LOCUS       NM_009592               5759 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family B member 7 (Abcb7),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_009592 XM_907304 XM_920355
VERSION     NM_009592.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5759)
  AUTHORS   Lehrke,M.J., Shapiro,M.J., Rajcula,M.J., Kennedy,M.M., McCue,S.A.,
            Medina,K.L. and Shapiro,V.S.
  TITLE     The mitochondrial iron transporter ABCB7 is required for B cell
            development, proliferation, and class switch recombination in mice
  JOURNAL   Elife 10, e69621 (2021)
   PUBMED   34762046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5759)
  AUTHORS   Maio,N., Kim,K.S., Holmes-Hampton,G., Singh,A. and Rouault,T.A.
  TITLE     Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an
            architecturally defined molecular complex required for heme
            biosynthesis
  JOURNAL   Haematologica 104 (9), 1756-1767 (2019)
   PUBMED   30765471
REFERENCE   3  (bases 1 to 5759)
  AUTHORS   Borensztein,M., Okamoto,I., Syx,L., Guilbaud,G., Picard,C.,
            Ancelin,K., Galupa,R., Diabangouaya,P., Servant,N., Barillot,E.,
            Surani,A., Saitou,M., Chen,C.J., Anastassiadis,K. and Heard,E.
  TITLE     Contribution of epigenetic landscapes and transcription factors to
            X-chromosome reactivation in the inner cell mass
  JOURNAL   Nat Commun 8 (1), 1297 (2017)
   PUBMED   29101321
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5759)
  AUTHORS   Martelli,A., Schmucker,S., Reutenauer,L., Mathieu,J.R.R.,
            Peyssonnaux,C., Karim,Z., Puy,H., Galy,B., Hentze,M.W. and
            Puccio,H.
  TITLE     Iron regulatory protein 1 sustains mitochondrial iron loading and
            function in frataxin deficiency
  JOURNAL   Cell Metab 21 (2), 311-323 (2015)
   PUBMED   25651183
REFERENCE   5  (bases 1 to 5759)
  AUTHORS   Williams,L.H., Kalantry,S., Starmer,J. and Magnuson,T.
  TITLE     Transcription precedes loss of Xist coating and depletion of
            H3K27me3 during X-chromosome reprogramming in the mouse inner cell
            mass
  JOURNAL   Development 138 (10), 2049-2057 (2011)
   PUBMED   21471155
REFERENCE   6  (bases 1 to 5759)
  AUTHORS   Taketani,S., Kakimoto,K., Ueta,H., Masaki,R. and Furukawa,T.
  TITLE     Involvement of ABC7 in the biosynthesis of heme in erythroid cells:
            interaction of ABC7 with ferrochelatase
  JOURNAL   Blood 101 (8), 3274-3280 (2003)
   PUBMED   12480705
  REMARK    GeneRIF: ABC7 positively regulates the expression of
            extramitochondrial thioredoxin & that of an intramitochondrial
            iron-sulfur-containing protein, ferrochelatase. ABC7 contributes to
            the production of heme during the differentiation of erythroid
            cells.
REFERENCE   7  (bases 1 to 5759)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 5759)
  AUTHORS   Schriml,L.M. and Dean,M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (bases 1 to 5759)
  AUTHORS   Senbongi,H., Ling,F. and Shibata,T.
  TITLE     A mutation in a mitochondrial ABC transporter results in
            mitochondrial dysfunction through oxidative damage of mitochondrial
            DNA
  JOURNAL   Mol Gen Genet 262 (3), 426-436 (1999)
   PUBMED   10589829
REFERENCE   10 (bases 1 to 5759)
  AUTHORS   Savary,S., Allikmets,R., Denizot,F., Luciani,M.F., Mattei,M.G.,
            Dean,M. and Chimini,G.
  TITLE     Isolation and chromosomal mapping of a novel ATP-binding cassette
            transporter conserved in mouse and human
  JOURNAL   Genomics 41 (2), 275-278 (1997)
   PUBMED   9143506
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB612154.1, AK152535.1, AK040069.1 and AL663052.8.
            
            On or before Mar 2, 2008 this sequence version replaced
            XM_907304.2, XM_920355.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151037.1, AK152535.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BB612154.1         1-15
            16-1176             AK152535.1         2-1162
            1177-2114           AK040069.1         1174-2111
            2115-5759           AL663052.8         57261-60905         c
FEATURES             Location/Qualifiers
     source          1..5759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 46.58 cM"
     gene            1..5759
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /note="ATP-binding cassette, sub-family B member 7"
                     /db_xref="GeneID:11306"
                     /db_xref="MGI:MGI:109533"
     exon            1..190
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..2281
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /note="ATP-binding cassette sub-family B member 7,
                     mitochondrial; ABC transporter 7 protein; ATP-binding
                     cassette transporter 7; ATP-binding cassette 7;
                     ATP-binding cassette, sub-family B (MDR/TAP), member 7"
                     /codon_start=1
                     /product="iron-sulfur clusters transporter ABCB7,
                     mitochondrial"
                     /protein_id="NP_033722.1"
                     /db_xref="CCDS:CCDS53167.1"
                     /db_xref="GeneID:11306"
                     /db_xref="MGI:MGI:109533"
                     /translation="MALLAIHSWRWAAAAVAFEKHKHSAVLTRALVSMCGSGPRWSSS
                     QRGASGSARLSQTTESLRNTTQQRWGKDNSRQLLDATKALQTWPLIEKRTCWHGHAGG
                     GLHTDPKEGLKDVDTRKIIKAMLSYVWPEDRPDLRARVAISLGFLGGAKAMNIVVPFM
                     FKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVA
                     QNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIVF
                     EMMLVSSVLYYKCGAQFALVTLGTLGAYTAFTVAVTRWRTRFRIEMNKADNDAGNAAI
                     DSLLNYETVKYFNNEKYEAQRYDGFLKTYETASLKSTSTLAMLNFGQNAIFSVGLTAI
                     MVLASQGIVAGALTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKV
                     DTRIKDKVMAPPLQITPQTATVAFDNVHFEYIEGQKVLNGVSFEVPAGKKVAIVGGSG
                     SGKSTIVRLLFRFYEPQKGSIYLAGQNLQDVSLESLRRAVGVVPQDAVLFHNTIYYNL
                     LYGNINASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAIL
                     KNPPVILYDEATSSLDSITEETILGAMRDVVKHRTSIFIAHRLSTVVDADEIIVLSQG
                     KVAERGTHYGLLANSSSIYSEMWHTQSNRVQNQDSLGWDAKKESLSKEEERKKLQEEI
                     VNSVKGCGNCSC"
     exon            191..268
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            269..355
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            356..475
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            476..608
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            609..877
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            878..966
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1054
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1229
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1387
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1551
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1681
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1853
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1957
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2065
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..5759
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5639..5644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /note="hexamer: AATAAA"
     polyA_site      5667
                     /gene="Abcb7"
                     /gene_synonym="Abc7"
                     /note="major polyA site"
ORIGIN      
        1 ggttcctttt tcctcgctca agatggcgct gctcgcgata cattcctggc gctgggcagc
       61 cgcggcggtc gctttcgaaa agcacaagca ttcggcagtt ctgacccggg ctctagtctc
      121 catgtgcggc tcaggcccgc gatggagttc gtcccagcgc ggcgcgtcag gaagcgctcg
      181 gctgtcccag actacagaat cattaagaaa tactacacag cagagatggg gaaaagacaa
      241 ctccagacag ttactagatg ctacaaaggc tctccagaca tggccattga tagaaaagag
      301 aacatgttgg catgggcacg caggaggagg actccacaca gacccaaaag aagggttaaa
      361 ggatgttgat actagaaaaa tcatcaaagc catgctttct tatgtgtggc ctgaagatag
      421 gccagatcta cgagccagag ttgccatctc cctgggattt ttgggtggtg caaaggccat
      481 gaatattgtg gttcctttca tgtttaaata tgctgtagac agcctcaacc agatgtcggg
      541 aaacatgctg aacctgagtg atgcaccaaa tacagttgca accatggcaa cagcagttct
      601 gattggctat ggtgtatcaa gagccggagc tgcctttttc aatgaagttc gaaatgcagt
      661 atttggcaaa gtagcacaaa attcaatacg aagaatagcc aaaaatgtat ttctccatct
      721 ccacaacttg gatctgggtt tccatctgag cagacagaca ggagctttat ctaaggctat
      781 tgacagagga acaaggggca ttagttttgt cctcagtgcg ttagtattta atcttctccc
      841 tattgtgttt gagatgatgc ttgtcagtag tgttttgtat tacaaatgtg gtgcccagtt
      901 tgcattggta accctaggaa cacttggtgc atatacagca ttcacagttg cagttacacg
      961 gtggagaact agatttagaa tagaaatgaa caaagcagat aacgatgcag gtaatgctgc
     1021 tatcgactca ctgctgaatt atgaaactgt gaagtatttt aataatgaaa aatatgaagc
     1081 acaaagatat gatggattcc tgaagacata tgagactgct tcattgaaaa gtacctctac
     1141 tctggcaatg ctgaattttg gccaaaatgc tattttcagt gtcggattaa cagctataat
     1201 ggtgcttgcc agtcagggaa ttgtggcagg tgcccttact gttggagatc tagtgatggt
     1261 gaatggactg ctttttcaac tgtcattacc ccttaacttc ctgggaactg tatatagaga
     1321 gacaagacaa gcactcatag atatgaacac cttgtttact ctgctcaagg tagacacacg
     1381 gattaaagac aaagtgatgg cacctcccct tcaaataaca ccacagacag ccacggtggc
     1441 ctttgataat gtgcattttg aatacatcga aggacagaaa gtccttaatg gagtatcttt
     1501 tgaagtccct gcaggaaaga aagtggccat tgtaggaggt agtgggtcag gaaaaagcac
     1561 gatagtgagg ctgctgtttc gcttctatga gcctcaaaag ggtagcattt accttgctgg
     1621 tcaaaattta caagatgtga gcctggaaag tcttcggcgg gcagtgggag tagtacctca
     1681 ggatgctgtc ctcttccata ataccatcta ctacaacctc ttatatggaa acatcaatgc
     1741 ttcacctgag gaagtatatg cagtcgcaaa attagctggt cttcatgatg caattcttcg
     1801 aatgccacat ggatatgaca cacaagtagg agaacgagga ctcaagctat caggcggaga
     1861 aaagcagagg gtagcaattg caagagccat tttgaagaat cccccagtta ttctctatga
     1921 tgaagctact tcatcattag attcaattac tgaagagact attcttggtg ccatgagaga
     1981 tgtggtcaag cacagaactt ctattttcat tgcacataga ttgtcaacag tggttgatgc
     2041 agatgaaatc attgtcctga gccaggggaa ggtagctgaa cgtggtaccc actatggtct
     2101 gcttgctaac tctagcagta tctattcaga gatgtggcat acacagagca accgtgtaca
     2161 gaaccaggat agcctcggat gggatgcaaa gaaagagagt ctctccaaag aggaggaaag
     2221 aaagaagctc caagaagaaa ttgtcaacag tgtgaaaggc tgtggaaatt gttcctgcta
     2281 aggaacacag acattttctt atctctcttt ttgttgtctt gtttggtttt gtttggcatt
     2341 agcatttgca ctgaagtaga accaggtcac aaaaacacaa atcatacatt cccattcctt
     2401 taatcctatt aaatatgatt tatttaaagg agggttggat ttttatgtct ttcaccatct
     2461 tttgaatgtg acatctataa ttatccccaa attattttct tgttcctgcc ccaagcgtgc
     2521 tcaatacata atttttgtta ccacttgatt ttaccttaca actgtgtttg aagtctgaca
     2581 tccatttgat atcaataacg aggtgaatta gagtgtttct gaatttaagt agtctttaaa
     2641 aacctccttt atgctgacaa gttgtaagga gaccattttt tttctcttaa aattaaacag
     2701 gaataaaaac agaagtgtag gggttttttt ctcctctttc ctccttccag ttatatttcc
     2761 ttgtcaatct gaaaattagt ttgaaaacat ataagttaga atttatcaaa aaatgagcta
     2821 tatttgtact ttgggcattt tacttttaga tacctataat tacagttttt tattgtgccc
     2881 tttttagaaa aaaagtcatg ttatctttaa tcaccactgt tgctcttatc tagtgattag
     2941 tattttgttt ttacccccaa aagttttgtt ttaaatgaaa attaattttt ctctaaagtc
     3001 tcatgaacct tgatgtcatt tgagagttat ttatactgag aatgatccca aaagcttagg
     3061 gagttaatag cctttcctat ttccaacttc agtgcactgc attggctatc aagttataca
     3121 gagacagaag taaaatggat gttgtacacc cacacatgtg tctgtgtaca cgctcataca
     3181 tttatctaaa ccagtgtcca cataacaact ccttaaaaca tttggtaaaa agcaaaggat
     3241 tccatatata catacactgt ttagatgacc aggtatctta atctatagtg atacttcaga
     3301 attgctgttt actataaggc tttttcttat tcgtaattta atgaattctg ttcagcctaa
     3361 tgtaaaaaaa gacttaagtg atatattcaa gttttactga gataaaatag gaaattattt
     3421 tacatattag aaataattat taaaacgaga tacacatttc acttaaaaag ttgttcttgg
     3481 gctggtgaga tggctcagct ggtaagagca cccaactgtt cttccaaagg tcctgagttc
     3541 aaatcccagc aactacatgg tggctcacaa ccattcataa ggaaatctga tgccctcttc
     3601 tggagtgtat gaagacagct acagtgaact tacatataat aaataaataa atcggttttt
     3661 ttattttaaa ttgttctttt aagctaggca tggtactatg caccaggagc cacatcagga
     3721 aattgaagtc aggaatttga ggctatcctg gacaatatag gaagaccctg tctcttaaag
     3781 ctgaaaaaga aagaaagttc ttctcttgat tcagtatgaa ttaaatttgt tcaaaacaca
     3841 tgtctatcgt gacttgccac ataatcattt gtaatgtggt ttgatttctc aggaaaggtc
     3901 ctaaactgcc tataacgtta tggttttaat gttaatgata atttagtatg ggagagatta
     3961 ttattttttg atttgtaaat tagtattagt taatgaatat cttcaattat attacaatag
     4021 tttgataaac tgaggccagt atttcattta gtctttgata gcaaagtaag ttatgtggga
     4081 tcttgctttt aaagttgaag gtatgtcctg gactggaaac cagctttggt ttggtttgtt
     4141 ggtatttctt actttcaaga cataggtatg agtgctgttc tcaaggggag atggagtaca
     4201 tcctttgaat aagtcaggtc cgttctagga gatgtggtta aatgtatata aacgtcttgc
     4261 ttctgtgtta attcctatgt ttacactgat gctgatggag atgatgaaac tcagttacac
     4321 agacaagcag tgtgtactaa tcattaggaa gaattgttct tgacatgtat acagcagtgt
     4381 tcaaagcaag ttattttgtg atatggagaa cattttactc cagggaagta ggaatatttt
     4441 cagggtaggg ataatttccc cactaggatt ttgaaacttt tttttttcat atgattgcag
     4501 atggtcccaa ggccactgta gtcattaacc tgttatcagc taacaaaact taaattacct
     4561 gaaaaagaca cttggtgcag aggccataac taagtcttaa agacatcttt ttaaaaacta
     4621 catcatcctt aggtagttct atagagggaa ataatagaca gattaagatg aaagaaaagc
     4681 tttctgggat gattcagtta taggaaatgc caagaaaagg gcatttaatt ataatatcct
     4741 aattttacat cacaacatta cagaattaca caaaaggata atgtgtgtat tttttttaaa
     4801 ttagtgttgc aggaatgttc ttttaaatgt actaggggat gaataatttg agctctgaaa
     4861 atagaggaag atgatggggt tcatttctca cctctcttta ttttaaatat taaaaaatat
     4921 attttcttcc taaaggaatt ccagtttaca aaagttaact tgaaaccaag gtaatttagg
     4981 attataaaaa cggggccaga tgccttcctg atcgctctta acataggact gtcttggtat
     5041 gcagatgggc ttctttgtga tcagggagag cttcgcatct ggacatgaac aagctcaaga
     5101 tatgcattcc cttttcctct gcagggattt gcgtctttta tataccttaa gagaaacatt
     5161 ttgtctttcc cctctatgtt gacagatctc agtttgagtg gatggttgtt ttttaaaact
     5221 tgttttgctc taagtgctag gtatttaaaa actgtgtgat tccttggttc tagagccttt
     5281 tccctgctgc catcttgttg ctatccttcc tacttgctga atatgtcacc aagtagcaac
     5341 ctttgctaga atatattcct aatttcctca tcttgtaact tattacaggg tattctgttg
     5401 tgaattagca gtttagagtg tttaaatatg tttgtaatta tagtttgttt ttaattatag
     5461 aaaaattcct tcttttcccc tctatgagtg tattgatttg gaatgtaaat tgtatgataa
     5521 atcataacat tgagtgaaac actctggata aagctgatta agacaaaaca tctcagccaa
     5581 gcatttacct tagcacagtt ctcttgttta tagcaaccta tgcagataat cactactgaa
     5641 taaacataat gtctttgtgc ctagaaatga gtgtctggtg gaaatcactt ttctgcaatg
     5701 ttcatggaag ctgatttttg taccttatac acttgaaata aatacaggta attactagc
//
