LOCUS       NM_008576               5959 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus ATP-binding cassette, sub-family C member 1 (Abcc1),
            mRNA.
ACCESSION   NM_008576
VERSION     NM_008576.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5959)
  AUTHORS   Maltbaek JH, Cambier S, Snyder JM and Stetson DB.
  TITLE     ABCC1 transporter exports the immunostimulatory cyclic dinucleotide
            cGAMP
  JOURNAL   Immunity 55 (10), 1799-1812 (2022)
   PUBMED   36070769
  REMARK    GeneRIF: ABCC1 transporter exports the immunostimulatory cyclic
            dinucleotide cGAMP.
REFERENCE   2  (bases 1 to 5959)
  AUTHORS   Chen L, Chen H, Xing Y and Li J.
  TITLE     ABCC1 regulates cocaine-associated memory, spine plasticity and
            GluA1 and GluA2 surface expression
  JOURNAL   Neuroreport 32 (10), 833-839 (2021)
   PUBMED   34029289
  REMARK    GeneRIF: ABCC1 regulates cocaine-associated memory, spine
            plasticity and GluA1 and GluA2 surface expression.
REFERENCE   3  (bases 1 to 5959)
  AUTHORS   Gallman AE, Wolfreys FD, Nguyen DN, Sandy M, Xu Y, An J, Li Z,
            Marson A, Lu E and Cyster JG.
  TITLE     Abcc1 and Ggt5 support lymphocyte guidance through export and
            catabolism of S-geranylgeranyl-l-glutathione
  JOURNAL   Sci Immunol 6 (60) (2021)
   PUBMED   34088745
  REMARK    GeneRIF: Abcc1 and Ggt5 support lymphocyte guidance through export
            and catabolism of S-geranylgeranyl-l-glutathione.
REFERENCE   4  (bases 1 to 5959)
  AUTHORS   Krohn M, Zoufal V, Mairinger S, Wanek T, Paarmann K, Bruning T,
            Eiriz I, Brackhan M, Langer O and Pahnke J.
  TITLE     Generation and Characterization of an Abcc1 Humanized Mouse Model
            (hABCC1flx/flx) with Knockout Capability
  JOURNAL   Mol Pharmacol 96 (2), 138-147 (2019)
   PUBMED   31189668
REFERENCE   5  (bases 1 to 5959)
  AUTHORS   Chandra S, Gray J, Kiosses WB, Khurana A, Hitomi K, Crosby CM,
            Chawla A, Fu Z, Zhao M, Veerapen N, Richardson SK, Porcelli SA,
            Besra G, Howell AR, Sharma S, Peters B and Kronenberg M.
  TITLE     Mrp1 is involved in lipid presentation and iNKT cell activation by
            Streptococcus pneumoniae
  JOURNAL   Nat Commun 9 (1), 4279 (2018)
   PUBMED   30323255
  REMARK    GeneRIF: Infected Mrp1 knockout mice show decreased iNKT cell
            responses to antigens from Streptococcus pneumoniae and were
            associated with increased mortality.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5959)
  AUTHORS   Leier I, Jedlitschky G, Buchler M, Buchholz U, Brom M and Keppler
            D.
  TITLE     Identification of the biosynthetic leukotriene C4 export pump in
            murine mastocytoma cells as a homolog of the multidrug-resistance
            protein
  JOURNAL   Eur J Biochem 242 (2), 201-205 (1996)
   PUBMED   8973633
REFERENCE   7  (bases 1 to 5959)
  AUTHORS   Lorico A, Rappa G, Flavell RA and Sartorelli AC.
  TITLE     Double knockout of the MRP gene leads to increased drug sensitivity
            in vitro
  JOURNAL   Cancer Res 56 (23), 5351-5355 (1996)
   PUBMED   8968083
REFERENCE   8  (bases 1 to 5959)
  AUTHORS   Stride BD, Valdimarsson G, Gerlach JH, Wilson GM, Cole SP and
            Deeley RG.
  TITLE     Structure and expression of the messenger RNA encoding the murine
            multidrug resistance protein, an ATP-binding cassette transporter
  JOURNAL   Mol Pharmacol 49 (6), 962-971 (1996)
   PUBMED   8649356
REFERENCE   9  (bases 1 to 5959)
  AUTHORS   Lorico A, Rappa G, Srimatkandada S, Catapano CV, Fernandes DJ,
            Germino JF and Sartorelli AC.
  TITLE     Increased rate of adenosine triphosphate-dependent etoposide
            (VP-16) efflux in a murine leukemia cell line overexpressing the
            multidrug resistance-associated protein (MRP) gene
  JOURNAL   Cancer Res 55 (19), 4352-4360 (1995)
   PUBMED   7671247
REFERENCE   10 (bases 1 to 5959)
  AUTHORS   Doggett NA and Callen DF.
  TITLE     Report and abstracts of the third international workshop on human
            chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 165-184 (1995)
   PUBMED   7842732
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK029876.1, BC090617.1 and
            BP762240.1.
            
            [WARNING] On Oct 31, 2023 this sequence was replaced by
            NM_008576.4.
            
            On Nov 17, 2011 this sequence version replaced NM_008576.2.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This full transporter is a member of the MRP subfamily
            which is involved in multi-drug resistance. This protein plays an
            essential role in the defense against toxic compounds and serves as
            the major high-affinity transporter of leukotriene C4. The encoded
            protein may also play an essential role in steroid hormone
            homeostasis as a transporter for steroid hormones and their
            metabolites. [provided by RefSeq, Nov 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090617.1, AK029876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK029876.1         2-30
            30-5932             BC090617.1         1-5903
            5933-5959           BP762240.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..5959
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 9.75 cM"
     gene            1..5959
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /note="ATP-binding cassette, sub-family C member 1"
                     /db_xref="GeneID:17250"
                     /db_xref="MGI:MGI:102676"
     exon            1..86
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..4625
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="ATP-binding cassette, sub-family C (CFTR/MRP),
                     member 1a; multiple drug resistance-associated protein;
                     LTC4 transporter; leukotriene C(4) transporter;
                     ATP-binding cassette, sub-family C (CFTR/MRP), member 1b;
                     glutathione-S-conjugate-translocating ATPase ABCC1"
                     /codon_start=1
                     /product="multidrug resistance-associated protein 1"
                     /protein_id="NP_032602.1"
                     /db_xref="CCDS:CCDS37264.1"
                     /db_xref="GeneID:17250"
                     /db_xref="MGI:MGI:102676"
                     /translation="MALRSFCSADGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCF
                     YLWSCFPLYFFYLSRHDRGYIQMTHLNKTKTALGFFLWIICWADLFYSFWERSQGVLR
                     APVLLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALLCALAILRSKIISA
                     LKKDAHVDVFRDSTFYLYFTLVLVQLVLSCFSDCSPLFSETVHDRNPCPESSASFLSR
                     ITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIV
                     YAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFGPYFLMSFLYKA
                     LHDLMMFAGPKILELIINFVNDREAPDWQGYFYTALLFVSACLQTLALHQYFHICFVS
                     GMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPL
                     QVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNE
                     ILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTF
                     AVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHE
                     ELEPDSIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGC
                     GKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAV
                     MEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAV
                     DAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELL
                     DRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNS
                     SSHSGDTSQQHSSIAELQKAGAKEETWKLMEADKAQTGQVQLSVYWNYMKAIGLFITF
                     LSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRNFRLSVYGALGILQGAAIFGY
                     SMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVI
                     KMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRS
                     PVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVG
                     NCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLK
                     EYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKV
                     GIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFS
                     GSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVC
                     LARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRV
                     IVLDKGEVRECGAPSELLQQRGIFYSMAKDAGLV"
     exon            87..263
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..389
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..527
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..653
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..715
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..847
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1081
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1259
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1421
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1514
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1718
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1865
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1953
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2026
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2153
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2330
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2498
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2682
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2764
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2897
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3108
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3419
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3619
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3746
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3747..3848
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..3995
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3996..4154
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4155..4321
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4322..4516
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4517..5935
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5935
                     /gene="Abcc1"
                     /gene_synonym="Abcc1a; Abcc1b; Mdrap; MRP; Mrp1"
ORIGIN      
        1 gcgcggcgct gcgcctcctc gctcagccgg ccgcccgcat ggcgctgcgc agcttctgca
       61 gcgctgatgg ctccgatcca ctctgggact ggaatgtcac atggcacacc agcaaccccg
      121 actttaccaa gtgctttcag aacacggtcc tcacatgggt gccttgtttc tacctctggt
      181 cctgtttccc cctctacttc ttctatctct ctcgccatga ccggggctac atccagatga
      241 cacacctcaa caaaaccaaa actgccttag gattctttct gtggatcatc tgctgggcag
      301 acctcttcta ctctttctgg gaaagaagtc agggagtgct ccgagcccca gtgttactgg
      361 tcagcccaac actgctgggc atcaccatgc tgctcgccac ctttttgata cagcttgaac
      421 ggaggaaggg agtccaatcc tcgggaatta tgcttacttt ctggctcgta gccctactct
      481 gtgcccttgc catcttgaga tctaagatca tctctgcctt aaaaaaggat gctcatgtgg
      541 acgtgtttcg agattccacg ttctatctgt acttcaccct tgtgcttgtt cagctcgtgc
      601 tgtcctgctt ctcagactgc tcacccctgt tctctgaaac tgtccatgac cggaatccat
      661 gcccagaatc cagtgcctct ttcctttcca ggattacttt ctggtggatt acagggatga
      721 tggtgcacgg ctaccgccag cccctggaga gcagtgacct ctggtcattg aataaggagg
      781 acacatcaga agaagtggta cctgtgctgg tgaataactg gaagaaggaa tgtgataagt
      841 caaggaagca gcctgtacgg attgtgtatg cccctcccaa agatcccagc aagcctaagg
      901 gaagttccca gttggatgtg aatgaggagg tggaggcact gattgtcaag tcaccccaca
      961 aggatcggga gccctctctg ttcaaggtgt tatacaagac ttttggtccc tacttcctca
     1021 tgagcttcct gtacaaggcc cttcatgacc tgatgatgtt tgccggcccc aagatcttgg
     1081 aattgattat caacttcgtg aatgacaggg aggctcccga ctggcagggc tacttttaca
     1141 cagcactgct gtttgtcagc gcctgtctgc agacactggc actccaccag tactttcata
     1201 tctgcttcgt cagtggcatg cgcatcaaga ctgctgtggt gggcgctgtc tatcgtaagg
     1261 ctcttttgat caccaatgca gctagaaaat cttccacggt cggagagatt gtcaacctca
     1321 tgtccgtgga tgctcagcgc ttcatggact tggccacgta cattaacatg atctggtcag
     1381 cccctctgca agtcatccta gccctctact tcctgtggct gagcctgggc ccttctgtgc
     1441 tggctggagt ggctgtgatg attctcatgg tacccttaaa tgctgtgatg gccatgaaga
     1501 ccaagaccta ccaggtggca cacatgaaga gcaaagacaa ccgaatcaag ctgatgaacg
     1561 agatcctcaa tgggatcaaa gtcctcaagc tgtacgcctg ggagctggcc ttccaggaca
     1621 aagtcatgag catcaggcag gaggagctca aggtgctgaa gaaatctgcc tacttggcag
     1681 ctgtaggcac attcacgtgg gtgtgcacac ctttcctggt ggccctgtca acctttgctg
     1741 tctttgtgac tgtggatgag agaaatatcc tagatgcaaa gaaagccttt gtgtccctag
     1801 ccctgttcaa tatcttgcgc ttcccactca acatcctgcc catggttatc agcagcattg
     1861 tgcaggccag cgtgtccctc aagcgtctca ggatttttct gtctcatgag gagctggagc
     1921 cagacagcat tgagcggagg tcgatcaaga gtggcgaagg gaatagcatc actgtgaaga
     1981 atgcaacctt cacttgggcc aggggtgaac ctcccacact gaatggcatc accttctcca
     2041 ttcctgaagg agcccttgtg gccgtggtgg gccaggtagg ctgcgggaag tcatctctgc
     2101 tgtcagccct gctggctgag atggacaagg tggagggaca tgtgactctc aagggctccg
     2161 tggcctacgt gccccagcag gcctggattc agaatgactc tctccgagag aacatactgt
     2221 ttgggcaccc cctgcaggaa aattactaca aggcagttat ggaagcctgt gcccttcttc
     2281 cagatttgga aatcctgccc agtggggacc gcacagagat cggtgagaag ggtgtgaacc
     2341 tgtcaggggg ccagaagcag cgtgtgagcc tggcccgggc tgtgtactct aactctgaca
     2401 tctacctctt tgatgacccc ctctcggctg tggatgcaca tgttgggaag cacatctttg
     2461 agaaggtggt tggtcccatg ggcctactga agaacaagac acggatcctg gtcacccatg
     2521 gtatcagcta cctgccccaa gtggatgtca tcattgtcat gagtggcggc aagatctcag
     2581 agatgggttc ttatcaggag ctgctagacc gggatggggc cttcgctgag ttcctgcgca
     2641 cctatgccaa cgctgagcag gacctggcct cggaggatga cagtgtcagt ggttcaggga
     2701 aggagtcaaa gccggtggaa aatgggatgc tggtgacaga caccgtagga aagcacctgc
     2761 agaggcatct cagcaactcg tcttcccaca gtggggatac cagccagcaa cacagcagca
     2821 tagccgaact gcagaaggct ggagctaagg aggagacgtg gaagctaatg gaagcagaca
     2881 aggcccagac agggcaggtg cagctgtcag tgtactggaa ctacatgaag gccattggcc
     2941 tcttcatcac cttcttgagt atcttccttt tcctgtgcaa ccatgtatct gcactggcct
     3001 ctaactattg gctgagcctc tggacagatg acccccctgt tgtcaatggg actcaggcga
     3061 acaggaattt tcggctgagt gtctatgggg ccttgggcat cttgcaaggt gcagcaatat
     3121 ttggctactc catggctgtg tccatcgggg gcatctttgc ctcccgtcgc ttgcacctgg
     3181 acctgctata caatgttctg cgatcaccca tgagtttctt tgagcgtaca cccagtggga
     3241 acctagtgaa ccgattctcc aaggagctgg acacagtgga ctccatgatc ccgcaggtca
     3301 tcaagatgtt catgggttca ctcttcagtg tcattggagc tgtcatcatc atcctactgg
     3361 ccacgcccat tgccgcagtc atcatcccac ccttgggtct ggtttacttc tttgtgcaga
     3421 ggttctatgt ggcttcctca agacaactga agcgcctgga gtctgtcagc cgttcccctg
     3481 tgtactcaca cttcaatgag accttgctgg gagtcagtgt catccgtgct tttgaggagc
     3541 aggagcgctt cattcaccag agtgacctga aagtagatga gaaccagaag gcctactacc
     3601 ccagcattgt ggccaacagg tggcttgctg tgcgccttga gtgtgtgggc aactgcattg
     3661 tgctgtttgc tgccctcttt gcagtcatct cccggcacag cctcagtgct ggcttggtgg
     3721 gcctctctgt gtcttactca ctgcagataa ctgcatactt gaactggctg gttcgaatgt
     3781 cctcggagat ggagaccaac attgtggcag tggagagact gaaggagtat tctgaaacag
     3841 agaaggaggc tccttggcaa atccaggaaa cagctccacc cagcacctgg ccccattcag
     3901 gccgtgtaga gttccgggat tactgcctga ggtatcgaga agacttggac ttggttctca
     3961 agcacataaa tgtcaccatt gagggtggag aaaaggtggg tattgtaggt cgtacgggag
     4021 ctgggaaatc atctctcacc ctgggtttgt tccggatcaa tgagtctgca gaaggggaga
     4081 tcatcattga tggggtcaac atcgccaaga tcggcctgca caacctgcgc ttcaagatca
     4141 ccatcattcc acaggatcct gttttgttct cgggttccct ccgcatgaac ttggaccctt
     4201 tcagtcagta ttctgatgaa gaagtctgga tggccctgga gcttgctcac ctaaagggct
     4261 ttgtgtcagc tttgcctgac aagctgaacc atgagtgtgc agaaggtgga gagaacctga
     4321 gtgtggggca gcgacagctt gtgtgcctgg cccgggctct gctgaggaag acaaagattc
     4381 tagtgttgga cgaggctacc gcagctgtgg acctagagac agataacctt atccagtcca
     4441 ccatccggac acagtttgaa gactgtactg tgctcacgat tgctcatcgg cttaacacca
     4501 taatggacta cacgcgggtg attgtcctgg acaaaggaga agttcgggag tgtggtgcac
     4561 cctctgagct cctgcagcaa agaggcatct tctacagcat ggccaaggat gctggcttgg
     4621 tgtgagctgg tctctggcat atccaatgag gactgcaggg ccaggatccc agagtccagg
     4681 catgagccag caaccctgga aacctacgct tcccagacaa aacccaaaaa tttaaaacga
     4741 aaccaaacta aaaggaagca aaatacttag gcgtctgtca ccatttggct tcatcctgga
     4801 tctgaccttg aagaagctgg aagacagatg caccccactt cagatacacg tctggcctct
     4861 ggcaccctga aagttcaccc atgctcctgc cgtatcccac ggcaagtcca tgggcagcta
     4921 aacatactag tgaccaaaca caagccacac tgcctcatgt ctcttcagcc acgtctacgg
     4981 atgccaagcc ttgtagcctc tcctggcctt gccagctctc tgtcacctat agtcgtgttg
     5041 gttacagaag agtgcatctt gccttcaggt cttgcagttg aaacatggga accaaaatga
     5101 acaaaaagga gagaaagaaa acccctaaaa agttcctgtc cttgttatgt cagtgatgtc
     5161 cccttcctgc catctggtct tcatgcacgc tgacactgtc ccctgcgttc agcacagctt
     5221 tcacaggacc tgcttaagac acagccttgt gaagggacct aggcagacag gcttggaacc
     5281 cggccaggca acactccctt cacaaggact tacaccttgc ccctgctttc tgtttcttcc
     5341 tgttcaaagc tggggagggc tcactcctca cataaggtct atgaatagtt ataagcagca
     5401 aaagtcaaga gcagaaggga tggtgcccac gggcaagaat ctggtatcaa agacagccag
     5461 agttccttat agggccagaa gagaaccatt cacaaatatc agtgatttct cccccctact
     5521 tatgagcatc gtttcgtgga gaaggatagt cccaagaatt tgatgtctgg gagaaggtac
     5581 tagattcagg gagcagccat gcccagctct gcacttgatc ctcagtctga atacttcaaa
     5641 gtggtcctct aggttgtgtg agttacagac caaagagaga cccccatggt tagcaagaac
     5701 ttgatgccag ccacagttca tacttgcttt gaattttggc tctaatgtca gtcccagaga
     5761 agcatccttt ttctttaggt ggcaatatat gtatttattt tttgtaagtt aataccattc
     5821 tttcacttta aagggcccag atttctcctg agagtctttt tgtaatgaca ctggaaacat
     5881 gactatttga aaataatttg cagtaaagaa aaatatttca tttctttcta aacgaaaaaa
     5941 aaaaaaaaaa aaaaaaaaa
//
