LOCUS       NM_011076               5177 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus ATP-binding cassette, sub-family B member 1A (Abcb1a),
            mRNA.
ACCESSION   NM_011076 XM_006503555
VERSION     NM_011076.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5177)
  AUTHORS   Furukawa,K., Okamoto-Matsuda,K., Harada,K.H., Minata,M., Hitomi,T.,
            Kobayashi,H. and Koizumi,A.
  TITLE     Role of ABCB1 and ABCB4 in renal and biliary excretion of
            perfluorooctanoic acid in mice
  JOURNAL   Environ Health Prev Med 29, 21 (2024)
   PUBMED   38522903
REFERENCE   2  (bases 1 to 5177)
  AUTHORS   Nabi,D., Bosi,D., Gupta,N., Thaker,N., Fissore,R. and Brayboy,L.M.
  TITLE     Multidrug resistance transporter-1 dysfunction perturbs meiosis and
            Ca2+ homeostasis in oocytes
  JOURNAL   Reproduction 165 (1), 79-91 (2022)
   PUBMED   36215093
  REMARK    GeneRIF: Multidrug resistance transporter-1 dysfunction perturbs
            meiosis and Ca2+ homeostasis in oocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5177)
  AUTHORS   Puris,E., Saveleva,L., Gorova,V., Vartiainen,P., Kortelainen,M.,
            Lamberg,H., Sippula,O., Malm,T., Jalava,P.I., Auriola,S.,
            Fricker,G. and Kanninen,K.M.
  TITLE     Air pollution exposure increases ABCB1 and ASCT1 transporter levels
            in mouse cortex
  JOURNAL   Environ Toxicol Pharmacol 96, 104003 (2022)
   PUBMED   36283621
  REMARK    GeneRIF: Air pollution exposure increases ABCB1 and ASCT1
            transporter levels in mouse cortex.
REFERENCE   4  (bases 1 to 5177)
  AUTHORS   Fujita,A., Noguchi,S., Hamada,R., Inoue,S., Shimada,T.,
            Katakura,S., Maruyama,T., Sai,Y., Nishimura,T. and Tomi,M.
  TITLE     Limited Impact of Murine Placental MDR1 on Fetal Exposure of
            Certain Drugs Explained by Bypass Transfer Between Adjacent
            Syncytiotrophoblast Layers
  JOURNAL   Pharm Res 39 (7), 1645-1658 (2022)
   PUBMED   35083640
  REMARK    GeneRIF: Limited Impact of Murine Placental MDR1 on Fetal Exposure
            of Certain Drugs Explained by Bypass Transfer Between Adjacent
            Syncytiotrophoblast Layers.
REFERENCE   5  (bases 1 to 5177)
  AUTHORS   Song,Y.K., Kim,M.J., Kim,M.S., Lee,J.H., Chung,S.J., Song,J.S.,
            Chae,Y.J. and Lee,K.R.
  TITLE     Role of the efflux transporters Abcb1 and Abcg2 in the brain
            distribution of olaparib in mice
  JOURNAL   Eur J Pharm Sci 173, 106177 (2022)
   PUBMED   35341895
  REMARK    GeneRIF: Role of the efflux transporters Abcb1 and Abcg2 in the
            brain distribution of olaparib in mice.
REFERENCE   6  (bases 1 to 5177)
  AUTHORS   Kuo,M.T., Zhao,J.Y., Teeter,L.D., Ikeguchi,M. and Chisari,F.V.
  TITLE     Activation of multidrug resistance (P-glycoprotein) mdr3/mdr1a gene
            during the development of hepatocellular carcinoma in hepatitis B
            virus transgenic mice
  JOURNAL   Cell Growth Differ 3 (8), 531-540 (1992)
   PUBMED   1356418
REFERENCE   7  (bases 1 to 5177)
  AUTHORS   Sugawara,I., Hirata,A., Ueda,K. and Itoyama,S.
  TITLE     Preparation and characterization of a murine monoclonal antibody
            (MDR3M) reactive with mdr3 gene product
  JOURNAL   Jpn J Cancer Res 83 (8), 795-797 (1992)
   PUBMED   1328122
REFERENCE   8  (bases 1 to 5177)
  AUTHORS   Kirschner,L.S., Greenberger,L.M., Hsu,S.I., Yang,C.P., Cohen,D.,
            Piekarz,R.L., Castillo,G., Han,E.K., Yu,L.J. and Horwitz,S.B.
  TITLE     Biochemical and genetic characterization of the multidrug
            resistance phenotype in murine macrophage-like J774.2 cells
  JOURNAL   Biochem Pharmacol 43 (1), 77-87 (1992)
   PUBMED   1346495
REFERENCE   9  (bases 1 to 5177)
  AUTHORS   Ikeguchi,M., Teeter,L.D., Eckersberg,T., Ganapathi,R. and Kuo,M.T.
  TITLE     Structural and functional analyses of the promoter of the murine
            multidrug resistance gene mdr3/mdr1a reveal a negative element
            containing the AP-1 binding site
  JOURNAL   DNA Cell Biol 10 (9), 639-649 (1991)
   PUBMED   1684503
REFERENCE   10 (bases 1 to 5177)
  AUTHORS   Raymond,M., Rose,E., Housman,D.E. and Gros,P.
  TITLE     Physical mapping, amplification, and overexpression of the mouse
            mdr gene family in multidrug-resistant cells
  JOURNAL   Mol Cell Biol 10 (4), 1642-1651 (1990)
   PUBMED   1969609
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107733.14, AC121955.2 and AC140398.2.
            
            On or before Dec 20, 2017 this sequence version replaced
            XM_006503555.3, NM_011076.2.
            
            Summary: The membrane-associated protein encoded by this gene is a
            member of the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the MDR/TAP subfamily. Members
            of the MDR/TAP subfamily are involved in multidrug resistance as
            well as antigen presentation. This gene encodes a p-glycoprotein
            which actively transports a variety of hydrophobic amphipathic
            drugs and plays a major role in the blood-brain barrier
            permeability of certain drugs. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.196846.1,
                                           SRR6116558.127839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC107733.14        179010-179148
            140-184             AC121955.2         73792-73836
            185-326             AC121955.2         128577-128718
            327-397             AC121955.2         129158-129228
            398-446             AC121955.2         133042-133090
            447-606             AC121955.2         143179-143338
            607-658             AC121955.2         151880-151931
            659-761             AC121955.2         153717-153819
            762-850             AC140398.2         131920-132008       c
            851-1022            AC140398.2         131034-131205       c
            1023-1147           AC140398.2         123142-123266       c
            1148-1319           AC140398.2         118675-118846       c
            1320-1433           AC140398.2         115610-115723       c
            1434-1544           AC140398.2         115355-115465       c
            1545-1670           AC140398.2         115054-115179       c
            1671-1874           AC140398.2         114760-114963       c
            1875-2045           AC140398.2         114369-114539       c
            2046-2207           AC140398.2         103984-104145       c
            2208-2384           AC140398.2         102269-102445       c
            2385-2531           AC140398.2         101444-101590       c
            2532-2639           AC140398.2         98246-98353         c
            2640-2717           AC140398.2         97264-97341         c
            2718-2801           AC140398.2         94090-94173         c
            2802-3005           AC140398.2         90356-90559         c
            3006-3106           AC140398.2         84940-85040         c
            3107-3247           AC140398.2         83593-83733         c
            3248-3404           AC140398.2         79561-79717         c
            3405-3602           AC140398.2         78440-78637         c
            3603-3809           AC140398.2         76717-76923         c
            3810-3956           AC140398.2         70677-70823         c
            3957-5177           AC140398.2         68757-69977         c
FEATURES             Location/Qualifiers
     source          1..5177
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.43 cM"
     gene            1..5177
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /note="ATP-binding cassette, sub-family B member 1A"
                     /db_xref="GeneID:18671"
                     /db_xref="MGI:MGI:97570"
     exon            1..139
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            140..184
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            185..326
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            327..397
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..4163
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.1"
                     /note="ecotropic viral integration site 32; ATP-binding
                     cassette, sub-family B (MDR/TAP), member 4; multi-drug
                     resistance 3; ATP-binding cassette, subfamily B, member
                     1A; ATP-binding cassette, sub-family B (MDR/TAP), member
                     1A; multidrug resistance protein 3; P-glycoprotein 3;
                     multiple drug resistant 1a; phospholipid transporter
                     ABCB1"
                     /codon_start=1
                     /product="ATP-dependent translocase ABCB1"
                     /protein_id="NP_035206.2"
                     /db_xref="CCDS:CCDS19084.1"
                     /db_xref="GeneID:18671"
                     /db_xref="MGI:MGI:97570"
                     /translation="MELEEDLKGRADKNFSKMGKKSKKEKKEKKPAVSVLTMFRYAGW
                     LDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAK
                     LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFD
                     VHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAIS
                     PVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNN
                     LEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSV
                     LIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKN
                     IHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSID
                     GQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDF
                     IMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ
                     AALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMT
                     QTAGNEIELGNEACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSICGPHDQDRKLSTKE
                     ALDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGP
                     PETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVS
                     WFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLL
                     LLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFET
                     MYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLL
                     VFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGN
                     VQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAG
                     SVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAK
                     EANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDT
                     ESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGI
                     YFSMVSVQAGAKRS"
     exon            398..446
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            447..606
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            607..658
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            659..850
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1022
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1147
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1319
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1433
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1544
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1670
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1874
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2045
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2207
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2384
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2531
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2639
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2717
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2801
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..3005
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3106
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3247
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3404
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3405..3602
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3603..3809
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3810..3956
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..5177
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4511..4516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /note="hexamer: TATAAA"
     polyA_site      4535
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /note="major polyA site"
     regulatory      5095..5100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /note="hexamer: AATAAA"
     polyA_site      5120
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /note="major polyA site"
     regulatory      5152..5157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
                     /note="hexamer: ATTAAA"
     polyA_site      5175
                     /gene="Abcb1a"
                     /gene_synonym="Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp;
                     Pgp; Pgy-3; Pgy3"
ORIGIN      
        1 ttaaagacta tcatttctct ttgtccgcgg agtcagacag aacaagaaga aatccacttg
       61 attcaggtac tctcaagatt ctgacaggat taaattctcc ttctttaagc gcttatgcct
      121 ggaagcattc agataaaagg gggaatggag taagaaggct gactctgtaa gcacattctt
      181 caagaaagcc caggcacagt ggaacagcgg tttccaggag ctgctggtcc catcttccaa
      241 ggctctgctc aactcagagc cgcttcttcc aaagtctaca tcttggtgga ctttgcagag
      301 gaaaccggga ggtagagaca cgtgaggtcg tgatggaact tgaagaggac cttaagggaa
      361 gagcagacaa gaacttctca aagatgggca aaaagagtaa aaaggagaag aaagaaaaga
      421 aaccagcagt cagtgtgctt acaatgtttc gttatgcagg ttggctggac aggttgtaca
      481 tgctggtggg aactctggct gctattatcc atggagtggc gctcccactt atgatgctga
      541 tctttggtga catgacagat agctttgcaa gtgtaggaaa cgtctctaaa aacagtacta
      601 atatgagtga ggccgataaa agagccatgt ttgccaaact ggaggaagaa atgaccacgt
      661 acgcctacta ttacaccggg attggtgctg gtgtgctcat agttgcctac atccaggttt
      721 cattttggtg cctggcagct ggaagacaga tacacaagat caggcagaag ttttttcatg
      781 ctataatgaa tcaggagata ggctggtttg atgtgcatga cgttggggag ctcaacaccc
      841 ggctcacaga tgatgtttcc aaaattaatg aaggaattgg tgacaaaatc ggaatgttct
      901 tccaggcaat ggcaacattt tttggtggtt ttataatagg atttacccgt ggctggaagc
      961 taacccttgt gattttggcc atcagccctg ttcttggact gtcagctggt atttgggcaa
     1021 agatattgtc ttcatttact gataaggaac tccatgctta tgcaaaagct ggagcagttg
     1081 ctgaagaagt cttagcagcc atcagaactg tgattgcgtt tggaggacaa aagaaggaac
     1141 ttgaaaggta caataacaac ttggaagaag ctaaaaggct ggggataaag aaagctatca
     1201 cggccaacat ctccatgggt gcagcttttc tccttatcta tgcatcatat gctctggcat
     1261 tctggtatgg gacttccttg gtcatctcca aagaatactc tattggacaa gtgctcactg
     1321 tcttcttttc cgtgttaatt ggagcattca gtgttggaca ggcatctcca aatattgaag
     1381 ccttcgccaa tgcacgagga gcagcttatg aagtcttcaa aataattgat aataagccca
     1441 gtatagacag cttctcaaag agtgggcaca aaccagacaa catacaagga aatctggaat
     1501 ttaagaatat tcacttcagt tacccatctc gaaaagaagt tcagatcttg aagggcctca
     1561 atctgaaggt gaagagcgga cagacggtgg ccctggttgg caacagtggc tgtggaaaaa
     1621 gcacaactgt ccagctgatg caaaggctct acgaccccct agatggcatg gtcagtatcg
     1681 acggacagga catcagaacc atcaatgtga ggtatctgag ggagatcatt ggtgtggtga
     1741 gtcaggaacc tgtgctgttt gccaccacga tcgccgagaa cattcgctat ggccgagaag
     1801 atgtcaccat ggatgagatt gagaaagctg tcaaggaagc caatgcctat gacttcatca
     1861 tgaaactgcc ccaccaattt gacaccctgg ttggtgagag aggggcgcag ctgagtgggg
     1921 gacagaaaca gagaatcgcc attgcccggg ccctggtccg caatcccaag atccttttgt
     1981 tggacgaggc cacctcagcc ctggatacag aaagtgaagc tgtggttcag gccgcactgg
     2041 ataaggctag agaaggccgg accaccattg tgatagctca tcgcttgtct accgttcgta
     2101 atgctgacgt cattgctggt tttgatggtg gtgtcattgt ggagcaagga aatcatgatg
     2161 agctcatgag agaaaagggc atttacttca aacttgtcat gacacagaca gcaggaaatg
     2221 aaattgaatt aggaaatgaa gcttgtaaat ctaaggatga aattgataat ttagacatgt
     2281 cttcaaaaga ttcaggatcc agtctaataa gaagaagatc aactcgcaaa agcatctgtg
     2341 gaccacatga ccaagacagg aagcttagta ccaaagaggc cctggatgaa gatgtacctc
     2401 cagcttcctt ttggcggatc ctgaagttga attcaactga atggccttat tttgtggttg
     2461 gtatattctg tgccataata aatggaggct tacagccagc attctccgta atattttcaa
     2521 aagttgtagg ggtttttaca aatggtggcc cccctgaaac ccagcggcag aacagcaact
     2581 tgttttcctt gttgtttctg atccttggga tcatttcttt cattacattt tttcttcagg
     2641 gcttcacatt tggcaaagct ggagagatcc tcaccaagcg actccgatac atggttttca
     2701 aatccatgct gagacaggat gtgagctggt ttgatgaccc taaaaacacc accggagcac
     2761 tgaccaccag gctcgccaac gatgctgctc aagtgaaagg ggctacaggg tctaggcttg
     2821 ctgtgatttt ccagaacata gcaaatcttg ggacaggaat catcatatcc ctaatctatg
     2881 gctggcaact aacactttta ctcttagcaa ttgtacccat cattgcgata gcaggagtgg
     2941 ttgaaatgaa aatgttgtct ggacaagcac tgaaagataa gaaggaacta gaaggttctg
     3001 gaaagattgc tacggaagca attgaaaact tccgcactgt tgtctctttg actcgggagc
     3061 agaagtttga aaccatgtat gcccagagct tgcagatacc atacagaaat gcgatgaaga
     3121 aagcacacgt gtttgggatc acgttctcct tcacccaggc catgatgtat ttttcttatg
     3181 ctgcttgttt ccggttcggt gcctacttgg tgacacaaca actcatgact tttgaaaatg
     3241 ttctgttagt attctcagct attgtctttg gtgccatggc agtggggcag gtcagttcat
     3301 tcgctcctga ctatgcgaaa gccacagtgt cagcatccca catcatcagg atcattgaga
     3361 aaacccccga gattgacagc tacagcacgc aaggcctaaa gccgaatatg ttggaaggaa
     3421 atgtgcaatt tagtggagtc gtgttcaact atcccacccg acccagcatc ccagtgcttc
     3481 aggggctgag ccttgaggtg aagaagggcc agacgctggc cctggtgggc agcagtggct
     3541 gcgggaagag cacagtggtc cagctgctcg agcgcttcta cgaccccatg gctggatcag
     3601 tgtttctaga tggcaaagaa ataaagcaac tgaatgtcca gtggctccga gcacagctgg
     3661 gcattgtgtc ccaagagccc attctctttg actgcagcat cgcagagaac attgcctacg
     3721 gagacaacag ccgggtcgtg tcttatgagg agattgtgag ggcagccaag gaggccaaca
     3781 tccaccagtt catcgactcg ctacctgata aatacaacac cagagtagga gacaaaggca
     3841 ctcagctgtc gggtgggcag aagcagcgca tcgccatcgc acgcgccctc gtcagacagc
     3901 ctcacatttt acttctggac gaagcaacat cagctctgga tacagaaagt gaaaaggttg
     3961 tccaggaagc gctggacaaa gccagggaag gccgcacctg cattgtgatc gctcaccgcc
     4021 tgtccaccat ccagaacgcg gacttgatcg tggtgattca gaacggcaag gtcaaggagc
     4081 acggcaccca ccagcagctg ctggcgcaga agggcatcta cttctcaatg gtcagtgtgc
     4141 aggctggagc aaagcgctca tgaactgtga ccatgtaaga tgttaagtat ttttattgtt
     4201 tgtattcata tatggtgttt aatccaagtc aaaaggaaaa cacttactaa aatagccagt
     4261 tatctatttt ctgccacagt ggaaagcatt tagtttggtt tagagtcttc agaggctttg
     4321 taattaaaaa aacaaaaata gatacagcat caaatggaga ttaatgcttt aaaatgcact
     4381 ataaaattta taaaagggtt aaaagtgaat gtttgataat atatactttt atttatactt
     4441 tctcatttgt aactataact gatttctgct taacaaatta tgtatgtatc aaaaattact
     4501 gaaatgtttg tataaagtat atatagtgaa actgagcatt catatttttg agttattttg
     4561 ctcaaaatgc atgcgaaatt atatattgtc ccaactggaa tattgtacat aattttagcc
     4621 tttaaaaaac agtccattac tggggggagg gggcatcact ctatgggcaa agtgttactc
     4681 agacatgggc acctgagttc agatccctac cacctaagta agcagcaagg tgtggtgttt
     4741 ttgtaatgcc agtgctagag gcagaaacag acagatcctg caggctcagt ggctggccaa
     4801 acagcctagc caacatagcg cgttccaggt tcagtgagaa aacttgtctc aaaaatcaga
     4861 gggaaaagca aatgagggtg tcagccatgt gcactcatgc aaatgccata catgcagaag
     4921 tatgtgcaca cacacgcaca cattaaccaa cgactagcaa ggaaaatgaa ggtggataag
     4981 aggggtggga ctgggacaaa ggagggtacc tggatgaata tgactgaagg acgttatgta
     5041 cacatatgaa aacgtcgtac tgaaactcac tacaatgtat acttaatata tgctaataaa
     5101 atatttttaa aagaaaaaaa tatccataat tgtaaataag aggatcttat aattaaaaga
     5161 ccctaaggat tctaaca
//
