LOCUS       NM_019875               3334 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ATP-binding cassette, sub-family B member 9 (Abcb9),
            mRNA.
ACCESSION   NM_019875
VERSION     NM_019875.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3334)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3334)
  AUTHORS   Park,J.G., Kim,S., Jang,E., Choi,S.H., Han,H., Ju,S., Kim,J.W.,
            Min,D.S. and Jin,M.S.
  TITLE     The lysosomal transporter TAPL has a dual role as peptide
            translocator and phosphatidylserine floppase
  JOURNAL   Nat Commun 13 (1), 5851 (2022)
   PUBMED   36195619
  REMARK    GeneRIF: The lysosomal transporter TAPL has a dual role as peptide
            translocator and phosphatidylserine floppase.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3334)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3334)
  AUTHORS   van Endert,P. and Lawand,M.
  TITLE     Unexpected lack of specificity of a rabbit polyclonal TAP-L (ABCB9)
            antibody
  JOURNAL   F1000Res 4, 125 (2015)
   PUBMED   27335633
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3334)
  AUTHORS   Demirel,O., Jan,I., Wolters,D., Blanz,J., Saftig,P., Tampe,R. and
            Abele,R.
  TITLE     The lysosomal polypeptide transporter TAPL is stabilized by
            interaction with LAMP-1 and LAMP-2
  JOURNAL   J Cell Sci 125 (Pt 18), 4230-4240 (2012)
   PUBMED   22641697
REFERENCE   6  (bases 1 to 3334)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   7  (bases 1 to 3334)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 3334)
  AUTHORS   Uinuk-ool,T.S., Mayer,W.E., Sato,A., Takezaki,N., Benyon,L.,
            Cooper,M.D. and Klein,J.
  TITLE     Identification and characterization of a TAP-family gene in the
            lamprey
  JOURNAL   Immunogenetics 55 (1), 38-48 (2003)
   PUBMED   12679854
REFERENCE   9  (bases 1 to 3334)
  AUTHORS   Kobayashi,A., Kasano,M., Maeda,T., Hori,S., Motojima,K., Suzuki,M.,
            Fujiwara,T., Takahashi,E., Yabe,T., Tanaka,K., Kasahara,M.,
            Yamaguchi,Y. and Maeda,M.
  TITLE     A half-type ABC transporter TAPL is highly conserved between rodent
            and man, and the human gene is not responsive to interferon-gamma
            in contrast to TAP1 and TAP2
  JOURNAL   J Biochem 128 (4), 711-718 (2000)
   PUBMED   11011155
REFERENCE   10 (bases 1 to 3334)
  AUTHORS   Zhang,F., Zhang,W., Liu,L., Fisher,C.L., Hui,D., Childs,S.,
            Dorovini-Zis,K. and Ling,V.
  TITLE     Characterization of ABCB9, an ATP binding cassette protein
            associated with lysosomes
  JOURNAL   J Biol Chem 275 (30), 23287-23294 (2000)
   PUBMED   10748049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113474.18 and AK044140.1.
            
            On Jun 3, 2005 this sequence version replaced NM_019875.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the MDR/TAP subfamily. Members
            of the MDR/TAP subfamily are involved in multidrug resistance as
            well as antigen presentation. The function of this half-transporter
            has not yet been determined; however, it may be associated with
            lysosome activity. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053014.1, AF216495.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC113474.18        113099-113121       c
            24-3334             AK044140.1         2-3312
FEATURES             Location/Qualifiers
     source          1..3334
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.36 cM"
     gene            1..3334
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /note="ATP-binding cassette, sub-family B member 9"
                     /db_xref="GeneID:56325"
                     /db_xref="MGI:MGI:1861729"
     exon            1..153
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            154..828
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..2528
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /EC_number="7.4.2.6"
                     /note="mABCB9; TAP-like protein; ABC transporter 9
                     protein; ATP-binding cassette transporter 9; ATP-binding
                     cassette, sub-family B (MDR/TAP), member 9"
                     /codon_start=1
                     /product="ABC-type oligopeptide transporter ABCB9"
                     /protein_id="NP_063928.2"
                     /db_xref="CCDS:CCDS19671.1"
                     /db_xref="GeneID:56325"
                     /db_xref="MGI:MGI:1861729"
                     /translation="MRLWKAVVVTLAFVSTDVGVTTAIYAFSHLDRSLLEDIRHFNIF
                     DSVLDLWAACLYRSCLLLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMAKLL
                     LFSEVRRPIRDPWFWALFVWTYISLAASFLLWGLLATVRPDAEALEPGNEGFHGEGGA
                     PAEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDSIVIQKSM
                     DQFTTAVVVVCLLAIGSSLAAGIRGGIFTLVFARLNIRLRNCLFRSLVSQETSFFDEN
                     RTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPI
                     IMMVSNIYGKYYKRLSKEVQSALARASTTAEETISAMKTVRSFANEEEEAEVFLRKLQ
                     QVYKLNRKEAAAYMSYVWGSGLTLLVVQVSILYYGGHLVISGQMSSGNLIAFIIYEFV
                     LGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFT
                     YRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGKPI
                     GAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMEL
                     QDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIH
                     GNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLG
                     LEHPLDYTASHKEPPSNTEHKA"
     exon            829..943
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1074
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1280
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1478
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1607
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1796
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1970
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2130
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2267
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..3334
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3308..3313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /note="hexamer: AATAAA"
     polyA_site      3334
                     /gene="Abcb9"
                     /gene_synonym="mKIAA1520; TAPL"
                     /note="major polyA site"
ORIGIN      
        1 gtcagcgggc agctgggcta ggctccgacc ttgtagcggc gcagcgccgg ctccgagcaa
       61 agcggtgccc agagcgggct cggtgagagg caggatcctg tgtccccgcg tcccggccac
      121 ggtgtcaccc tctgacgact cacctggtgg caggtgtggc cctgcccagc tgtcagtgat
      181 ggccttgccc cggtgagcca aagcctgccc ctctcacccg ccggccacca gccagcagga
      241 tgaggctgtg gaaggcggta gtagtgacgc tggccttcgt gagcacggac gtcggggtga
      301 ccacggccat ctacgccttc agccacctgg accgtagcct gctggaggac atccgacact
      361 ttaacatctt cgactcggtg ctggacctct gggctgcctg cctgtaccgc agctgcctgc
      421 tgctgggggc taccataggc gtggccaaga acagcgctct ggggccaagg cgcctgcggg
      481 cttcgtggct cgtcatcacc ctcgtgtgcc tctttgtggg catctatgcc atggccaaac
      541 tgctactctt ctcagaagtg cgcaggccca tccgggaccc atggttctgg gcgctcttcg
      601 tgtggaccta catctcgctg gctgcctcct tcctgctgtg ggggctgctg gccactgtgc
      661 ggccggacgc agaggccctg gagccaggga atgagggctt ccacggggag ggtggggccc
      721 ctgctgagca ggcatcggga gccacactac agaagctgtt gtcctacaca aagcctgacg
      781 tggccttcct agtagctgcc tcctttttcc tcatcgtagc agctctgggt gagaccttcc
      841 tgccctacta cactggccgg gccattgaca gcattgtgat ccagaaaagc atggatcagt
      901 tcaccacagc cgttgtcgtc gtttgcctgc tggccatcgg cagctcattg gccgcaggta
      961 ttcggggcgg tattttcacc ctcgtatttg ccagactgaa cattcgcctc cggaactgtc
     1021 tcttccgctc actggtgtca caggagacaa gcttctttga tgagaaccgc acaggggacc
     1081 tcatctcccg cctcacctct gataccacca tggtcagcga cctggtctcc cagaacatca
     1141 acatcttcct gaggaacacg gtcaaagtca cgggcgtggt ggtcttcatg ttcagcctct
     1201 cctggcagct ttccctggtc accttcatgg gcttccctat catcatgatg gtgtccaaca
     1261 tctacggcaa gtactacaag aggctctcca aggaggtcca gagcgccctg gccagagcca
     1321 gcaccacagc cgaggaaacc atcagcgcga tgaagacggt gcgcagcttt gccaacgagg
     1381 aggaggaggc cgaggtgttc ctgcggaagc ttcagcaggt gtacaagctc aacaggaagg
     1441 aagcagcggc ctacatgtcc tacgtctggg gcagcgggct cacactcctg gtggtccagg
     1501 tcagtattct ctactacggg ggccacctag tcatctcggg gcagatgagc agcggcaacc
     1561 tcatcgcctt catcatctac gaatttgtcc tgggagactg catggagtcc gtgggctccg
     1621 tctacagtgg cctgatgcag ggagtggggg ccgccgagaa ggtgttcgag ttcatcgacc
     1681 ggcagcccac catggtgcat gacggaagct tggcccccga ccacctcgag ggcagggtgg
     1741 actttgagaa tgtgaccttc acctaccgca ctcggcccca cacacaggtc ctacagaatg
     1801 tctccttcag cctgtccccc ggcaaggtga cagctctggt ggggccgtcg ggcagcggga
     1861 agagctcgtg tgtgaacatc ctggagaact tctaccctct gcagggcggc cgtgtattgt
     1921 tggatggcaa gcccattggc gcctatgacc acaagtacct gcatcgtgtg atctcactgg
     1981 tgagccagga gcccgtgctg ttcgcccgct ccatcacaga caacatctcc tacggcctgc
     2041 ctaccgtgcc cttcgagatg gtggtggagg ctgcacagaa ggccaatgcc catggcttca
     2101 tcatggaact gcaggacggg tacagcacag agaccgggga gaagggagcc cagctgtcag
     2161 gtgggcagaa gcagcgggtg gccatggccc gagcacttgt gcggaaccca cctgtgctta
     2221 tcctggacga agccaccagt gccctggatg ccgagagcga atacctgatt cagcaggcca
     2281 tccacggcaa cctgcagaga cacacggtgc tcatcattgc acaccggctg agcaccgtgg
     2341 agcgggcaca cctcatcgtg gtgctggaca agggccgggt ggtacagcag ggcacacacc
     2401 agcagctgtt ggcacagggc ggcctctatg ccaagctggt gcagcgtcag atgttggggc
     2461 tcgagcaccc cttggactac acagccagcc acaaggagcc acccagcaac actgaacaca
     2521 aggcctgaca gtggccccca ggctgaagca ctggaggcga cctgccaagt cccactcctg
     2581 cttcctgcat cttgcctcct tccacttgct ccccaggcac ccgccagctg ccatgggctt
     2641 acccccttct actgtgtcct tcttggctcc tccaggcctg ccaaggtaga gcagcctttt
     2701 taaaccaagc taccagggtt tttactgctc agttcaacgc actccagtca actctgagat
     2761 ttcaaaaaga acctttttgg gactggcagt gagcaagctc actaagatgt ttccaagact
     2821 tctgagccaa gagtgcagga ccctttctga ctgcctggag gatgtctggg agagaactaa
     2881 gcaccaccct ttgcctctcg ggagaagcag cctccctgtc ccctaggggg acacaagggt
     2941 tggcctttcc atccttccag tctcccggct ctgtgagtca ggccagaggt ggggcaagag
     3001 agtgggaggt ggcccactgc ccatcacccc cctgccactc aaagccagtc tcactgtgaa
     3061 ccactgggac ctcagcagag gaggggctgg ccgggcctgg tgggcctcgg ggtgccctca
     3121 gccccgcacc cagcacttga acccttcacc ctctcccctg gctggcacct tccctcctgt
     3181 ccacccctgc aactctgcgg aggaacctgt cgtttgtaag atgtattctc agattggtgg
     3241 agggggacca aggcaatgcc cagggtctgg ctttgtcctg gtttcaagat tttgggagaa
     3301 ctgggtcaat aaagtgtact acctctgacc tcta
//
