LOCUS       NM_172912               4511 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family C member 12 (Abcc12),
            mRNA.
ACCESSION   NM_172912 XM_908312
VERSION     NM_172912.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4511)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4511)
  AUTHORS   Chambers,I.G., Kumar,P., Lichtenberg,J., Wang,P., Yu,J.,
            Phillips,J.D., Kane,M.A., Bodine,D. and Hamza,I.
  TITLE     MRP5 and MRP9 play a concerted role in male reproduction and
            mitochondrial function
  JOURNAL   Proc Natl Acad Sci U S A 119 (6) (2022)
   PUBMED   35121660
  REMARK    GeneRIF: MRP5 and MRP9 play a concerted role in male reproduction
            and mitochondrial function.
REFERENCE   3  (bases 1 to 4511)
  AUTHORS   Pham,D.H., Kudira,R., Xu,L., Valencia,C.A., Ellis,J.L., Shi,T.,
            Evason,K.J., Osuji,I., Matuschek,N., Pfuhler,L., Mullen,M.,
            Mohanty,S.K., Husami,A., Bull,L.N., Zhang,K., Wali,S., Yin,C. and
            Miethke,A.
  TITLE     Deleterious Variants in ABCC12 are Detected in Idiopathic Chronic
            Cholestasis and Cause Intrahepatic Bile Duct Loss in Model
            Organisms
  JOURNAL   Gastroenterology 161 (1), 287-300 (2021)
   PUBMED   33771553
  REMARK    GeneRIF: Deleterious Variants in ABCC12 are Detected in Idiopathic
            Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model
            Organisms.
REFERENCE   4  (bases 1 to 4511)
  AUTHORS   McLachlan,S., Lee,S.M., Steele,T.M., Hawthorne,P.L., Zapala,M.A.,
            Eskin,E., Schork,N.J., Anderson,G.J. and Vulpe,C.D.
  TITLE     In silico QTL mapping of basal liver iron levels in inbred mouse
            strains
  JOURNAL   Physiol Genomics 43 (3), 136-147 (2011)
   PUBMED   21062905
REFERENCE   5  (bases 1 to 4511)
  AUTHORS   Ono,N., Van der Heijden,I., Scheffer,G.L., Van de Wetering,K., Van
            Deemter,E., De Haas,M., Boerke,A., Gadella,B.M., De Rooij,D.G.,
            Neefjes,J.J., Groothuis,T.A., Oomen,L., Brocks,L., Ishikawa,T. and
            Borst,P.
  TITLE     Multidrug resistance-associated protein 9 (ABCC12) is present in
            mouse and boar sperm
  JOURNAL   Biochem J 406 (1), 31-40 (2007)
   PUBMED   17472575
  REMARK    GeneRIF: Full-length Mrp9 was detected only in testicular germ
            cells and mouse sperm. In mouse and boar sperm, Mrp9 localizes to
            the midpiece, a structure containing all sperm mitochondria.
REFERENCE   6  (bases 1 to 4511)
  AUTHORS   Maher,J.M., Slitt,A.L., Cherrington,N.J., Cheng,X. and
            Klaassen,C.D.
  TITLE     Tissue distribution and hepatic and renal ontogeny of the multidrug
            resistance-associated protein (Mrp) family in mice
  JOURNAL   Drug Metab Dispos 33 (7), 947-955 (2005)
   PUBMED   15802388
REFERENCE   7  (bases 1 to 4511)
  AUTHORS   Shimizu,H., Taniguchi,H., Hippo,Y., Hayashizaki,Y., Aburatani,H.
            and Ishikawa,T.
  TITLE     Characterization of the mouse Abcc12 gene and its transcript
            encoding an ATP-binding cassette transporter, an orthologue of
            human ABCC12
  JOURNAL   Gene 310, 17-28 (2003)
   PUBMED   12801629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132147.4 and AC159262.3.
            
            On Nov 17, 2006 this sequence version replaced NM_172912.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF502146.1, BC171952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC132147.4         135222-135373
            153-308             AC132147.4         137822-137977
            309-456             AC159262.3         233529-233676       c
            457-693             AC159262.3         233013-233249       c
            694-867             AC159262.3         230888-231061       c
            868-1015            AC159262.3         230334-230481       c
            1016-1164           AC159262.3         226009-226157       c
            1165-1272           AC159262.3         223265-223372       c
            1273-1551           AC159262.3         221267-221545       c
            1552-1623           AC159262.3         216569-216640       c
            1624-1748           AC159262.3         214077-214201       c
            1749-1821           AC159262.3         212763-212835       c
            1822-2025           AC159262.3         211060-211263       c
            2026-2160           AC159262.3         207611-207745       c
            2161-2236           AC159262.3         207425-207500       c
            2237-2305           AC159262.3         207260-207328       c
            2306-2395           AC159262.3         204261-204350       c
            2396-2499           AC159262.3         203254-203357       c
            2500-2697           AC159262.3         200953-201150       c
            2698-2924           AC159262.3         200000-200226       c
            2925-3062           AC159262.3         197427-197564       c
            3063-3249           AC159262.3         190044-190230       c
            3250-3339           AC159262.3         185011-185100       c
            3340-3529           AC159262.3         182425-182614       c
            3530-3689           AC159262.3         181818-181977       c
            3690-3768           AC159262.3         180635-180713       c
            3769-3882           AC159262.3         179560-179673       c
            3883-4047           AC159262.3         178151-178315       c
            4048-4511           AC159262.3         177578-178041       c
FEATURES             Location/Qualifiers
     source          1..4511
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 42.06 cM"
     gene            1..4511
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /note="ATP-binding cassette, sub-family C member 12"
                     /db_xref="GeneID:244562"
                     /db_xref="MGI:MGI:2441679"
     exon            1..152
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            153..308
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            309..456
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            457..693
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            694..867
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1015
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1164
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1272
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1551
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1623
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1748
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1821
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..2025
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2160
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2236
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2305
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2395
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2499
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2697
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2924
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3062
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3249
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3339
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3529
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3689
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..3768
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..3882
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..4047
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4511
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaagagtc gagggctcca gaacaccatc aagatggtgg gtgaaggccc gtaccttatc
       61 tcagacctgg atcgcagagg ccatcggaga tcctttgccg agagatatga ccccagcctg
      121 aaaaccatga tcccagtgcg accccgtgca aggttggcac ccaatcctgt ggatgatgct
      181 gggctgctgt ccttcgccac gttttcctgg ctcacaccgg tgatgattcg aagttacaag
      241 cacacgctga ctgtggacac cctgccccca ctgtctcctt atgactcatc ggacatcaac
      301 gccaagagat tccagatcct ttgggaagaa gaaataaaga gggtagggcc tgagaaggcc
      361 tccctgggcc gcgtggtctg gaaattccag agaacccgag ttctgatgga cgttgtagcc
      421 aacatcctgt gcatcgtcat ggcagccttg gggccgacag ttctcattca ccaaatcctc
      481 cagcacatta ccagcatctc ctccggacac atcgggatcg gcatctgctt gtgtctggcc
      541 ctctttacca ccgagttcac caaagtcctc ttttgggccc ttgcctgggc cataaattac
      601 cgcacagcga tccgactgaa ggtggccctc tccacgctaa tcttcgaaaa cctgctgtcc
      661 tttaagacgt taactcacat ctctgcaggc gaggtactca atatactatc aagtgatagc
      721 tattccttgt ttgaggctgc cttgttttgt cccttgccag ccaccatccc gatcctaatg
      781 gtcgtttgtg cagtgtacgc ctttttcatt ctggggtcca cagctcttgt cgggataagt
      841 gtgtatctca tattcatccc gatccagatg tttatggcca aactcaactc aactttccga
      901 aggtcagcaa tttcagtgac agacaaacgg gttcagacaa tgaatgagtt tctgacctgc
      961 atcaagctga ttaaaatgta cgcctgggag gaatctttta taaacaccat tcacgacata
     1021 agaaagagag agaaaaaatt actggaaaag gctggctatg tccaaagtgg aaactcagcc
     1081 ctggctccca ttgtgtccac catagccatt gtgtctactt tcacctgcca cattttcctg
     1141 aaacgcaagc tcactgcccc tgtggcattt agtgtgattg ccatgtttaa tgtaatgaag
     1201 ttttccattg caatcttgcc tttctcggtc aaagcagtgg ccgaagccag tgtctctcta
     1261 aggagaatga agaaaatcct catagctaaa agtcccccat cctacatcac tcaacctgaa
     1321 gacccagata ctatcttgct tttagcaaat gccaccttga catgggaaca agaaatcaac
     1381 aggaaaagtg acccgccgaa ggcacaaatt cagaaaaggc acgttttcaa gaaacagagg
     1441 ccagagctat acagcgagca aagtcgatca gatcagggag ttgctagccc ggagtggcaa
     1501 agtggcagcc ccaagtcagt gctacacaac atcagttttg tggtgagaaa ggggaaggtc
     1561 ttgggaatat gcgggaatgt tggaagcggg aagagttccc tcatttcagc tctcctagga
     1621 cagatgcagt tacagaaagg ggtcgtggct gtcaatggac ctttggctta cgtttcccag
     1681 caagcatgga tcttccatgg aaatgtgagg gagaacatac tgtttggaga gaaatacaac
     1741 caccaaaggt accaacacac agttcatgtc tgtggtctcc agaaggactt gaacagcctc
     1801 ccttatggag acctgactga gattggagag cggggtgtca acctctctgg gggacagagg
     1861 cagaggatca gcctggcccg tgctgtgtat gctaatcgtc agctctacct gctggatgac
     1921 ccgctctcgg ctgtggatgc ccacgtgggg aagcatgtct ttgaagaatg cattaagaag
     1981 acactcaaag ggaagacagt tgtgctggtt acccaccagt tgcagttcct ggagtcttgt
     2041 gatgaggtca ttctgttaga agatggagag atctgtgaaa agggcaccca caaggagttg
     2101 atggaagaga gggggcgcta tgcaaagctt atccacaacc tccggggact gcaattcaag
     2161 gatccagagc acatttacaa tgtagccatg gtggagaccc tgaaggagag cccagctcag
     2221 agggatgaag acgctgtctt ggcttcagga gatgagaagg acgaaggaaa agaacctgaa
     2281 acagaagaat ttgtggacac aaacgctccc gctcaccagc tcatccagac tgaatccccc
     2341 caagaaggaa tcgtgacctg gaaaacatat cacacgtata tcaaggcttc tggagggtac
     2401 ctggtctcct tcctggtttt gtgtctcttc ttcctgatga tgggcagctc tgctttcagc
     2461 acctggtggc tggggatctg gttagacagg ggttcccagg tcgtctgtgc atcccagaac
     2521 aataagacag cctgcaacgt cgaccagacc ctgcaagaca ccaaacacca catgtaccag
     2581 ttggtttaca tagcaagcat ggtgtctgtg ttgatgtttg gcatcatcaa aggctttacc
     2641 ttcaccaaca ctacactgat ggcgtcttcc tctctccaca acagagtatt taacaagatc
     2701 gtcaggagcc caatgagctt cttcgacaca actcccacag gccggctaat gaaccgcttc
     2761 tctaaagaca tggacgagct ggacgtgagg ctgccgtttc acgccgagaa ctttctgcag
     2821 cagtttttta tggtggtgtt tattctggtg atcatggctg ccgtgtttcc tgttgtcctt
     2881 gtggtgctgg ctggcctggc tgtaatcttc ctcattcttt tacgcatctt ccatcgagga
     2941 gttcaggagc tcaagcaggt ggagaacatc agccggtcac cttggttctc tcacatcacc
     3001 tcctccatac agggtctggg cgtcatccac gcctacgaca aaaaggacga ctgcatcagc
     3061 aagtttaaga cactcaacga cgaaaactcc agccacctcc tgtacttcaa ctgcgcgctc
     3121 aggtggtttg ctctcagaat ggacattctc atgaacattg tcacctttgt tgtggccttg
     3181 ctggtgaccc ttagtttttc ttcaatcagc gcctcatcca aaggcttgtc attgtcttac
     3241 atcatccagc tcagtggatt gcttcaagtg tgtgtgcgaa caggaacaga gacccaagcc
     3301 aagttcacct ccgcagagct actgagggag tacattttga cctgtgttcc tgaacacact
     3361 caccccttca aagtggggac ctgtcccaaa gactggccga gccgagggga gataacgttc
     3421 aaggactatc ggatgagata cagagacaac acccctctcg ttcttgatgg cctgaacttg
     3481 aacatccaaa gcgggcagac agttgggatt gtgggaagga cgggctccgg aaaatcatcc
     3541 ctgggcatgg ccctgtttcg tctggtggaa ccagcctctg gtaccatcat cattgacgag
     3601 gtggacatct gcactgtggg tctggaagac ctccgaacca agctgaccat gatcccccag
     3661 gatcctgtcc tgtttgtagg tacagtaagg tacaacttgg accccttggg gagccacacc
     3721 gacgagatgc tctggcatgt tttggaaaga acgttcatga gagacacaat aatgaaactc
     3781 ccagagaaat tacaggcaga agtcacagaa aatggggaaa acttctcagt aggagaacgc
     3841 cagctgcttt gtatggcccg ggcacttctc cgtaattcaa aaatcattct ccttgatgaa
     3901 gctactgcct ccatggattc caagacagac acccttgttc agagcaccat aaaggaggcc
     3961 ttcaaaagct gcacagtgtt gaccatcgct catcgcctga acaccgttct caactgtgac
     4021 cttgtcctgg tgatggaaaa tgggaaggtg attgagtttg acaagcctga agtcctcgct
     4081 gagaagcccg actctgcatt tgcgatgtta ctagctgcag aggttggact gtaaaggtcc
     4141 tgtgggtgat ttgagaggag gcgatggaca tgtgagaaca gaagcccgac catggagcca
     4201 agcagccctg gccacagccc ctcccaccca tggagcacat ggtgagctgg ggctgagatg
     4261 tgtcccttgt tcttctggcc atctctcttg gcagactcag ggttggttct ggatggtgaa
     4321 gagtgcagac aaagctggta ggttggaagc tgcctctcac ttctgaaaac cccaagggtc
     4381 cctcacgtgt cctcaccaat actacataat gtctgagaat gggaacattc taactttctg
     4441 tccaaaagca gtaaaagcaa atgagatggg aaaatgccca aggctggaga tgacagcgtt
     4501 cctggatttt g
//
