LOCUS       NM_029020               2940 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family B member 8 (Abcb8),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_029020
VERSION     NM_029020.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2940)
  AUTHORS   Chang,H.C., Shapiro,J.S., Jiang,X., Senyei,G., Sato,T., Geier,J.,
            Sawicki,K.T. and Ardehali,H.
  TITLE     Augmenter of liver regeneration regulates cellular iron homeostasis
            by modulating mitochondrial transport of ATP-binding cassette B8
  JOURNAL   Elife 10, e65158 (2021)
   PUBMED   33835027
  REMARK    GeneRIF: Augmenter of liver regeneration regulates cellular iron
            homeostasis by modulating mitochondrial transport of ATP-binding
            cassette B8.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2940)
  AUTHORS   Paggio,A., Checchetto,V., Campo,A., Menabo,R., Di Marco,G., Di
            Lisa,F., Szabo,I., Rizzuto,R. and De Stefani,D.
  TITLE     Identification of an ATP-sensitive potassium channel in
            mitochondria
  JOURNAL   Nature 572 (7771), 609-613 (2019)
   PUBMED   31435016
REFERENCE   3  (bases 1 to 2940)
  AUTHORS   Chang,H.C., Wu,R., Shang,M., Sato,T., Chen,C., Shapiro,J.S.,
            Liu,T., Thakur,A., Sawicki,K.T., Prasad,S.V. and Ardehali,H.
  TITLE     Reduction in mitochondrial iron alleviates cardiac damage during
            injury
  JOURNAL   EMBO Mol Med 8 (3), 247-267 (2016)
   PUBMED   26896449
REFERENCE   4  (bases 1 to 2940)
  AUTHORS   Ichikawa,Y., Ghanefar,M., Bayeva,M., Wu,R., Khechaduri,A., Naga
            Prasad,S.V., Mutharasan,R.K., Naik,T.J. and Ardehali,H.
  TITLE     Cardiotoxicity of doxorubicin is mediated through mitochondrial
            iron accumulation
  JOURNAL   J Clin Invest 124 (2), 617-630 (2014)
   PUBMED   24382354
REFERENCE   5  (bases 1 to 2940)
  AUTHORS   Ichikawa,Y., Bayeva,M., Ghanefar,M., Potini,V., Sun,L.,
            Mutharasan,R.K., Wu,R., Khechaduri,A., Jairaj Naik,T. and
            Ardehali,H.
  TITLE     Disruption of ATP-binding cassette B8 in mice leads to
            cardiomyopathy through a decrease in mitochondrial iron export
  JOURNAL   Proc Natl Acad Sci U S A 109 (11), 4152-4157 (2012)
   PUBMED   22375032
  REMARK    GeneRIF: These results indicate that ABCB8 is essential for normal
            cardiac function, maintenance of mitochondrial iron homeostasis and
            maturation of cytosolic Fe/S proteins.
REFERENCE   6  (bases 1 to 2940)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   7  (bases 1 to 2940)
  AUTHORS   Wang,C. and Brennan,W.A. Jr.
  TITLE     Rat skeletal muscle, liver and brain have different fetal and adult
            forms of the glucose transporter
  JOURNAL   Biochim Biophys Acta 946 (1), 11-18 (1988)
   PUBMED   3145016
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113055.9.
            
            On Aug 16, 2018 this sequence version replaced NM_029020.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015301.1, AK166704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               AC113055.9         31469-31896         c
            429-738             AC113055.9         25830-26139         c
            739-894             AC113055.9         25372-25527         c
            895-989             AC113055.9         25201-25295         c
            990-1095            AC113055.9         24972-25077         c
            1096-1257           AC113055.9         24128-24289         c
            1258-1343           AC113055.9         23922-24007         c
            1344-1441           AC113055.9         23713-23810         c
            1442-1547           AC113055.9         22874-22979         c
            1548-1581           AC113055.9         20204-20237         c
            1582-1718           AC113055.9         19798-19934         c
            1719-1813           AC113055.9         19558-19652         c
            1814-1947           AC113055.9         19251-19384         c
            1948-2095           AC113055.9         18597-18744         c
            2096-2346           AC113055.9         17234-17484         c
            2347-2940           AC113055.9         16105-16698         c
FEATURES             Location/Qualifiers
     source          1..2940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 11.57 cM"
     gene            1..2940
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /note="ATP-binding cassette, sub-family B member 8"
                     /db_xref="GeneID:74610"
                     /db_xref="MGI:MGI:1351667"
     exon            1..428
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..2487
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /note="ATP-binding cassette sub-family B member 8,
                     mitochondrial; mitochondrial sulfonylurea-receptor;
                     mitochondrial potassium channel ATP-binding subunit;
                     ATP-binding cassette, sub-family B (MDR/TAP), member 8"
                     /codon_start=1
                     /product="mitochondrial potassium channel ATP-binding
                     subunit precursor"
                     /protein_id="NP_083296.2"
                     /db_xref="CCDS:CCDS19118.1"
                     /db_xref="GeneID:74610"
                     /db_xref="MGI:MGI:1351667"
                     /translation="MLVHLFRFGIRGGPVPGWSLQSLRFQTFSAARSSDDRLSSHLLR
                     TVAQLRVQLRAHLPRAPPASHWSPSAWCWVGGTLVVPAVLWQHPRLCLIALCEAKESP
                     PAQPTRAPELRFNWKLFWHFLHPHLLALGAAIVLALGAALVNVQIPLLLGQLVEIVAK
                     YTRDHMGSFVSESRKLSVQLLLLYGVQGLLTFGYLVLLSHIGERMAMDMRKALFSSLL
                     RQDIAFFDAKKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVIGSLVSLSMLSPRL
                     TLMLAVVTPALMGVGTLMGSGLRKLSRQCQEQIARATGVADEALGNVRTVRAFAMEKR
                     EEERYQAELESCCCKAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLKGGD
                     LMSFLVASQTVQRSMASLSVLFGQVVRGLSAGARVFEYMALSPVIPLTGGYCIPNKDI
                     RGSITFQNVTFSYPCRPGFNVLKDFTLKLPSGKIVALVGQSGGGKTTVASLLERFYDP
                     EAGSVTLDGHDLRTLNPSWLRGQVIGFISQEPVLFATTIMENIRFGKLDASDEEVYTA
                     AREANAHEFISSFPDGYSTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSAL
                     DAESERVVQEALDRASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGTHEELLKKG
                     GLYSELIRRQTLDASLTSTPPAEKPEDPKSCQSKA"
     exon            429..738
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            739..894
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            895..989
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1095
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1257
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1343
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1441
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1547
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1581
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1718
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1813
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1947
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2095
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2346
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2940
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2897..2902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /note="hexamer: AACAAA"
     polyA_site      2910
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /note="major polyA site"
     regulatory      2915..2920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /note="hexamer: AATAAA"
     polyA_site      2916
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /note="major polyA site"
     polyA_site      2940
                     /gene="Abcb8"
                     /gene_synonym="4833412N02Rik; MITOSUR"
                     /note="major polyA site"
ORIGIN      
        1 ggagcataga gattgtctgg aacaactcta gagaaagggc tcaaggtcag aagcgccagg
       61 acgtcctcta atgtgagaat gaacgtcgca caacctctga cccgcacctg acttcaggcc
      121 actgagcaaa tagctagagc tgcttctgct cggtcccgcc tacagccaac attttatcca
      181 atcacagctt gcagcaagac tgatgtgtct tttctccaat catcgctgag aatgggaagg
      241 ggttgtcggg atggggccat agcgaacatg gaaccctcgg taggataagt gtgagattgc
      301 cgttgctggc tgcccctatc ttattgcctc aacatgttgg tgcacttatt tcggttcgga
      361 atccggggtg gcccagttcc aggatggtcg ctacaatccc tgcgcttcca gacgttctct
      421 gccgccaggt cctcagatga ccggctcagc tcacacctcc tgcggactgt agcccagctc
      481 cgtgtacagc tccgggctca cctccctcga gccccaccag cttcccactg gagcccctct
      541 gcctggtgtt gggttggggg gaccttggtg gtccctgcag tcctgtggca gcatccacgc
      601 ctctgcctta tagcactatg tgaggccaaa gagtcccctc ctgcccagcc cacacgtgcc
      661 ccagagctgc gctttaattg gaagctcttc tggcatttcc ttcaccccca cctgctggcc
      721 ttgggggcag ccattgtgct ggccttaggt gcggcactag tgaatgtgca gatccccttg
      781 ctcctgggcc agctggtgga gattgtcgcc aagtacacga gggaccacat ggggagtttc
      841 gtgtctgagt cccgtaagct cagcgtccag ctgctcctac tgtacggtgt tcagggactg
      901 ctgacctttg gatacctagt gctgctgtcc cacattggtg agcgcatggc catggacatg
      961 cggaaagccc ttttcagctc cctgctccgg caagacattg ctttctttga tgccaaaaag
     1021 acagggcagc tagtgagtcg cttgactact gatgtgcaag aattcaagtc atccttcaag
     1081 cttgtcatct cccagggact gcgcagctgc acccaggtga ttggtagcct ggtgtccctg
     1141 tctatgctgt cccctcgcct taccctgatg ctggctgtcg tcacacccgc cctcatggga
     1201 gtgggcaccc tgatgggctc aggcctccga aagctgtctc gccagtgtca ggagcagatt
     1261 gccagggcaa caggtgtagc agatgaggcc cttggcaatg ttcggactgt gcgggccttc
     1321 gcgatggaga agagggagga ggaacgctat caagcagaac tggagtcatg ctgctgtaaa
     1381 gcagaagaac tgggcagggg catcgccttg ttccaagggc tctccaacat cgctttcaac
     1441 tgtatggtct tgggcaccct gttcattggg ggctcccttg tggctggaca gcagctgaaa
     1501 gggggagacc tcatgtcctt cctggtggct tcccagacag tacagaggtc tatggccagc
     1561 ctctctgtcc tgtttggtca ggtggtacgt gggctgagtg cgggagcccg agtcttcgaa
     1621 tacatggccc tgagccctgt catcccattg accgggggct actgcatccc caacaaggac
     1681 attcgtggtt ccatcacctt ccaaaatgtc accttcagct acccctgcag acctggcttc
     1741 aatgtgctca aggacttcac cctgaagctg ccctctggca agattgtggc tcttgtgggc
     1801 cagtctgggg gaggaaagac cacagttgcc tccttgctgg aacgcttcta tgaccctgaa
     1861 gctggctcgg tgacgttgga tgggcatgac ctgcgaactc tcaacccctc ctggctccgg
     1921 ggccaggtca taggtttcat cagccaggag ccagtcctgt ttgcaacaac catcatggag
     1981 aatatccgat ttgggaagct ggatgcttcc gatgaagagg tgtacacagc tgcacgagaa
     2041 gccaatgccc acgagttcat cagcagcttc cccgatggct acagcactgt ggttggtgag
     2101 cggggcacaa ccttgtctgg tggccagaag cagcgcctag ccatcgcacg tgccctcatc
     2161 aagcagccca cagtgctgat cctggacgag gccaccagtg cgctagatgc agaatccgag
     2221 agggtggtac aggaggccct ggaccgggcc agtgctggcc gcaccgtgtt ggtcattgcc
     2281 caccggctta gtactgtccg tgcagcccac tccatcattg tcatggccaa tggccaagtc
     2341 tgtgaggctg ggacccacga agaactcctt aaaaaaggcg ggctctattc agagcttatc
     2401 cggagacaaa ccctggacgc ctcactgacc tcaacccctc ctgcagagaa gcctgaagac
     2461 cccaaaagct gccagtccaa agcctgagag gccccctggg gtcaggtcac tgcaagacat
     2521 cagtctgagg ctggagctct gctggggaca gagcccttgg aaggccagtg tgctggagtg
     2581 tggcctgcac tactgccccc ttaaaggagc tgggctcaac agctggggtg ggaaatggct
     2641 ctccgcccac ctgctctgac catcctgact cagctctgtg gtcacgggat gtacacagtg
     2701 agacagagtc cctggacacc tctgcttgac cctctcaggc tggcctggtt ctgcccaaca
     2761 ctcagttgtt tgggccctca ctccaggaga ctggccaggc ctggtagaat gggttgtaat
     2821 cccagcactt gggagacaga agtgggaggg tcaagagttc aaggccatcc tgggctaaat
     2881 agtgagaccc tctctcaaca aaaagaaaaa cctaaataaa gaggaaaaat tttcaaagag
//
