LOCUS       NM_023732               3043 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family B member 6 (Abcb6),
            mRNA.
ACCESSION   NM_023732
VERSION     NM_023732.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3043)
  AUTHORS   Baril,S.A., Wilson,K.A., Shaik,M.M., Fukuda,Y., Umans,R.A.,
            Barbieri,A., Lynch,J., Gose,T., Myasnikov,A., Oldham,M.L., Wang,Y.,
            Zhu,J., Fang,J., Zuo,J., Kalathur,R.C., Ford,R.C., Coffin,A.,
            Taylor,M.R., O'Mara,M.L. and Schuetz,J.D.
  TITLE     The role of ATP-binding Cassette subfamily B member 6 in the inner
            ear
  JOURNAL   Nat Commun 15 (1), 9885 (2024)
   PUBMED   39557842
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3043)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3043)
  AUTHORS   Fan,J., Campioli,E., Sottas,C., Zirkin,B. and Papadopoulos,V.
  TITLE     Amhr2-Cre-Mediated Global Tspo Knockout
  JOURNAL   J Endocr Soc 4 (2), bvaa001 (2020)
   PUBMED   32099945
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3043)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3043)
  AUTHORS   Fukuda,Y., Cheong,P.L., Lynch,J., Brighton,C., Frase,S., Kargas,V.,
            Rampersaud,E., Wang,Y., Sankaran,V.G., Yu,B., Ney,P.A., Weiss,M.J.,
            Vogel,P., Bond,P.J., Ford,R.C., Trent,R.J. and Schuetz,J.D.
  TITLE     The severity of hereditary porphyria is modulated by the porphyrin
            exporter and Lan antigen ABCB6
  JOURNAL   Nat Commun 7, 12353 (2016)
   PUBMED   27507172
  REMARK    GeneRIF: homozygous disruption of the Abcb6 gene in mice
            exacerbates porphyria phenotypes in the mouse model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3043)
  AUTHORS   Ulrich,D.L., Lynch,J., Wang,Y., Fukuda,Y., Nachagari,D., Du,G.,
            Sun,D., Fan,Y., Tsurkan,L., Potter,P.M., Rehg,J.E. and Schuetz,J.D.
  TITLE     ATP-dependent mitochondrial porphyrin importer ABCB6 protects
            against phenylhydrazine toxicity
  JOURNAL   J Biol Chem 287 (16), 12679-12690 (2012)
   PUBMED   22294697
  REMARK    GeneRIF: Abcb6 is the sole ATP-dependent porphyrin importer, and
            loss of Abcb6 produces up-regulation of heme and iron pathways
            necessary for normal development.
REFERENCE   7  (bases 1 to 3043)
  AUTHORS   Kiss,K., Brozik,A., Kucsma,N., Toth,A., Gera,M., Berry,L.,
            Vallentin,A., Vial,H., Vidal,M. and Szakacs,G.
  TITLE     Shifting the paradigm: the putative mitochondrial protein ABCB6
            resides in the lysosomes of cells and in the plasma membrane of
            erythrocytes
  JOURNAL   PLoS One 7 (5), e37378 (2012)
   PUBMED   22655043
REFERENCE   8  (bases 1 to 3043)
  AUTHORS   Fukuda,Y., Aguilar-Bryan,L., Vaxillaire,M., Dechaume,A., Wang,Y.,
            Dean,M., Moitra,K., Bryan,J. and Schuetz,J.D.
  TITLE     Conserved intramolecular disulfide bond is critical to trafficking
            and fate of ATP-binding cassette (ABC) transporters ABCB6 and
            sulfonylurea receptor 1 (SUR1)/ABCC8
  JOURNAL   J Biol Chem 286 (10), 8481-8492 (2011)
   PUBMED   21199866
  REMARK    GeneRIF: Conserved intramolecular disulfide bond is critical to
            trafficking and fate of ATP-binding cassette (ABC) transporters
            ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8.
REFERENCE   9  (bases 1 to 3043)
  AUTHORS   Krishnamurthy,P.C., Du,G., Fukuda,Y., Sun,D., Sampath,J.,
            Mercer,K.E., Wang,J., Sosa-Pineda,B., Murti,K.G. and Schuetz,J.D.
  TITLE     Identification of a mammalian mitochondrial porphyrin transporter
  JOURNAL   Nature 443 (7111), 586-589 (2006)
   PUBMED   17006453
  REMARK    GeneRIF: ABCB6 is uniquely located in the outer mitochondrial
            membrane and is required for mitochondrial porphyrin uptake
REFERENCE   10 (bases 1 to 3043)
  AUTHORS   Pondarre,C., Antiochos,B.B., Campagna,D.R., Clarke,S.L.,
            Greer,E.L., Deck,K.M., McDonald,A., Han,A.P., Medlock,A.,
            Kutok,J.L., Anderson,S.A., Eisenstein,R.S. and Fleming,M.D.
  TITLE     The mitochondrial ATP-binding cassette transporter Abcb7 is
            essential in mice and participates in cytosolic iron-sulfur cluster
            biogenesis
  JOURNAL   Hum Mol Genet 15 (6), 953-964 (2006)
   PUBMED   16467350
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151165.1, AK004605.1, AI843102.1 and AC166150.2.
            
            On Sep 1, 2015 this sequence version replaced NM_023732.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006634.1, AK151165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK151165.1         2-30
            30-2843             AK004605.1         1-2814
            2844-2967           AI843102.1         17-140              c
            2968-3043           AC166150.2         194204-194279
FEATURES             Location/Qualifiers
     source          1..3043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.62 cM"
     gene            1..3043
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /note="ATP-binding cassette, sub-family B member 6"
                     /db_xref="GeneID:74104"
                     /db_xref="MGI:MGI:1921354"
     exon            1..823
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..2803
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /EC_number="7.6.2.5"
                     /note="ATP-binding cassette sub-family B member 6,
                     mitochondrial; ABC-type heme transporter ABCB6;
                     ATP-binding cassette, sub-family B (MDR/TAP), member 6"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family B member 6"
                     /protein_id="NP_076221.1"
                     /db_xref="CCDS:CCDS15065.1"
                     /db_xref="GeneID:74104"
                     /db_xref="MGI:MGI:1921354"
                     /translation="MVTVGNYCETEGPAGPAWTQNGLSPCFFFTLVPSTLLTLGVLAL
                     VLVLPRRRREVPAGPEELSWAAGPRVAPYVLQLFLATLQMALPLAGLAGRVGTARGVR
                     LPGYLLLASVLESLASVCGLWLLVVERSQARQSLAMGVWMKFRHSLGLLLLWTVTFAA
                     ENLALVSWNSPQWWWARADLGQQVQFGLWVLRYVTSGGLFILGLWAPGLRPQSYTLHV
                     HEEDQDVGGNQGRSTDRRSTWRDLGRKLRLLSSYLWPRGSPSLQLIVLICLGLMGLER
                     ALNVLVPIFYRDIVNLLTAKAPWSSLAWTVTTYVFLKFLQGGGTGSTGFVSNLRTFLW
                     IRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLLSYLVFSII
                     PTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLILTIVVTEWRAKFRRDMNTQENATR
                     ARAVDSLLNFETVKYYGAEGYEVDRYREAILKFQGLEWKSTASLVVLNQTQNLVIGLG
                     LLAGSLLCAYFVSEQKLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFD
                     LLKEETEVKDVPGAGPLRFHKGRIEFENVHFSYADGQETLQDVSFTVMPGQTVALVGP
                     SGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQISLRSHIGVVPQDTVLFNDTIAN
                     NIRYGRVTAGDSEVEAAAQAAGIHDAILSFPEGYETQVGERGLKLSGGEKQRVAIART
                     ILKAPDIILLDEATSALDTSNERAIQASLAKVCTNRTTIVIAHRLSTVVNADQILVIK
                     DGCIIERGRHEALLSRGGVYAEMWQLQQQGQETVPEESKPQDTA"
     exon            824..961
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1142
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1244
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1428
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1550
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1660
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1726
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1852
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1929
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..1993
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2079
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2137
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2242
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2417
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2530
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2625
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2694
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..3043
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2947..2952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2967
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
                     /note="major polyA site"
     polyA_site      3033
                     /gene="Abcb6"
                     /gene_synonym="1200005B17Rik"
ORIGIN      
        1 aacatttttg tgcggcggct ccgagcctta gggtcccagc tgctagcgag tgggaaccgg
       61 caagcacggc gtacgtggct tgcgtgagta tgcgtggtag cggcgcgtgc gtgaagagag
      121 tgggcagtgt agcaggtcca cgtgcgtccc ttcccgcgac ccaagcggcg tagctccatg
      181 tcccaggaca ccctggcatc tgcggccctc tctgaagggt cagcccgact ctttgtgcag
      241 tgacctcaag ttcagccagc agccacacat cgccatggtg actgtgggca actactgcga
      301 gaccgaaggg ccggcggggc ccgcttggac tcagaatggc ttgagtccct gcttcttctt
      361 cacgctagtg ccctcgacac tcctgactct gggggtactg gccttggtgc tggttcttcc
      421 ccgcaggcgt cgggaggtgc ctgctggccc agaagagctg tcttgggcgg ctggccctcg
      481 ggtggcccca tatgtgctgc agctgtttct ggccacactt cagatggcac tgcccctggc
      541 tggtctggct ggccgagtgg gcactgctcg gggggtccgt ctgccaggct acctactgct
      601 ggcttctgtg ctggagagtc tggccagcgt ctgtggcttg tggctgctcg tggtggaacg
      661 gagccaggca cggcagagtc tggcaatggg cgtctggatg aagttcaggc atagcttggg
      721 tctcctgctc ctctggactg tgacatttgc agccgagaac ttggccctag tatcttggaa
      781 cagcccgcag tggtggtggg ccagagcaga tctgggccag caggttcaat ttggcctgtg
      841 ggtcctgcgt tatgtgacct ctggagggct atttatcttg gggctctggg ccccaggact
      901 tcgcccccag tcttatactc tacacgttca tgaagaagac caagatgtag gagggaacca
      961 gggccgctca acagaccgac gatccacctg gagagacctt ggccggaagc ttcgactgct
     1021 gagtagctac ttgtggcctc ggggaagtcc atcactacag ctgatagtgc tcatatgcct
     1081 gggactcatg gggttggaac gagcactcaa tgtgttggtc cccatcttct atagggacat
     1141 tgtgaactta ctgactgcga aggctccttg gagctccctg gcctggaccg ttaccaccta
     1201 tgtcttcctc aagttcctcc aggggggtgg cactggcagt acaggttttg tgagcaacct
     1261 gcgaaccttc ctatggatcc gggtgcagca gtttacgtcc cgaggtgtgg agctacgtct
     1321 cttctctcac ctgcatgaac tctcactgcg ctggcacctg ggccggcgta ccggggaggt
     1381 gcttcggatc gtggaccggg gaacatctag tgtcacagga ctactcagct acctggtgtt
     1441 cagcatcatc cccaccctgg ctgacatcat cattggcatc atctacttca gcatgttctt
     1501 caatgcctgg tttggcctca tcgtgttcct gtgcatgagt ctttacctca tcctgactat
     1561 cgtggtcacc gagtggagag ccaagtttcg ccgtgatatg aacacacagg aaaacgccac
     1621 ccgggcacga gcagtagact ctctgctcaa ctttgaaacg gtgaaatact atggtgccga
     1681 gggttatgaa gtagaccgct atcgagaggc catcctcaag tttcagggtt tggagtggaa
     1741 gtcaaccgcc tcactggttg tgctgaatca gacacagaac ctggtgatcg ggcttggcct
     1801 ccttgctggc tccttgcttt gcgcatactt cgtcagtgag cagaagctac aggttgggga
     1861 ctttgtgctt tttggcactt acatcaccca actgtacatg cctctcaact ggtttggcac
     1921 ctactacagg atgatccaga ctaacttcat tgacatggag aacatgtttg acttgctgaa
     1981 agaggagaca gaagtgaagg atgttcctgg tgcagggccc cttcgttttc ataagggccg
     2041 gattgagttt gaaaatgtgc acttcagcta cgctgatggg caggagacct tacaagatgt
     2101 gtccttcact gtgatgcctg gacagacggt ggctctggta ggtccatctg gggcaggaaa
     2161 gagcacaatt ttgcgcctgc tatttcgctt ctatgacatc agctctggct gcatccgaat
     2221 agatggacag gatatttcac aggtgaccca gatctctctc cgatctcaca ttggagttgt
     2281 gccccaggac actgtcctct tcaacgacac cattgctaac aatatccgct atggccgtgt
     2341 cacagctggg gacagtgagg tagaggctgc tgctcaggct gcaggcattc atgatgccat
     2401 cttgtctttc cctgaagggt atgagacaca ggtcggggag cggggtctga agctgagtgg
     2461 tggcgagaag cagcgagtgg ccatcgcccg caccatcctt aaggctcctg acatcattct
     2521 gctggatgag gccacatcag cactggatac atctaatgag agagccatcc aggcctctct
     2581 ggccaaagtc tgcaccaacc gcaccaccat cgtcatagca cacaggctct caactgtggt
     2641 caatgctgac cagattctgg tcatcaagga cggttgcatc atagagagag gaaggcacga
     2701 agccctgctg tcccgaggtg gcgtttatgc cgagatgtgg cagctgcagc agcaaggaca
     2761 agaaactgtc cctgaagaat ctaaacctca ggacacggca tagtaataaa agggacctct
     2821 ttccttccaa aggcgaactc aggagaaaaa gatatgtccc ctctcttgcc ttcatttcat
     2881 cctggtgtag gagtttggtg ctagctattg taaggaaaag ggaccttcca gaaagcatcg
     2941 tgaggaaata aatggcctgc gcaaggacgg ctgtggtttg gttgtgtggg gtactgcaag
     3001 gggtctctcc ccttgagctg aatgaacatt cccgaaaaag aaa
//
