LOCUS       NM_011075               4344 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family B member 1B (Abcb1b),
            mRNA.
ACCESSION   NM_011075
VERSION     NM_011075.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4344)
  AUTHORS   Li,Y., Cui,W.W., Yang,Z.F., Liu,W.H., Bian,M.W., Deng,J. and
            Wang,T.
  TITLE     Influence of GPRC5A-Regulated ABCB1 Expression on Lung
            Adenocarcinoma Proliferation
  JOURNAL   Chin Med Sci J 39 (1), 9-18 (2024)
   PUBMED   38426412
  REMARK    GeneRIF: Influence of GPRC5A-Regulated ABCB1 Expression on Lung
            Adenocarcinoma Proliferation.
REFERENCE   2  (bases 1 to 4344)
  AUTHORS   Furukawa,K., Okamoto-Matsuda,K., Harada,K.H., Minata,M., Hitomi,T.,
            Kobayashi,H. and Koizumi,A.
  TITLE     Role of ABCB1 and ABCB4 in renal and biliary excretion of
            perfluorooctanoic acid in mice
  JOURNAL   Environ Health Prev Med 29, 21 (2024)
   PUBMED   38522903
  REMARK    GeneRIF: Role of ABCB1 and ABCB4 in renal and biliary excretion of
            perfluorooctanoic acid in mice.
REFERENCE   3  (bases 1 to 4344)
  AUTHORS   Wu,X., Song,L., Chen,X., Zhang,Y., Li,S. and Tang,X.
  TITLE     Long non-coding RNA LUCAT1 regulates the RAS pathway to promote the
            proliferation and invasion of malignant glioma cells through ABCB1
  JOURNAL   Exp Cell Res 421 (2), 113390 (2022)
   PUBMED   36270516
  REMARK    GeneRIF: Long non-coding RNA LUCAT1 regulates the RAS pathway to
            promote the proliferation and invasion of malignant glioma cells
            through ABCB1.
REFERENCE   4  (bases 1 to 4344)
  AUTHORS   Yamasaki,Y., Moriwaki,T., Ogata,S., Ito,S., Ohtsuki,S.,
            Minegishi,G., Abe,S., Ohta,Y., Kazuki,K., Kobayashi,K. and
            Kazuki,Y.
  TITLE     Influence of MDR1 gene polymorphism (2677G>T) on expression and
            function of P-glycoprotein at the blood-brain barrier: utilizing
            novel P-glycoprotein humanized mice with mutation
  JOURNAL   Pharmacogenet Genomics 32 (8), 288-292 (2022)
   PUBMED   35997049
  REMARK    GeneRIF: Influence of MDR1 gene polymorphism (2677G>T) on
            expression and function of P-glycoprotein at the blood-brain
            barrier: utilizing novel P-glycoprotein humanized mice with
            mutation.
REFERENCE   5  (bases 1 to 4344)
  AUTHORS   Song,Y.K., Kim,M.J., Kim,M.S., Lee,J.H., Chung,S.J., Song,J.S.,
            Chae,Y.J. and Lee,K.R.
  TITLE     Role of the efflux transporters Abcb1 and Abcg2 in the brain
            distribution of olaparib in mice
  JOURNAL   Eur J Pharm Sci 173, 106177 (2022)
   PUBMED   35341895
  REMARK    GeneRIF: Role of the efflux transporters Abcb1 and Abcg2 in the
            brain distribution of olaparib in mice.
REFERENCE   6  (bases 1 to 4344)
  AUTHORS   Chin,H., Mock,B., Kim,H.L., Kim,H. and Kozak,C.A.
  TITLE     The gene for the dihydropyridine-sensitive calcium channel alpha 2
            subunit (CCHL2A) maps to the proximal region of mouse chromosome 5
  JOURNAL   Genomics 13 (4), 1325-1327 (1992)
   PUBMED   1324224
REFERENCE   7  (bases 1 to 4344)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   8  (bases 1 to 4344)
  AUTHORS   Barrand,M.A. and Twentyman,P.R.
  TITLE     Differential recognition of mdr1a and mdr1b gene products in
            multidrug resistant mouse tumour cell lines by different monoclonal
            antibodies
  JOURNAL   Br J Cancer 65 (2), 239-245 (1992)
   PUBMED   1346747
REFERENCE   9  (bases 1 to 4344)
  AUTHORS   Kirschner,L.S., Greenberger,L.M., Hsu,S.I., Yang,C.P., Cohen,D.,
            Piekarz,R.L., Castillo,G., Han,E.K., Yu,L.J. and Horwitz,S.B.
  TITLE     Biochemical and genetic characterization of the multidrug
            resistance phenotype in murine macrophage-like J774.2 cells
  JOURNAL   Biochem Pharmacol 43 (1), 77-87 (1992)
   PUBMED   1346495
REFERENCE   10 (bases 1 to 4344)
  AUTHORS   Johnson,K.R., Cook,S.A., Bustin,M. and Davisson,M.T.
  TITLE     Genetic mapping of the murine gene and 14 related sequences
            encoding chromosomal protein HMG-14
  JOURNAL   Mamm Genome 3 (11), 625-632 (1992)
   PUBMED   1360278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030328.1, BQ829721.1, AK139854.1, BG080311.2, DV651684.1 and
            BY435708.1.
            
            On Nov 28, 2007 this sequence version replaced NM_011075.1.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the MDR/TAP subfamily. Members
            of the MDR/TAP subfamily are involved in multidrug resistance. This
            gene encodes a membrane glycoprotein which confers a
            multidrug-resistance phenotype. The protein encoded by the human
            gene is an ATP-dependent drug efflux pump for xenobiotic compounds
            which is responsible for decreased drug accumulation in
            multidrug-resistant cells and mediates the development of
            resistance to anticancer drugs. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-426               AK030328.1         2-427
            427-676             BQ829721.1         316-565
            677-2828            AK030328.1         620-2771
            2829-3227           AK139854.1         165-563
            3228-3632           BG080311.2         23-427
            3633-3997           DV651684.1         393-757
            3998-4344           BY435708.1         68-414
FEATURES             Location/Qualifiers
     source          1..4344
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.43 cM"
     gene            1..4344
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /note="ATP-binding cassette, sub-family B member 1B"
                     /db_xref="GeneID:18669"
                     /db_xref="MGI:MGI:97568"
     exon            1..143
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            144..214
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..3980
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.1"
                     /note="P glycoprotein 1; multidrug resistance protein 1;
                     ATP-binding cassette sub-family B member 1; ATP-binding
                     cassette, sub-family B (MDR/TAP), member 1B; multidrug
                     resistance protein 1B; phospholipid transporter ABCB1"
                     /codon_start=1
                     /product="ATP-dependent translocase ABCB1"
                     /protein_id="NP_035205.1"
                     /db_xref="CCDS:CCDS19085.1"
                     /db_xref="GeneID:18669"
                     /db_xref="MGI:MGI:97568"
                     /translation="MEFEENLKGRADKNFSKMGKKSKKEKKEKKPAVGVFGMFRYADW
                     LDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQSGPNSTLIIS
                     NSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIG
                     WFDVHDVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFISGWKLTLVIL
                     AVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQQKELERY
                     NKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGEVLTVF
                     FSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPDSIMGNLE
                     FKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVV
                     SIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANA
                     YDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA
                     VVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKL
                     VMTQTRGNEIEPGNNAYGSQSDTDASELTSEESKSPLIRRSIYRSVHRKQDQERRLSM
                     KEAVDEDVPLVSFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRD
                     DDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQD
                     ISWFDDHKNSTGSLTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLT
                     LLLVVIIPLIVLGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKF
                     ETMYAQSLQVPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENV
                     MLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLE
                     GNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPM
                     AGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRA
                     AKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSAL
                     DTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQK
                     GIYFSMVQAGAKRS"
     exon            215..263
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..426
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..484
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..676
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..848
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..973
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1145
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1259
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1370
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1496
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1700
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1871
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2033
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2207
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2354
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2462
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2540
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2624
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2828
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2929
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3070
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3227
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3425
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..3632
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3779
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
     exon            3780..4344
                     /gene="Abcb1b"
                     /gene_synonym="Abcb1; mdr; Mdr1; Mdr1b; Pgy-1; Pgy1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctccttcc cgcagtggct cttgaagccg taagaggctg aggccgctgc ttccatcttc
       61 tgaggttccg ctcaactcag agctacttcc aaattctaca tcttggctga ctttgcgaag
      121 gaaacccgga ggtggcacgt gaggtggtga tggagtttga agagaacctt aagggaagag
      181 cagacaagaa cttctcgaag atgggcaaaa agagtaaaaa ggagaagaaa gaaaagaaac
      241 ctgctgttgg cgtatttggg atgtttcgct atgcagattg gctggacaag ctgtgcatga
      301 ttctgggaac tctcgctgct attatccatg gaacattact tcccctcttg atgctggtgt
      361 ttggaaacat gacagatagt tttacaaaag cagaagccag tattctgcca agcattacta
      421 atcaaagtgg acccaacagt actctgatca tcagcaacag cagtctggag gaagagatgg
      481 ccatatacgc ctactattac accgggattg gtgctggtgt gctcatagtt gcctacatcc
      541 aggtttcact ttggtgcctg gcagctggaa gacagataca caagattagg cagaagtttt
      601 tccatgctat aatgaatcag gagataggct ggtttgatgt gcatgatgtt ggggagctca
      661 acacccggct cacagatgat gtctccaaaa ttaatgacgg aattggtgac aaaattggga
      721 tgttttttca gtccataacc acatttttag ccggttttat cataggattt ataagtggtt
      781 ggaagctaac ccttgtcatt ttggctgtca gccctcttat tggattgtca tctgctttgt
      841 gggcaaaggt attgacttca tttactaata aggaactcca ggcttatgca aaagctggag
      901 cagttgctga agaagtctta gcagccatca gaactgtgat tgcctttgga ggacaacaga
      961 aggaacttga aaggtacaat aaaaatttag aagaagctaa aaatgttggc ataaagaaag
     1021 ctatcacagc cagcatttcg ataggcattg cctacctgtt ggtctatgca tcatatgcac
     1081 tggcattctg gtatgggaca tccttggtcc tctcaaatga atattctatt ggagaagtgc
     1141 ttactgtctt cttctctatt ttgttgggga cttttagtat tggacacttg gccccaaaca
     1201 tagaagcctt tgcaaacgca cgaggggcag cctttgaaat cttcaagata attgataacg
     1261 agccaagcat tgacagcttc tcaacaaagg gctacaaacc agacagtata atgggaaact
     1321 tagagtttaa aaatgttcac ttcaactacc catcgagaag cgaagttcag atcttgaagg
     1381 gcctcaatct gaaggtgaag agcggacaga cggtggccct ggttggcaac agtggctgtg
     1441 gaaaaagcac aactgtccag ctgatgcaga ggctctacga ccccctggag ggcgtggtca
     1501 gtatcgacgg acaagacatc agaaccatca atgtgaggta tctgagggag atcattggtg
     1561 tggtgagtca ggaacctgtg ctgtttgcca ccacgatcgc cgagaacatt cgctatggcc
     1621 gagaagatgt caccatggat gagattgaga aagctgtcaa ggaagccaat gcctatgact
     1681 tcatcatgaa actgccccac caatttgaca ccctggttgg tgagagaggg gcgcagctga
     1741 gtgggggaca gaaacagaga atcgccattg cccgggccct ggtccgcaat cccaagatcc
     1801 ttttgttgga cgaggccacc tcagccctgg atacagaaag tgaagctgtg gtgcaggccg
     1861 cactggataa ggctagagaa ggccggacca ccattgtgat agctcatcgc ttgtctacag
     1921 ttcgtaatgc tgacgtcatt gctggttttg atggtggtgt cattgtggag caaggaaatc
     1981 atgatgagct catgagagaa aagggcattt acttcaaact tgtcatgaca cagactagag
     2041 gaaatgaaat tgaaccagga aataatgctt atggatccca gagtgacact gatgcttctg
     2101 aactgacttc agaagaatcc aaatcacctt taataaggag atcaatttac agaagtgtcc
     2161 acagaaagca agaccaagag agaagactta gtatgaaaga ggctgtggat gaagatgtgc
     2221 ctctggtttc cttttggcgg atcctaaatc taaatctaag tgaatggcct tatttacttg
     2281 ttggcgtact ttgcgctgtt ataaatgggt gcatacaacc agtgtttgcc atagtatttt
     2341 caaggattgt aggggttttt tcaagagatg atgaccatga aactaaacga cagaattgta
     2401 atttgttttc cctgttcttt ctggttatgg ggctgatttc ttttgttaca tatttctttc
     2461 agggcttcac atttggcaaa gccggagaga tcctcaccaa gcgagtccga tacatggttt
     2521 tcaaatccat gctgagacag gatataagct ggttcgatga ccataagaac agcactggct
     2581 cactgaccac caggctcgcc agtgatgctt ctagtgttaa aggggcgatg ggcgccaggc
     2641 ttgctgtagt tacccagaat gtagcaaacc tcgggacagg agtcatcctc tccttagtct
     2701 atggctggca gctgacactt ctacttgtag taattatacc gctcattgta ttgggcggaa
     2761 ttattgaaat gaagctgttg tctggccaag ccttgaagga caagaaacag cttgagatct
     2821 ctgggaagat tgctacagaa gcaattgaaa acttccgcac tattgtctct ttgactcggg
     2881 agcagaagtt tgaaaccatg tatgcccaga gcttgcaggt accatacaga aatgcgatga
     2941 agaaagcaca cgtgtttggg atcacgttct ccttcaccca ggccatgatg tatttttctt
     3001 atgctgcttg tttccggttc ggtgcctact tggtggcaca acaactcatg acttttgaaa
     3061 atgttatgtt ggtattttct gctgttgtct ttggtgccat ggcagctggg aatactagtt
     3121 catttgctcc tgactatgcg aaagccaaag tatcagcatc tcatatcatc aggatcattg
     3181 agaaaacccc tgagattgac agctacagca cagagggctt gaagcctact ctgttagaag
     3241 gaaatgtaaa atttaatgga gtccagttta actatcccac ccgacccaac atcccagtgc
     3301 ttcaggggct gagcctcgag gtgaagaagg gccagacgtt ggccctggtg ggcagcagtg
     3361 gctgtgggaa gagcacagtg gtccagctgc tcgagcgctt ctacgacccc atggctggat
     3421 cagtgtttct agatggcaaa gaaataaagc aactgaatgt ccagtggctc cgagctcacc
     3481 ttggcattgt gtcccaggag cccattctct ttgactgcag cattgcagag aacatcgcct
     3541 atggagacaa cagccgggcc gtgtctcatg aggagattgt gagggcagcc aaggaggcca
     3601 acatccacca gttcatcgac tcactgcctg ataaatacaa caccagagta ggagacaaag
     3661 gcactcagct gtcgggtggg cagaagcagc gcatcgccat cgcacgtgcc ctcgtcagac
     3721 agcctcacat tttacttctg gacgaagcaa catcagctct ggatacagaa agtgaaaagg
     3781 ttgtccagga agcgctggac aaagccaggg aaggccgcac ctgcattgtg atcgctcacc
     3841 gcctgtccac catccagaac gcggacttga tcgtggtgat tgagaacggc aaagtcaagg
     3901 agcacggcac ccaccagcag ctgctggcgc agaagggcat ctacttctca atggtccagg
     3961 ctggagcaaa gcgctcatga gctgtgacta tctgaggtgc taagtatttt taatattggt
     4021 gtttaaacat ggcaccaaac caaagttaaa aggcaagggc tgttaaaggt aactccatca
     4081 agatgagaag ccttccgaga ctttgtaatt aaatgaacca aaatcggaaa caaacaaaca
     4141 aacaaacaaa caagccatag ttaaacaggg ccatgttttt aattgcatta cgtgattcat
     4201 aagagaacat atagtttttt aaaataaaat gtataatttt gtttcagttt ttaatttcta
     4261 ccctactttc ttaaatgatt ataaagattg taaaaagcac tatttcttaa attgcctata
     4321 aaaattaaat tttcatataa ttgg
//
