wijnholds,J.
  TITLE     The multidrug resistance protein family
  JOURNAL   Biochim Biophys Acta 1461 (2), 347-357 (1999)
   PUBMED   10581366
REFERENCE   8  (bases 1 to 5389)
  AUTHORS   Ji,W., Herron,B., Jones,J.M., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., Swank,R., Flaherty,L. and Meisler,M.H.
  TITLE     Identification of genes within the Krd deletion on mouse chromosome
            19
  JOURNAL   Mamm Genome 10 (4), 399-401 (1999)
   PUBMED   10087301
REFERENCE   9  (bases 1 to 5389)
  AUTHORS   Ito,K., Suzuki,H., Hirohashi,T., Kume,K., Shimizu,T. and
            Sugiyama,Y.
  TITLE     Functional analysis of a canalicular multispecific organic anion
            transporter cloned from rat liver
  JOURNAL   J Biol Chem 273 (3), 1684-1688 (1998)
   PUBMED   9430713
REFERENCE   10 (bases 1 to 5389)
  AUTHORS   Lammert,F., Cohen,D.E., Paigen,B., Carey,M.C. and Beier,D.R.
  TITLE     The gene encoding the multispecific organic anion transporter
            (Cmoat) of the hepatocyte canalicular membrane maps to mouse
            chromosome 19
  JOURNAL   Mamm Genome 9 (1), 87-88 (1998)
   PUBMED   9434956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141888.4, AF282773.1 and AC132251.3.
            
            On Oct 12, 2006 this sequence version replaced NM_013806.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the MRP subfamily which is
            involved in multi-drug resistance. This protein functions in the
            canalicular surface of the hepatocyte and in biliary transport, and
            appears to contribute to drug resistance in mammalian cells.
            Several different mutations in the human gene have been observed in
            patients with Dubin-Johnson syndrome (DJS), an autosomal recessive
            disorder characterized by conjugated hyperbilirubinemia.
            Alternative splice variants have been observed for this gene;
            however, they have not been fully described. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF282772.1, AF282773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC141888.4         53602-53697         c
            97-4728             AF282773.1         1-4632
            4729-5389           AC132251.3         122506-123166       c
FEATURES             Location/Qualifiers
     source          1..5389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57L/J"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.67 cM"
     gene            1..5389
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /note="ATP-binding cassette, sub-family member 2"
                     /db_xref="GeneID:12780"
                     /db_xref="MGI:MGI:1352447"
     exon            1..126
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            127..300
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            301..426
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..561
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..669
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..725
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..957
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1121
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1299
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1554
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1620
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1758
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1905
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..1990
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2057
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2184
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2361
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2529
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2710
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2837
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2973
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3193
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3348
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3504
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3704
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3831
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..3933
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4077
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4236
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4237..4403
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4404..4598
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            4599..5389
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4911..4916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /note="hexamer: AATAAA"
     regulatory      4923..4928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /note="hexamer: AATAAA"
     polyA_site      4933
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
                     /note="major polyA site"
     polyA_site      4945
                     /gene="Abcc2"
                     /gene_synonym="Abc30; Cmoat; cMRP; Mrp2"
ORIGIN      
        1 ttgctcctta acatctgctt cccttgaggc agatggtaaa gaagaaacaa gacaatcata
       61 gaaagtcatc gtaacagaag tgccctggaa atcacgatgg acgaattctg caactctact
      121 ttttggaatc tctcattatt gaaaagtccg gaagccgacc tgcctctttg ttttgaacaa
      181 actgttcttg tgtggattcc cttgggcttt ctttggctct tggcgccttg gcaactttac
      241 agaatataca gatccaggac caagagattt gctataacta aattctacct tgccaagcag
      301 gtgttcgttg tgtgtcttct tattttagca gccatagacc tgtctcttgc actcacagaa
      361 gatactggac aagccacaat tcctcctgtt aaatatacaa atccaattct ctacctatgc
      421 acttggctcc tggtgttggt gatccaacac tgcaggcaat gctgtataca gaagaattct
      481 tggttcctgt ccatgttctg gattctctct ctattatgtg gcatattcca gtttcagact
      541 ctgatacgag cactcctgca ggatagcaag tccaacatga cctattcctg cctgttcttc
      601 gtctcctatg gtttccagat tgtcattttg atcctttcag ccttttcaga atcaagcgac
      661 tcaacacacg ccccatcagc tacagcttca tttctgagta gcgttacgtt tagttggtat
      721 gacagcactg ttctgaaagg ttacaagcat ccattgacaa tagaagatgt gtgggatatt
      781 gaagaaaatc ttaaagccaa gtcactcacc agcaagttta agacgatcat gacaaaggac
      841 ctgcagaaag ccaggcaggc tcttcagagg cggctgaaga agtcccagca gagccctgag
      901 ggcacgtcac acggattgac caagaagcag agtcagagcc aagatgtcct tgtcctggaa
      961 gactcgaaaa agaagaaaaa gaagtctgag gccaccaaag actttcccaa atcctggttg
     1021 gtgaaggctc tcttcaaaac gttctacgtg gtgatcctga agtcatttat tctgaaatta
     1081 gcacatgata ttcttttgtt tctgaatcct cagctgctga aatttctcat tggcttcgtg
     1141 aaagaccctg actcatatcc gtgggttgga tatatctatg caatcctaat gttctctgtg
     1201 actctcatcc agtctttctt ccttcagtgt tattttcaat tttgttttgt gttgggaatg
     1261 actgtacgga caaccatcat agcttccgta tataagaagg cactaaccct atctaacttg
     1321 gctaggaggc agtacacgat tggagagacg gtgaacttga tgtctgtaga ttcccagaag
     1381 ctaatggacg tgaccaacta catacacttg ctgtggtcca gtgttttaca gattgctttg
     1441 tccattttct tcctgtggag agagttggga ccttcgattt tagcaggtgt tgggcttatg
     1501 gttctcctgg tcccagttaa tggcgtcctg gctaccaaga tcaggaaaat tcaggtccag
     1561 aatatgaaga ataaagacaa acgcttaaaa atcatgaatg agattcttag tgggattaag
     1621 atcctgaaat actttgcctg ggaaccttcc tttaaagagc aagtgaacag cattcggaag
     1681 aaagaactca ggaacttgct gcgcttcagc cagctgcaga cgattttgat tttcatctta
     1741 cacctaactc caaccctggt gtccgtgatc acattttctg tttacgtcct ggtggatagt
     1801 caaaatgttt tgaacgcgga gaaggctttc acctccatca ccctcttcaa tatcctgcgc
     1861 tttcctctgg ccatgcttcc catggtgatc tcttcagtca tccaggccag cgtctctgta
     1921 gaccggctgg agcagtacct gggaagcgat gatctggact tgtctgccat tcgccatgtc
     1981 tgccattttg ataaagctgt gcagttctca gaagcctctt ttacttggga ccgggacttg
     2041 gaagccacaa tccaagatgt gaacctggac ataaaaccag gccaactggt ggctgtggtg
     2101 ggcactgtag gctctgggaa gtcctctttg atatcagcca tgctgggaga aatggagaat
     2161 gtccatgggc atatcaccat caagggctcc atagcctacg tccctcagca ggcctggatt
     2221 cagaacggga ccatcaaaga taacatcctg tttgggtcag aatacgatga aaagaagtac
     2281 cagcgagtta tcgaagcgtg cgctctcctc ccagacttgg aaatgttgcc tggaggagac
     2341 atggctgaga tcggagagaa gggtataaat ctcagtggcg gtcagaagca tcgagtcagc
     2401 ctggcccggg ccacctatca agatgcagac atctatattc tagacgaccc cctgtcggct
     2461 gtggacactc acgtgggaaa acacattttc aacaaggttg tgggccccaa tggcctgctg
     2521 agcggcaaga ctcggatctt ggttacacat ggcattcact tccttcccca agtggatgag
     2581 attgtcgttc tggggaaagg caccatctta gagaagggat cctatagtga cctgatggac
     2641 aagaaaggag tgttcgctaa gaactggaag acattcatga agcattcggg acctgaagga
     2701 gaggctacag tcgataacga cagtgaggaa gaggatggtg actgtgggct gatcccaact
     2761 gtggaggaaa ttcctgacga tgcagcttcc ttgaccatga gaagggagaa cagccttcgc
     2821 cgaacactga gccgcagctc taggtccggc agcaggcgtg ggaagtccct caaaagctcc
     2881 ttgaaaatta aaagtgtgaa tgccttgaat aagaaggagg aagtagtgaa aggacaaaaa
     2941 ctaattaaga aggaatttgt ggaaactggg aaggtaaagt tctccatcta cctgaaatat
     3001 ctgcaggcgg taggatggtg gtccctgctc ttcatcgtca tcttctacgt attgaactat
     3061 gtggctttta ttggcactaa cctctggctg agtgcttgga ccagtgactc tgaaaaacag
     3121 aatgggaccg acaattcacc ttctcagagg gacatgagaa tcggggtctt tggagctctg
     3181 ggaatagcac aaggtatatt tttgcttagt tcaagtctat ggagtatata tgcttgcaga
     3241 aatgcatcca aaactttgca caggcagctg ttaaccaaca ttctccgcgc acccatgagt
     3301 ttttttgaca caactcccac aggccggatt gtgaacagat ttgccgggga tatttctacg
     3361 gtggacgaca cactccccca gactttgcga agctggctgc tgtgtttctt cggcatagtt
     3421 agcactctcg tgatgatctg catggccacc cccatcttca tcatcatcat catccctctc
     3481 agcattctct atgtatctgt gcaggtgttt tatgtggcta catcccgcca gctgagacgg
     3541 ctggattctg tcaccaaatc tccgatctat tctcacttta gtgagactgt ctctggtttg
     3601 cctgttattc gggcctttga gcaccagcag agatttctag caaacagtga gaagcagatt
     3661 gacaccaacc agaaatgcgt cttttcctgg attacctcca accggtggct tgccattcgc
     3721 ctggagctgg ttggaaacct gattgtcttc tgctcggcct tgcttctggt tatttataag
     3781 aattccttaa ccggggacac tgtgggcttt gttctgtcca acgccctcaa catcacacaa
     3841 accctgaact ggctagtgag gatgacgtca gaagtagaga ccaacatcgt ggctgttgag
     3901 cgaataaatg aatacataaa tgtggataat gaggcgccgt gggtgaccga caagaagcct
     3961 ccggcagatt ggcccaaaaa aggtgagatc cagttcaaca actatcaagt gcggtatcgg
     4021 ccggagctgg atctggtcct gaaagggatt acttgtaaca tcaagagcac cgagaaggtc
     4081 ggtgtggtgg gcaggaccgg agctggaaaa tcatccctca caaactgcct cttcagaatc
     4141 ttagagtctg caggtggcca gatcatcatt gatgggattg atattgcctc cattggactg
     4201 cacgaccttc gagggagact gaccatcatt ccccaggacc ccattttgtt ctctgggaat
     4261 ctgaggatga atctcgaccc tttcaacaaa tactcggatg aggagatctg gagggccctg
     4321 gaattggctc atctcaaatc ctttgtggct ggcctgcaac ttgggttgct ccatgaagtg
     4381 acagagggcg gtgacaacct gagcataggg cagaggcagc tcctatgcct gggtagggcc
     4441 gtgcttcgaa aatccaaaat cctggtcctg gacgaagcca cagccgcagt ggatctagag
     4501 acggatagcc tcattcagac gaccatccgg aacgagttct cccagtgcac ggtcatcact
     4561 atcgcacaca ggctgcacac catcatggac agtgacaaga taatggtcct agacagcggc
     4621 aagattgttg aatacggcag tcctgaagaa ctgctgtcca atatgggtcc cttctacttg
     4681 atggccaagg aagccggcat tgaaagtgtg aaccacacgg agctctagca gtgctccctg
     4741 gctagcggac tagaagaaca tttcttagtt acttttgttc ttgtgactgt gtcatagggg
     4801 cacagataca cagtttgttg ctgttgctca ggttggcctc aaactctaag gctcaagcaa
     4861 tctctggtct caaccaccct gtaaaaaaat acacttaaaa gggtatcata aataaatact
     4921 taaataaata gtatcaggta ccttagaaaa tccacaactg agctggggag atagctcggt
     4981 tgttagggtg cttgccttga aagcgtgagg gtccgatttg atccctagaa cccccttatt
     5041 atcatttttt ttaaagtacg ggcatagttg tccatgataa cagtttgagt gttggacagc
     5101 cagaggtagt caggtcctgg ggctcactag ccagccagca gagctagcct gcttggaaaa
     5161 tcccagatca ggaagagacc ctgtctcaaa aaaacaaaaa aacaacaaca aaacccctag
     5221 gtggacagag ccaaaggcct caacacgcac aaacatctgc atacacacct caaaatggaa
     5281 gcctcgttgc cttgccttga tcataagttc ttgctacccc accattccca gaaataaccg
     5341 ctattcctaa gtttcacagt tcttttgcct gttgttttag tgtttactg
//
