LOCUS       NM_008830               4083 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family B member 4 (Abcb4),
            mRNA.
ACCESSION   NM_008830
VERSION     NM_008830.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4083)
  AUTHORS   Schmithals,C., Kakoschky,B., Denk,D., von Harten,M., Klug,J.H.,
            Hintermann,E., Dropmann,A., Hamza,E., Jacomin,A.C., Marquardt,J.U.,
            Zeuzem,S., Schirmacher,P., Herrmann,E., Christen,U., Vogl,T.J.,
            Waidmann,O., Dooley,S., Finkelmeier,F. and Piiper,A.
  TITLE     Tumour-specific activation of a tumour-blood transport improves the
            diagnostic accuracy of blood tumour markers in mice
  JOURNAL   EBioMedicine 105, 105178 (2024)
   PUBMED   38889481
REFERENCE   2  (bases 1 to 4083)
  AUTHORS   Chen,J., Li,F., Lee,J., Manirujjaman,M., Zhang,L., Song,Z.H.,
            McClain,C. and Feng,W.
  TITLE     Peripherally Restricted CB1 Receptor Inverse Agonist JD5037
            Treatment Exacerbates Liver Injury in MDR2-Deficient Mice
  JOURNAL   Cells 13 (13), 1101 (2024)
   PUBMED   38994954
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4083)
  AUTHORS   Blazquez-Garcia,I., Guerrero,L., Cacho-Navas,C., Djouder,N.,
            Millan,J., Paradela,A., Carmona-Rodriguez,L. and Corrales,F.J.
  TITLE     Molecular Insights of Cholestasis in MDR2 Knockout Murine Liver
            Organoids
  JOURNAL   J Proteome Res 23 (4), 1433-1442 (2024)
   PUBMED   38488493
  REMARK    GeneRIF: Molecular Insights of Cholestasis in MDR2 Knockout Murine
            Liver Organoids.
REFERENCE   4  (bases 1 to 4083)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4083)
  AUTHORS   Furukawa,K., Okamoto-Matsuda,K., Harada,K.H., Minata,M., Hitomi,T.,
            Kobayashi,H. and Koizumi,A.
  TITLE     Role of ABCB1 and ABCB4 in renal and biliary excretion of
            perfluorooctanoic acid in mice
  JOURNAL   Environ Health Prev Med 29, 21 (2024)
   PUBMED   38522903
  REMARK    GeneRIF: Role of ABCB1 and ABCB4 in renal and biliary excretion of
            perfluorooctanoic acid in mice.
REFERENCE   6  (bases 1 to 4083)
  AUTHORS   Buschman,E., Arceci,R.J., Croop,J.M., Che,M., Arias,I.M.,
            Housman,D.E. and Gros,P.
  TITLE     mdr2 encodes P-glycoprotein expressed in the bile canalicular
            membrane as determined by isoform-specific antibodies
  JOURNAL   J Biol Chem 267 (25), 18093-18099 (1992)
   PUBMED   1381362
REFERENCE   7  (bases 1 to 4083)
  AUTHORS   Teeter,L.D., Petersen,D.D., Nebert,D.W. and Kuo,M.T.
  TITLE     Murine mdr-1, mdr-2, and mdr-3 gene expression: no coinduction with
            the Cyp1a-1 and Nmo-1 genes in liver by
            2,3,7,8-tetrachlorodibenzo-p-dioxin
  JOURNAL   DNA Cell Biol 10 (6), 433-441 (1991)
   PUBMED   2069718
REFERENCE   8  (bases 1 to 4083)
  AUTHORS   Buschman,E. and Gros,P.
  TITLE     Functional analysis of chimeric genes obtained by exchanging
            homologous domains of the mouse mdr1 and mdr2 genes
  JOURNAL   Mol Cell Biol 11 (2), 595-603 (1991)
   PUBMED   1990275
REFERENCE   9  (bases 1 to 4083)
  AUTHORS   Raymond,M., Rose,E., Housman,D.E. and Gros,P.
  TITLE     Physical mapping, amplification, and overexpression of the mouse
            mdr gene family in multidrug-resistant cells
  JOURNAL   Mol Cell Biol 10 (4), 1642-1651 (1990)
   PUBMED   1969609
REFERENCE   10 (bases 1 to 4083)
  AUTHORS   Dhir,R., Buschman,E. and Gros,P.
  TITLE     Structural and functional characterization of the mouse multidrug
            resistance gene family
  JOURNAL   Bull Cancer 77 (11), 1125-1129 (1990)
   PUBMED   1980424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144024.1, AK050345.1, CJ071650.1, AA239419.1, CB951185.1 and
            CX204859.1.
            
            On Nov 27, 2007 this sequence version replaced NM_008830.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150687.1, SRR13422597.1036308.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               AK144024.1         2-188
            188-2662            AK050345.1         141-2615
            2663-2911           CJ071650.1         214-462
            2912-3246           AA239419.1         45-379
            3247-3726           CB951185.1         45-524
            3727-4083           CX204859.1         226-582
FEATURES             Location/Qualifiers
     source          1..4083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.43 cM"
     gene            1..4083
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /note="ATP-binding cassette, sub-family B member 4"
                     /db_xref="GeneID:18670"
                     /db_xref="MGI:MGI:97569"
     exon            1..187
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            188..264
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..4024
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /EC_number="7.6.2.1"
                     /note="P glycoprotein 2; multidrug resistance protein 2;
                     P-glycoprotein 3; multidrug resistance protein 3;
                     ATP-binding cassette, sub-family B (MDR/TAP), member 4"
                     /codon_start=1
                     /product="phosphatidylcholine translocator ABCB4"
                     /protein_id="NP_032856.2"
                     /db_xref="CCDS:CCDS19086.1"
                     /db_xref="GeneID:18670"
                     /db_xref="MGI:MGI:97569"
                     /translation="MDLEAARNGTARRLDGDFELGSISNQGREKKKKVNLIGLLTLFR
                     YSDWQDKLFMFLGTLMAIAHGSGLPLMMIVFGEMTDKFVDNTGNFSLPVNFSLSMLNP
                     GRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQKFFHAILRQEMG
                     WFDIKGTTELNTRLTDDVSKISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTLVIM
                     AISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERY
                     QKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVF
                     FSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDNIKGNLE
                     FSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGKI
                     SIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKAVKEANA
                     YDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA
                     EVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSELMKKEGIYFRL
                     VNMQTAGSQILSEEFEVELSDEKAAGDVAPNGWKARIFRNSTKKSLKSPHQNRLDEET
                     NELDANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGALQPAFSIILSEMIAIFGPGD
                     DAVKQQKCNMFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMS
                     WFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLL
                     LLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFES
                     MYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVIL
                     VFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSGEGLWPDKFEGS
                     VTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAG
                     SVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVPHDEIVRAAK
                     EANIHPFIETLPQKYNTRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDT
                     ESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGI
                     YFSMVNIQAGTQNL"
     exon            265..319
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            320..470
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            471..528
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            529..720
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..892
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1017
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1189
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1303
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1414
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1540
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1744
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1915
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2077
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2248
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2395
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2500
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2578
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2662
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2866
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2967
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3108
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3265
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3463
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            3464..3670
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3817
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     exon            3818..4075
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4049..4054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /note="hexamer: AATAAA"
     polyA_site      4075
                     /gene="Abcb4"
                     /gene_synonym="mdr-2; Mdr2; Pgy-2; Pgy2"
                     /note="major polyA site"
ORIGIN      
        1 ggtggcgctg gggcctgcag agcctgcggg gcttgcggga gctctcctgc gggcccgggc
       61 cctcgccccc gccgcagcgg gaggcgtcgc cggcgccggg tgcgtgtggg aggcggggac
      121 gagccgcggc gagcaaagtc caggtctgcg cgccacccgc tgcggccaac acgcgcgtga
      181 agttcaggct gagatggatc ttgaggcagc gagaaacgga acagcacggc gcctggacgg
      241 cgactttgaa ctaggcagca tcagcaacca aggcagagaa aagaagaaga aagtgaattt
      301 aattggcctg ttgacactgt tccgatactc tgactggcag gataaattgt ttatgttcct
      361 gggcaccctc atggccatag ctcatggatc aggtcttccc ctcatgatga tagtctttgg
      421 agaaatgaca gataagtttg tagataatac tgggaacttt tccttgccag tgaatttttc
      481 attgtcaatg ctaaatccag gaagaatttt ggaagaagaa atgactagat atgcatacta
      541 ctattcggga ctaggtggtg gagttcttgt ggctgcctat atccaagtct cattctggac
      601 tttggcagct ggccgacaaa taaagaaaat caggcaaaaa ttttttcatg ccatcctccg
      661 acaagaaatg ggctggtttg acatcaaggg caccactgaa ctcaacacac gtctaacaga
      721 tgacgtctcc aaaatcagtg aaggaattgg tgacaaggtt ggaatgttct ttcaagcaat
      781 agccacgttt tttgcaggat tcatagtggg gttcatcaga ggatggaagc tcaccctcgt
      841 gatcatggcc atcagcccca tcctggggct ctctacagct gtttgggcaa agatactctc
      901 aacatttagt gacaaagagc tagctgcata tgcaaaagca ggtgccgtgg ctgaagaggc
      961 tctgggagcc atcaggaccg tgatagcttt cgggggccag aacaaagagc tagaaaggta
     1021 tcagaaacat ttagaaaatg ccaaaaagat tggaattaaa aaggctatct cagccaacat
     1081 ctccatgggt attgctttct tgttaatata tgcatcctat gcactggcct tctggtatgg
     1141 atccactctg gttatatcaa aagaatatac aattggaaat gcaatgacag tcttcttctc
     1201 aatcctcatc ggggctttca gtgtggggca ggctgccccc tgtattgatg ctttcgctaa
     1261 tgcaagagga gcagcctatg tgatctttga cattattgat aataatccta aaattgacag
     1321 tttttcagag agaggacaca aaccagacaa catcaaagga aatttggagt tcagtgatgt
     1381 tcatttttcc tatccatctc gggctaatat caagatcttg aagggcctca acctgaaggt
     1441 gaagagtgga cagacagtgg ctctggttgg caacagcggc tgtggaaaaa gcacaactgt
     1501 ccagctgctg cagaggctct acgaccccac agagggtaag attagcatcg atgggcagga
     1561 tatcaggaac tttaacgtca ggtgtctaag ggaaatcatt ggtgtggtaa gtcaagagcc
     1621 cgtgctgttc tctactacga tcgctgaaaa tatccgctat ggccgtggga atgtaacgat
     1681 ggatgagatt gagaaagccg tcaaagaggc caatgcctat gacttcatca tgaaactgcc
     1741 ccagaaattt gacaccctgg ttggtgatag aggggcgcag ctgagtgggg gacagaaaca
     1801 gagaatcgcc attgcccggg ccctggtccg caaccccaag atcctcctgc tggacgaggc
     1861 cacctcagcc ctggacactg aaagtgaagc tgaggtgcag gccgcactgg ataaggccag
     1921 agaaggccga accaccattg tgatagctca ccgattgtct accatccgga acgcagatgt
     1981 catcgctggg tttgaggatg gagtcattgt ggaacaagga agtcacagtg agctgatgaa
     2041 gaaggaaggg atctacttca gactcgttaa catgcagaca gcaggaagcc agatcctgtc
     2101 agaagaattt gaagttgagc taagtgacga aaaggctgct ggagatgtgg ccccaaatgg
     2161 ctggaaagca cgcatattta ggaattctac aaagaaaagt cttaaaagtc cacatcagaa
     2221 taggctggat gaagaaacca atgaacttga tgcaaacgtg ccaccagtgt cttttctgaa
     2281 ggtcttaaaa ctgaataaaa cagagtggcc ctactttgtg gtgggaacag tctgtgccat
     2341 tgccaatgga gccctccagc cggctttctc catcatcctg tctgagatga tagctatctt
     2401 tggccctggg gatgacgcag tgaagcagca aaagtgtaac atgttctccc tggtcttctt
     2461 gggcctagga gtcctctcct tctttacttt cttccttcag ggcttcacgt ttgggaaagc
     2521 tggagagatc ctcaccacaa ggctccggtc catggccttt aaagcgatgc taaggcagga
     2581 catgagctgg tttgatgatc ataaaaacag tactggagca ctttctacaa gactcgccac
     2641 agatgctgcg caagtccaag gagccacggg aaccaggttg gctttaattg cacagaacac
     2701 agccaacctt ggaaccggta ttattatatc atttatttac ggttggcaac tgacacttct
     2761 gctgttatcg gttgttccat tcattgctgt agcaggaatt gttgaaatga aaatgttggc
     2821 tggcaatgcc aagagagata aaaaggaaat ggaagctgct ggaaagattg caacagaggc
     2881 aatagaaaat attcgaactg ttgtatcctt gacccaagaa agaaaatttg agtcaatgta
     2941 tgttgaaaaa ttgcatggac cttacaggaa ttcggtgcgg aaggcacaca tctacggcat
     3001 cacttttagc atctcccaag cattcatgta tttttcttat gctggctgtt ttcgatttgg
     3061 ttcttaccta attgtgaatg gacatatgcg cttcaaagat gtcattctgg tcttttctgc
     3121 aattgtgctt ggcgcggtgg ctctaggaca cgccagctca tttgctccgg actatgcaaa
     3181 agccaagctg tctgcagcat acttgttcag cctgtttgaa agacaacctc tgattgacag
     3241 ctacagtgga gaagggctgt ggcctgataa gtttgaagga agcgtgacat ttaatgaagt
     3301 cgtgttcaac tatcccaccc gggccaacgt gccagtgctt caggggctga gccttgaggt
     3361 gaagaagggc cagacgctgg ccctggtggg cagcagtggc tgcgggaaga gcacagtggt
     3421 ccagctgctc gagcgcttct atgaccccat ggctggatca gtgctcttag atggtcaaga
     3481 agcaaagaaa ctcaatgtcc agtggctccg agctcaactg ggcattgtgt cccaggaacc
     3541 cattctcttt gactgcagca tcgcagagaa catcgcctat ggagacaaca gccgggtcgt
     3601 gcctcatgat gagattgtga gggcagccaa ggaggccaac atccacccct tcatcgagac
     3661 gctgccccaa aaatataaca caagagtagg agacaagggg acgcagctct ctgggggcca
     3721 gaagcagagg attgccatcg cccgagccct catcagacag cctcgggtcc tactgctgga
     3781 tgaagccacg tcagctctgg atactgagag tgaaaaggtt gtccaggaag cactggacaa
     3841 agccagggaa ggccgcacct gcattgtgat cgctcaccgc ctgtccacca tccagaacgc
     3901 ggacttgatc gtggtgattg agaacggcaa ggtcaaggag cacggcaccc accagcagct
     3961 gctggcgcag aagggcatct atttctcaat ggtcaacatc caggccggca cacagaactt
     4021 atgaactctt gttacagtat atttttaaaa taaattcaaa tcgtttttca ctttaaaaaa
     4081 aaa
//
