LOCUS       NP_766500               1366 aa            linear   ROD 30-APR-2024
DEFINITION  ATP-binding cassette sub-family C member 12 [Mus musculus].
ACCESSION   NP_766500 XP_913405
VERSION     NP_766500.3
DBSOURCE    REFSEQ: accession NM_172912.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1366)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1366)
  AUTHORS   Chambers,I.G., Kumar,P., Lichtenberg,J., Wang,P., Yu,J.,
            Phillips,J.D., Kane,M.A., Bodine,D. and Hamza,I.
  TITLE     MRP5 and MRP9 play a concerted role in male reproduction and
            mitochondrial function
  JOURNAL   Proc Natl Acad Sci U S A 119 (6) (2022)
   PUBMED   35121660
  REMARK    GeneRIF: MRP5 and MRP9 play a concerted role in male reproduction
            and mitochondrial function.
REFERENCE   3  (residues 1 to 1366)
  AUTHORS   Pham,D.H., Kudira,R., Xu,L., Valencia,C.A., Ellis,J.L., Shi,T.,
            Evason,K.J., Osuji,I., Matuschek,N., Pfuhler,L., Mullen,M.,
            Mohanty,S.K., Husami,A., Bull,L.N., Zhang,K., Wali,S., Yin,C. and
            Miethke,A.
  TITLE     Deleterious Variants in ABCC12 are Detected in Idiopathic Chronic
            Cholestasis and Cause Intrahepatic Bile Duct Loss in Model
            Organisms
  JOURNAL   Gastroenterology 161 (1), 287-300 (2021)
   PUBMED   33771553
  REMARK    GeneRIF: Deleterious Variants in ABCC12 are Detected in Idiopathic
            Chronic Cholestasis and Cause Intrahepatic Bile Duct Loss in Model
            Organisms.
REFERENCE   4  (residues 1 to 1366)
  AUTHORS   McLachlan,S., Lee,S.M., Steele,T.M., Hawthorne,P.L., Zapala,M.A.,
            Eskin,E., Schork,N.J., Anderson,G.J. and Vulpe,C.D.
  TITLE     In silico QTL mapping of basal liver iron levels in inbred mouse
            strains
  JOURNAL   Physiol Genomics 43 (3), 136-147 (2011)
   PUBMED   21062905
REFERENCE   5  (residues 1 to 1366)
  AUTHORS   Ono,N., Van der Heijden,I., Scheffer,G.L., Van de Wetering,K., Van
            Deemter,E., De Haas,M., Boerke,A., Gadella,B.M., De Rooij,D.G.,
            Neefjes,J.J., Groothuis,T.A., Oomen,L., Brocks,L., Ishikawa,T. and
            Borst,P.
  TITLE     Multidrug resistance-associated protein 9 (ABCC12) is present in
            mouse and boar sperm
  JOURNAL   Biochem J 406 (1), 31-40 (2007)
   PUBMED   17472575
  REMARK    GeneRIF: Full-length Mrp9 was detected only in testicular germ
            cells and mouse sperm. In mouse and boar sperm, Mrp9 localizes to
            the midpiece, a structure containing all sperm mitochondria.
REFERENCE   6  (residues 1 to 1366)
  AUTHORS   Maher,J.M., Slitt,A.L., Cherrington,N.J., Cheng,X. and
            Klaassen,C.D.
  TITLE     Tissue distribution and hepatic and renal ontogeny of the multidrug
            resistance-associated protein (Mrp) family in mice
  JOURNAL   Drug Metab Dispos 33 (7), 947-955 (2005)
   PUBMED   15802388
REFERENCE   7  (residues 1 to 1366)
  AUTHORS   Shimizu,H., Taniguchi,H., Hippo,Y., Hayashizaki,Y., Aburatani,H.
            and Ishikawa,T.
  TITLE     Characterization of the mouse Abcc12 gene and its transcript
            encoding an ATP-binding cassette transporter, an orthologue of
            human ABCC12
  JOURNAL   Gene 310, 17-28 (2003)
   PUBMED   12801629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132147.4 and AC159262.3.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_913405.1, NP_766500.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF502146.1, BC171952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1366
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 42.06 cM"
     Protein         1..1366
                     /product="ATP-binding cassette sub-family C member 12"
                     /note="multidrug resistance-associated protein 9;
                     ATP-binding cassette transporter sub-family C member 12;
                     ATP-binding cassette, sub-family C (CFTR/MRP), member 12"
                     /calculated_mol_wt=152930
     Region          43..1366
                     /region_name="MRP_assoc_pro"
                     /note="multi drug resistance-associated protein (MRP);
                     TIGR00957"
                     /db_xref="CDD:188098"
     Site            125..145
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Site            152..172
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Site            235..255
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Site            257..277
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Site            349..369
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Site            377..397
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Site            439
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Region          470..492
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Region          726..749
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Site            788..808
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Site            850..870
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Site            931..951
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Site            978
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80WJ6.1)"
     Site            1038..1058
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WJ6.1)"
     CDS             1..1366
                     /gene="Abcc12"
                     /gene_synonym="4930467B22Rik; MRP9"
                     /coded_by="NM_172912.4:34..4134"
                     /db_xref="CCDS:CCDS22502.1"
                     /db_xref="GeneID:244562"
                     /db_xref="MGI:MGI:2441679"
ORIGIN      
        1 mvgegpylis dldrrghrrs faerydpslk tmipvrprar lapnpvddag llsfatfswl
       61 tpvmirsykh tltvdtlppl spydssdina krfqilweee ikrvgpekas lgrvvwkfqr
      121 trvlmdvvan ilcivmaalg ptvlihqilq hitsissghi gigiclclal ftteftkvlf
      181 walawainyr tairlkvals tlifenllsf ktlthisage vlnilssdsy slfeaalfcp
      241 lpatipilmv vcavyaffil gstalvgisv ylifipiqmf maklnstfrr saisvtdkrv
      301 qtmnefltci klikmyawee sfintihdir krekklleka gyvqsgnsal apivstiaiv
      361 stftchiflk rkltapvafs viamfnvmkf siailpfsvk avaeasvslr rmkkiliaks
      421 ppsyitqped pdtilllana tltweqeinr ksdppkaqiq krhvfkkqrp elyseqsrsd
      481 qgvaspewqs gspksvlhni sfvvrkgkvl gicgnvgsgk sslisallgq mqlqkgvvav
      541 ngplayvsqq awifhgnvre nilfgekynh qryqhtvhvc glqkdlnslp ygdlteiger
      601 gvnlsggqrq rislaravya nrqlyllddp lsavdahvgk hvfeecikkt lkgktvvlvt
      661 hqlqflescd evilledgei cekgthkelm eergryakli hnlrglqfkd pehiynvamv
      721 etlkespaqr dedavlasgd ekdegkepet eefvdtnapa hqliqtespq egivtwktyh
      781 tyikasggyl vsflvlclff lmmgssafst wwlgiwldrg sqvvcasqnn ktacnvdqtl
      841 qdtkhhmyql vyiasmvsvl mfgiikgftf tnttlmasss lhnrvfnkiv rspmsffdtt
      901 ptgrlmnrfs kdmdeldvrl pfhaenflqq ffmvvfilvi maavfpvvlv vlaglavifl
      961 illrifhrgv qelkqvenis rspwfshits siqglgviha ydkkddcisk fktlndenss
     1021 hllyfncalr wfalrmdilm nivtfvvall vtlsfssisa sskglslsyi iqlsgllqvc
     1081 vrtgtetqak ftsaellrey iltcvpehth pfkvgtcpkd wpsrgeitfk dyrmryrdnt
     1141 plvldglnln iqsgqtvgiv grtgsgkssl gmalfrlvep asgtiiidev dictvgledl
     1201 rtkltmipqd pvlfvgtvry nldplgshtd emlwhvlert fmrdtimklp eklqaevten
     1261 genfsvgerq llcmarallr nskiilldea tasmdsktdt lvqstikeaf ksctvltiah
     1321 rlntvlncdl vlvmengkvi efdkpevlae kpdsafamll aaevgl
//
