LOCUS       NM_029961               3876 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family B member 5 (Abcb5),
            mRNA.
ACCESSION   NM_029961 XM_001002680 XM_906632
VERSION     NM_029961.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3876)
  AUTHORS   Meshko,B., Volatier,T.L.A., Hadrian,K., Deng,S., Hou,Y.,
            Kluth,M.A., Ganss,C., Frank,M.H., Frank,N.Y., Ksander,B.,
            Cursiefen,C. and Notara,M.
  TITLE     ABCB5+ Limbal Epithelial Stem Cells Inhibit Developmental but
            Promote Inflammatory (Lymph) Angiogenesis While Preventing Corneal
            Inflammation
  JOURNAL   Cells 12 (13), 1731 (2023)
   PUBMED   37443766
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3876)
  AUTHORS   Saeed,M.E.M., Boulos,J.C., Machel,K., Andabili,N., Marouni,T.,
            Roth,W. and Efferth,T.
  TITLE     Expression of the Stem Cell Marker ABCB5 in Normal and Tumor
            Tissues
  JOURNAL   In Vivo 36 (4), 1651-1666 (2022)
   PUBMED   35738589
  REMARK    GeneRIF: Expression of the Stem Cell Marker ABCB5 in Normal and
            Tumor Tissues.
REFERENCE   4  (bases 1 to 3876)
  AUTHORS   King,R., Struebing,F.L., Li,Y., Wang,J., Koch,A.A., Cooke
            Bailey,J.N., Gharahkhani,P., MacGregor,S., Allingham,R.R.,
            Hauser,M.A., Wiggs,J.L. and Geisert,E.E.
  CONSRTM   International Glaucoma Genetics Consortium; NEIGHBORHOOD Consortium
  TITLE     Genomic locus modulating corneal thickness in the mouse identifies
            POU6F2 as a potential risk of developing glaucoma
  JOURNAL   PLoS Genet 14 (1), e1007145 (2018)
   PUBMED   29370175
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3876)
  AUTHORS   Kondo,S., Hongama,K., Hanaya,K., Yoshida,R., Kawanobe,T.,
            Katayama,K., Noguchi,K. and Sugimoto,Y.
  TITLE     Upregulation of cellular glutathione levels in human ABCB5- and
            murine Abcb5-transfected cells
  JOURNAL   BMC Pharmacol Toxicol 16, 37 (2015)
   PUBMED   26666373
  REMARK    GeneRIF: Results suggest that ATP binding cassette subfamily B
            member 5 ABCB5/Abcb5 upregulates cellular glutathione levels to
            protect cells from various poisons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3876)
  AUTHORS   Zheng,M., Zhang,H., Dill,D.L., Clark,J.D., Tu,S.,
            Yablonovitch,A.L., Tan,M.H., Zhang,R., Rujescu,D., Wu,M.,
            Tessarollo,L., Vieira,W., Gottesman,M.M., Deng,S., Eberlin,L.S.,
            Zare,R.N., Billard,J.M., Gillet,J.P., Li,J.B. and Peltz,G.
  TITLE     The role of Abcb5 alleles in susceptibility to haloperidol-induced
            toxicity in mice and humans
  JOURNAL   PLoS Med 12 (2), e1001782 (2015)
   PUBMED   25647612
  REMARK    GeneRIF: ABCB5 alleles alter susceptibility to haloperidol-induced
            toxicity (HIT) in mouse and humans.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3876)
  AUTHORS   Ksander,B.R., Kolovou,P.E., Wilson,B.J., Saab,K.R., Guo,Q., Ma,J.,
            McGuire,S.P., Gregory,M.S., Vincent,W.J., Perez,V.L.,
            Cruz-Guilloty,F., Kao,W.W., Call,M.K., Tucker,B.A., Zhan,Q.,
            Murphy,G.F., Lathrop,K.L., Alt,C., Mortensen,L.J., Lin,C.P.,
            Zieske,J.D., Frank,M.H. and Frank,N.Y.
  TITLE     ABCB5 is a limbal stem cell gene required for corneal development
            and repair
  JOURNAL   Nature 511 (7509), 353-357 (2014)
   PUBMED   25030174
  REMARK    GeneRIF: ATP-binding cassette, sub-family B, member 5 (ABCB5) marks
            limbal stem cells (LSCs) and is required for LSC maintenance,
            corneal development and repair
REFERENCE   8  (bases 1 to 3876)
  AUTHORS   Linley,A.J., Mathieu,M.G., Miles,A.K., Rees,R.C., McArdle,S.E. and
            Regad,T.
  TITLE     The helicase HAGE expressed by malignant melanoma-initiating cells
            is required for tumor cell proliferation in vivo
  JOURNAL   J Biol Chem 287 (17), 13633-13643 (2012)
   PUBMED   22393060
  REMARK    GeneRIF: the helicase HAGE is required for ABCB5+ MMIC-dependent
            tumor growth through promoting RAS protein expression
REFERENCE   9  (bases 1 to 3876)
  AUTHORS   Frank,N.Y. and Frank,M.H.
  TITLE     ABCB5 gene amplification in human leukemia cells
  JOURNAL   Leuk Res 33 (10), 1303-1305 (2009)
   PUBMED   19477512
  REMARK    GeneRIF: Expression of Abcb5.ts (testis-specific) (AY766239), a
            transporter consisting of 1255 amino acids and comprising two
            transmembrane and nucleotide binding domains, is restricted to
            testis tissue. In contrast, Abcb5.e (AY766238) is ubiquitously
            expressed.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK020318.1, AC126277.3, AK139832.1 and AC131717.3.
            
            On Aug 11, 2009 this sequence version replaced NM_029961.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY766239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-871               AK020318.1         2-872
            872-890             AC126277.3         103184-103202       c
            891-1068            AC126277.3         102923-103100       c
            1069-1182           AC126277.3         99471-99584         c
            1183-1293           AC126277.3         98827-98937         c
            1294-1419           AC126277.3         95664-95789         c
            1420-1623           AC126277.3         94198-94401         c
            1624-2424           AK139832.1         102-902
            2425-2508           AC126277.3         68333-68416         c
            2509-2712           AC126277.3         57527-57730         c
            2713-2813           AC126277.3         54084-54184         c
            2814-2954           AC126277.3         53133-53273         c
            2955-3111           AC131717.3         188910-189066       c
            3112-3309           AC131717.3         185829-186026       c
            3310-3516           AC131717.3         183971-184177       c
            3517-3663           AC131717.3         179887-180033       c
            3664-3876           AC131717.3         179052-179264       c
FEATURES             Location/Qualifiers
     source          1..3876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 63.48 cM"
     gene            1..3876
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /note="ATP-binding cassette, sub-family B member 5"
                     /db_xref="GeneID:77706"
                     /db_xref="MGI:MGI:1924956"
     exon            1..63
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            64..137
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..3852
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /EC_number="7.6.2.2"
                     /note="ABCB5 P-gp; P-glycoprotein ABCB5; ATP-binding
                     cassette, sub-family B (MDR/TAP), member 5"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family B member 5"
                     /protein_id="NP_084237.1"
                     /db_xref="CCDS:CCDS49198.1"
                     /db_xref="GeneID:77706"
                     /db_xref="MGI:MGI:1924956"
                     /translation="MANSERTNGLQETNQRYGPLQEQVPKVGNQAVGPIEIFRFADNL
                     DIVLMTLGILASMINGATVPLMSLVLGEISDHLINGCLVQTNRTKYQNCSQTQEKLNE
                     DIIVLTLYYIGIGAAALIFGYVQISFWVITAARQTTRIRKQFFHSILAQDISWFDGSD
                     ICELNTRMTGDINKLCDGIGDKIPLMFQNISGFSIGLVISLIKSWKLSLVVLSTSPLI
                     MASSALCSRMIISLTSKELDAYSKAGAVAEEALSSIQTVTAFGAQEKEIQRYTQHLKD
                     AKDAGIKRATASKLSLGAVYFFMNGAYGLAFWYGTSLIFGGEPGYTIGTILAVFFSVI
                     HSSYCIGSVAPHLETFTVARGAAFNIFQVIDKKPNIDNFSTAGFVPECIEGNIEFKNV
                     SFSYPSRPSAKVLKGLNLKIKAGETVALVGPSGSGKSTTVQLLQRLYDPEDGCITVDE
                     NDIRAQNVRHYREQIGVVRQEPVLFGTTIGNNIKFGREGVGEKEMEQAAREANAYDFI
                     MAFPKKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDTESESLVQT
                     ALEKASKGRTTIVVAHRLSTIRGADLIVTMKDGMVVEKGTHAELMAKQGLYYSLAMAQ
                     DIKKVDEQMESRTCSTAGNASYGSLCDVNSAKAPCTDQLEEAVHHQKTSLPEVSLLKI
                     FKLSKSEWPFVVLGTLASALNGSVHPVFSIIFGKLVTMFEDKNKATLKQDAELYSMML
                     VVLGIVALVTYLMQGLFYGRAEENLAMRLRHSAFKAMLYQDMAWYDDKENNTGALTTT
                     LAVDVAQIQGAATSRLGIVTQDVSNMSLSILISFIYGWEMTLLILSFAPVLAVTGMIQ
                     TAAMAGFANRDKQALKRAGKIATEAVENIRTVVSLTRERAFEQMYEETLQTQHRNALK
                     RAHITGCCYAVSHAFVHFAHAAGFRFGAYLIQAGRMMPEGMFIVFTAIAYGAMAIGET
                     LVWAPEYSKAKAGASHLFALLKNKPTINSCSQSGEKPDTCEGNLEFREVSFVYPCRPE
                     VPVLQNMSLSIEKGKTVAFVGSSGCGKSTCVQLLQRFYDPMKGQVLLDGVDVKELNVQ
                     WLRSQTAIVSQEPVLFNCSIAENIAYGDNSRMVPLEEIKEVADAANIHSFIEGLPRKY
                     NTLVGLRGVQLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKVVQQALDKARR
                     GKTCLVVAHRLSTIQNADMIVVLQNGSIKEQGTHQELLRNGDTYFKLVAAH"
     exon            138..195
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            196..346
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            347..401
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            402..593
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            594..765
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            766..890
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1068
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1182
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1293
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1419
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1623
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1794
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1956
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2097
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2241
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2346
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2424
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2508
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2712
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2813
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2954
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3111
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3309
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3516
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3663
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3876
                     /gene="Abcb5"
                     /gene_synonym="9230106F14Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgaggaga aaagccacac acgaatcttg tgtccatgga caacagatca tgttcttact
       61 gaggagaatt aaactataaa caatatggca aattctgaaa gaaccaacgg gttgcaagaa
      121 actaatcaga gatatggacc tctgcaagaa caagtgccta aagtgggaaa tcaagctgtt
      181 ggacctattg agatattccg ctttgctgat aatctggaca ttgtcctcat gactctggga
      241 atattagcat ccatgataaa tggagccacc gttcctttaa tgtccctggt tttaggagaa
      301 ataagtgatc atttaattaa tggatgccta gtacaaacta acagaactaa atatcagaac
      361 tgttctcaga ctcaagaaaa gctgaatgaa gatatcattg tgttgactct atattatatt
      421 ggaataggag cagctgccct catttttggc tatgtacaga tttccttctg ggtcataact
      481 gcagcccggc aaaccacaag aatccgaaaa cagttttttc attcaatttt ggcacaagac
      541 atcagctggt ttgatggcag tgacatctgt gaacttaaca cccgcatgac tggtgacatc
      601 aacaaactct gtgatggtat tggagataag atccctctga tgtttcagaa catatctggg
      661 ttttctattg gcctggtgat aagtttgata aaaagctgga aactctccct ggtggttctg
      721 tctacatctc ctctcataat ggcttcatcg gcactgtgct ctaggatgat tatctcattg
      781 accagcaagg agctggatgc ctattccaaa gctggggctg tggctgaaga agccttgtca
      841 tcaatccaaa cagtcacagc ctttggagcc caagagaaag aaattcaaag gtatacacag
      901 cacttaaagg acgcaaagga cgctggcata aagagggcta cggcttcaaa gctgtctctt
      961 ggagcagtct acttctttat gaatggagcc tatggactgg ctttttggta tggaacctcc
     1021 ttgatttttg gcggagagcc tggttacacc atcggaacta ttcttgctgt tttcttcagt
     1081 gtgatccata gtagttactg cattggatct gtagcccctc acctggaaac cttcacagta
     1141 gccagaggag ctgcctttaa tattttccag gttattgata agaaacccaa tatagataac
     1201 ttttcaacag ctggatttgt acctgaatgt atagaaggaa acatagaatt taaaaatgtt
     1261 tctttcagct atccatcaag accttctgcc aaggttctga aaggtctcaa tctgaagatt
     1321 aaggctggag agacagtagc cttggttggt cccagtggca gtggcaagag tacgacagtg
     1381 cagcttctgc agaggctgta tgacccagag gacggctgta tcaccgtaga tgagaatgac
     1441 atccgagccc aaaacgtgcg acattaccga gagcaaattg gagtggtcag acaagagcca
     1501 gttctgtttg ggaccaccat cggtaacaat attaagtttg ggcgcgaagg tgtgggtgaa
     1561 aaggaaatgg aacaggcagc gagggaggca aacgcctacg acttcataat ggcctttcct
     1621 aagaaattta atacactagt aggggaaaaa ggagctcaaa tgagtggagg ccagaaacag
     1681 aggattgcca ttgctcgagc gctagttcga aaccccaaaa ttctgatctt agatgaggct
     1741 acatctgccc tggacacaga gagtgaatca cttgttcaaa ctgcactgga gaaggcaagc
     1801 aaaggccgga ctacaattgt ggtagcacac aggctctcca ccattcgtgg ggcagacctg
     1861 attgtgacaa tgaaggatgg catggtggtg gagaaaggga cccatgctga actaatggca
     1921 aagcaggggc tgtactactc cctcgccatg gcacaggata ttaaaaaggt cgatgaacaa
     1981 atggaatcaa ggacatgttc cactgcagga aatgccagct atggttctct gtgcgatgtg
     2041 aatagtgcca aggccccctg cactgaccag ctggaggaag ccgtacacca tcaaaagaca
     2101 agtcttcctg aagtttcact attaaaaata tttaaattaa gcaagtctga atggcctttt
     2161 gtggttctgg gaacactggc ttctgcttta aatggatctg ttcatccagt attttccatc
     2221 atctttggaa aattagtcac tatgtttgaa gataaaaata aagctacatt aaagcaggat
     2281 gcagagctct actccatgat gttagtcgtc ttgggcatag tagctcttgt cacctacttg
     2341 atgcagggat tgttttatgg cagagcagag gaaaatttag ccatgagatt aagacactcg
     2401 gcattcaaag ccatgctcta ccaggatatg gcctggtatg atgataaaga gaacaacact
     2461 ggagccctga ccacaacgtt agctgtggat gtagcacaga ttcagggtgc agcaacttca
     2521 agacttggga tcgtaacaca agatgtgagc aacatgagtc tgtccattct catctccttc
     2581 atatatggat gggagatgac actcctgatt ctcagcttcg cgcctgtact tgcggtgaca
     2641 ggaatgattc aaaccgcagc aatggctggc tttgccaaca gggataagca ggcgctcaag
     2701 cgtgctggaa agatagcaac agaagctgtg gagaacatac gtacggtagt gtcattaaca
     2761 agagagagag cctttgagca aatgtatgag gagacacttc agactcaaca cagaaacgcc
     2821 ttgaagagag cacacatcac tggatgctgt tatgcagtca gccatgcttt tgtgcatttt
     2881 gcccatgcag cagggttccg atttggagcc tatttgattc aagcaggacg gatgatgccg
     2941 gaaggcatgt tcatagtctt taccgccatt gcatatgggg ctatggccat tggagaaaca
     3001 cttgtatggg ctcctgaata ttccaaagcc aaagctggag cttcgcatct gtttgctttg
     3061 ctgaaaaata aaccaactat aaacagctgc agtcaaagtg gggaaaaacc agacacctgt
     3121 gaagggaact tagaatttcg agaggtctct ttcgtctatc cttgtcgtcc agaagttcct
     3181 gtccttcaga acatgtccct cagcattgag aaagggaaga ctgtagcatt cgttgggagc
     3241 agcggctgtg gaaaaagcac atgtgttcaa ctgctgcaaa gattttatga ccccatgaaa
     3301 ggacaagtgc tgcttgacgg agttgatgta aaagaattga acgtgcagtg gctgcgttcc
     3361 cagacagcca tcgtctccca agagcctgtg ctgttcaact gtagcatcgc tgagaacatt
     3421 gcctatggtg ataacagccg catggtgccc ttagaggaga tcaaagaggt cgcagatgca
     3481 gccaacattc attctttcat tgaagggctc ccaaggaaat acaacaccct agtgggacta
     3541 agaggcgtgc agctttctgg cggccagaaa caaagactgg ctattgcaag ggctcttctc
     3601 cggaagccaa aaattttact gctggatgag gccacttcag cccttgataa tgagagtgag
     3661 aaggtggtcc aacaggctct tgataaagcc cggagaggga agacctgcct agtggtggct
     3721 cacagactct ctacaataca gaatgcagat atgatcgttg ttctgcaaaa tggaagcatc
     3781 aaggagcagg gaactcatca ggagctcctg agaaatggag atacatactt taaattagta
     3841 gctgcacatt agtaattgct tcattgggtg cactga
//
